| | gene | name | fitness | t score | description | |
|---|
| b2414 | cysK | -9.6 | -6.6 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0072 | leuC | -9.4 | -6.5 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0907 | serC | -9.2 | -6.4 | phosphoserine aminotransferase (NCBI) | compare |
| b0242 | proB | -9.1 | -6.3 | gamma-glutamyl kinase (NCBI) | compare |
| b0074 | leuA | -9.0 | -6.2 | 2-isopropylmalate synthase (NCBI) | compare |
| b3774 | ilvC | -9.0 | -8.8 | ketol-acid reductoisomerase (NCBI) | compare |
| b0002 | thrA | -9.0 | -8.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2019 | hisG | -9.0 | -6.2 | ATP phosphoribosyltransferase (NCBI) | compare |
| b1260 | trpA | -8.9 | -6.9 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0071 | leuD | -8.9 | -6.2 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b2021 | hisC | -8.9 | -6.1 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0073 | leuB | -8.9 | -8.6 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b1261 | trpB | -8.8 | -5.4 | tryptophan synthase subunit beta (NCBI) | compare |
| b2026 | hisI | -8.8 | -8.6 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b0243 | proA | -8.8 | -6.1 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3172 | argG | -8.7 | -6.0 | argininosuccinate synthase (NCBI) | compare |
| b3772 | ilvA | -8.6 | -10.3 | threonine dehydratase (NCBI) | compare |
| b3941 | metF | -8.6 | -13.2 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3770 | ilvE | -8.6 | -10.2 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b4013 | metA | -8.6 | -8.4 | homoserine O-succinyltransferase (NCBI) | compare |
| b0004 | thrC | -8.6 | -5.9 | threonine synthase (NCBI) | compare |
| b3771 | ilvD | -8.5 | -11.7 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0033 | carB | -8.5 | -15.3 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2020 | hisD | -8.5 | -11.6 | histidinol dehydrogenase (NCBI) | compare |
| b3960 | argH | -8.4 | -11.6 | argininosuccinate lyase (NCBI) | compare |
| b3281 | aroE | -8.4 | -12.8 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b2838 | lysA | -8.3 | -8.1 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b2600 | tyrA | -8.3 | -9.8 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b4383 | deoB | -8.2 | -8.0 | phosphopentomutase (NCBI) | conserved |
| b3939 | metB | -8.2 | -12.5 | cystathionine gamma-synthase (NCBI) | compare |
| b2022 | hisB | -8.1 | -5.6 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b3389 | aroB | -8.1 | -7.9 | 3-dehydroquinate synthase (NCBI) | compare |
| b1192 | ldcA | -8.1 | -5.6 | L,D-carboxypeptidase A (NCBI) | compare |
| b3956 | ppc | -8.0 | -20.1 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b4388 | serB | -7.9 | -7.7 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2913 | serA | -7.9 | -5.4 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b2025 | hisF | -7.8 | -5.4 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2762 | cysH | -7.5 | -7.3 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2784 | relA | -7.4 | -11.4 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b1693 | aroD | -7.4 | -5.1 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2763 | cysI | -7.3 | -10.0 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0908 | aroA | -7.3 | -5.0 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0386 | proC | -7.2 | -5.0 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2329 | aroC | -7.2 | -5.0 | chorismate synthase (NCBI) | compare |
| b0592 | fepB | -7.2 | -13.8 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2750 | cysC | -7.1 | -8.9 | adenylylsulfate kinase (NCBI) | compare |
| b3008 | metC | -7.0 | -14.6 | cystathionine beta-lyase (NCBI) | compare |
| b3368 | cysG | -6.8 | -22.0 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b0080 | fruR | -6.8 | -9.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0720 | gltA | -6.8 | -10.4 | citrate synthase (NCBI) | compare |
| b2764 | cysJ | -6.7 | -15.1 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b0032 | carA | -6.7 | -9.1 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0003 | thrB | -6.5 | -7.6 | homoserine kinase (NCBI) | compare |
| b4214 | cysQ | -6.5 | -19.1 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2752 | cysD | -6.4 | -7.8 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b2024 | hisA | -6.4 | -3.1 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3390 | aroK | -6.3 | -4.4 | shikimate kinase I (NCBI) | compare |
| b2479 | gcvR | -6.3 | -6.2 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b2751 | cysN | -6.1 | -9.9 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b3204 | ptsN | -6.0 | -5.9 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0589 | fepG | -6.0 | -12.4 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0590 | fepD | -6.0 | -13.4 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0588 | fepC | -5.9 | -10.1 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3773 | ilvY | -5.9 | -12.6 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0912 | ihfB | -5.8 | -6.1 | integration host factor subunit beta (NCBI) | compare |
| b1232 | purU | -5.7 | -8.2 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b0726 | sucA | -5.4 | -3.7 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b2839 | lysR | -5.3 | -5.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0585 | fes | -5.3 | -11.4 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b1262 | trpC | -5.2 | -6.2 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b2340 | sixA | -5.2 | -7.1 | phosphohistidine phosphatase (NCBI) | compare |
| b1865 | nudB | -5.1 | -3.5 | dATP pyrophosphohydrolase (NCBI) | compare |
| b3781 | trxA | -4.8 | -8.1 | thioredoxin 1 (VIMSS) | compare |
| b1263 | trpD | -4.7 | -4.5 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0817 | mntR | -4.7 | -6.2 | DNA-binding transcriptional regulator of mntH (NCBI) | compare |
| b2282 | nuoH | -4.6 | -6.2 | NADH dehydrogenase subunit H (NCBI) | compare |
| b0049 | apaH | -4.5 | -4.4 | diadenosinetetraphosphatase (NCBI) | compare |
| b3870 | glnA | -4.5 | -3.1 | glutamine synthetase (NCBI) | compare |
| b0113 | pdhR | -4.4 | -4.2 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0145 | dksA | -4.4 | -3.0 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0740 | tolB | -4.4 | -8.9 | translocation protein TolB precursor (NCBI) | compare |
| b1292 | sapC | -4.3 | -5.1 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0888 | trxB | -4.3 | -7.1 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b0739 | tolA | -4.3 | -6.5 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b0142 | folK | -4.2 | -1.5 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b3849 | trkH | -4.1 | -19.1 | potassium transporter (NCBI) | compare |
| b1264 | trpE | -4.0 | -6.2 | anthranilate synthase component I (NCBI) | compare |
| b2279 | nuoK | -3.7 | -3.4 | NADH dehydrogenase subunit K (NCBI) | compare |
| b0741 | pal | -3.7 | -7.9 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b2285 | nuoE | -3.7 | -3.2 | NADH dehydrogenase subunit E (NCBI) | compare |
| b2964 | nupG | -3.6 | -15.5 | transport of nucleosides, permease protein (VIMSS) | compare |
| b0737 | tolQ | -3.6 | -6.4 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3916 | pfkA | -3.6 | -2.5 | 6-phosphofructokinase (NCBI) | compare |
| b1290 | sapF | -3.6 | -4.1 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2290 | yfbQ | -3.5 | -14.6 | aspartate aminotransferase (NCBI) | compare |
| b2168 | fruK | -3.5 | -2.3 | 1-phosphofructokinase (NCBI) | compare |
| b2599 | pheA | -3.4 | -4.8 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3650 | spoT | -3.4 | -7.1 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b2277 | nuoM | -3.3 | -10.9 | NADH dehydrogenase subunit M (NCBI) | compare |
| b2567 | rnc | -3.3 | -2.3 | ribonuclease III (NCBI) | compare |
| b0738 | tolR | -3.3 | -6.2 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3205 | yhbJ | -3.3 | -6.7 | hypothetical protein (NCBI) | compare |
| b3959 | argB | -3.3 | -12.5 | acetylglutamate kinase (RefSeq) | compare |
| b3831 | udp | -3.2 | -13.5 | uridine phosphorylase (NCBI) | conserved |
| b3236 | mdh | -3.2 | -8.9 | malate dehydrogenase (NCBI) | compare |
| b3726 | pstA | -3.2 | -8.4 | phosphate transporter subunit (NCBI) | compare |
| b1712 | ihfA | -3.2 | -2.2 | integration host factor subunit alpha (NCBI) | compare |
| b1291 | sapD | -3.1 | -4.2 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2276 | nuoN | -3.1 | -7.6 | NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) | compare |
| b2286 | nuoC | -3.1 | -10.0 | NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) | compare |
| b1784 | yeaH | -3.0 | -9.6 | yeaH component of nitrogen-related signalling system (of yeaGH-ycgB) (from data) | compare |
| b3764 | yifE | -3.0 | -6.8 | hypothetical protein (NCBI) | compare |
| b1188 | ycgB | -2.9 | -10.5 | ycgB component of nitrogen-related signalling system (of yeaGH-ycgB) (from data) | compare |
| b2284 | nuoF | -2.9 | -8.2 | NADH:ubiquinone oxidoreductase, chain F (NCBI) | compare |
| b2278 | nuoL | -2.9 | -12.7 | NADH dehydrogenase subunit L (NCBI) | compare |
| b0440 | hupB | -2.9 | -8.5 | HU, DNA-binding transcriptional regulator, beta subunit (NCBI) | compare |
| b3839 | tatC | -2.9 | -11.5 | TatABCE protein translocation system subunit (NCBI) | compare |
| b3290 | trkA | -2.9 | -2.0 | potassium transporter peripheral membrane component (NCBI) | compare |
| b0890 | ftsK | -2.9 | -6.7 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1285 | gmr | -2.9 | -6.6 | modulator of Rnase II stability (NCBI) | compare |
| b0014 | dnaK | -2.9 | -4.1 | molecular chaperone DnaK (NCBI) | compare |
| b0200 | gmhB | -2.8 | -3.3 | hypothetical protein (NCBI) | compare |
| b4480 | hdfR | -2.8 | -6.7 | transcriptional regulator HdfR (NCBI) | compare |
| b0724 | sdhB | -2.8 | -9.7 | succinate dehydrogenase, FeS subunit (NCBI) | compare |
| b1783 | yeaG | -2.8 | -10.0 | yeaG component of nitrogen-related signalling system (of yeaGH-ycgB) (from data) | compare |
| b1676 | pykF | -2.7 | -6.5 | pyruvate kinase (NCBI) | compare |
| b2283 | nuoG | -2.7 | -10.7 | NADH:ubiquinone oxidoreductase, chain G (RefSeq) | compare |
| b4603 | rseX | -2.7 | -1.3 | sRNA regulating ompA and ompC translation, with Hfq (RefSeq) | compare |
| b2287 | nuoB | -2.7 | -6.0 | NADH dehydrogenase subunit B (NCBI) | compare |
| b2281 | nuoI | -2.7 | -5.1 | NADH dehydrogenase subunit I (NCBI) | compare |
| b3957 | argE | -2.6 | -15.0 | acetylornithine deacetylase (NCBI) | compare |
| b0722 | sdhD | -2.6 | -7.0 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b3958 | argC | -2.6 | -12.8 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b1861 | ruvA | -2.6 | -2.9 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b0750 | nadA | -2.6 | -7.5 | quinolinate synthetase (NCBI) | compare |
| b2023 | hisH | -2.6 | -2.7 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b0676 | nagC | -2.5 | -10.6 | DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) | compare |
| b3728 | pstS | -2.5 | -4.2 | phosphate transporter subunit (NCBI) | compare |
| b0721 | sdhC | -2.5 | -6.2 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b2424 | cysU | -2.5 | -5.4 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b0460 | hha | -2.4 | -6.3 | modulator of gene expression, with H-NS (NCBI) | compare |
| b0723 | sdhA | -2.4 | -14.0 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b3671 | ilvB | -2.4 | -15.9 | acetolactate synthase large subunit (NCBI) | compare |
| b3169 | nusA | -2.3 | -4.1 | transcription elongation factor NusA (NCBI) | compare |
| b2393 | nupC | -2.3 | -9.7 | nucleoside (except guanosine) transporter (NCBI) | conserved |
| b3021 | ygiT | -2.3 | -3.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b2820 | recB | -2.2 | -1.5 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b0114 | aceE | -2.2 | -1.5 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b0109 | nadC | -2.2 | -10.4 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b0430 | cyoC | -2.2 | -7.8 | cytochrome o ubiquinol oxidase subunit III (NCBI) | compare |
| b3082 | ygjM | -2.2 | -3.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b2741 | rpoS | -2.1 | -9.3 | RNA polymerase sigma factor (NCBI) | compare |
| b2280 | nuoJ | -2.1 | -5.8 | NADH dehydrogenase subunit J (NCBI) | compare |
| b0767 | ybhE | -2.1 | -6.0 | 6-phosphogluconolactonase (NCBI) | compare |
| b2603 | yfiR | -2.0 | -9.3 | hypothetical protein (NCBI) | compare |
| b4179 | vacB | -2.0 | -8.4 | putative enzyme (VIMSS) | compare |
| b2818 | argA | -2.0 | -10.1 | N-acetylglutamate synthase (NCBI) | compare |
| b1103 | ycfF | -2.0 | -1.6 | orf, hypothetical protein (VIMSS) | compare |
| b3828 | metR | -2.0 | -9.3 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0428 | cyoE | -1.9 | -9.5 | protoheme IX farnesyltransferase (NCBI) | compare |
| b2531 | iscR | -1.9 | -2.0 | DNA-binding transcriptional repressor (NCBI) | compare |
| b2422 | cysA | -1.9 | -10.1 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b4191 | ulaR | -1.9 | -4.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3162 | deaD | -1.9 | -7.0 | inducible ATP-independent RNA helicase (VIMSS) | compare |
| b0075 | leuL | -1.9 | -3.4 | leu operon leader peptide (NCBI) | compare |
| b3601 | mtlR | -1.9 | -7.7 | DNA-binding repressor (NCBI) | compare |
| b2423 | cysW | -1.9 | -7.9 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b4685 | yrbN | -1.9 | -3.8 | expressed protein (RefSeq) | compare |
| b0431 | cyoB | -1.9 | -12.9 | cytochrome o ubiquinol oxidase subunit I (NCBI) | compare |
| b0143 | pcnB | -1.8 | -8.0 | poly(A) polymerase I (VIMSS) | compare |
| b1551 | b1551 | -1.8 | -1.2 | orf, hypothetical protein (VIMSS) | compare |
| b0964 | yccT | -1.8 | -7.5 | hypothetical protein (NCBI) | compare |
| b2289 | lrhA | -1.8 | -11.6 | DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) | compare |
| b0432 | cyoA | -1.8 | -11.8 | cytochrome o ubiquinol oxidase subunit II (NCBI) | compare |
| b3811 | xerC | -1.7 | -2.6 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b0863 | artI | -1.7 | -7.4 | arginine transporter subunit (NCBI) | compare |
| b2363 | yfdT | -1.7 | -3.9 | CPS-53 (KpLE1) prophage; predicted protein (NCBI) | compare |
| b1863 | ruvC | -1.7 | -3.3 | Holliday junction resolvase (NCBI) | compare |
| b3908 | sodA | -1.7 | -10.0 | superoxide dismutase, manganese (VIMSS) | compare |
| b2689 | yqaA | -1.7 | -1.9 | conserved inner membrane protein (NCBI) | compare |
| b1660 | ydhC | -1.7 | -5.6 | predicted transporter (NCBI) | conserved |
| b3672 | ivbL | -1.7 | -4.1 | ilvB operon leader peptide (NCBI) | compare |
| b3385 | gph | -1.6 | -11.9 | phosphoglycolate phosphatase (NCBI) | compare |
| b1594 | dgsA | -1.6 | -4.9 | DNA-binding transcriptional repressor (NCBI) | compare |
| b2569 | lepA | -1.6 | -6.4 | GTP-binding protein LepA (NCBI) | compare |
| b0439 | lon | -1.6 | -6.8 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b1422 | ydcI | -1.6 | -5.3 | putative transcriptional regulator LYSR-type (VIMSS) | compare |
| b3636 | rpmG | -1.6 | -2.0 | 50S ribosomal protein L33 (NCBI) | compare |
| b2707 | srlR | -1.6 | -6.2 | DNA-bindng transcriptional repressor (NCBI) | compare |
| b0730 | mngR | -1.6 | -2.4 | DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) | compare |
| b0429 | cyoD | -1.6 | -5.6 | cytochrome o ubiquinol oxidase subunit IV (NCBI) | compare |
| b1659 | ydhB | -1.6 | -4.6 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b0232 | yafN | -1.5 | -1.0 | predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) | compare |
| b3806 | cyaA | -1.5 | -7.4 | adenylate cyclase (NCBI) | compare |
| b4018 | iclR | -1.5 | -9.6 | repressor of aceBA operon (VIMSS) | compare |
| b1545 | pinQ | -1.5 | -0.5 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b4395 | ytjC | -1.5 | -7.0 | phosphoglycerate mutase (NCBI) | compare |
| b2501 | ppk | -1.5 | -9.8 | polyphosphate kinase (NCBI) | compare |
| b4384 | deoD | -1.5 | -10.3 | purine nucleoside phosphorylase (NCBI) | conserved |
| b2574 | nadB | -1.5 | -10.0 | L-aspartate oxidase (NCBI) | compare |