Experiment set58S332 for Escherichia coli BW25113

Compare to:

DRT_type_3

200 most important genes:

  gene name fitness t score description  
b2819 recD -9.9 -6.8 exonuclease V (RecBCD complex), alpha chain (NCBI) compare
b2945 endA -9.8 -5.8 DNA-specific endonuclease I (NCBI) compare
b3163 nlpI -6.2 -3.9 hypothetical protein (NCBI) compare
b2784 relA -6.1 -16.1 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b1830 prc -6.1 -4.2 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0611 rna -5.9 -6.8 ribonuclease I (NCBI) compare
b0053 surA -5.2 -6.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3791 rffA -4.9 -13.1 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3035 tolC -4.7 -12.8 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0222 lpcA -4.7 -2.3 phosphoheptose isomerase (NCBI) compare
b3341 rpsG -4.6 -1.3 30S ribosomal protein S7 (NCBI) compare
b3786 rffE -4.6 -18.0 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3790 rffC -4.5 -8.1 TDP-fucosamine acetyltransferase (RefSeq) compare
b3181 greA -4.3 -5.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0142 folK -4.3 -0.7 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b3787 rffD -4.2 -14.0 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b0439 lon -4.1 -4.8 DNA-binding ATP-dependent protease La (NCBI) compare
b1334 fnr -4.1 -3.8 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b3784 rfe -4.0 -17.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1279 yciS -4.0 -1.1 conserved inner membrane protein (NCBI) compare
b3621 rfaC -3.9 -3.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0903 pflB -3.9 -16.9 pyruvate formate lyase I (NCBI) compare
b0014 dnaK -3.9 -2.6 molecular chaperone DnaK (NCBI) compare
b3052 rfaE -3.8 -7.3 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3620 rfaF -3.8 -6.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0902 pflA -3.7 -8.8 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b3916 pfkA -3.7 -2.6 6-phosphofructokinase (NCBI) compare
b3794 rffM -3.6 -8.0 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3026 qseC -3.5 -5.8 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0049 apaH -3.5 -2.2 diadenosinetetraphosphatase (NCBI) compare
b3839 tatC -3.5 -11.6 TatABCE protein translocation system subunit (NCBI) compare
b0462 acrB -3.5 -21.7 multidrug efflux system protein (NCBI) compare
b4481 rffT -3.5 -7.9 4-alpha-L-fucosyltransferase (NCBI) compare
b2518 ndk -3.5 -3.2 nucleoside diphosphate kinase (NCBI) compare
b3183 obgE -3.4 -1.1 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1865 nudB -3.4 -2.1 dATP pyrophosphohydrolase (NCBI) compare
b0463 acrA -3.3 -13.9 multidrug efflux system (NCBI) compare
b3778 rep -3.3 -11.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1863 ruvC -3.3 -1.6 Holliday junction resolvase (NCBI) compare
b3162 deaD -3.3 -5.4 inducible ATP-independent RNA helicase (VIMSS) compare
b4025 pgi -3.2 -10.4 glucose-6-phosphate isomerase (NCBI) compare
b1361 ydaW -3.2 -0.7 orf, hypothetical protein (VIMSS) compare
b1861 ruvA -3.2 -1.2 Holliday junction DNA helicase motor protein (NCBI) compare
b3387 dam -3.2 -15.9 DNA adenine methylase (NCBI) compare
b1241 adhE -3.2 -12.5 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b3619 rfaD -3.2 -4.8 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1236 galU -3.0 -7.4 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2512 yfgL -3.0 -7.4 protein assembly complex, lipoprotein component (NCBI) compare
b3164 pnp -3.0 -3.7 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1290 sapF -2.9 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3871 bipA -2.9 -12.6 GTP-binding protein (NCBI) compare
b2830 nudH -2.9 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b4171 miaA -2.9 -2.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0738 tolR -2.9 -2.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1231 tyrT -2.8 -1.0 tRNA-Tyr (NCBI) compare
b4647 mokA -2.8 -0.9 no description compare
b0739 tolA -2.8 -3.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1677 lpp -2.8 -2.0 murein lipoprotein (NCBI) compare
b1292 sapC -2.8 -2.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1185 dsbB -2.7 -4.1 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0386 proC -2.7 -5.1 pyrroline-5-carboxylate reductase (NCBI) compare
b3390 aroK -2.7 -1.9 shikimate kinase I (NCBI) compare
b0149 mrcB -2.7 -15.2 penicillin-binding protein 1b (NCBI) compare
b2501 ppk -2.7 -13.6 polyphosphate kinase (NCBI) compare
b0683 fur -2.7 -0.7 ferric uptake regulator (NCBI) compare
b0088 murD -2.7 -2.6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1252 tonB -2.6 -4.8 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3631 rfaG -2.6 -17.2 glucosyltransferase I (NCBI) compare
b2576 srmB -2.6 -4.5 ATP-dependent RNA helicase (NCBI) compare
b1860 ruvB -2.6 -0.9 Holliday junction DNA helicase B (NCBI) compare
b1613 manA -2.6 -3.0 mannose-6-phosphate isomerase (VIMSS) compare
b1192 ldcA -2.6 -6.6 L,D-carboxypeptidase A (NCBI) compare
b1685 ydiH -2.5 -1.8 predicted protein (RefSeq) compare
b0232 yafN -2.5 -0.6 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1187 fadR -2.5 -6.5 fatty acid metabolism regulator (NCBI) compare
b2281 nuoI -2.5 -4.2 NADH dehydrogenase subunit I (NCBI) compare
b3838 tatB -2.5 -6.2 sec-independent translocase (NCBI) compare
b3927 glpF -2.5 -13.1 glycerol facilitator (NCBI) compare
b4701 sokX -2.4 -1.1 sok-related sRNA, function unknown (RefSeq) compare
b3493 pitA -2.4 -10.4 phosphate transporter, low-affinity (NCBI) compare
b2620 smpB -2.4 -0.8 SsrA-binding protein (NCBI) compare
b0741 pal -2.4 -4.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1176 minC -2.4 -4.0 septum formation inhibitor (NCBI) compare
b0737 tolQ -2.3 -3.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2330 yfcB -2.3 -1.0 putative adenine-specific methylase (VIMSS) compare
b3652 recG -2.3 -11.2 ATP-dependent DNA helicase (NCBI) compare
b0051 ksgA -2.3 -7.2 dimethyladenosine transferase (NCBI) compare
b3860 dsbA -2.3 -8.9 periplasmic protein disulfide isomerase I (NCBI) compare
b1831 proQ -2.2 -3.2 putative solute/DNA competence effector (NCBI) compare
b2569 lepA -2.2 -5.7 GTP-binding protein LepA (NCBI) compare
b4201 priB -2.2 -2.7 primosomal replication protein N (NCBI) compare
b3781 trxA -2.2 -4.0 thioredoxin 1 (VIMSS) compare
b3613 yibP -2.2 -2.1 putative membrane protein (VIMSS) compare
b1332 ynaJ -2.2 -0.8 predicted inner membrane protein (NCBI) compare
b4416 rybA -2.2 -1.5 unknown RNA (NCBI) compare
b0082 mraW -2.2 -3.6 S-adenosyl-methyltransferase (NCBI) compare
b3500 gor -2.1 -1.7 glutathione reductase (NCBI) compare
b4139 aspA -2.1 -10.0 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b1175 minD -2.1 -4.4 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b1291 sapD -2.0 -2.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3630 rfaP -2.0 -12.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2808 gcvA -2.0 -4.2 DNA-binding transcriptional dual regulator (NCBI) compare
b1286 rnb -2.0 -2.8 exoribonuclease II (NCBI) compare
b0721 sdhC -2.0 -4.9 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0145 dksA -1.9 -3.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2288 nuoA -1.8 -3.1 NADH dehydrogenase I chain A (VIMSS) compare
b3863 polA -1.8 -0.7 DNA polymerase I (NCBI) compare
b1765 ydjA -1.8 -1.0 predicted oxidoreductase (NCBI) compare
b2287 nuoB -1.8 -3.0 NADH dehydrogenase subunit B (NCBI) compare
b3147 yraM -1.8 -11.2 hypothetical protein (NCBI) compare
b3806 cyaA -1.8 -6.6 adenylate cyclase (NCBI) compare
b3935 priA -1.7 -2.9 primosome assembly protein PriA (NCBI) compare
b3658 selC -1.7 -1.9 tRNA-Sec (NCBI) compare
b3933 ftsN -1.7 -9.1 essential cell division protein (NCBI) compare
b0912 ihfB -1.7 -3.1 integration host factor subunit beta (NCBI) compare
b3396 mrcA -1.7 -12.5 peptidoglycan synthetase; penicillin-binding protein 1A (VIMSS) compare
b3389 aroB -1.7 -9.6 3-dehydroquinate synthase (NCBI) compare
b1095 fabF -1.6 -6.5 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1712 ihfA -1.6 -1.5 integration host factor subunit alpha (NCBI) compare
b0143 pcnB -1.6 -4.2 poly(A) polymerase I (VIMSS) compare
b4509 ylcG -1.6 -1.6 DLP12 prophage; predicted protein (NCBI) compare
b2616 recN -1.6 -9.0 recombination and repair protein (NCBI) compare
b2531 iscR -1.6 -1.4 DNA-binding transcriptional repressor (NCBI) compare
b1129 phoQ -1.6 -2.1 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b4203 rplI -1.6 -3.3 50S ribosomal protein L9 (NCBI) compare
b0018 mokC -1.6 -1.3 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b3388 damX -1.6 -10.5 hypothetical protein (NCBI) compare
b2937 speB -1.6 -6.8 agmatinase (NCBI) compare
b4041 plsB -1.5 -1.6 glycerol-3-phosphate acyltransferase (VIMSS) compare
b3706 trmE -1.5 -3.7 tRNA modification GTPase (NCBI) compare
b2283 nuoG -1.5 -6.9 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3005 exbD -1.5 -4.6 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0548 ninE -1.5 -2.7 DLP12 prophage; conserved protein (NCBI) compare
b3868 glnG -1.5 -5.6 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b4179 vacB -1.5 -6.1 putative enzyme (VIMSS) compare
b3405 ompR -1.5 -4.5 osmolarity response regulator (NCBI) compare
b4685 yrbN -1.5 -2.9 expressed protein (RefSeq) compare
b2284 nuoF -1.5 -4.3 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0888 trxB -1.5 -2.1 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1084 rne -1.5 -4.2 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b0722 sdhD -1.5 -4.8 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b3764 yifE -1.4 -3.9 hypothetical protein (NCBI) compare
b3609 secB -1.4 -2.0 export protein SecB (NCBI) compare
b3842 rfaH -1.4 -6.1 transcriptional activator RfaH (NCBI) compare
b1164 ycgZ -1.4 -1.6 hypothetical protein (NCBI) compare
b2168 fruK -1.4 -0.9 1-phosphofructokinase (NCBI) compare
b1261 trpB -1.4 -2.1 tryptophan synthase subunit beta (NCBI) compare
b2085 b2085 -1.4 -4.3 orf, hypothetical protein (VIMSS) compare
b0740 tolB -1.4 -3.2 translocation protein TolB precursor (NCBI) compare
b3792 wzxE -1.4 -6.0 O-antigen translocase (NCBI) compare
b2951 yggS -1.4 -4.8 predicted enzyme (NCBI) compare
b0904 focA -1.4 -3.5 formate transporter (NCBI) compare
b2276 nuoN -1.4 -4.3 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b0724 sdhB -1.4 -4.4 succinate dehydrogenase, FeS subunit (NCBI) compare
b2286 nuoC -1.4 -4.4 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b1058 yceO -1.4 -0.3 hypothetical protein (NCBI) compare
b0059 hepA -1.4 -9.3 ATP-dependent helicase HepA (NCBI) compare
b2278 nuoL -1.4 -7.7 NADH dehydrogenase subunit L (NCBI) compare
b2071 yegJ -1.3 -1.4 hypothetical protein (NCBI) compare
b1130 phoP -1.3 -1.9 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b0688 pgm -1.3 -3.4 phosphoglucomutase (NCBI) compare
b2905 gcvT -1.3 -5.5 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1505 ydeT -1.3 -0.8 hypothetical protein (RefSeq) compare
b3803 hemX -1.3 -7.4 predicted uroporphyrinogen III methylase (NCBI) compare
b4375 prfC -1.3 -1.3 peptide chain release factor 3 (NCBI) compare
b0191 yaeJ -1.3 -2.9 hypothetical protein (NCBI) compare
b0819 ybiS -1.3 -5.3 hypothetical protein (NCBI) compare
b2893 dsbC -1.3 -6.1 protein disulfide isomerase II (NCBI) compare
b1101 ptsG -1.3 -6.4 fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) compare
b0723 sdhA -1.3 -7.2 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b2897 ygfY -1.3 -2.7 hypothetical protein (NCBI) compare
b2113 mrp -1.3 -4.7 putative ATPase (VIMSS) compare
b4042 dgkA -1.3 -0.7 diacylglycerol kinase (NCBI) compare
b3438 gntR -1.3 -5.0 DNA-binding transcriptional repressor (NCBI) compare
b4603 rseX -1.3 -0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1726 yniB -1.3 -1.8 predicted inner membrane protein (NCBI) compare
b2699 recA -1.3 -0.6 recombinase A (NCBI) compare
b3107 yhaL -1.2 -1.2 orf, hypothetical protein (VIMSS) compare
b1105 ycfM -1.2 -2.7 predicted outer membrane lipoprotein (NCBI) compare
b3237 argR -1.2 -3.9 arginine repressor (NCBI) compare
b2938 speA -1.2 -7.3 arginine decarboxylase (NCBI) compare
b1258 yciF -1.2 -1.0 hypothetical protein (NCBI) compare
b0605 ahpC -1.2 -2.3 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3236 mdh -1.2 -6.2 malate dehydrogenase (NCBI) compare
b1351 racC -1.2 -0.5 Rac prophage; predicted protein (NCBI) compare
b2285 nuoE -1.2 -1.5 NADH dehydrogenase subunit E (NCBI) compare
b4046 yjbK -1.2 -4.6 putative regulator (VIMSS) compare
b1591 b1591 -1.2 -1.1 putative oxidoreductase component (VIMSS) compare
b1724 ydiZ -1.2 -1.8 hypothetical protein (NCBI) compare
b0720 gltA -1.2 -3.9 citrate synthase (NCBI) compare
b1109 ndh -1.2 -2.7 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b0406 tgt -1.2 -5.4 queuine tRNA-ribosyltransferase (NCBI) compare
b2318 truA -1.2 -2.0 tRNA pseudouridine synthase A (NCBI) compare
b4480 hdfR -1.2 -4.4 transcriptional regulator HdfR (NCBI) compare
b0133 panC -1.2 -3.9 pantoate--beta-alanine ligase (NCBI) compare
b0113 pdhR -1.2 -4.4 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b2494 yfgC -1.2 -5.2 predicted peptidase (NCBI) compare
b2564 pdxJ -1.2 -3.4 pyridoxal phosphate biosynthetic protein (NCBI) compare
b2277 nuoM -1.2 -5.4 NADH dehydrogenase subunit M (NCBI) compare
b1424 mdoD -1.1 -5.0 glucan biosynthesis protein, periplasmic (RefSeq) compare


Specific Phenotypes

For 10 genes in this experiment

For drt_type_3 Kanamycin sulfate in Escherichia coli BW25113

For drt_type_3 Kanamycin sulfate across organisms