Experiment set57IT048 for Escherichia coli BW25113

Compare to:

Ying_sugar7 rep C; time point 3

200 most detrimental genes:

  gene name fitness t score description  
b2904 gcvH +5.6 35.8 glycine cleavage system protein H (NCBI) compare
b2903 gcvP +5.6 47.8 glycine dehydrogenase (NCBI) compare
b2905 gcvT +4.2 14.1 glycine cleavage system aminomethyltransferase T (NCBI) compare
b3181 greA +3.5 23.6 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3643 rph +3.2 7.4 ribonuclease PH (NCBI) conserved
b2808 gcvA +2.7 14.8 DNA-binding transcriptional dual regulator (NCBI) compare
b3206 npr +2.6 14.7 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b2830 nudH +2.5 5.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b2829 ptsP +2.3 16.0 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b0059 hepA +2.2 18.8 ATP-dependent helicase HepA (NCBI) compare
b4203 rplI +2.2 10.4 50S ribosomal protein L9 (NCBI) compare
b2947 gshB +2.2 14.0 glutathione synthetase (NCBI) compare
b2688 gshA +2.1 13.9 glutamate--cysteine ligase (NCBI) compare
b1824 yobF +2.0 4.4 hypothetical protein (NCBI) compare
b4141 yjeH +1.8 15.2 predicted transporter (NCBI) compare
b3979 thrT +1.8 1.6 tRNA-Thr (NCBI) compare
b3778 rep +1.8 14.2 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1038 csgF +1.6 7.0 predicted transport protein (NCBI) compare
b0882 clpA +1.6 12.6 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b2951 yggS +1.5 8.7 predicted enzyme (NCBI) compare
b3755 yieP +1.5 9.1 predicted transcriptional regulator (NCBI) compare
b4048 yjbM +1.4 3.4 hypothetical protein (NCBI) compare
b4171 miaA +1.4 5.1 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0852 rimK +1.3 7.8 ribosomal protein S6 modification protein (NCBI) compare
b1190 dadX +1.3 6.7 alanine racemase (NCBI) compare
b2297 pta +1.2 1.9 phosphate acetyltransferase (NCBI) compare
b1628 rsxB +1.2 4.4 electron transport complex protein RnfB (NCBI) compare
b1085 b1085 +1.2 4.3 orf, hypothetical protein (VIMSS) compare
b0949 uup +1.2 8.4 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1642 slyA +1.2 3.1 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b1493 gadB +1.2 1.4 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b0053 surA +1.1 7.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1222 narX +1.1 5.0 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b3706 trmE +1.1 2.9 tRNA modification GTPase (NCBI) compare
b1341 b1341 +1.1 6.2 orf, hypothetical protein (VIMSS) compare
b1630 rsxD +1.1 5.2 electron transport complex protein RnfD (NCBI) compare
b2642 yfjW +1.1 1.6 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b3027 ygiZ +1.1 0.9 conserved inner membrane protein (NCBI) compare
b1095 fabF +1.1 7.7 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3863 polA +1.1 1.4 DNA polymerase I (NCBI) compare
b1358 ydaT +1.1 2.2 Rac prophage; predicted protein (NCBI) compare
b2741 rpoS +1.1 5.5 RNA polymerase sigma factor (NCBI) compare
b2617 smpA +1.1 4.7 small membrane protein A (VIMSS) compare
b0381 ddlA +1.0 5.9 D-alanylalanine synthetase (NCBI) compare
b0051 ksgA +1.0 4.8 dimethyladenosine transferase (NCBI) compare
b1627 rsxA +1.0 4.4 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b3806 cyaA +1.0 6.0 adenylate cyclase (NCBI) compare
b1233 ychJ +1.0 0.9 hypothetical protein (NCBI) compare
b2962 yggX +1.0 5.0 hypothetical protein (NCBI) compare
b2948 yqgE +1.0 4.2 orf, hypothetical protein (VIMSS) compare
b1037 csgG +1.0 7.2 outer membrane lipoprotein (NCBI) compare
b0661 miaB +1.0 6.3 isopentenyl-adenosine A37 tRNA methylthiolase (NCBI) compare
b0178 hlpA +1.0 2.7 periplasmic chaperone (NCBI) compare
b1823 cspC +1.0 1.9 stress protein, member of the CspA-family (NCBI) compare
b2189 proL +1.0 2.5 tRNA-Pro (NCBI) compare
b1422 ydcI +0.9 4.6 putative transcriptional regulator LYSR-type (VIMSS) compare
b1607 ydgC +0.9 1.9 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b2684 mprA +0.9 5.0 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1259 yciG +0.9 2.0 orf, hypothetical protein (VIMSS) compare
b1041 csgB +0.9 5.0 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b1632 rsxE +0.9 6.4 NADH-ubiquinone oxidoreductase (NCBI) compare
b4135 yjdC +0.9 4.7 orf, hypothetical protein (VIMSS) compare
b1438 ydcQ +0.9 2.6 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2127 mlrA +0.9 4.6 DNA-binding transcriptional regulator (NCBI) compare
b0605 ahpC +0.9 3.5 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4406 yaeP +0.9 2.2 hypothetical protein (NCBI) compare
b2096 gatY +0.9 5.1 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b1831 proQ +0.8 2.3 putative solute/DNA competence effector (NCBI) compare
b1042 csgA +0.8 6.2 cryptic curlin major subunit (NCBI) compare
b0998 torD +0.8 1.6 chaperone protein TorD (NCBI) compare
b0556 rzpD +0.8 1.4 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b1013 ycdC +0.8 3.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0627 tatE +0.8 2.0 twin arginine translocase protein E (NCBI) compare
b2421 cysM +0.8 4.0 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b0549 ybcO +0.8 2.4 DLP12 prophage; predicted protein (NCBI) compare
b1606 folM +0.8 5.4 short chain dehydrogenase (NCBI) compare
b0965 b0965 +0.8 2.0 orf, hypothetical protein (VIMSS) compare
b2494 yfgC +0.8 4.2 predicted peptidase (NCBI) compare
b2433 b2433 +0.8 2.8 orf, hypothetical protein (VIMSS) compare
b1731 cedA +0.8 3.5 cell division modulator (RefSeq) compare
b3929 rraA +0.8 5.3 ribonuclease activity regulator protein RraA (NCBI) compare
b0685 ybfE +0.8 2.6 orf, hypothetical protein (VIMSS) compare
b1582 ynfA +0.8 3.3 hypothetical protein (NCBI) compare
b1557 cspB +0.8 1.3 Qin prophage; cold shock protein (NCBI) compare
b2937 speB +0.8 5.0 agmatinase (NCBI) compare
b1685 ydiH +0.7 1.3 predicted protein (RefSeq) compare
b1595 ynfL +0.7 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2183 rsuA +0.7 3.2 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b1150 ymfR +0.7 1.0 e14 prophage; predicted protein (NCBI) compare
b4241 treR +0.7 5.7 trehalose repressor (NCBI) compare
b1567 intK +0.7 2.4 Qin prophage; predicted protein (RefSeq) compare
b3869 glnL +0.7 4.1 sensory histidine kinase in two-component regulatory system with GlnG (NCBI) compare
b4651 yibW +0.7 0.6 no description compare
b0238 gpt +0.7 2.9 xanthine phosphoribosyltransferase (NCBI) compare
b2303 folX +0.7 5.1 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b4443 gcvB +0.7 0.4 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b2042 galF +0.7 4.8 predicted subunit with GalU (NCBI) compare
b1849 purT +0.7 3.5 phosphoribosylglycinamide formyltransferase 2 (NCBI) compare
b0310 ykgH +0.7 1.9 predicted inner membrane protein (NCBI) compare
b2786 barA +0.7 6.4 hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) compare
b2809 b2809 +0.7 2.0 orf, hypothetical protein (VIMSS) compare
b0545 ybcL +0.7 4.4 DLP12 prophage; predicted kinase inhibitor (NCBI) compare
b0303 ykgI +0.7 1.0 orf, hypothetical protein (VIMSS) compare
b1725 yniA +0.7 2.8 predicted phosphotransferase/kinase (NCBI) compare
b4436 ryeC +0.7 1.8 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b3644 yicC +0.7 2.0 hypothetical protein (NCBI) compare
b4692 oweE +0.7 3.1 no description compare
b1871 yecP +0.7 3.0 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b1446 ydcY +0.7 2.3 hypothetical protein (NCBI) compare
b1465 narV +0.7 1.7 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b4543 ypaA +0.7 2.6 predicted protein (NCBI) compare
b2749 ygbE +0.7 3.2 conserved inner membrane protein (NCBI) compare
b2058 wcaB +0.6 1.1 predicted acyl transferase (NCBI) compare
b3351 kefG +0.6 3.2 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b0686 ybfF +0.6 4.5 hypothetical protein (NCBI) compare
b3563 yiaB +0.6 3.0 orf, hypothetical protein (VIMSS) compare
b4110 yjcZ +0.6 4.0 orf, hypothetical protein (VIMSS) compare
b2111 yehD +0.6 2.3 predicted fimbrial-like adhesin protein (NCBI) compare
b0854 potF +0.6 3.2 putrescine transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b1066 rimJ +0.6 3.2 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b1070 flgN +0.6 1.2 export chaperone for FlgK and FlgL (NCBI) compare
b3194 yrbE +0.6 4.6 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1914 uvrY +0.6 3.0 response regulator (NCBI) compare
b4402 yjjY +0.6 0.9 hypothetical protein (NCBI) compare
b2326 yfcM +0.6 3.0 hypothetical protein (NCBI) compare
b2342 yfcY +0.6 3.8 acetyl-CoA acetyltransferase (NCBI) compare
b0580 ybdJ +0.6 1.6 predicted inner membrane protein (NCBI) compare
b4030 yjbA +0.6 2.3 phosphate-starvation-inducible protein PsiE (NCBI) compare
b1591 b1591 +0.6 1.7 putative oxidoreductase component (VIMSS) compare
b0610 rnk +0.6 1.6 nucleoside diphosphate kinase regulator (NCBI) compare
b4163 glyV +0.6 1.2 tRNA-Gly (NCBI) compare
b3119 tdcR +0.6 1.5 threonine dehydratase operon activator protein (VIMSS) compare
b4256 yjgM +0.6 4.3 predicted acetyltransferase (NCBI) compare
b4391 yjjK +0.6 3.9 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3146 yraL +0.6 2.9 predicted methyltransferase (NCBI) compare
b0710 ybgI +0.6 3.2 conserved metal-binding protein (NCBI) compare
b0881 clpS +0.6 1.6 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b4017 arpA +0.6 2.8 regulator of acetyl CoA synthetase (NCBI) compare
b2141 yohJ +0.6 2.8 hypothetical protein (NCBI) compare
b1758 b1758 +0.6 0.9 putative cytochrome oxidase (VIMSS) compare
b4373 rimI +0.6 1.3 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1629 rsxC +0.6 3.1 electron transport complex protein RnfC (NCBI) compare
b4053 alr +0.5 3.9 alanine racemase (NCBI) compare
b0339 cynT +0.5 3.1 carbonic anhydrase (NCBI) compare
b2218 rcsC +0.5 3.7 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b2572 rseA +0.5 1.3 anti-sigma factor (NCBI) compare
b2128 yehW +0.5 2.9 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0550 rusA +0.5 1.9 DLP12 prophage; endonuclease RUS (NCBI) compare
b0856 potH +0.5 2.9 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2447 yffP +0.5 2.9 CPZ-55 prophage; predicted protein (NCBI) compare
b2114 metG +0.5 0.9 methionyl-tRNA synthetase (NCBI) compare
b0471 ybaB +0.5 1.6 hypothetical protein (NCBI) compare
b2587 kgtP +0.5 3.5 alpha-ketoglutarate transporter (NCBI) compare
b0968 yccX +0.5 1.8 predicted acylphosphatase (NCBI) compare
b2512 yfgL +0.5 2.5 protein assembly complex, lipoprotein component (NCBI) compare
b3484 yhhI +0.5 1.6 predicted transposase (NCBI) compare
b0857 potI +0.5 2.2 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b4461 yfjD +0.5 3.4 predicted inner membrane protein (RefSeq) compare
b4458 oxyS +0.5 1.0 global regulatory RNA (NCBI) compare
b0199 metN +0.5 4.1 DL-methionine transporter subunit (NCBI) compare
b1335 ogt +0.5 1.6 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b2341 yfcX +0.5 3.2 fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI) compare
b3350 kefB +0.5 4.5 glutathione-regulated potassium-efflux system protein (NCBI) compare
b0508 hyi +0.5 2.1 hydroxypyruvate isomerase (NCBI) compare
b1923 fliC +0.5 2.9 flagellin (NCBI) compare
b4644 ypjI +0.5 2.5 no description compare
b3934 cytR +0.5 3.8 DNA-binding transcriptional dual regulator (NCBI) compare
b1754 b1754 +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b1284 yciT +0.5 2.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1090 plsX +0.5 2.0 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b4260 pepA +0.5 3.6 leucyl aminopeptidase (NCBI) compare
b0695 kdpD +0.5 2.4 fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein (NCBI) compare
b3261 fis +0.5 1.2 DNA-binding protein Fis (NCBI) compare
b4376 osmY +0.5 2.5 periplasmic protein (NCBI) compare
b0197 metQ +0.5 3.2 DL-methionine transporter subunit (NCBI) compare
b1806 yeaY +0.5 2.2 predicted lipoprotein (NCBI) compare
b1583 ynfB +0.5 2.2 hypothetical protein (NCBI) compare
b1819 manZ +0.5 2.0 mannose-specific enzyme IID component of PTS (NCBI) compare
b3616 tdh +0.5 2.6 L-threonine 3-dehydrogenase (NCBI) compare
b4041 plsB +0.5 1.1 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4546 ypeB +0.5 0.8 hypothetical protein (NCBI) compare
b1676 pykF +0.5 1.8 pyruvate kinase (NCBI) compare
b3632 rfaQ +0.5 4.2 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0830 yliB +0.5 3.0 predicted peptide transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b1703 ydiA +0.5 3.1 hypothetical protein (NCBI) compare
b1247 oppF +0.5 1.7 oligopeptide transporter subunit (NCBI) compare
b2186 yejK +0.5 3.2 nucleoid-associated protein NdpA (NCBI) compare
b3769 ilvM +0.5 1.6 acetolactate synthase II, small subunit (NCBI) compare
b4232 fbp +0.5 3.3 fructose-1,6-bisphosphatase (NCBI) compare
b1427 rimL +0.5 1.8 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b1141 ymfG +0.5 1.2 e14 prophage; predicted excisionase (NCBI) compare
b3382 yhfY +0.5 2.1 orf, hypothetical protein (VIMSS) compare
b2538 hcaE +0.5 1.7 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b2445 yffN +0.5 1.8 CPZ-55 prophage; predicted protein (RefSeq) compare
b4409 blr +0.5 2.4 beta-lactam resistance membrane protein (NCBI) compare
b1115 ycfT +0.5 1.7 predicted inner membrane protein (NCBI) compare
b2513 yfgM +0.5 1.1 hypothetical protein (NCBI) compare
b1079 flgH +0.5 2.2 flagellar L-ring protein precursor H (NCBI) compare
b0619 citA +0.5 2.6 sensory histidine kinase in two-component regulatory system with citB (NCBI) compare
b1243 oppA +0.5 2.5 oligopeptide transporter subunit (NCBI) compare


Specific Phenotypes

For 15 genes in this experiment

For carbon source Ying_sugar7 in Escherichia coli BW25113

For carbon source Ying_sugar7 across organisms