Experiment set58S331 for Escherichia coli BW25113

Compare to:

retron_Ec_48_control

200 most important genes:

  gene name fitness t score description  
b2819 recD -9.7 -6.5 exonuclease V (RecBCD complex), alpha chain (NCBI) compare
b0611 rna -9.5 -4.4 ribonuclease I (NCBI) compare
b2945 endA -8.0 -7.0 DNA-specific endonuclease I (NCBI) compare
b2784 relA -7.3 -14.0 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b3387 dam -6.4 -17.6 DNA adenine methylase (NCBI) compare
b3163 nlpI -6.0 -3.6 hypothetical protein (NCBI) compare
b1830 prc -5.9 -4.1 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3035 tolC -5.6 -13.6 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0053 surA -5.2 -3.6 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1685 ydiH -5.1 -1.4 predicted protein (RefSeq) compare
b4201 priB -5.1 -2.9 primosomal replication protein N (NCBI) compare
b3052 rfaE -4.8 -4.7 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3790 rffC -4.7 -6.7 TDP-fucosamine acetyltransferase (RefSeq) compare
b0014 dnaK -4.7 -2.2 molecular chaperone DnaK (NCBI) compare
b0143 pcnB -4.6 -8.4 poly(A) polymerase I (VIMSS) compare
b3181 greA -4.6 -5.1 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3784 rfe -4.5 -17.6 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b0222 lpcA -4.5 -2.1 phosphoheptose isomerase (NCBI) compare
b0463 acrA -4.5 -14.5 multidrug efflux system (NCBI) compare
b3341 rpsG -4.5 -1.2 30S ribosomal protein S7 (NCBI) compare
b3839 tatC -4.4 -8.0 TatABCE protein translocation system subunit (NCBI) compare
b0462 acrB -4.3 -20.8 multidrug efflux system protein (NCBI) compare
b3791 rffA -4.2 -9.1 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b2808 gcvA -4.2 -6.5 DNA-binding transcriptional dual regulator (NCBI) compare
b4203 rplI -4.2 -5.4 50S ribosomal protein L9 (NCBI) compare
b3935 priA -4.1 -2.7 primosome assembly protein PriA (NCBI) compare
b0142 folK -4.1 -0.6 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b0903 pflB -4.1 -14.5 pyruvate formate lyase I (NCBI) compare
b3786 rffE -4.1 -16.5 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b0439 lon -4.0 -3.9 DNA-binding ATP-dependent protease La (NCBI) compare
b3631 rfaG -4.0 -23.3 glucosyltransferase I (NCBI) compare
b3778 rep -4.0 -8.6 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3620 rfaF -4.0 -3.9 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3794 rffM -3.9 -9.1 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b0902 pflA -3.8 -8.6 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b3621 rfaC -3.8 -3.7 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3026 qseC -3.7 -4.4 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2071 yegJ -3.7 -1.1 hypothetical protein (NCBI) compare
b4481 rffT -3.7 -9.2 4-alpha-L-fucosyltransferase (NCBI) compare
b4025 pgi -3.6 -10.8 glucose-6-phosphate isomerase (NCBI) compare
b3787 rffD -3.6 -12.3 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b2512 yfgL -3.5 -7.4 protein assembly complex, lipoprotein component (NCBI) compare
b3916 pfkA -3.5 -2.4 6-phosphofructokinase (NCBI) compare
b1175 minD -3.5 -4.9 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b3500 gor -3.5 -1.4 glutathione reductase (NCBI) compare
b3630 rfaP -3.5 -15.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b0145 dksA -3.5 -4.7 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1236 galU -3.4 -6.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3619 rfaD -3.4 -2.4 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b2501 ppk -3.3 -12.2 polyphosphate kinase (NCBI) compare
b3977 tyrU -3.3 -0.7 tRNA-Tyr (NCBI) compare
b3162 deaD -3.3 -3.9 inducible ATP-independent RNA helicase (VIMSS) compare
b3183 obgE -3.3 -1.0 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0688 pgm -3.2 -4.5 phosphoglucomutase (NCBI) compare
b2279 nuoK -3.2 -1.6 NADH dehydrogenase subunit K (NCBI) compare
b1863 ruvC -3.1 -1.5 Holliday junction resolvase (NCBI) compare
b1176 minC -3.1 -3.4 septum formation inhibitor (NCBI) compare
b1861 ruvA -3.1 -1.1 Holliday junction DNA helicase motor protein (NCBI) compare
b3021 ygiT -3.0 -3.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2569 lepA -3.0 -5.6 GTP-binding protein LepA (NCBI) compare
b1334 fnr -2.9 -3.7 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1241 adhE -2.9 -13.3 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b1677 lpp -2.9 -1.7 murein lipoprotein (NCBI) compare
b3860 dsbA -2.9 -10.5 periplasmic protein disulfide isomerase I (NCBI) compare
b1185 dsbB -2.7 -3.9 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0049 apaH -2.7 -2.8 diadenosinetetraphosphatase (NCBI) compare
b0737 tolQ -2.7 -2.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0149 mrcB -2.7 -13.8 penicillin-binding protein 1b (NCBI) compare
b4647 mokA -2.7 -0.8 no description compare
b0015 dnaJ -2.7 -9.2 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b1192 ldcA -2.6 -4.8 L,D-carboxypeptidase A (NCBI) compare
b0739 tolA -2.6 -3.7 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3871 bipA -2.6 -11.1 GTP-binding protein (NCBI) compare
b2576 srmB -2.6 -4.5 ATP-dependent RNA helicase (NCBI) compare
b0683 fur -2.6 -0.7 ferric uptake regulator (NCBI) compare
b0888 trxB -2.5 -2.6 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2830 nudH -2.5 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b1860 ruvB -2.5 -0.8 Holliday junction DNA helicase B (NCBI) compare
b2617 smpA -2.4 -3.6 small membrane protein A (VIMSS) compare
b1865 nudB -2.4 -1.6 dATP pyrophosphohydrolase (NCBI) compare
b2518 ndk -2.4 -3.2 nucleoside diphosphate kinase (NCBI) compare
b2284 nuoF -2.3 -5.8 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0386 proC -2.3 -4.0 pyrroline-5-carboxylate reductase (NCBI) compare
b0740 tolB -2.3 -4.4 translocation protein TolB precursor (NCBI) compare
b3838 tatB -2.3 -5.5 sec-independent translocase (NCBI) compare
b1346 ydaQ -2.3 -1.7 orf, hypothetical protein (VIMSS) compare
b3933 ftsN -2.3 -9.4 essential cell division protein (NCBI) compare
b0721 sdhC -2.3 -4.3 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b3842 rfaH -2.2 -5.1 transcriptional activator RfaH (NCBI) compare
b4171 miaA -2.2 -2.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2620 smpB -2.2 -0.7 SsrA-binding protein (NCBI) compare
b3493 pitA -2.2 -9.4 phosphate transporter, low-affinity (NCBI) compare
b1613 manA -2.2 -2.0 mannose-6-phosphate isomerase (VIMSS) compare
b1286 rnb -2.2 -2.7 exoribonuclease II (NCBI) compare
b2330 yfcB -2.2 -0.9 putative adenine-specific methylase (VIMSS) compare
b3438 gntR -2.2 -6.1 DNA-binding transcriptional repressor (NCBI) compare
b3636 rpmG -2.1 -1.4 50S ribosomal protein L33 (NCBI) compare
b3652 recG -2.1 -9.0 ATP-dependent DNA helicase (NCBI) compare
b2318 truA -2.1 -2.5 tRNA pseudouridine synthase A (NCBI) compare
b1279 yciS -2.1 -0.9 conserved inner membrane protein (NCBI) compare
b3389 aroB -2.1 -10.2 3-dehydroquinate synthase (NCBI) compare
b3613 yibP -2.0 -2.0 putative membrane protein (VIMSS) compare
b0051 ksgA -2.0 -5.4 dimethyladenosine transferase (NCBI) compare
b1831 proQ -2.0 -3.3 putative solute/DNA competence effector (NCBI) compare
b2579 yfiD -2.0 -1.9 pyruvate formate lyase subunit (NCBI) compare
b2498 upp -2.0 -4.0 uracil phosphoribosyltransferase (VIMSS) compare
b3726 pstA -2.0 -4.4 phosphate transporter subunit (NCBI) compare
b2276 nuoN -2.0 -5.3 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b4480 hdfR -2.0 -5.5 transcriptional regulator HdfR (NCBI) compare
b4139 aspA -1.9 -10.4 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b4685 yrbN -1.9 -2.9 expressed protein (RefSeq) compare
b1252 tonB -1.9 -4.0 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3868 glnG -1.8 -3.6 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b1187 fadR -1.8 -3.7 fatty acid metabolism regulator (NCBI) compare
b4603 rseX -1.8 -0.7 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b0738 tolR -1.8 -2.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3017 sufI -1.8 -9.5 repressor protein for FtsI (NCBI) compare
b3927 glpF -1.8 -9.6 glycerol facilitator (NCBI) compare
b1258 yciF -1.7 -0.7 hypothetical protein (NCBI) compare
b1129 phoQ -1.7 -1.2 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b2894 xerD -1.7 -0.6 site-specific tyrosine recombinase XerD (NCBI) compare
b1648 b1648 -1.7 -1.4 orf, hypothetical protein (VIMSS) compare
b2282 nuoH -1.7 -3.2 NADH dehydrogenase subunit H (NCBI) compare
b3863 polA -1.7 -0.6 DNA polymerase I (NCBI) compare
b3781 trxA -1.7 -3.1 thioredoxin 1 (VIMSS) compare
b1130 phoP -1.6 -1.1 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b0819 ybiS -1.6 -6.1 hypothetical protein (NCBI) compare
b2494 yfgC -1.6 -7.0 predicted peptidase (NCBI) compare
b2897 ygfY -1.6 -3.2 hypothetical protein (NCBI) compare
b0605 ahpC -1.6 -2.7 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b0957 ompA -1.6 -2.6 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b3388 damX -1.6 -10.2 hypothetical protein (NCBI) compare
b2281 nuoI -1.6 -2.2 NADH dehydrogenase subunit I (NCBI) compare
b2616 recN -1.6 -9.2 recombination and repair protein (NCBI) compare
b4179 vacB -1.6 -6.9 putative enzyme (VIMSS) compare
b0232 yafN -1.6 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1109 ndh -1.5 -3.3 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b0912 ihfB -1.5 -3.0 integration host factor subunit beta (NCBI) compare
b2893 dsbC -1.5 -4.5 protein disulfide isomerase II (NCBI) compare
b1482 osmC -1.5 -2.1 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3706 trmE -1.5 -2.9 tRNA modification GTPase (NCBI) compare
b0904 focA -1.5 -2.9 formate transporter (NCBI) compare
b1101 ptsG -1.5 -7.4 fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) compare
b2189 proL -1.5 -1.4 tRNA-Pro (NCBI) compare
b0741 pal -1.5 -2.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3803 hemX -1.5 -8.2 predicted uroporphyrinogen III methylase (NCBI) compare
b0082 mraW -1.5 -2.8 S-adenosyl-methyltransferase (NCBI) compare
b3281 aroE -1.5 -9.5 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b2287 nuoB -1.5 -2.2 NADH dehydrogenase subunit B (NCBI) compare
b3226 yhcK -1.5 -4.5 putative FADA-type transcriptional regulator (VIMSS) compare
b3844 fre -1.4 -3.8 NAD(P)H-flavin reductase (NCBI) compare
b0263 afuB -1.4 -2.6 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b3147 yraM -1.4 -8.8 hypothetical protein (NCBI) compare
b2286 nuoC -1.4 -4.4 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b0722 sdhD -1.4 -3.5 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b1231 tyrT -1.4 -0.7 tRNA-Tyr (NCBI) compare
b2413 cysZ -1.4 -5.8 putative sulfate transport protein CysZ (NCBI) compare
b3396 mrcA -1.4 -10.5 peptidoglycan synthetase; penicillin-binding protein 1A (VIMSS) compare
b2278 nuoL -1.4 -7.6 NADH dehydrogenase subunit L (NCBI) compare
b2937 speB -1.4 -5.9 agmatinase (NCBI) compare
b2903 gcvP -1.4 -8.4 glycine dehydrogenase (NCBI) compare
b1159 mcrA -1.4 -1.0 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b1724 ydiZ -1.4 -1.5 hypothetical protein (NCBI) compare
b1281 pyrF -1.4 -3.3 orotidine 5'-phosphate decarboxylase (NCBI) compare
b4613 dinQ -1.4 -1.3 Damage inducible, function unknown (RefSeq) compare
b2822 recC -1.4 -2.4 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1143 ymfI -1.4 -1.2 orf, hypothetical protein (VIMSS) compare
b0720 gltA -1.4 -4.6 citrate synthase (NCBI) compare
b0548 ninE -1.3 -2.1 DLP12 prophage; conserved protein (NCBI) compare
b2951 yggS -1.3 -4.6 predicted enzyme (NCBI) compare
b3792 wzxE -1.3 -5.7 O-antigen translocase (NCBI) compare
b1084 rne -1.3 -4.0 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b0723 sdhA -1.3 -8.2 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b0406 tgt -1.3 -4.3 queuine tRNA-ribosyltransferase (NCBI) compare
b3164 pnp -1.3 -2.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0059 hepA -1.3 -9.2 ATP-dependent helicase HepA (NCBI) compare
b1058 yceO -1.3 -0.3 hypothetical protein (NCBI) compare
b3390 aroK -1.3 -1.2 shikimate kinase I (NCBI) compare
b1095 fabF -1.3 -4.8 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3870 glnA -1.3 -2.7 glutamine synthetase (NCBI) compare
b2564 pdxJ -1.3 -3.2 pyridoxal phosphate biosynthetic protein (NCBI) compare
b0908 aroA -1.3 -5.0 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b0724 sdhB -1.3 -4.5 succinate dehydrogenase, FeS subunit (NCBI) compare
b4177 purA -1.3 -2.4 adenylosuccinate synthetase (NCBI) compare
b4416 rybA -1.3 -1.0 unknown RNA (NCBI) compare
b2905 gcvT -1.3 -5.2 glycine cleavage system aminomethyltransferase T (NCBI) compare
b3199 yrbK -1.3 -2.1 hypothetical protein (NCBI) compare
b2277 nuoM -1.3 -5.0 NADH dehydrogenase subunit M (NCBI) compare
b2911 ssrS -1.3 -1.2 6S regulatory RNA (NCBI) compare
b2904 gcvH -1.3 -1.9 glycine cleavage system protein H (NCBI) compare
b4585 sroB -1.3 -0.9 Novel sRNA, function unknown (RefSeq) compare
b3180 yhbY -1.3 -2.9 predicted RNA-binding protein (NCBI) compare
b1558 cspF -1.3 -1.8 Qin prophage; cold shock protein (NCBI) compare
b1712 ihfA -1.2 -1.2 integration host factor subunit alpha (NCBI) compare
b0430 cyoC -1.2 -3.5 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b4260 pepA -1.2 -7.4 leucyl aminopeptidase (NCBI) compare
b3005 exbD -1.2 -3.4 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2938 speA -1.2 -6.2 arginine decarboxylase (NCBI) compare
b2531 iscR -1.2 -1.0 DNA-binding transcriptional repressor (NCBI) compare
b2198 ccmD -1.2 -1.8 cytochrome c biogenesis protein (NCBI) compare


Specific Phenotypes

For 17 genes in this experiment

For retron_ec_48_control Kanamycin sulfate in Escherichia coli BW25113

For retron_ec_48_control Kanamycin sulfate across organisms