Experiment set57IT045 for Escherichia coli BW25113

Compare to:

Ying_OrganicAcid7 rep C; time point 3

200 most detrimental genes:

  gene name fitness t score description  
b2741 rpoS +6.2 49.8 RNA polymerase sigma factor (NCBI) compare
b2903 gcvP +4.8 40.7 glycine dehydrogenase (NCBI) compare
b2904 gcvH +4.8 30.7 glycine cleavage system protein H (NCBI) compare
b2808 gcvA +3.9 28.1 DNA-binding transcriptional dual regulator (NCBI) compare
b2905 gcvT +3.9 19.4 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2951 yggS +3.2 21.2 predicted enzyme (NCBI) compare
b1095 fabF +2.8 24.2 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1422 ydcI +2.3 13.9 putative transcriptional regulator LYSR-type (VIMSS) compare
b1831 proQ +2.2 5.0 putative solute/DNA competence effector (NCBI) compare
b1190 dadX +2.2 11.8 alanine racemase (NCBI) compare
b3027 ygiZ +2.0 2.4 conserved inner membrane protein (NCBI) compare
b0059 hepA +2.0 17.7 ATP-dependent helicase HepA (NCBI) compare
b4203 rplI +1.9 10.9 50S ribosomal protein L9 (NCBI) compare
b1085 b1085 +1.9 3.9 orf, hypothetical protein (VIMSS) compare
b3164 pnp +1.8 6.2 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b3341 rpsG +1.6 4.1 30S ribosomal protein S7 (NCBI) compare
b1824 yobF +1.6 6.0 hypothetical protein (NCBI) compare
b2688 gshA +1.6 11.1 glutamate--cysteine ligase (NCBI) compare
b2829 ptsP +1.6 12.0 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b2947 gshB +1.6 7.8 glutathione synthetase (NCBI) compare
b3977 tyrU +1.5 2.9 tRNA-Tyr (NCBI) compare
b4071 nrfB +1.5 1.5 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b0882 clpA +1.4 11.6 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1236 galU +1.4 9.4 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1159 mcrA +1.3 2.8 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b1855 lpxM +1.2 8.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3979 thrT +1.2 1.0 tRNA-Thr (NCBI) compare
b1361 ydaW +1.2 1.2 orf, hypothetical protein (VIMSS) compare
b1725 yniA +1.2 2.3 predicted phosphotransferase/kinase (NCBI) compare
b3929 rraA +1.2 9.2 ribonuclease activity regulator protein RraA (NCBI) compare
b1294 sapA +1.2 6.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4172 hfq +1.2 1.8 RNA-binding protein Hfq (NCBI) compare
b1557 cspB +1.2 1.8 Qin prophage; cold shock protein (NCBI) compare
b0955 ycbZ +1.2 8.3 predicted peptidase (NCBI) compare
b3778 rep +1.1 8.2 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4701 sokX +1.1 1.5 sok-related sRNA, function unknown (RefSeq) compare
b3753 rbsR +1.1 9.5 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b2846 yqeH +1.0 1.1 orf, hypothetical protein (VIMSS) compare
b1823 cspC +1.0 2.3 stress protein, member of the CspA-family (NCBI) compare
b3454 livF +1.0 2.9 ATP-binding component of leucine transport (VIMSS) compare
b0178 hlpA +1.0 4.9 periplasmic chaperone (NCBI) compare
b0082 mraW +1.0 3.7 S-adenosyl-methyltransferase (NCBI) compare
b1191 b1191 +1.0 5.2 orf, hypothetical protein (VIMSS) compare
b3752 rbsK +1.0 7.8 ribokinase (NCBI) compare
b1040 csgD +1.0 2.6 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b0471 ybaB +1.0 5.1 hypothetical protein (NCBI) compare
b3842 rfaH +1.0 5.6 transcriptional activator RfaH (NCBI) compare
b3644 yicC +0.9 5.5 hypothetical protein (NCBI) compare
b4450 arcZ +0.9 4.8 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b3672 ivbL +0.9 1.2 ilvB operon leader peptide (NCBI) compare
b4030 yjbA +0.9 5.2 phosphate-starvation-inducible protein PsiE (NCBI) compare
b2937 speB +0.9 6.2 agmatinase (NCBI) compare
b1038 csgF +0.9 2.5 predicted transport protein (NCBI) compare
b0852 rimK +0.9 5.2 ribosomal protein S6 modification protein (NCBI) compare
b0960 b0960 +0.9 7.5 orf, hypothetical protein (VIMSS) compare
b3632 rfaQ +0.9 8.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3630 rfaP +0.9 7.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2576 srmB +0.9 2.9 ATP-dependent RNA helicase (NCBI) compare
b1743 spy +0.9 1.1 envelope stress induced periplasmic protein (NCBI) compare
b4373 rimI +0.9 3.5 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b3863 polA +0.9 1.4 DNA polymerase I (NCBI) compare
b3181 greA +0.8 4.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1299 puuR +0.8 4.9 DNA-binding transcriptional repressor (NCBI) compare
b4255 yjgD +0.8 5.3 hypothetical protein (NCBI) compare
b3102 yqjG +0.8 2.1 predicted S-transferase (NCBI) compare
b2123 yehR +0.8 0.9 orf, hypothetical protein (VIMSS) compare
b1685 ydiH +0.8 1.6 predicted protein (RefSeq) compare
b1606 folM +0.8 5.6 short chain dehydrogenase (NCBI) compare
b4174 hflK +0.8 6.0 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1634 tppB +0.8 3.8 putative tripeptide transporter permease (NCBI) compare
b1189 dadA +0.8 5.4 D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) compare
b0866 ybjQ +0.8 1.5 hypothetical protein (NCBI) compare
b0503 ybbB +0.8 1.2 tRNA 2-selenouridine synthase, selenophosphate-dependent (NCBI) compare
b4097 phnK +0.8 1.7 carbon-phosphorus lyase complex subunit (NCBI) compare
b2259 pmrD +0.8 1.3 polymyxin resistance protein B (VIMSS) compare
b2830 nudH +0.8 1.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b3146 yraL +0.8 5.2 predicted methyltransferase (NCBI) compare
b2954 yggV +0.8 1.0 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b1160 elbA +0.8 1.2 hypothetical protein (NCBI) compare
b4391 yjjK +0.8 5.6 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1279 yciS +0.8 1.2 conserved inner membrane protein (NCBI) compare
b1187 fadR +0.8 3.5 fatty acid metabolism regulator (NCBI) compare
b3624 rfaZ +0.8 2.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3106 yhaK +0.8 1.6 predicted pirin-related protein (NCBI) compare
b0508 hyi +0.7 3.5 hydroxypyruvate isomerase (NCBI) compare
b2303 folX +0.7 5.2 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b3455 livG +0.7 4.2 leucine/isoleucine/valine transporter subunit (NCBI) compare
b4646 yrdE +0.7 3.1 no description compare
b0696 kdpC +0.7 2.3 potassium-transporting ATPase subunit C (NCBI) compare
b1090 plsX +0.7 3.7 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b3523 yhjE +0.7 6.0 predicted transporter (NCBI) compare
b4175 hflC +0.7 5.2 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b0381 ddlA +0.7 4.1 D-alanylalanine synthetase (NCBI) compare
b2229 b2229 +0.7 0.8 orf, hypothetical protein (VIMSS) compare
b3911 cpxA +0.7 5.7 two-component sensor protein (NCBI) compare
b2944 sprT +0.7 1.3 hypothetical protein (NCBI) compare
b2643 yfjX +0.7 0.9 CP4-57 prophage; predicted antirestriction protein (NCBI) compare
b1581 rspA +0.7 2.8 predicted dehydratase (NCBI) compare
b1222 narX +0.7 3.0 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b3206 npr +0.7 3.3 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b4000 hupA +0.7 3.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b0685 ybfE +0.7 3.2 orf, hypothetical protein (VIMSS) compare
b2521 sseA +0.7 5.3 putative thiosulfate sulfurtransferase (VIMSS) compare
b4595 yciY +0.7 2.5 hypothetical protein (RefSeq) compare
b3468 yhhN +0.7 5.6 conserved inner membrane protein (NCBI) compare
b3346 yheO +0.7 5.1 orf, hypothetical protein (VIMSS) compare
b0310 ykgH +0.7 1.8 predicted inner membrane protein (NCBI) compare
b3156 yhbS +0.6 4.7 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b2175 spr +0.6 2.8 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b3803 hemX +0.6 5.1 predicted uroporphyrinogen III methylase (NCBI) compare
b2665 ygaU +0.6 1.5 hypothetical protein (NCBI) compare
b0610 rnk +0.6 2.8 nucleoside diphosphate kinase regulator (NCBI) compare
b4570 lomR +0.6 2.0 no description compare
b4533 ynfO +0.6 2.0 Qin prophage; predicted protein (NCBI) compare
b4493 gapC +0.6 2.9 no description compare
b1916 sdiA +0.6 3.5 DNA-binding transcriptional activator (NCBI) compare
b4293 fecI +0.6 1.4 KpLE2 phage-like element; RNA polymerase, sigma 19 factor (NCBI) compare
b3741 gidA +0.6 3.2 glucose-inhibited division protein A (NCBI) compare
b1753 ynjA +0.6 1.5 hypothetical protein (NCBI) compare
b3670 ilvN +0.6 3.7 acetolactate synthase small subunit (NCBI) compare
b1438 ydcQ +0.6 2.1 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1593 b1593 +0.6 2.1 orf, hypothetical protein (VIMSS) compare
b3780 rhlB +0.6 4.1 ATP-dependent RNA helicase (NCBI) compare
b3133 agaV +0.6 1.5 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b0240 crl +0.6 3.8 DNA-binding transcriptional regulator (NCBI) compare
b2421 cysM +0.6 2.2 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b1329 b1329 +0.6 3.7 putative transport periplasmic protein (VIMSS) compare
b1132 hflD +0.6 2.6 hypothetical protein (NCBI) compare
b3740 gidB +0.6 4.1 glucose-inhibited division protein B (NCBI) compare
b1822 rrmA +0.6 1.7 23S rRNA m1G745 methyltransferase (NCBI) compare
b2058 wcaB +0.6 1.1 predicted acyl transferase (NCBI) compare
b4371 rsmC +0.6 4.3 16S ribosomal RNA m2G1207 methyltransferase (NCBI) compare
b1566 flxA +0.6 2.7 Qin prophage; predicted protein (NCBI) compare
b4482 yigE +0.6 1.7 hypothetical protein (NCBI) compare
b0167 glnD +0.6 1.9 PII uridylyl-transferase (NCBI) compare
b1380 ldhA +0.6 1.8 D-lactate dehydrogenase (NCBI) compare
b2474 ypfI +0.6 3.8 predicted hydrolase (NCBI) compare
b1731 cedA +0.6 2.2 cell division modulator (RefSeq) compare
b4654 yjdQ +0.6 2.4 no description compare
b1390 paaC +0.6 3.0 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b4294 insA-7 +0.6 1.5 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b4397 creA +0.6 0.9 hypothetical protein (NCBI) compare
b1334 fnr +0.5 2.1 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b3928 yiiU +0.5 2.8 hypothetical protein (NCBI) compare
b3616 tdh +0.5 3.1 L-threonine 3-dehydrogenase (NCBI) compare
b3881 yihT +0.5 2.0 predicted aldolase (NCBI) compare
b1609 rstB +0.5 1.8 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b2625 yfjI +0.5 1.5 CP4-57 prophage; predicted protein (NCBI) compare
b2199 ccmC +0.5 0.8 heme exporter subunit (NCBI) compare
b1765 ydjA +0.5 0.6 predicted oxidoreductase (NCBI) compare
b4461 yfjD +0.5 3.4 predicted inner membrane protein (RefSeq) compare
b1394 paaG +0.5 2.2 enoyl-CoA hydratase (NCBI) compare
b3867 hemN +0.5 4.2 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b3197 kdsD +0.5 3.2 D-arabinose 5-phosphate isomerase (NCBI) compare
b4242 mgtA +0.5 3.1 magnesium transporter (NCBI) compare
b0556 rzpD +0.5 2.2 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b0791 ybhQ +0.5 2.1 predicted inner membrane protein (NCBI) compare
b2101 yegW +0.5 2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b2876 b2876 +0.5 2.2 orf, hypothetical protein (VIMSS) compare
b4603 rseX +0.5 0.5 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3628 rfaB +0.5 3.8 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b2946 yggJ +0.5 1.7 orf, hypothetical protein (VIMSS) compare
b2262 menB +0.5 1.3 naphthoate synthase (NCBI) compare
b3686 ibpB +0.5 1.4 heat shock chaperone (NCBI) compare
b0382 yaiB +0.5 3.2 hypothetical protein (NCBI) compare
b2377 yfdY +0.5 2.0 predicted inner membrane protein (NCBI) compare
b1575 dicB +0.5 1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b4135 yjdC +0.5 3.2 orf, hypothetical protein (VIMSS) compare
b1037 csgG +0.5 4.1 outer membrane lipoprotein (NCBI) compare
b2433 b2433 +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b0605 ahpC +0.5 2.2 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4402 yjjY +0.5 0.8 hypothetical protein (NCBI) compare
b1332 ynaJ +0.5 0.5 predicted inner membrane protein (NCBI) compare
b3198 kdsC +0.5 2.3 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3631 rfaG +0.5 4.3 glucosyltransferase I (NCBI) compare
b1854 pykA +0.5 3.1 pyruvate kinase (NCBI) compare
b1075 flgD +0.5 2.3 flagellar basal body rod modification protein D (NCBI) compare
b2910 zapA +0.5 2.3 protein that localizes to the cytokinetic ring (NCBI) compare
b2341 yfcX +0.5 2.7 fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI) compare
b0217 yafT +0.5 1.6 predicted aminopeptidase (NCBI) compare
b1591 b1591 +0.5 1.4 putative oxidoreductase component (VIMSS) compare
b3257 yhdT +0.5 2.1 conserved inner membrane protein (NCBI) compare
b1846 yebE +0.5 2.5 hypothetical protein (NCBI) compare
b4260 pepA +0.5 3.7 leucyl aminopeptidase (NCBI) compare
b1819 manZ +0.5 2.3 mannose-specific enzyme IID component of PTS (NCBI) compare
b2480 bcp +0.5 1.9 thioredoxin-dependent thiol peroxidase (NCBI) compare
b0279 yagM +0.5 0.8 CP4-6 prophage; predicted protein (NCBI) compare
b1628 rsxB +0.5 1.9 electron transport complex protein RnfB (NCBI) compare
b3460 livJ +0.5 3.5 leucine/isoleucine/valine transporter subunit (NCBI) compare
b1111 ycfQ +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b3293 yhdN +0.5 0.8 hypothetical protein (NCBI) compare
b3196 yrbG +0.5 3.2 predicted calcium/sodium:proton antiporter (NCBI) compare
b1651 gloA +0.5 0.8 glyoxalase I, Ni-dependent (NCBI) compare
b3351 kefG +0.5 1.7 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b0779 uvrB +0.5 3.4 excinuclease ABC subunit B (NCBI) compare
b3706 trmE +0.5 1.9 tRNA modification GTPase (NCBI) compare
b1395 paaH +0.5 3.2 3-hydroxybutyryl-CoA dehydrogenase (NCBI) compare
b4041 plsB +0.4 1.2 glycerol-3-phosphate acyltransferase (VIMSS) compare
b2644 yfjY +0.4 0.7 CP4-57 prophage; predicted DNA repair protein (NCBI) compare
b4048 yjbM +0.4 1.0 hypothetical protein (NCBI) compare


Specific Phenotypes

For 15 genes in this experiment

For carbon source Ying_OrganicAcid7 in Escherichia coli BW25113

For carbon source Ying_OrganicAcid7 across organisms