Experiment set60S309 for Escherichia coli BW25113

Compare to:

TN_18CS_warm37C_5dbl_rep3

200 most detrimental genes:

  gene name fitness t score description  
b1332 ynaJ +1.9 1.0 predicted inner membrane protein (NCBI) compare
b3181 greA +1.5 10.0 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0145 dksA +1.2 3.8 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3119 tdcR +1.1 2.5 threonine dehydratase operon activator protein (VIMSS) compare
b0889 lrp +1.0 5.3 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1942 fliJ +1.0 2.5 flagellar biosynthesis chaperone (NCBI) compare
b0059 hepA +0.9 8.4 ATP-dependent helicase HepA (NCBI) compare
b2829 ptsP +0.9 7.0 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1882 cheY +0.8 0.5 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b4416 rybA +0.8 2.0 unknown RNA (NCBI) compare
b1182 hlyE +0.8 0.5 hemolysin E (VIMSS) compare
b2946 yggJ +0.8 5.3 orf, hypothetical protein (VIMSS) compare
b0310 ykgH +0.7 1.7 predicted inner membrane protein (NCBI) compare
b4480 hdfR +0.7 3.7 transcriptional regulator HdfR (NCBI) compare
b1823 cspC +0.7 1.4 stress protein, member of the CspA-family (NCBI) compare
b1461 ydcE +0.7 2.2 4-oxalocrotonate tautomerase (NCBI) compare
b3206 npr +0.7 3.1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b0688 pgm +0.7 2.5 phosphoglucomutase (NCBI) compare
b2110 yehC +0.7 1.7 predicted periplasmic pilin chaperone (NCBI) compare
b2058 wcaB +0.7 1.4 predicted acyl transferase (NCBI) compare
b4529 ydbJ +0.6 0.9 hypothetical protein (NCBI) compare
b0564 appY +0.6 1.1 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2136 yohD +0.6 1.6 orf, hypothetical protein (VIMSS) compare
b0178 hlpA +0.6 2.5 periplasmic chaperone (NCBI) compare
b4000 hupA +0.6 4.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b1344 ydaO +0.6 2.4 predicted C32 tRNA thiolase (NCBI) compare
b0440 hupB +0.6 4.1 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b2904 gcvH +0.6 1.7 glycine cleavage system protein H (NCBI) compare
b4373 rimI +0.6 3.0 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1013 ycdC +0.6 1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b4436 ryeC +0.6 1.8 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b2617 smpA +0.6 3.0 small membrane protein A (VIMSS) compare
b2750 cysC +0.6 3.1 adenylylsulfate kinase (NCBI) compare
b1348 lar +0.6 1.1 Rac prophage; restriction alleviation protein (NCBI) compare
b2646 ypjF +0.6 2.7 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b0843 ybjH +0.6 1.6 hypothetical protein (NCBI) compare
b0937 ssuE +0.6 1.1 NAD(P)H-dependent FMN reductase (NCBI) compare
b4535 yniD +0.6 0.8 predicted protein (RefSeq) compare
b1540 ydfH +0.6 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1518 lsrG +0.5 1.2 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b4653 yicT +0.5 2.0 no description compare
b1362 rzpR +0.5 1.7 putative Rac prophage endopeptidase (VIMSS) compare
b3644 yicC +0.5 3.3 hypothetical protein (NCBI) compare
b2903 gcvP +0.5 4.7 glycine dehydrogenase (NCBI) compare
b1062 pyrC +0.5 3.3 dihydroorotase (NCBI) compare
b0234 yafP +0.5 1.4 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b4239 treC +0.5 1.8 trehalose-6-P hydrolase (NCBI) compare
b4593 ymgI +0.5 0.4 hypothetical protein (RefSeq) compare
b0627 tatE +0.5 1.2 twin arginine translocase protein E (NCBI) compare
b0852 rimK +0.5 1.9 ribosomal protein S6 modification protein (NCBI) compare
b3764 yifE +0.5 3.6 hypothetical protein (NCBI) compare
b4520 ymgF +0.5 1.1 hypothetical protein (NCBI) compare
b3780 rhlB +0.5 4.5 ATP-dependent RNA helicase (NCBI) compare
b3629 rfaS +0.5 2.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4461 yfjD +0.5 3.6 predicted inner membrane protein (RefSeq) compare
b1427 rimL +0.5 2.0 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b0705 ybfL +0.5 0.5 putative receptor protein (VIMSS) compare
b1575 dicB +0.5 1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b2042 galF +0.5 3.7 predicted subunit with GalU (NCBI) compare
b1735 chbR +0.5 1.8 DNA-binding transcriptional dual regulator (NCBI) compare
b1478 adhP +0.5 2.7 alcohol dehydrogenase (VIMSS) compare
b1661 cfa +0.5 2.2 cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) (NCBI) compare
b4595 yciY +0.5 1.5 hypothetical protein (RefSeq) compare
b2911 ssrS +0.5 1.8 6S regulatory RNA (NCBI) compare
b1333 uspE +0.5 1.7 stress-induced protein (NCBI) compare
b3977 tyrU +0.5 0.9 tRNA-Tyr (NCBI) compare
b1493 gadB +0.5 0.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2376 ypdI +0.5 1.7 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b0535 fimZ +0.5 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2111 yehD +0.5 1.5 predicted fimbrial-like adhesin protein (NCBI) compare
b1726 yniB +0.5 1.7 predicted inner membrane protein (NCBI) compare
b0866 ybjQ +0.5 0.9 hypothetical protein (NCBI) compare
b1273 yciN +0.5 1.2 hypothetical protein (NCBI) compare
b0142 folK +0.5 0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2085 b2085 +0.4 2.0 orf, hypothetical protein (VIMSS) compare
b1595 ynfL +0.4 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1217 chaB +0.4 0.7 cation transport regulator (NCBI) compare
b2934 cmtB +0.4 0.7 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b1607 ydgC +0.4 0.9 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1758 b1758 +0.4 0.9 putative cytochrome oxidase (VIMSS) compare
b2198 ccmD +0.4 2.1 cytochrome c biogenesis protein (NCBI) compare
b4215 ytfI +0.4 1.4 hypothetical protein (NCBI) compare
b2554 yfhA +0.4 3.2 predicted DNA-binding response regulator in two-component system (NCBI) compare
b2175 spr +0.4 2.3 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b2754 ygbF +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b4541 yehK +0.4 2.5 hypothetical protein (NCBI) compare
b4066 yjcF +0.4 0.4 hypothetical protein (NCBI) compare
b1698 ydiR +0.4 1.6 predicted electron transfer flavoprotein, FAD-binding (NCBI) compare
b1151 ymfO +0.4 1.4 e14 prophage; conserved protein (RefSeq) compare
b1141 ymfG +0.4 2.1 e14 prophage; predicted excisionase (NCBI) compare
b4598 yncL +0.4 1.4 hypothetical protein (RefSeq) compare
b4521 ycgI +0.4 2.7 hypothetical protein (NCBI) compare
b1874 cutC +0.4 1.3 copper homeostasis protein (NCBI) compare
b3646 yicG +0.4 3.1 orf, hypothetical protein (VIMSS) compare
b4641 yoeH +0.4 2.1 no description compare
b1454 yncG +0.4 1.1 predicted enzyme (NCBI) compare
b1556 b1556 +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b4325 yjiC +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b4260 pepA +0.4 3.4 leucyl aminopeptidase (NCBI) compare
b2259 pmrD +0.4 0.8 polymyxin resistance protein B (VIMSS) compare
b4345 mcrC +0.4 1.0 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b2123 yehR +0.4 1.7 orf, hypothetical protein (VIMSS) compare
b0407 yajC +0.4 1.8 preprotein translocase subunit YajC (NCBI) compare
b4640 yoeG +0.4 1.3 no description compare
b2124 yehS +0.4 2.4 hypothetical protein (NCBI) compare
b1358 ydaT +0.4 0.6 Rac prophage; predicted protein (NCBI) compare
b0367 tauC +0.4 1.6 taurine transporter subunit (NCBI) compare
b1843 yobB +0.4 1.4 hypothetical protein (NCBI) compare
b1760 ynjH +0.4 1.5 hypothetical protein (NCBI) compare
b3806 cyaA +0.4 2.2 adenylate cyclase (NCBI) compare
b1161 ycgX +0.4 0.6 hypothetical protein (NCBI) compare
b3742 mioC +0.4 2.5 flavodoxin (NCBI) compare
b2555 yfhG +0.4 3.1 hypothetical protein (NCBI) compare
b1148 ymfM +0.4 1.4 e14 prophage; predicted protein (NCBI) compare
b4410 ecnA +0.4 1.1 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b0865 ybjP +0.4 1.2 predicted lipoprotein (NCBI) compare
b1520 b1520 +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b1526 yneJ +0.4 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1895 yecG +0.4 1.8 universal stress protein (NCBI) compare
b1722 ydiY +0.4 2.4 hypothetical protein (NCBI) compare
b2752 cysD +0.4 2.2 sulfate adenylyltransferase subunit 2 (NCBI) compare
b1670 ydhU +0.4 1.7 predicted cytochrome (NCBI) compare
b1618 uidR +0.4 1.3 DNA-binding transcriptional repressor (NCBI) compare
b2811 ygdK +0.4 2.2 predicted Fe-S metabolism protein (NCBI) compare
b2823 ppdC +0.4 1.6 hypothetical protein (NCBI) compare
b1918 yecS +0.4 1.5 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1853 yebK +0.4 0.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1296 ycjJ +0.4 1.3 putative amino acid/amine transport protein (VIMSS) compare
b3238 yhcN +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b1160 elbA +0.4 0.4 hypothetical protein (NCBI) compare
b3280 yrdB +0.4 1.5 hypothetical protein (NCBI) compare
b1739 osmE +0.3 1.1 DNA-binding transcriptional activator (NCBI) compare
b4441 glmY +0.3 1.1 sRNA activator of glmS mRNA (RefSeq) compare
b0989 cspH +0.3 1.2 stress protein, member of the CspA-family (NCBI) compare
b2905 gcvT +0.3 2.5 glycine cleavage system aminomethyltransferase T (NCBI) compare
b4151 frdD +0.3 1.2 fumarate reductase subunit D (NCBI) compare
b2571 rseB +0.3 2.2 periplasmic negative regulator of sigmaE (NCBI) compare
b1235 rssB +0.3 2.3 response regulator of RpoS (NCBI) compare
b1793 yoaF +0.3 1.4 conserved outer membrane protein (NCBI) compare
b0131 panD +0.3 1.7 aspartate 1-decarboxylase precursor (NCBI) compare
b0548 ninE +0.3 1.8 DLP12 prophage; conserved protein (NCBI) compare
b3580 lyxK +0.3 2.6 L-xylulose kinase (NCBI) compare
b0468 ybaN +0.3 2.5 conserved inner membrane protein (NCBI) compare
b1006 ycdG +0.3 1.5 putative transport protein (VIMSS) compare
b0797 rhlE +0.3 2.0 RNA helicase (NCBI) compare
b4654 yjdQ +0.3 1.9 no description compare
b1837 yebW +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b0647 ybeT +0.3 2.2 conserved outer membrane protein (NCBI) compare
b1066 rimJ +0.3 1.8 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b3912 cpxR +0.3 2.5 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b1732 katE +0.3 1.6 hydroperoxidase HPII(III) (catalase) (NCBI) compare
b1878 flhE +0.3 1.8 hypothetical protein (NCBI) compare
b1730 ydjO +0.3 0.6 predicted protein (RefSeq) compare
b4001 yjaH +0.3 2.1 hypothetical protein (NCBI) compare
b3740 gidB +0.3 2.8 glucose-inhibited division protein B (NCBI) compare
b4631 ykgQ +0.3 0.7 no description compare
b2572 rseA +0.3 1.5 anti-sigma factor (NCBI) compare
b3260 dusB +0.3 1.1 tRNA-dihydrouridine synthase B (NCBI) compare
b2499 purM +0.3 1.9 phosphoribosylaminoimidazole synthetase (NCBI) compare
b2804 fucU +0.3 1.0 L-fucose mutarotase (NCBI) compare
b3102 yqjG +0.3 1.7 predicted S-transferase (NCBI) compare
b3642 pyrE +0.3 1.5 orotate phosphoribosyltransferase (NCBI) compare
b0975 hyaD +0.3 1.7 protein involved in processing of HyaA and HyaB proteins (NCBI) compare
b4603 rseX +0.3 0.4 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2343 b2343 +0.3 0.5 orf, hypothetical protein (VIMSS) compare
b1411 ynbD +0.3 1.8 predicted phosphatase, inner membrane protein (NCBI) compare
b3117 tdcB +0.3 2.6 threonine dehydratase (NCBI) compare
b2783 chpR +0.3 0.7 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b3662 nepI +0.3 2.6 predicted transporter (RefSeq) compare
b1752 ydjZ +0.3 1.3 conserved inner membrane protein (NCBI) compare
b2556 yfhK +0.3 2.3 putative 2-component sensor protein (VIMSS) compare
b4462 ygaQ +0.3 0.8 hypothetical protein (RefSeq) compare
b1604 ydgH +0.3 1.1 hypothetical protein (NCBI) compare
b0389 yaiA +0.3 1.2 hypothetical protein (NCBI) compare
b3562 yiaA +0.3 2.7 orf, hypothetical protein (VIMSS) compare
b1134 ymfB +0.3 0.5 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b2064 asmA +0.3 2.2 predicted assembly protein (NCBI) compare
b1184 umuC +0.3 2.2 DNA polymerase V subunit UmuC (NCBI) compare
b0706 ybfD +0.3 0.9 hypothetical protein (NCBI) compare
b1150 ymfR +0.3 0.5 e14 prophage; predicted protein (NCBI) compare
b4702 mgtL +0.3 0.8 regulatory leader peptide for mgtA (NCBI) compare
b0488 ybbJ +0.3 1.9 conserved inner membrane protein (RefSeq) compare
b2586 yfiM +0.3 1.4 predicted protein (RefSeq) compare
b1085 b1085 +0.3 0.9 orf, hypothetical protein (VIMSS) compare
b1940 fliH +0.3 2.2 flagellar biosynthesis; export of flagellar proteins? (VIMSS) compare
b1431 ydcL +0.3 0.8 predicted lipoprotein (NCBI) compare
b1754 b1754 +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b2079 baeR +0.3 1.6 DNA-binding response regulator in two-component regulatory system with BaeS (NCBI) compare
b4686 yshB +0.3 1.2 expressed protein (RefSeq) compare
b1527 yneK +0.3 0.9 hypothetical protein (NCBI) compare
b1329 b1329 +0.3 1.8 putative transport periplasmic protein (VIMSS) compare
b1338 ydaJ +0.3 1.5 putative aminohydrolase (EC 3.5.1.14) (VIMSS) compare
b2579 yfiD +0.3 1.0 pyruvate formate lyase subunit (NCBI) compare
b1113 ycfS +0.3 1.7 hypothetical protein (NCBI) compare
b2012 yeeD +0.3 0.9 hypothetical protein (NCBI) compare
b0547 ybcN +0.3 1.7 DLP12 prophage; predicted protein (NCBI) compare
b0624 crcB +0.3 0.8 camphor resistance protein CrcB (NCBI) compare
b4053 alr +0.3 2.4 alanine racemase (NCBI) compare
b4527 b1354 +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b1476 fdnI +0.3 0.4 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare


Specific Phenotypes

None in this experiment