Experiment set61S90 for Escherichia coli BW25113

Compare to:

Control_Tn1

200 most detrimental genes:

  gene name fitness t score description  
b4313 fimE +2.3 16.3 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b1183 umuD +1.2 2.5 DNA polymerase V, subunit D (NCBI) compare
b1434 ydcN +1.2 3.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b1837 yebW +0.9 3.6 orf, hypothetical protein (VIMSS) compare
b1575 dicB +0.8 1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b1563 relE +0.8 2.9 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b1984 asnW +0.8 1.4 tRNA-Asn (NCBI) compare
b0707 ybgA +0.8 2.1 hypothetical protein (NCBI) compare
b0142 folK +0.8 0.7 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2579 yfiD +0.8 1.9 pyruvate formate lyase subunit (NCBI) compare
b1963 b1963 +0.8 4.0 orf, hypothetical protein (VIMSS) compare
b1348 lar +0.8 1.7 Rac prophage; restriction alleviation protein (NCBI) compare
b4545 ypdJ +0.8 1.6 no description compare
b1954 dsrA +0.8 1.7 regulatory antisense RNA (NCBI) compare
b1502 ydeQ +0.8 2.4 predicted fimbrial-like adhesin protein (NCBI) compare
b1644 b1644 +0.8 3.6 putative membrane protein (VIMSS) compare
b1380 ldhA +0.7 2.9 D-lactate dehydrogenase (NCBI) compare
b0806 ybiM +0.7 3.4 orf, hypothetical protein (VIMSS) compare
b1347 ydaC +0.7 0.4 Rac prophage; predicted protein (NCBI) compare
b2110 yehC +0.7 1.5 predicted periplasmic pilin chaperone (NCBI) compare
b4520 ymgF +0.7 1.6 hypothetical protein (NCBI) compare
b0564 appY +0.7 1.0 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b1160 elbA +0.7 1.1 hypothetical protein (NCBI) compare
b4045 yjbJ +0.7 2.2 predicted stress response protein (NCBI) compare
b1684 sufA +0.7 2.2 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b1423 ydcJ +0.7 3.5 hypothetical protein (NCBI) compare
b4435 isrC +0.7 1.7 unknown RNA (NCBI) compare
b4676 yoaK +0.7 0.5 expressed protein (RefSeq) compare
b3961 oxyR +0.7 4.3 DNA-binding transcriptional dual regulator (NCBI) compare
b1533 ydeD +0.7 2.1 orf, hypothetical protein (VIMSS) compare
b0937 ssuE +0.7 1.7 NAD(P)H-dependent FMN reductase (NCBI) compare
b1712 ihfA +0.6 1.3 integration host factor subunit alpha (NCBI) compare
b0920 ycbC +0.6 4.1 conserved inner membrane protein (NCBI) compare
b1696 ydiP +0.6 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b1795 yeaQ +0.6 2.2 conserved inner membrane protein (NCBI) compare
b4704 arrS +0.6 0.3 Antisense sRNA ArrS, function unknown (NCBI) compare
b0389 yaiA +0.6 1.9 hypothetical protein (NCBI) compare
b1482 osmC +0.6 1.5 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b1973 yodA +0.6 2.3 conserved metal-binding protein (NCBI) compare
b1823 cspC +0.6 1.4 stress protein, member of the CspA-family (NCBI) compare
b1999 yeeP +0.6 2.7 putative histone (VIMSS) compare
b4650 yibS +0.6 2.0 no description compare
b1063 yceB +0.6 1.7 predicted lipoprotein (NCBI) compare
b0843 ybjH +0.6 1.6 hypothetical protein (NCBI) compare
b1147 ymfL +0.6 1.7 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b4215 ytfI +0.6 1.4 hypothetical protein (NCBI) compare
b2782 chpA +0.5 2.9 toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease (NCBI) compare
b2939 yqgB +0.5 1.2 predicted protein (RefSeq) compare
b4513 kdpF +0.5 0.8 potassium ion accessory transporter subunit (NCBI) compare
b1060 yceP +0.5 2.1 orf, hypothetical protein (VIMSS) compare
b2831 mutH +0.5 1.6 DNA mismatch repair protein (NCBI) compare
b1346 ydaQ +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b2638 yfjU +0.5 2.6 CP4-57 prophage; conserved protein (RefSeq) compare
b2300 yfcE +0.5 2.9 orf, hypothetical protein (VIMSS) compare
b1486 ddpB +0.5 1.3 D-ala-D-ala transporter subunit (NCBI) compare
b2998 yghW +0.5 2.1 hypothetical protein (NCBI) compare
b2818 argA +0.5 3.1 N-acetylglutamate synthase (NCBI) compare
b1917 yecC +0.5 2.4 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b4209 ytfE +0.5 2.4 predicted regulator of cell morphogenesis and cell wall metabolism (NCBI) compare
b1772 b1772 +0.5 2.2 putative kinase (VIMSS) compare
b0976 hyaE +0.5 1.5 protein involved in processing of HyaA and HyaB proteins (NCBI) compare
b1344 ydaO +0.5 1.8 predicted C32 tRNA thiolase (NCBI) compare
b0001 thrL +0.5 1.7 thr operon leader peptide (NCBI) compare
b1251 yciI +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b4184 yjfL +0.5 2.4 conserved inner membrane protein (NCBI) compare
b1843 yobB +0.5 2.6 hypothetical protein (NCBI) compare
b1525 b1525 +0.5 2.2 putative aldehyde dehydrogenase (VIMSS) compare
b4527 b1354 +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b1377 ompN +0.5 2.7 outer membrane pore protein N, non-specific (NCBI) compare
b2229 b2229 +0.5 2.5 orf, hypothetical protein (VIMSS) compare
b1177 ycgJ +0.5 2.3 hypothetical protein (NCBI) compare
b1597 asr +0.5 1.7 acid shock protein (VIMSS) compare
b1233 ychJ +0.5 2.1 hypothetical protein (NCBI) compare
b0559 ybcW +0.4 2.8 DLP12 prophage; predicted protein (NCBI) compare
b1869 yecN +0.4 2.7 orf, hypothetical protein (VIMSS) compare
b0791 ybhQ +0.4 1.8 predicted inner membrane protein (NCBI) compare
b4508 peaD +0.4 0.9 putative sensory transduction regulator (VIMSS) compare
b2376 ypdI +0.4 1.8 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b1542 ydfI +0.4 2.2 predicted mannonate dehydrogenase (NCBI) compare
b1550 b1550 +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b1456 rhsE +0.4 3.0 rhsE element core protein RshE (RefSeq) compare
b1258 yciF +0.4 0.6 hypothetical protein (NCBI) compare
b1444 ydcW +0.4 1.9 medium chain aldehyde dehydrogenase (NCBI) compare
b1664 ydhQ +0.4 2.4 hypothetical protein (NCBI) compare
b4594 ymgJ +0.4 1.3 hypothetical protein (RefSeq) compare
b4577 sgrS +0.4 1.1 small antisense RNA (NCBI) compare
b4224 chpS +0.4 1.9 suppressor of inhibitory function of ChpB, PemI-like, autoregulated (VIMSS) compare
b4697 yrdF +0.4 1.7 no description compare
b2456 cchB +0.4 1.2 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b2424 cysU +0.4 1.8 sulfate/thiosulfate transporter subunit (NCBI) compare
b1103 ycfF +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b2532 yfhQ +0.4 1.5 predicted methyltransferase (NCBI) compare
b0178 hlpA +0.4 1.7 periplasmic chaperone (NCBI) compare
b1010 ycdK +0.4 1.8 hypothetical protein (NCBI) compare
b3360 pabA +0.4 2.5 para-aminobenzoate synthase component II (NCBI) compare
b2104 thiM +0.4 1.8 hydroxyethylthiazole kinase (NCBI) compare
b1776 ydjL +0.4 2.0 predicted oxidoreductase, Zn-dependent and NAD(P)-binding (NCBI) compare
b1335 ogt +0.4 1.7 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b1635 gst +0.4 1.5 glutathionine S-transferase (NCBI) compare
b1218 chaC +0.4 2.1 regulatory protein for cation transport (RefSeq) compare
b4582 yoeA +0.4 1.9 no description compare
b4163 glyV +0.4 0.7 tRNA-Gly (NCBI) compare
b1839 yebY +0.4 1.3 hypothetical protein (NCBI) compare
b0623 cspE +0.4 1.2 cold shock protein E (NCBI) compare
b1667 ydhR +0.4 1.5 hypothetical protein (NCBI) compare
b0530 sfmA +0.4 1.5 putative fimbrial-like protein (VIMSS) compare
b1921 fliZ +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b2145 yeiS +0.4 1.6 predicted inner membrane protein (NCBI) compare
b1271 yciK +0.4 1.4 short chain dehydrogenase (NCBI) compare
b1476 fdnI +0.4 0.5 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b0611 rna +0.4 2.2 ribonuclease I (NCBI) compare
b1636 pdxY +0.4 1.6 pyridoxine kinase (NCBI) compare
b2960 yggH +0.4 2.4 tRNA(m7G46)-methyltransferase (NCBI) compare
b1313 ycjQ +0.4 2.2 predicted oxidoreductase, Zn-dependent and NAD(P)-binding (NCBI) compare
b2198 ccmD +0.4 0.9 cytochrome c biogenesis protein (NCBI) compare
b2734 pphB +0.4 1.7 serine/threonine-specific protein phosphatase 2 (NCBI) compare
b2409 yfeR +0.4 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0946 ycbW +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b4373 rimI +0.4 1.0 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b4030 yjbA +0.4 1.9 phosphate-starvation-inducible protein PsiE (NCBI) compare
b1708 nlpC +0.4 1.4 predicted lipoprotein (NCBI) compare
b1216 chaA +0.4 2.3 calcium/sodium:proton antiporter (NCBI) compare
b2398 yfeC +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b1556 b1556 +0.4 1.3 orf, hypothetical protein (VIMSS) compare
b2704 srlB +0.3 0.9 glucitol/sorbitol-specific enzyme IIA component of PTS (NCBI) compare
b0101 yacG +0.3 1.0 zinc-binding protein (NCBI) compare
b1481 b1481 +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b3761 trpT +0.3 0.7 tRNA-Trp (NCBI) compare
b4589 ylcI +0.3 0.7 hypothetical protein (RefSeq) compare
b4694 yagP +0.3 1.6 no description compare
b0527 ybcI +0.3 1.6 conserved inner membrane protein (NCBI) compare
b1358 ydaT +0.3 0.6 Rac prophage; predicted protein (NCBI) compare
b1791 yeaN +0.3 2.3 predicted transporter (NCBI) compare
b2488 hyfH +0.3 2.0 hydrogenase 4, Fe-S subunit (NCBI) compare
b0655 gltI +0.3 1.8 glutamate and aspartate transporter subunit (NCBI) compare
b3890 yiiF +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b0337 codA +0.3 2.0 cytosine deaminase (NCBI) compare
b2250 b2250 +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b4068 yjcH +0.3 1.6 required for glycolate transport, with actP (from data) compare
b4646 yrdE +0.3 1.0 no description compare
b2846 yqeH +0.3 0.3 orf, hypothetical protein (VIMSS) compare
b1072 flgA +0.3 1.7 flagellar basal body P-ring biosynthesis protein A (NCBI) compare
b1322 ycjF +0.3 1.6 hypothetical protein (NCBI) compare
b1900 araG +0.3 1.4 fused L-arabinose transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1949 fliQ +0.3 0.9 flagellar biosynthesis protein Q (NCBI) compare
b0851 nfsA +0.3 1.8 nitroreductase A, NADPH-dependent, FMN-dependent (NCBI) compare
b2132 bglX +0.3 2.3 beta-D-glucoside glucohydrolase, periplasmic (NCBI) compare
b0850 ybjC +0.3 1.5 predicted inner membrane protein (NCBI) compare
b2092 gatC +0.3 1.8 galactitol-specific enzyme IIC component of PTS (NCBI) compare
b4400 creD +0.3 2.3 inner membrane protein (NCBI) compare
b2433 b2433 +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b1278 pgpB +0.3 1.0 phosphatidylglycerophosphatase B (NCBI) compare
b0752 zitB +0.3 1.7 zinc transporter ZitB (NCBI) compare
b4458 oxyS +0.3 0.6 global regulatory RNA (NCBI) compare
b2174 b2174 +0.3 1.9 orf, hypothetical protein (VIMSS) compare
b1811 yoaH +0.3 1.4 hypothetical protein (NCBI) compare
b1953 b1953 +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b2123 yehR +0.3 1.8 orf, hypothetical protein (VIMSS) compare
b0951 pqiB +0.3 2.4 paraquat-inducible protein B (NCBI) compare
b2548 yphF +0.3 2.4 predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b2481 hyfA +0.3 1.1 hydrogenase 4 Fe-S subunit (VIMSS) compare
b4294 insA-7 +0.3 0.9 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b3875 ompL +0.3 1.1 predicted outer membrane porin L (NCBI) compare
b0601 ybdM +0.3 2.0 hypothetical protein (NCBI) compare
b3959 argB +0.3 2.0 acetylglutamate kinase (RefSeq) compare
b1584 speG +0.3 1.9 spermidine N1-acetyltransferase (NCBI) compare
b0814 ompX +0.3 1.6 outer membrane protein X (NCBI) compare
b1144 ymfJ +0.3 0.9 orf, hypothetical protein (VIMSS) compare
b1726 yniB +0.3 0.8 predicted inner membrane protein (NCBI) compare
b3995 rsd +0.3 1.5 stationary phase protein, binds sigma 70 RNA polymerase subunit (NCBI) compare
b2428 yfeU +0.3 1.9 N-acetylmuramic acid-6-phosphate etherase (NCBI) compare
b3964 yijD +0.3 1.8 conserved inner membrane protein (NCBI) compare
b1920 fliY +0.3 1.0 cystine transporter subunit (NCBI) compare
b2844 yqeF +0.3 2.0 putative acyltransferase (VIMSS) compare
b1659 ydhB +0.3 0.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b3858 yihD +0.3 1.1 hypothetical protein (NCBI) compare
b2358 oweS +0.3 2.0 CPS-53 (KpLE1) prophage; predicted defective phage replication protein O (RefSeq) compare
b1012 b1012 +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b0788 ybhN +0.3 1.2 conserved inner membrane protein (NCBI) compare
b2840 ygeA +0.3 1.8 predicted racemase (NCBI) compare
b3973 birA +0.3 1.1 biotin--protein ligase (NCBI) compare
b1539 ydfG +0.3 1.0 L-allo-threonine dehydrogenase, NAD(P)-binding (NCBI) compare
b3113 yhaR +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b2912 ygfA +0.3 1.1 putative ligase (VIMSS) compare
b1831 proQ +0.3 0.8 putative solute/DNA competence effector (NCBI) compare
b1730 ydjO +0.3 0.4 predicted protein (RefSeq) compare
b1672 ydhW +0.3 0.8 hypothetical protein (NCBI) compare
b3449 ugpQ +0.3 2.0 cytoplasmic glycerophosphodiester phosphodiesterase (NCBI) compare
b0346 mhpR +0.3 1.4 DNA-binding transcriptional activator, 3HPP-binding (RefSeq) compare
b1660 ydhC +0.3 1.3 predicted transporter (NCBI) compare
b3622 rfaL +0.3 1.2 O-antigen ligase (NCBI) compare
b2299 yfcD +0.3 1.4 predicted NUDIX hydrolase (NCBI) compare
b2082 ogrK +0.3 0.7 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b4571 wbbL +0.3 1.2 no description compare
b3780 rhlB +0.3 2.0 ATP-dependent RNA helicase (NCBI) compare
b0367 tauC +0.3 1.3 taurine transporter subunit (NCBI) compare
b1577 ydfE +0.3 1.4 Qin prophage; predicted protein (RefSeq) compare
b4538 yoeF +0.3 0.7 hypothetical protein (RefSeq) compare
b2919 ygfG +0.3 1.1 putative enzyme (VIMSS) compare
b2044 wcaL +0.3 1.8 predicted glycosyl transferase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in no phage control experiments