Experiment set64S268 for Escherichia coli BW25113

Compare to:

Lambda_ci1857

200 most important genes:

  gene name fitness t score description  
b0912 ihfB -5.2 -3.6 integration host factor subunit beta (NCBI) compare
b0685 ybfE -5.1 -3.5 orf, hypothetical protein (VIMSS) compare
b0015 dnaJ -4.3 -5.2 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b3149 yraO -4.2 -5.7 DnaA initiator-associating factor for replication initiation (NCBI) conserved
b0393 rdgC -4.1 -8.3 recombination associated protein (NCBI) conserved
b2314 dedD -4.0 -3.9 putative lipoprotein (VIMSS) compare
b0019 nhaA -4.0 -4.7 pH-dependent sodium/proton antiporter (NCBI) compare
b2678 proW -3.8 -6.3 glycine betaine transporter subunit (NCBI) compare
b3387 dam -3.8 -2.6 DNA adenine methylase (NCBI) compare
b1176 minC -3.7 -2.6 septum formation inhibitor (NCBI) compare
b4032 malG -3.7 -7.4 maltose transporter subunit (NCBI) conserved
b1334 fnr -3.5 -2.4 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0032 carA -3.5 -4.8 carbamoyl-phosphate synthase small subunit (NCBI) compare
b4033 malF -3.5 -9.1 maltose transporter subunit (NCBI) conserved
b1085 b1085 -3.5 -2.7 orf, hypothetical protein (VIMSS) compare
b3839 tatC -3.4 -3.3 TatABCE protein translocation system subunit (NCBI) compare
b0440 hupB -3.4 -4.1 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b4000 hupA -3.4 -4.6 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b2679 proX -3.4 -4.0 glycine betaine transporter subunit (NCBI) compare
b4201 priB -3.2 -2.2 primosomal replication protein N (NCBI) compare
b2904 gcvH -3.2 -2.8 glycine cleavage system protein H (NCBI) compare
b2531 iscR -3.1 -2.1 DNA-binding transcriptional repressor (NCBI) compare
b1062 pyrC -3.1 -4.8 dihydroorotase (NCBI) compare
b1493 gadB -3.1 -1.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b4245 pyrB -3.1 -7.9 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b3642 pyrE -3.1 -3.0 orotate phosphoribosyltransferase (NCBI) compare
b3021 ygiT -3.0 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b0438 clpX -3.0 -2.1 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3781 trxA -3.0 -2.9 thioredoxin 1 (VIMSS) compare
b0888 trxB -2.9 -2.0 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b3813 uvrD -2.9 -12.4 DNA-dependent ATPase I and helicase II (NCBI) conserved
b2017 yefM -2.9 -1.8 orf, hypothetical protein (VIMSS) compare
b2528 iscA -2.9 -1.9 iron-sulfur cluster assembly protein (NCBI) compare
b0033 carB -2.8 -10.7 carbamoyl-phosphate synthase large subunit (NCBI) compare
b1231 tyrT -2.8 -1.4 tRNA-Tyr (NCBI) compare
b3838 tatB -2.8 -7.0 sec-independent translocase (NCBI) compare
b4699 fnrS -2.8 -1.3 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b0437 clpP -2.8 -1.9 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b3973 birA -2.7 -3.0 biotin--protein ligase (NCBI) compare
b1175 minD -2.7 -4.2 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b1248 b1248 -2.7 -2.2 orf, hypothetical protein (VIMSS) compare
b3164 pnp -2.7 -1.8 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1594 dgsA -2.7 -1.8 DNA-binding transcriptional repressor (NCBI) compare
b1850 eda -2.7 -1.8 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1095 fabF -2.7 -7.4 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2597 yfiA -2.6 -1.8 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b3405 ompR -2.6 -1.8 osmolarity response regulator (NCBI) compare
b2388 glk -2.6 -5.6 glucokinase (NCBI) compare
b1109 ndh -2.6 -3.1 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b4045 yjbJ -2.6 -2.5 predicted stress response protein (NCBI) compare
b3778 rep -2.5 -2.5 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3414 gntY -2.5 -3.4 predicted gluconate transport associated protein (NCBI) compare
b2677 proV -2.5 -8.3 glycine betaine transporter subunit (NCBI) conserved
b3652 recG -2.5 -5.5 ATP-dependent DNA helicase (NCBI) compare
b3017 sufI -2.5 -8.3 repressor protein for FtsI (NCBI) compare
b3844 fre -2.5 -3.7 NAD(P)H-flavin reductase (NCBI) compare
b0945 pyrD -2.4 -4.4 dihydroorotate dehydrogenase (NCBI) compare
b0741 pal -2.4 -2.3 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1217 chaB -2.4 -1.6 cation transport regulator (NCBI) compare
b0740 tolB -2.3 -2.3 translocation protein TolB precursor (NCBI) compare
b1192 ldcA -2.3 -4.7 L,D-carboxypeptidase A (NCBI) compare
b0937 ssuE -2.3 -1.8 NAD(P)H-dependent FMN reductase (NCBI) compare
b2895 fldB -2.3 -2.9 flavodoxin 2 (NCBI) compare
b0386 proC -2.3 -3.1 pyrroline-5-carboxylate reductase (NCBI) compare
b4203 rplI -2.3 -3.1 50S ribosomal protein L9 (NCBI) compare
b0082 mraW -2.3 -3.1 S-adenosyl-methyltransferase (NCBI) compare
b4234 yjgA -2.3 -3.9 hypothetical protein (NCBI) compare
b2501 ppk -2.2 -6.4 polyphosphate kinase (NCBI) compare
b2954 yggV -2.2 -4.4 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b0853 ybjN -2.2 -4.4 predicted oxidoreductase (NCBI) compare
b3613 yibP -2.1 -2.1 putative membrane protein (VIMSS) compare
b1804 rnd -2.1 -3.5 ribonuclease D (NCBI) compare
b3636 rpmG -2.1 -1.6 50S ribosomal protein L33 (NCBI) compare
b1863 ruvC -2.1 -1.4 Holliday junction resolvase (NCBI) compare
b0806 ybiM -2.1 -2.0 orf, hypothetical protein (VIMSS) compare
b0471 ybaB -2.0 -2.4 hypothetical protein (NCBI) compare
b4414 tff -2.0 -3.0 unknown RNA (NCBI) compare
b1658 purR -2.0 -3.9 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b2435 amiA -2.0 -3.6 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b0053 surA -2.0 -1.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2796 sdaC -2.0 -9.5 predicted serine transporter (NCBI) conserved
b1438 ydcQ -2.0 -2.9 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1992 cobS -1.9 -1.7 cobalamin synthase (NCBI) compare
b0439 lon -1.9 -1.3 DNA-binding ATP-dependent protease La (NCBI) compare
b4410 ecnA -1.9 -1.3 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b3180 yhbY -1.9 -2.8 predicted RNA-binding protein (NCBI) conserved
b2276 nuoN -1.8 -2.8 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2363 yfdT -1.8 -1.3 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2673 nrdH -1.8 -2.2 glutaredoxin-like protein (NCBI) compare
b0746 valZ -1.8 -1.5 tRNA-Val (NCBI) compare
b3792 wzxE -1.8 -4.6 O-antigen translocase (NCBI) compare
b2377 yfdY -1.8 -2.4 predicted inner membrane protein (NCBI) compare
b1842 holE -1.8 -1.7 DNA polymerase III, theta subunit (NCBI) compare
b0739 tolA -1.8 -2.1 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1359 ydaU -1.8 -3.1 Rac prophage; conserved protein (NCBI) compare
b3162 deaD -1.8 -1.2 inducible ATP-independent RNA helicase (VIMSS) compare
b3871 bipA -1.8 -7.2 GTP-binding protein (NCBI) compare
b1355 b1355 -1.7 -2.9 orf, hypothetical protein (VIMSS) compare
b2506 yfgI -1.7 -1.7 hypothetical protein (NCBI) compare
b2909 ygfB -1.7 -5.1 orf, hypothetical protein (VIMSS) compare
b3250 mreC -1.7 -1.8 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b1874 cutC -1.7 -2.0 copper homeostasis protein (NCBI) compare
b2281 nuoI -1.7 -1.6 NADH dehydrogenase subunit I (NCBI) compare
b1882 cheY -1.7 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b4577 sgrS -1.7 -1.8 small antisense RNA (NCBI) compare
b1514 lsrC -1.7 -1.6 AI2 transporter (NCBI) compare
b0767 ybhE -1.7 -3.2 6-phosphogluconolactonase (NCBI) compare
b3183 obgE -1.7 -1.1 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0183 rnhB -1.6 -2.8 ribonuclease HII (NCBI) compare
b3933 ftsN -1.6 -7.2 essential cell division protein (NCBI) compare
b0406 tgt -1.6 -4.9 queuine tRNA-ribosyltransferase (NCBI) compare
b3341 rpsG -1.6 -1.1 30S ribosomal protein S7 (NCBI) compare
b3425 glpE -1.6 -6.2 thiosulfate sulfurtransferase (NCBI) compare
b4246 pyrL -1.6 -1.5 pyrBI operon leader peptide (NCBI) compare
b0737 tolQ -1.6 -2.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1949 fliQ -1.6 -1.6 flagellar biosynthesis protein Q (NCBI) compare
b4413 sokC -1.6 -1.3 regulatory antisense RNA (NCBI) compare
b2910 zapA -1.6 -3.5 protein that localizes to the cytokinetic ring (NCBI) compare
b4685 yrbN -1.6 -1.5 expressed protein (RefSeq) compare
b1103 ycfF -1.6 -1.3 orf, hypothetical protein (VIMSS) compare
b2569 lepA -1.6 -2.1 GTP-binding protein LepA (NCBI) compare
b0142 folK -1.5 -0.7 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1676 pykF -1.5 -2.7 pyruvate kinase (NCBI) compare
b4222 ytfP -1.5 -3.6 hypothetical protein (NCBI) compare
b2236 yfaE -1.5 -2.5 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b3836 b3836 -1.5 -3.4 orf, hypothetical protein (VIMSS) compare
b2906 visC -1.5 -4.0 hypothetical protein (NCBI) compare
b2518 ndk -1.5 -1.8 nucleoside diphosphate kinase (NCBI) compare
b3780 rhlB -1.5 -7.6 ATP-dependent RNA helicase (NCBI) compare
b1134 ymfB -1.5 -2.0 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b1281 pyrF -1.5 -1.9 orotidine 5'-phosphate decarboxylase (NCBI) compare
b2156 lysP -1.5 -6.3 lysine transporter (NCBI) compare
b4538 yoeF -1.5 -1.4 hypothetical protein (RefSeq) compare
b2911 ssrS -1.5 -1.2 6S regulatory RNA (NCBI) compare
b1836 yebV -1.5 -1.7 orf, hypothetical protein (VIMSS) compare
b4426 isrA -1.5 -1.6 unknown RNA (NCBI) compare
b1918 yecS -1.5 -2.4 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2797 sdaB -1.5 -7.5 L-serine deaminase II (NCBI) conserved
b2248 yfaX -1.5 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b0580 ybdJ -1.4 -1.7 predicted inner membrane protein (NCBI) compare
b1362 rzpR -1.4 -1.8 putative Rac prophage endopeptidase (VIMSS) compare
b0143 pcnB -1.4 -3.9 poly(A) polymerase I (VIMSS) compare
b1650 nemA -1.4 -2.8 N-ethylmaleimide reductase, FMN-linked (NCBI) compare
b1070 flgN -1.4 -1.2 export chaperone for FlgK and FlgL (NCBI) compare
b0357 yaiN -1.4 -0.8 putative alpha helix chain (VIMSS) compare
b3404 envZ -1.4 -6.2 osmolarity sensor protein (NCBI) compare
b4402 yjjY -1.4 -0.9 hypothetical protein (NCBI) compare
b1286 rnb -1.4 -1.9 exoribonuclease II (NCBI) compare
b2576 srmB -1.4 -1.6 ATP-dependent RNA helicase (NCBI) compare
b1305 pspB -1.4 -1.3 phage shock protein B (NCBI) compare
b4041 plsB -1.4 -1.3 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1861 ruvA -1.4 -0.9 Holliday junction DNA helicase motor protein (NCBI) compare
b2892 recJ -1.4 -4.8 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b1480 sra -1.3 -1.3 30S ribosomal subunit protein S22 (NCBI) compare
b2905 gcvT -1.3 -4.3 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2215 ompC -1.3 -4.8 outer membrane porin protein C (NCBI) compare
b1506 yneL -1.3 -0.9 predicted transcriptional regulator (NCBI) compare
b1486 ddpB -1.3 -1.7 D-ala-D-ala transporter subunit (NCBI) compare
b2688 gshA -1.3 -4.2 glutamate--cysteine ligase (NCBI) compare
b1865 nudB -1.3 -1.3 dATP pyrophosphohydrolase (NCBI) compare
b3935 priA -1.3 -2.1 primosome assembly protein PriA (NCBI) compare
b2447 yffP -1.3 -1.6 CPZ-55 prophage; predicted protein (NCBI) compare
b3388 damX -1.3 -6.6 hypothetical protein (NCBI) compare
b1696 ydiP -1.3 -0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4631 ykgQ -1.3 -0.9 no description compare
b3106 yhaK -1.3 -3.1 predicted pirin-related protein (NCBI) compare
b2283 nuoG -1.3 -3.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3146 yraL -1.3 -3.8 predicted methyltransferase (NCBI) compare
b3238 yhcN -1.3 -0.7 orf, hypothetical protein (VIMSS) compare
b3416 malQ -1.3 -6.6 4-alpha-glucanotransferase (amylomaltase) (NCBI) compare
b0623 cspE -1.3 -1.1 cold shock protein E (NCBI) compare
b1531 marA -1.3 -1.9 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1640 ydhH -1.2 -2.1 anhydro-N-acetylmuramic acid kinase (NCBI) compare
b4431 rprA -1.2 -1.2 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b1269 rluB -1.2 -1.9 23S rRNA pseudouridylate synthase (NCBI) compare
b0738 tolR -1.2 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3417 malP -1.2 -6.1 maltodextrin phosphorylase (NCBI) compare
b4101 phnG -1.2 -2.2 carbon-phosphorus lyase complex subunit (NCBI) compare
b0955 ycbZ -1.2 -3.3 predicted peptidase (NCBI) compare
b1105 ycfM -1.2 -2.5 predicted outer membrane lipoprotein (NCBI) compare
b0149 mrcB -1.2 -7.5 penicillin-binding protein 1b (NCBI) compare
b3928 yiiU -1.2 -3.7 hypothetical protein (NCBI) compare
b1686 ydiI -1.2 -1.4 hypothetical protein (NCBI) compare
b3026 qseC -1.2 -1.8 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2532 yfhQ -1.2 -2.4 predicted methyltransferase (NCBI) compare
b3816 corA -1.2 -4.8 magnesium/nickel/cobalt transporter (NCBI) compare
b2617 smpA -1.2 -1.8 small membrane protein A (VIMSS) compare
b0212 gloB -1.2 -1.9 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4701 sokX -1.2 -0.8 sok-related sRNA, function unknown (RefSeq) compare
b2476 purC -1.2 -1.7 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b0921 smtA -1.2 -3.8 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b2939 yqgB -1.2 -1.1 predicted protein (RefSeq) compare
b3616 tdh -1.2 -3.3 L-threonine 3-dehydrogenase (NCBI) compare
b2286 nuoC -1.2 -2.4 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b1400 paaY -1.2 -1.6 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b1084 rne -1.2 -2.9 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b0014 dnaK -1.2 -1.3 molecular chaperone DnaK (NCBI) compare
b2614 grpE -1.2 -1.5 heat shock protein (NCBI) compare
b3199 yrbK -1.1 -1.9 hypothetical protein (NCBI) compare
b1482 osmC -1.1 -1.0 osmotically inducible, stress-inducible membrane protein (NCBI) compare


Specific Phenotypes

For 22 genes in this experiment

For phage MOI 10 in Escherichia coli BW25113

For phage MOI 10 across organisms