| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -8.5 | -5.4 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0049 | apaH | -7.1 | -6.9 | diadenosinetetraphosphatase (NCBI) | compare |
| b3035 | tolC | -7.0 | -16.3 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b2838 | lysA | -6.9 | -12.4 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0386 | proC | -6.4 | -12.3 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b0243 | proA | -6.4 | -15.0 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3770 | ilvE | -6.3 | -19.1 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b1129 | phoQ | -6.3 | -13.2 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2312 | purF | -6.2 | -11.2 | amidophosphoribosyltransferase (NCBI) | compare |
| b0908 | aroA | -6.2 | -17.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0523 | purE | -6.2 | -6.9 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0033 | carB | -6.2 | -22.4 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b3774 | ilvC | -6.1 | -23.7 | ketol-acid reductoisomerase (NCBI) | compare |
| b0072 | leuC | -6.0 | -19.4 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b4242 | mgtA | -6.0 | -28.7 | magnesium transporter (NCBI) | compare |
| b0945 | pyrD | -6.0 | -19.0 | dihydroorotate dehydrogenase (NCBI) | compare |
| b0145 | dksA | -6.0 | -8.2 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0073 | leuB | -6.0 | -15.0 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b2499 | purM | -6.0 | -10.8 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2021 | hisC | -5.9 | -10.7 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2329 | aroC | -5.9 | -9.9 | chorismate synthase (NCBI) | compare |
| b2557 | purL | -5.9 | -16.6 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b3389 | aroB | -5.9 | -22.3 | 3-dehydroquinate synthase (NCBI) | compare |
| b0071 | leuD | -5.9 | -12.6 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b3082 | ygjM | -5.9 | -6.9 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3771 | ilvD | -5.8 | -20.6 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0004 | thrC | -5.8 | -14.5 | threonine synthase (NCBI) | compare |
| b2022 | hisB | -5.8 | -11.2 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b1130 | phoP | -5.7 | -12.2 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b4006 | purH | -5.7 | -19.7 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3172 | argG | -5.7 | -17.8 | argininosuccinate synthase (NCBI) | compare |
| b3956 | ppc | -5.6 | -26.8 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b1693 | aroD | -5.6 | -12.0 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b3281 | aroE | -5.6 | -25.9 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b1062 | pyrC | -5.5 | -13.2 | dihydroorotase (NCBI) | compare |
| b2023 | hisH | -5.5 | -10.5 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b3960 | argH | -5.5 | -19.8 | argininosuccinate lyase (NCBI) | compare |
| b4005 | purD | -5.5 | -15.7 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2020 | hisD | -5.4 | -11.9 | histidinol dehydrogenase (NCBI) | compare |
| b3941 | metF | -5.4 | -14.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0142 | folK | -5.4 | -2.3 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0522 | purK | -5.3 | -14.6 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3772 | ilvA | -5.3 | -21.4 | threonine dehydratase (NCBI) | compare |
| b0074 | leuA | -5.3 | -16.0 | 2-isopropylmalate synthase (NCBI) | compare |
| b1281 | pyrF | -5.2 | -7.2 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b3829 | metE | -5.1 | -21.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b3958 | argC | -5.1 | -20.3 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b1261 | trpB | -5.1 | -5.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b4702 | mgtL | -5.0 | -6.0 | regulatory leader peptide for mgtA (NCBI) | compare |
| b3828 | metR | -5.0 | -17.5 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b2818 | argA | -4.9 | -11.8 | N-acetylglutamate synthase (NCBI) | compare |
| b2025 | hisF | -4.9 | -8.9 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b4177 | purA | -4.9 | -4.8 | adenylosuccinate synthetase (NCBI) | compare |
| b4245 | pyrB | -4.9 | -14.4 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b3957 | argE | -4.9 | -15.6 | acetylornithine deacetylase (NCBI) | compare |
| b0032 | carA | -4.8 | -10.7 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3642 | pyrE | -4.8 | -8.0 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3741 | gidA | -4.8 | -19.6 | glucose-inhibited division protein A (NCBI) | compare |
| b0907 | serC | -4.8 | -11.1 | phosphoserine aminotransferase (NCBI) | compare |
| b3959 | argB | -4.6 | -17.7 | acetylglutamate kinase (RefSeq) | compare |
| b0242 | proB | -4.5 | -9.1 | gamma-glutamyl kinase (NCBI) | compare |
| b1260 | trpA | -4.5 | -10.0 | tryptophan synthase subunit alpha (NCBI) | compare |
| b2600 | tyrA | -4.5 | -7.2 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b2913 | serA | -4.5 | -15.1 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b4388 | serB | -4.4 | -10.6 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0002 | thrA | -4.4 | -18.1 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2026 | hisI | -4.4 | -11.6 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3706 | trmE | -4.3 | -10.3 | tRNA modification GTPase (NCBI) | compare |
| b4214 | cysQ | -4.2 | -16.7 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0912 | ihfB | -4.2 | -8.4 | integration host factor subunit beta (NCBI) | compare |
| b3939 | metB | -4.2 | -17.4 | cystathionine gamma-synthase (NCBI) | compare |
| b2019 | hisG | -4.2 | -5.5 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2024 | hisA | -4.2 | -3.3 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b4013 | metA | -4.2 | -10.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b3870 | glnA | -4.2 | -6.9 | glutamine synthetase (NCBI) | compare |
| b2318 | truA | -4.2 | -8.5 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0003 | thrB | -4.1 | -8.2 | homoserine kinase (NCBI) | compare |
| b2750 | cysC | -4.1 | -13.2 | adenylylsulfate kinase (NCBI) | compare |
| b3405 | ompR | -4.1 | -9.0 | osmolarity response regulator (NCBI) | compare |
| b2567 | rnc | -4.0 | -5.4 | ribonuclease III (NCBI) | compare |
| b0052 | pdxA | -4.0 | -15.6 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2414 | cysK | -3.9 | -15.9 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3386 | rpe | -3.9 | -6.4 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b2762 | cysH | -3.8 | -13.0 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0720 | gltA | -3.8 | -9.6 | citrate synthase (NCBI) | compare |
| b1712 | ihfA | -3.8 | -6.9 | integration host factor subunit alpha (NCBI) | compare |
| b2501 | ppk | -3.8 | -16.9 | polyphosphate kinase (NCBI) | compare |
| b4171 | miaA | -3.8 | -11.9 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0437 | clpP | -3.7 | -12.3 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b0051 | ksgA | -3.7 | -11.2 | dimethyladenosine transferase (NCBI) | compare |
| b3008 | metC | -3.6 | -13.6 | cystathionine beta-lyase (NCBI) | compare |
| b2764 | cysJ | -3.6 | -14.5 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2763 | cysI | -3.5 | -11.7 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b3839 | tatC | -3.4 | -13.1 | TatABCE protein translocation system subunit (NCBI) | compare |
| b2564 | pdxJ | -3.3 | -7.6 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b3671 | ilvB | -3.3 | -17.2 | acetolactate synthase large subunit (NCBI) | compare |
| b4202 | rpsR | -3.2 | -5.6 | 30S ribosomal protein S18 (NCBI) | compare |
| b1850 | eda | -3.0 | -3.6 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b2839 | lysR | -3.0 | -7.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3773 | ilvY | -2.8 | -10.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0439 | lon | -2.8 | -11.2 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b2599 | pheA | -2.8 | -6.4 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b1262 | trpC | -2.7 | -5.5 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b3368 | cysG | -2.7 | -18.0 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b4042 | dgkA | -2.6 | -8.4 | diacylglycerol kinase (NCBI) | compare |
| b2830 | nudH | -2.6 | -4.8 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b1438 | ydcQ | -2.6 | -8.0 | predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b0738 | tolR | -2.6 | -6.5 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0737 | tolQ | -2.5 | -6.3 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0889 | lrp | -2.5 | -5.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0740 | tolB | -2.5 | -11.2 | translocation protein TolB precursor (NCBI) | compare |
| b2017 | yefM | -2.5 | -3.0 | orf, hypothetical protein (VIMSS) | compare |
| b4172 | hfq | -2.5 | -3.7 | RNA-binding protein Hfq (NCBI) | compare |
| b2479 | gcvR | -2.5 | -9.0 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b2751 | cysN | -2.4 | -9.5 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0739 | tolA | -2.3 | -7.1 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b2820 | recB | -2.3 | -4.6 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b3670 | ilvN | -2.3 | -8.2 | acetolactate synthase small subunit (NCBI) | compare |
| b0726 | sucA | -2.2 | -6.4 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b1192 | ldcA | -2.2 | -7.9 | L,D-carboxypeptidase A (NCBI) | compare |
| b2752 | cysD | -2.2 | -8.7 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b2784 | relA | -2.2 | -13.8 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b3838 | tatB | -2.2 | -9.1 | sec-independent translocase (NCBI) | compare |
| b4155 | yjeA | -2.2 | -4.8 | putative lysyl-tRNA synthetase (VIMSS) | compare |
| b1863 | ruvC | -2.1 | -7.3 | Holliday junction resolvase (NCBI) | compare |
| b3021 | ygiT | -2.1 | -5.3 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3204 | ptsN | -2.1 | -8.2 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b3672 | ivbL | -2.0 | -4.4 | ilvB operon leader peptide (NCBI) | compare |
| b4480 | hdfR | -2.0 | -8.2 | transcriptional regulator HdfR (NCBI) | compare |
| b0113 | pdhR | -2.0 | -4.7 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3781 | trxA | -1.9 | -6.3 | thioredoxin 1 (VIMSS) | compare |
| b4443 | gcvB | -1.9 | -3.0 | GcvB sRNA gene divergent from gcvA (RefSeq) | compare |
| b3390 | aroK | -1.9 | -4.1 | shikimate kinase I (NCBI) | compare |
| b2340 | sixA | -1.9 | -8.0 | phosphohistidine phosphatase (NCBI) | compare |
| b3764 | yifE | -1.9 | -9.7 | hypothetical protein (NCBI) | compare |
| b2313 | cvpA | -1.8 | -3.5 | membrane protein required for colicin V production (NCBI) | compare |
| b0118 | acnB | -1.8 | -7.9 | aconitate hydratase (NCBI) | compare |
| b0890 | ftsK | -1.8 | -11.4 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b3613 | yibP | -1.8 | -8.3 | putative membrane protein (VIMSS) | compare |
| b1186 | nhaB | -1.8 | -10.3 | NhaB sodium/proton transporter (Katherine Huang) | compare |
| b0114 | aceE | -1.7 | -5.6 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b1291 | sapD | -1.7 | -4.1 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2188 | yejM | -1.7 | -8.3 | predicted hydrolase, inner membrane (NCBI) | compare |
| b0683 | fur | -1.7 | -4.1 | ferric uptake regulator (NCBI) | compare |
| b0741 | pal | -1.7 | -5.1 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b1264 | trpE | -1.7 | -4.3 | anthranilate synthase component I (NCBI) | compare |
| b3545 | proK | -1.6 | -4.6 | tRNA-Pro (NCBI) | compare |
| b0928 | aspC | -1.6 | -7.6 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0200 | gmhB | -1.6 | -3.1 | hypothetical protein (NCBI) | compare |
| b2822 | recC | -1.6 | -6.9 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b0888 | trxB | -1.6 | -6.4 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b2320 | pdxB | -1.5 | -9.3 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b0438 | clpX | -1.5 | -8.4 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3619 | rfaD | -1.5 | -5.8 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b1871 | yecP | -1.5 | -6.3 | predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) | compare |
| b0750 | nadA | -1.5 | -7.0 | quinolinate synthetase (NCBI) | compare |
| b0222 | lpcA | -1.5 | -5.6 | phosphoheptose isomerase (NCBI) | compare |
| b3916 | pfkA | -1.5 | -6.5 | 6-phosphofructokinase (NCBI) | compare |
| b3290 | trkA | -1.5 | -6.6 | potassium transporter peripheral membrane component (NCBI) | compare |
| b3493 | pitA | -1.5 | -10.6 | phosphate transporter, low-affinity (NCBI) | compare |
| b0080 | fruR | -1.5 | -6.8 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1084 | rne | -1.5 | -5.3 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3621 | rfaC | -1.5 | -8.1 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0075 | leuL | -1.5 | -3.5 | leu operon leader peptide (NCBI) | compare |
| b1292 | sapC | -1.5 | -5.4 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2424 | cysU | -1.5 | -4.0 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2215 | ompC | -1.4 | -9.0 | outer membrane porin protein C (NCBI) | compare |
| b2954 | yggV | -1.4 | -5.8 | putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) | compare |
| b3052 | rfaE | -1.4 | -6.9 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3725 | pstB | -1.4 | -5.2 | phosphate transporter subunit (NCBI) | compare |
| b3792 | wzxE | -1.3 | -9.3 | O-antigen translocase (NCBI) | compare |
| b3811 | xerC | -1.3 | -4.2 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b1263 | trpD | -1.3 | -2.2 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b1726 | yniB | -1.3 | -4.3 | predicted inner membrane protein (NCBI) | compare |
| b3147 | yraM | -1.3 | -10.3 | hypothetical protein (NCBI) | compare |
| b1874 | cutC | -1.3 | -4.6 | copper homeostasis protein (NCBI) | compare |
| b4179 | vacB | -1.3 | -9.2 | putative enzyme (VIMSS) | compare |
| b4246 | pyrL | -1.3 | -1.9 | pyrBI operon leader peptide (NCBI) | compare |
| b4146 | yjeK | -1.2 | -5.7 | predicted lysine aminomutase (NCBI) | compare |
| b3237 | argR | -1.2 | -5.3 | arginine repressor (NCBI) | compare |
| b1865 | nudB | -1.2 | -2.8 | dATP pyrophosphohydrolase (NCBI) | compare |
| b2683 | ygaH | -1.2 | -2.2 | predicted inner membrane protein (NCBI) | compare |
| b0109 | nadC | -1.2 | -6.7 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b2423 | cysW | -1.2 | -6.3 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3129 | sohA | -1.2 | -2.6 | predicted regulator (NCBI) | compare |
| b2808 | gcvA | -1.2 | -7.6 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3359 | argD | -1.2 | -9.8 | bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase (NCBI) | compare |
| b2422 | cysA | -1.2 | -8.2 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b0882 | clpA | -1.2 | -8.6 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) | compare |
| b3849 | trkH | -1.2 | -9.1 | potassium transporter (NCBI) | compare |
| b3026 | qseC | -1.2 | -8.3 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b0121 | speE | -1.2 | -4.9 | spermidine synthase (NCBI) | compare |
| b1293 | sapB | -1.2 | -4.0 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3164 | pnp | -1.2 | -4.5 | polynucleotide phosphorylase/polyadenylase (RefSeq) | compare |
| b3396 | mrcA | -1.1 | -10.7 | peptidoglycan synthetase; penicillin-binding protein 1A (VIMSS) | compare |
| b4218 | ytfL | -1.1 | -8.1 | predicted inner membrane protein (NCBI) | compare |
| b3169 | nusA | -1.1 | -2.1 | transcription elongation factor NusA (NCBI) | compare |
| b1290 | sapF | -1.1 | -1.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2574 | nadB | -1.1 | -7.8 | L-aspartate oxidase (NCBI) | compare |
| b2911 | ssrS | -1.1 | -1.5 | 6S regulatory RNA (NCBI) | compare |