| | gene | name | fitness | t score | description | |
|---|
| b1261 | trpB | -8.7 | -6.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b1260 | trpA | -6.9 | -8.2 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3035 | tolC | -6.7 | -14.9 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b0386 | proC | -6.2 | -13.2 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b1130 | phoP | -6.2 | -12.3 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b2025 | hisF | -6.1 | -10.2 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3389 | aroB | -6.1 | -19.9 | 3-dehydroquinate synthase (NCBI) | compare |
| b4702 | mgtL | -6.0 | -7.8 | regulatory leader peptide for mgtA (NCBI) | compare |
| b2021 | hisC | -5.9 | -10.6 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2312 | purF | -5.9 | -11.9 | amidophosphoribosyltransferase (NCBI) | compare |
| b4005 | purD | -5.8 | -14.9 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0908 | aroA | -5.6 | -18.3 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0072 | leuC | -5.6 | -17.8 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b1129 | phoQ | -5.5 | -16.5 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b4242 | mgtA | -5.5 | -32.4 | magnesium transporter (NCBI) | compare |
| b3960 | argH | -5.5 | -18.9 | argininosuccinate lyase (NCBI) | compare |
| b2557 | purL | -5.5 | -17.8 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0243 | proA | -5.5 | -13.7 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b1693 | aroD | -5.4 | -13.7 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0522 | purK | -5.4 | -14.9 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2020 | hisD | -5.4 | -15.4 | histidinol dehydrogenase (NCBI) | compare |
| b3772 | ilvA | -5.3 | -19.9 | threonine dehydratase (NCBI) | compare |
| b3941 | metF | -5.3 | -18.0 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3774 | ilvC | -5.3 | -21.7 | ketol-acid reductoisomerase (NCBI) | compare |
| b0242 | proB | -5.3 | -8.4 | gamma-glutamyl kinase (NCBI) | compare |
| b0145 | dksA | -5.2 | -10.0 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b3281 | aroE | -5.2 | -25.1 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0033 | carB | -5.2 | -23.3 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0074 | leuA | -5.2 | -17.4 | 2-isopropylmalate synthase (NCBI) | compare |
| b4388 | serB | -5.2 | -12.5 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0049 | apaH | -5.2 | -11.0 | diadenosinetetraphosphatase (NCBI) | compare |
| b0032 | carA | -5.1 | -9.0 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2329 | aroC | -5.1 | -12.2 | chorismate synthase (NCBI) | compare |
| b1062 | pyrC | -5.0 | -12.5 | dihydroorotase (NCBI) | compare |
| b3386 | rpe | -5.0 | -3.5 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3642 | pyrE | -5.0 | -8.3 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3956 | ppc | -5.0 | -26.0 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b0071 | leuD | -5.0 | -10.5 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b3770 | ilvE | -5.0 | -17.2 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2499 | purM | -4.9 | -9.5 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b3172 | argG | -4.9 | -17.3 | argininosuccinate synthase (NCBI) | compare |
| b0073 | leuB | -4.9 | -13.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b3741 | gidA | -4.9 | -20.3 | glucose-inhibited division protein A (NCBI) | compare |
| b2023 | hisH | -4.9 | -9.7 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b0945 | pyrD | -4.9 | -19.1 | dihydroorotate dehydrogenase (NCBI) | compare |
| b4245 | pyrB | -4.8 | -16.9 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b3771 | ilvD | -4.8 | -20.3 | dihydroxy-acid dehydratase (NCBI) | compare |
| b4006 | purH | -4.8 | -17.7 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2838 | lysA | -4.8 | -18.6 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b2024 | hisA | -4.8 | -6.3 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2022 | hisB | -4.7 | -13.4 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2476 | purC | -4.7 | -7.2 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0523 | purE | -4.7 | -6.9 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0004 | thrC | -4.6 | -12.3 | threonine synthase (NCBI) | compare |
| b3829 | metE | -4.6 | -20.4 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0720 | gltA | -4.6 | -12.1 | citrate synthase (NCBI) | compare |
| b2501 | ppk | -4.6 | -17.2 | polyphosphate kinase (NCBI) | compare |
| b3828 | metR | -4.5 | -15.8 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3957 | argE | -4.5 | -15.0 | acetylornithine deacetylase (NCBI) | compare |
| b0907 | serC | -4.5 | -9.7 | phosphoserine aminotransferase (NCBI) | compare |
| b3082 | ygjM | -4.4 | -4.6 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3958 | argC | -4.4 | -17.6 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b2818 | argA | -4.3 | -13.7 | N-acetylglutamate synthase (NCBI) | compare |
| b2913 | serA | -4.3 | -15.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b2026 | hisI | -4.2 | -8.1 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b4177 | purA | -4.2 | -7.4 | adenylosuccinate synthetase (NCBI) | compare |
| b1850 | eda | -4.0 | -5.4 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b0142 | folK | -4.0 | -2.6 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b3870 | glnA | -4.0 | -6.6 | glutamine synthetase (NCBI) | compare |
| b2019 | hisG | -4.0 | -5.1 | ATP phosphoribosyltransferase (NCBI) | compare |
| b3959 | argB | -4.0 | -16.8 | acetylglutamate kinase (RefSeq) | compare |
| b0002 | thrA | -4.0 | -18.6 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2318 | truA | -3.9 | -10.7 | tRNA pseudouridine synthase A (NCBI) | compare |
| b2784 | relA | -3.8 | -17.6 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b0912 | ihfB | -3.8 | -8.0 | integration host factor subunit beta (NCBI) | compare |
| b0003 | thrB | -3.8 | -8.7 | homoserine kinase (NCBI) | compare |
| b1281 | pyrF | -3.8 | -5.2 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b4171 | miaA | -3.8 | -9.9 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b2600 | tyrA | -3.7 | -7.9 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b0439 | lon | -3.6 | -12.3 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3390 | aroK | -3.6 | -6.1 | shikimate kinase I (NCBI) | compare |
| b3706 | trmE | -3.6 | -10.1 | tRNA modification GTPase (NCBI) | compare |
| b0437 | clpP | -3.5 | -13.7 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3939 | metB | -3.5 | -14.8 | cystathionine gamma-synthase (NCBI) | compare |
| b4013 | metA | -3.5 | -6.3 | homoserine O-succinyltransferase (NCBI) | compare |
| b3405 | ompR | -3.4 | -10.2 | osmolarity response regulator (NCBI) | compare |
| b0737 | tolQ | -3.4 | -8.7 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0052 | pdxA | -3.3 | -13.4 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b1712 | ihfA | -3.2 | -7.5 | integration host factor subunit alpha (NCBI) | compare |
| b0051 | ksgA | -3.2 | -12.9 | dimethyladenosine transferase (NCBI) | compare |
| b3671 | ilvB | -3.2 | -19.6 | acetolactate synthase large subunit (NCBI) | compare |
| b2567 | rnc | -3.1 | -4.0 | ribonuclease III (NCBI) | compare |
| b3839 | tatC | -3.1 | -13.0 | TatABCE protein translocation system subunit (NCBI) | compare |
| b3773 | ilvY | -3.0 | -9.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3008 | metC | -3.0 | -15.5 | cystathionine beta-lyase (NCBI) | compare |
| b0738 | tolR | -3.0 | -7.4 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2599 | pheA | -2.9 | -6.5 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b0726 | sucA | -2.8 | -8.2 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0740 | tolB | -2.8 | -10.7 | translocation protein TolB precursor (NCBI) | compare |
| b2839 | lysR | -2.7 | -5.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2017 | yefM | -2.7 | -2.3 | orf, hypothetical protein (VIMSS) | compare |
| b2564 | pdxJ | -2.6 | -9.5 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b1192 | ldcA | -2.6 | -11.3 | L,D-carboxypeptidase A (NCBI) | compare |
| b1291 | sapD | -2.5 | -4.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b4042 | dgkA | -2.4 | -6.7 | diacylglycerol kinase (NCBI) | compare |
| b0739 | tolA | -2.4 | -7.7 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b4172 | hfq | -2.4 | -3.7 | RNA-binding protein Hfq (NCBI) | compare |
| b0683 | fur | -2.4 | -4.8 | ferric uptake regulator (NCBI) | compare |
| b3204 | ptsN | -2.4 | -9.7 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0200 | gmhB | -2.4 | -3.3 | hypothetical protein (NCBI) | compare |
| b0741 | pal | -2.3 | -8.5 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b4202 | rpsR | -2.3 | -3.6 | 30S ribosomal protein S18 (NCBI) | compare |
| b1438 | ydcQ | -2.3 | -9.8 | predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b3545 | proK | -2.2 | -7.0 | tRNA-Pro (NCBI) | compare |
| b1262 | trpC | -2.2 | -5.7 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0114 | aceE | -2.1 | -6.0 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b0113 | pdhR | -2.1 | -6.2 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3764 | yifE | -2.1 | -7.9 | hypothetical protein (NCBI) | compare |
| b3613 | yibP | -1.9 | -9.4 | putative membrane protein (VIMSS) | compare |
| b2822 | recC | -1.9 | -7.2 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b1186 | nhaB | -1.9 | -10.5 | NhaB sodium/proton transporter (Katherine Huang) | compare |
| b3670 | ilvN | -1.9 | -9.4 | acetolactate synthase small subunit (NCBI) | compare |
| b1292 | sapC | -1.9 | -6.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0928 | aspC | -1.8 | -8.9 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0118 | acnB | -1.8 | -8.3 | aconitate hydratase (NCBI) | compare |
| b0080 | fruR | -1.8 | -7.8 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1232 | purU | -1.8 | -10.2 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b2479 | gcvR | -1.7 | -7.9 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0075 | leuL | -1.7 | -4.1 | leu operon leader peptide (NCBI) | compare |
| b3021 | ygiT | -1.7 | -8.2 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b2820 | recB | -1.7 | -4.8 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b0438 | clpX | -1.7 | -7.7 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3792 | wzxE | -1.7 | -11.0 | O-antigen translocase (NCBI) | compare |
| b3838 | tatB | -1.7 | -6.8 | sec-independent translocase (NCBI) | compare |
| b3619 | rfaD | -1.7 | -7.4 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b2188 | yejM | -1.6 | -8.4 | predicted hydrolase, inner membrane (NCBI) | compare |
| b3169 | nusA | -1.6 | -4.7 | transcription elongation factor NusA (NCBI) | compare |
| b0890 | ftsK | -1.6 | -10.9 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1293 | sapB | -1.6 | -3.7 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1865 | nudB | -1.6 | -2.5 | dATP pyrophosphohydrolase (NCBI) | compare |
| b3672 | ivbL | -1.6 | -3.9 | ilvB operon leader peptide (NCBI) | compare |
| b0889 | lrp | -1.6 | -5.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b2340 | sixA | -1.6 | -6.1 | phosphohistidine phosphatase (NCBI) | compare |
| b1863 | ruvC | -1.6 | -5.0 | Holliday junction resolvase (NCBI) | compare |
| b1871 | yecP | -1.6 | -5.1 | predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) | compare |
| b3781 | trxA | -1.6 | -6.9 | thioredoxin 1 (VIMSS) | compare |
| b3052 | rfaE | -1.6 | -7.1 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3493 | pitA | -1.6 | -10.5 | phosphate transporter, low-affinity (NCBI) | compare |
| b1084 | rne | -1.5 | -6.0 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3811 | xerC | -1.5 | -4.9 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b4480 | hdfR | -1.5 | -7.3 | transcriptional regulator HdfR (NCBI) | compare |
| b3621 | rfaC | -1.5 | -7.8 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b2894 | xerD | -1.5 | -2.6 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3359 | argD | -1.5 | -12.1 | bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase (NCBI) | compare |
| b0767 | ybhE | -1.4 | -5.8 | 6-phosphogluconolactonase (NCBI) | compare |
| b4155 | yjeA | -1.4 | -3.6 | putative lysyl-tRNA synthetase (VIMSS) | compare |
| b1290 | sapF | -1.4 | -2.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2830 | nudH | -1.4 | -3.2 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b4179 | vacB | -1.4 | -9.9 | putative enzyme (VIMSS) | compare |
| b1264 | trpE | -1.4 | -3.2 | anthranilate synthase component I (NCBI) | compare |
| b0750 | nadA | -1.4 | -7.4 | quinolinate synthetase (NCBI) | compare |
| b2954 | yggV | -1.4 | -4.9 | putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) | compare |
| b0888 | trxB | -1.4 | -6.5 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b2808 | gcvA | -1.3 | -8.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0222 | lpcA | -1.3 | -4.8 | phosphoheptose isomerase (NCBI) | compare |
| b3916 | pfkA | -1.3 | -6.2 | 6-phosphofructokinase (NCBI) | compare |
| b3849 | trkH | -1.3 | -10.0 | potassium transporter (NCBI) | compare |
| b3935 | priA | -1.3 | -1.5 | primosome assembly protein PriA (NCBI) | compare |
| b3026 | qseC | -1.3 | -7.5 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b3725 | pstB | -1.2 | -4.7 | phosphate transporter subunit (NCBI) | compare |
| b2320 | pdxB | -1.2 | -8.2 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b1861 | ruvA | -1.2 | -2.3 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b2683 | ygaH | -1.2 | -2.5 | predicted inner membrane protein (NCBI) | compare |
| b3791 | rffA | -1.2 | -8.1 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b4218 | ytfL | -1.2 | -8.0 | predicted inner membrane protein (NCBI) | compare |
| b3164 | pnp | -1.2 | -3.8 | polynucleotide phosphorylase/polyadenylase (RefSeq) | compare |
| b4180 | rlmB | -1.2 | -8.1 | 23S rRNA (Gm2251)-methyltransferase (NCBI) | compare |
| b1874 | cutC | -1.2 | -3.7 | copper homeostasis protein (NCBI) | compare |
| b4481 | rffT | -1.1 | -7.3 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b1096 | pabC | -1.1 | -5.1 | 4-amino-4-deoxychorismate lyase (NCBI) | compare |
| b2911 | ssrS | -1.1 | -2.4 | 6S regulatory RNA (NCBI) | compare |
| b2699 | recA | -1.1 | -3.5 | recombinase A (NCBI) | compare |
| b2330 | yfcB | -1.1 | -2.9 | putative adenine-specific methylase (VIMSS) | compare |
| b0088 | murD | -1.1 | -1.7 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b0400 | phoR | -1.1 | -6.3 | sensory histidine kinase in two-component regulatory system with PhoB (NCBI) | compare |
| b0109 | nadC | -1.1 | -6.9 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b4246 | pyrL | -1.1 | -1.6 | pyrBI operon leader peptide (NCBI) | compare |
| b4146 | yjeK | -1.1 | -4.6 | predicted lysine aminomutase (NCBI) | compare |
| b2313 | cvpA | -1.1 | -2.2 | membrane protein required for colicin V production (NCBI) | compare |
| b3398 | yrfF | -1.0 | -2.4 | predicted inner membrane protein (NCBI) | compare |
| b1860 | ruvB | -1.0 | -1.8 | Holliday junction DNA helicase B (NCBI) | compare |
| b3129 | sohA | -1.0 | -2.5 | predicted regulator (NCBI) | compare |
| b3396 | mrcA | -1.0 | -9.8 | peptidoglycan synthetase; penicillin-binding protein 1A (VIMSS) | compare |
| b0882 | clpA | -1.0 | -7.7 | ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) | compare |
| b3147 | yraM | -1.0 | -8.6 | hypothetical protein (NCBI) | compare |
| b3911 | cpxA | -1.0 | -7.4 | two-component sensor protein (NCBI) | compare |
| b0121 | speE | -1.0 | -4.7 | spermidine synthase (NCBI) | compare |
| b3463 | ftsE | -1.0 | -5.3 | predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) | compare |
| b1263 | trpD | -1.0 | -2.6 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b3863 | polA | -1.0 | -1.8 | DNA polymerase I (NCBI) | compare |