Experiment set57IT035 for Escherichia coli BW25113

Compare to:

Ying_Others16 rep B; time point 2

200 most detrimental genes:

  gene name fitness t score description  
b2127 mlrA +5.8 36.5 DNA-binding transcriptional regulator (NCBI) compare
b3753 rbsR +5.6 36.3 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b1040 csgD +5.6 22.6 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1341 b1341 +5.4 37.9 orf, hypothetical protein (VIMSS) compare
b4172 hfq +5.3 7.3 RNA-binding protein Hfq (NCBI) compare
b1038 csgF +4.9 28.2 predicted transport protein (NCBI) compare
b3755 yieP +4.6 39.5 predicted transcriptional regulator (NCBI) compare
b1584 speG +4.4 36.0 spermidine N1-acetyltransferase (NCBI) conserved
b1037 csgG +4.4 36.9 outer membrane lipoprotein (NCBI) compare
b2218 rcsC +4.3 28.2 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b2741 rpoS +4.3 25.1 RNA polymerase sigma factor (NCBI) compare
b3398 yrfF +4.1 6.0 predicted inner membrane protein (NCBI) compare
b2904 gcvH +4.0 20.6 glycine cleavage system protein H (NCBI) compare
b1831 proQ +3.8 13.4 putative solute/DNA competence effector (NCBI) compare
b2903 gcvP +3.8 16.8 glycine dehydrogenase (NCBI) compare
b2830 nudH +3.7 6.3 dinucleoside polyphosphate hydrolase (NCBI) compare
b3752 rbsK +3.5 11.1 ribokinase (NCBI) compare
b1185 dsbB +3.4 15.4 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b4155 yjeA +3.3 5.4 putative lysyl-tRNA synthetase (VIMSS) compare
b2664 ygaE +3.3 9.9 putative transcriptional regulator (VIMSS) compare
b2216 rcsD +3.3 12.8 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b3644 yicC +3.2 20.1 hypothetical protein (NCBI) compare
b4042 dgkA +3.0 7.2 diacylglycerol kinase (NCBI) compare
b2576 srmB +2.9 11.4 ATP-dependent RNA helicase (NCBI) compare
b2905 gcvT +2.9 16.4 glycine cleavage system aminomethyltransferase T (NCBI) compare
b3764 yifE +2.9 18.7 hypothetical protein (NCBI) compare
b1222 narX +2.8 4.8 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1824 yobF +2.6 10.2 hypothetical protein (NCBI) compare
b0882 clpA +2.6 18.4 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b3026 qseC +2.6 12.1 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1042 csgA +2.5 14.2 cryptic curlin major subunit (NCBI) compare
b4480 hdfR +2.5 15.7 transcriptional regulator HdfR (NCBI) compare
b1823 cspC +2.5 5.9 stress protein, member of the CspA-family (NCBI) compare
b4450 arcZ +2.5 13.3 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b0450 glnK +2.4 2.6 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b4171 miaA +2.4 8.7 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b4025 pgi +2.3 17.1 glucose-6-phosphate isomerase (NCBI) compare
b3181 greA +2.3 12.3 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3860 dsbA +2.3 13.8 periplasmic protein disulfide isomerase I (NCBI) compare
b3229 sspA +2.2 8.5 stringent starvation protein A (NCBI) compare
b3341 rpsG +2.1 2.0 30S ribosomal protein S7 (NCBI) compare
b2314 dedD +2.1 7.1 putative lipoprotein (VIMSS) compare
b2808 gcvA +2.0 5.8 DNA-binding transcriptional dual regulator (NCBI) compare
b4704 arrS +2.0 0.7 Antisense sRNA ArrS, function unknown (NCBI) compare
b1049 mdoH +1.9 13.0 glucosyltransferase MdoH (NCBI) compare
b0889 lrp +1.9 5.9 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1039 csgE +1.8 8.2 predicted transport protein (NCBI) compare
b0385 yaiC +1.8 9.0 predicted diguanylate cyclase (NCBI) compare
b1048 mdoG +1.7 9.0 glucan biosynthesis protein, periplasmic (NCBI) compare
b3934 cytR +1.7 10.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3133 agaV +1.7 3.0 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b1041 csgB +1.6 7.0 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b0082 mraW +1.6 7.2 S-adenosyl-methyltransferase (NCBI) compare
b0051 ksgA +1.6 5.8 dimethyladenosine transferase (NCBI) compare
b2055 wcaE +1.6 1.3 predicted glycosyl transferase (NCBI) compare
b4325 yjiC +1.6 2.6 orf, hypothetical protein (VIMSS) compare
b1583 ynfB +1.6 1.6 hypothetical protein (NCBI) compare
b3423 glpR +1.6 9.7 DNA-binding transcriptional repressor (NCBI) compare
b3454 livF +1.6 6.4 ATP-binding component of leucine transport (VIMSS) compare
b2847 yqeI +1.5 3.4 predicted transcriptional regulator (NCBI) compare
b1346 ydaQ +1.5 1.4 orf, hypothetical protein (VIMSS) compare
b4701 sokX +1.4 1.3 sok-related sRNA, function unknown (RefSeq) compare
b3871 bipA +1.4 9.3 GTP-binding protein (NCBI) compare
b0382 yaiB +1.4 7.4 hypothetical protein (NCBI) compare
b1542 ydfI +1.4 2.9 predicted mannonate dehydrogenase (NCBI) compare
b4655 ythA +1.3 1.7 expressed protein (RefSeq) compare
b3102 yqjG +1.3 2.3 predicted S-transferase (NCBI) compare
b3706 trmE +1.3 3.6 tRNA modification GTPase (NCBI) compare
b0209 yafD +1.3 5.8 hypothetical protein (NCBI) compare
b1531 marA +1.3 4.5 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b3164 pnp +1.3 2.9 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2501 ppk +1.3 7.9 polyphosphate kinase (NCBI) compare
b4552 yrhC +1.3 1.4 no description compare
b0990 cspG +1.3 2.0 DNA-binding transcriptional regulator (NCBI) compare
b1830 prc +1.3 6.1 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0707 ybgA +1.3 2.7 hypothetical protein (NCBI) compare
b1861 ruvA +1.3 1.1 Holliday junction DNA helicase motor protein (NCBI) compare
b2642 yfjW +1.2 1.0 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b3624 rfaZ +1.2 3.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2317 dedA +1.2 3.0 conserved inner membrane protein (NCBI) compare
b3929 rraA +1.2 7.5 ribonuclease activity regulator protein RraA (NCBI) compare
b1085 b1085 +1.2 1.6 orf, hypothetical protein (VIMSS) compare
b1765 ydjA +1.2 1.1 predicted oxidoreductase (NCBI) compare
b0357 yaiN +1.2 1.5 putative alpha helix chain (VIMSS) compare
b0610 rnk +1.2 3.8 nucleoside diphosphate kinase regulator (NCBI) compare
b0059 hepA +1.2 8.9 ATP-dependent helicase HepA (NCBI) compare
b2330 yfcB +1.2 1.4 putative adenine-specific methylase (VIMSS) compare
b1709 btuD +1.1 1.1 vitamin B12-transporter ATPase (NCBI) compare
b1523 yneG +1.1 2.4 hypothetical protein (NCBI) compare
b0880 cspD +1.1 2.9 cold shock protein homolog (NCBI) compare
b1422 ydcI +1.1 4.3 putative transcriptional regulator LYSR-type (VIMSS) conserved
b2749 ygbE +1.1 5.9 conserved inner membrane protein (NCBI) compare
b0088 murD +1.1 2.3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b4589 ylcI +1.1 3.7 hypothetical protein (RefSeq) compare
b1743 spy +1.1 1.9 envelope stress induced periplasmic protein (NCBI) compare
b0613 citG +1.1 1.8 triphosphoribosyl-dephospho-CoA transferase (NCBI) compare
b1961 dcm +1.1 2.1 DNA cytosine methylase (NCBI) compare
b0018 mokC +1.1 1.5 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1332 ynaJ +1.1 0.6 predicted inner membrane protein (NCBI) compare
b0872 hcr +1.0 0.8 HCP oxidoreductase, NADH-dependent (NCBI) compare
b4071 nrfB +1.0 1.3 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b3512 GadE +1.0 4.8 acid-responsive regulator of gadA and gadBC (Katherine Huang) compare
b2262 menB +1.0 1.2 naphthoate synthase (NCBI) compare
b1236 galU +1.0 3.7 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1550 b1550 +1.0 1.2 orf, hypothetical protein (VIMSS) compare
b3442 yhhZ +1.0 0.4 hypothetical protein (NCBI) compare
b4543 ypaA +1.0 3.4 predicted protein (NCBI) compare
b3035 tolC +1.0 6.0 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1582 ynfA +1.0 1.9 hypothetical protein (NCBI) compare
b3933 ftsN +1.0 5.1 essential cell division protein (NCBI) compare
b2318 truA +1.0 2.9 tRNA pseudouridine synthase A (NCBI) compare
b2829 ptsP +1.0 7.5 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b3043 ygiL +1.0 3.9 predicted fimbrial-like adhesin protein (NCBI) compare
b3613 yibP +1.0 3.7 putative membrane protein (VIMSS) compare
b3785 wzzE +1.0 6.9 putative transport protein (VIMSS) compare
b3620 rfaF +1.0 3.2 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4436 ryeC +1.0 1.8 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b3156 yhbS +1.0 6.0 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b3121 yhaC +1.0 0.4 hypothetical protein (NCBI) compare
b3863 polA +0.9 0.9 DNA polymerase I (NCBI) compare
b1013 ycdC +0.9 2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b2911 ssrS +0.9 1.6 6S regulatory RNA (NCBI) compare
b0688 pgm +0.9 3.2 phosphoglucomutase (NCBI) compare
b3649 rpoZ +0.9 1.8 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0279 yagM +0.9 1.5 CP4-6 prophage; predicted protein (NCBI) compare
b2498 upp +0.9 2.3 uracil phosphoribosyltransferase (VIMSS) compare
b1842 holE +0.9 2.1 DNA polymerase III, theta subunit (NCBI) compare
b1739 osmE +0.9 1.2 DNA-binding transcriptional activator (NCBI) compare
b2742 nlpD +0.9 4.1 predicted outer membrane lipoprotein (NCBI) compare
b2007 yeeX +0.9 0.9 conserved protein (RefSeq) compare
b1573 ydfC +0.9 1.1 Qin prophage; predicted protein (RefSeq) compare
b2229 b2229 +0.9 1.5 orf, hypothetical protein (VIMSS) compare
b4660 yhiL +0.9 0.5 no description compare
b2688 gshA +0.9 4.0 glutamate--cysteine ligase (NCBI) compare
b2199 ccmC +0.9 2.0 heme exporter subunit (NCBI) compare
b1164 ycgZ +0.9 1.3 hypothetical protein (NCBI) compare
b3443 yrhA +0.9 0.9 orf, hypothetical protein (VIMSS) compare
b1286 rnb +0.9 2.5 exoribonuclease II (NCBI) compare
b4493 gapC +0.9 2.6 no description compare
b1465 narV +0.9 1.4 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b0503 ybbB +0.9 1.4 tRNA 2-selenouridine synthase, selenophosphate-dependent (NCBI) compare
b2859 ygeO +0.8 2.0 hypothetical protein (RefSeq) compare
b4515 ybgT +0.8 1.4 hypothetical protein (NCBI) compare
b1429 tehA +0.8 0.9 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3672 ivbL +0.8 1.7 ilvB operon leader peptide (NCBI) compare
b4045 yjbJ +0.8 1.2 predicted stress response protein (NCBI) compare
b0197 metQ +0.8 3.4 DL-methionine transporter subunit (NCBI) compare
b1363 trkG +0.8 1.3 Rac prophage; potassium transporter subunit (NCBI) compare
b1190 dadX +0.8 2.8 alanine racemase (NCBI) compare
b0310 ykgH +0.8 1.9 predicted inner membrane protein (NCBI) compare
b0050 apaG +0.8 4.7 hypothetical protein (NCBI) compare
b4513 kdpF +0.8 1.5 potassium ion accessory transporter subunit (NCBI) compare
b4293 fecI +0.8 1.9 KpLE2 phage-like element; RNA polymerase, sigma 19 factor (NCBI) compare
b4260 pepA +0.8 5.5 leucyl aminopeptidase (NCBI) compare
b4702 mgtL +0.8 0.8 regulatory leader peptide for mgtA (NCBI) compare
b3504 yhiS +0.8 0.5 hypothetical protein (RefSeq) compare
b3199 yrbK +0.8 2.6 hypothetical protein (NCBI) compare
b4614 sokA +0.8 1.5 no description compare
b0706 ybfD +0.8 2.1 hypothetical protein (NCBI) compare
b1493 gadB +0.8 0.6 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b3836 b3836 +0.8 1.9 orf, hypothetical protein (VIMSS) compare
b3293 yhdN +0.8 1.6 hypothetical protein (NCBI) compare
b2256 yfbH +0.8 3.1 hypothetical protein (NCBI) compare
b0118 acnB +0.8 1.2 aconitate hydratase (NCBI) compare
b4558 yifL +0.8 3.5 predicted lipoprotein (NCBI) compare
b0530 sfmA +0.8 2.1 putative fimbrial-like protein (VIMSS) compare
b0500 ybbD +0.8 0.3 hypothetical protein (RefSeq) compare
b1258 yciF +0.8 0.8 hypothetical protein (NCBI) compare
b0802 ybiJ +0.8 2.2 hypothetical protein (NCBI) compare
b3769 ilvM +0.8 3.0 acetolactate synthase II, small subunit (NCBI) compare
b4253 yjgL +0.8 3.4 orf, hypothetical protein (VIMSS) compare
b2467 yffH +0.7 3.0 predicted NUDIX hydrolase (NCBI) compare
b1671 ydhX +0.7 0.9 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b0955 ycbZ +0.7 4.5 predicted peptidase (NCBI) compare
b3741 gidA +0.7 2.6 glucose-inhibited division protein A (NCBI) compare
b4535 yniD +0.7 0.7 predicted protein (RefSeq) compare
b1892 flhD +0.7 2.5 DNA-binding transcriptional dual regulator with FlhC (RefSeq) compare
b1095 fabF +0.7 3.2 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2635 ypjK +0.7 2.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1144 ymfJ +0.7 0.7 orf, hypothetical protein (VIMSS) compare
b0623 cspE +0.7 0.5 cold shock protein E (NCBI) compare
b1150 ymfR +0.7 0.7 e14 prophage; predicted protein (NCBI) compare
b2620 smpB +0.7 0.8 SsrA-binding protein (NCBI) compare
b3626 rfaJ +0.7 2.9 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b3858 yihD +0.7 1.7 hypothetical protein (NCBI) compare
b4345 mcrC +0.7 1.1 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b1670 ydhU +0.7 2.7 predicted cytochrome (NCBI) compare
b1344 ydaO +0.7 1.1 predicted C32 tRNA thiolase (NCBI) compare
b2947 gshB +0.7 2.5 glutathione synthetase (NCBI) compare
b2049 cpsB +0.7 2.5 mannose-1-phosphate guanyltransferase (NCBI) compare
b4375 prfC +0.7 2.7 peptide chain release factor 3 (NCBI) compare
b3740 gidB +0.7 3.9 glucose-inhibited division protein B (NCBI) compare
b4438 cyaR +0.7 1.8 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b4017 arpA +0.7 3.2 regulator of acetyl CoA synthetase (NCBI) compare
b1930 yedF +0.7 3.0 hypothetical protein (NCBI) compare
b3387 dam +0.7 4.6 DNA adenine methylase (NCBI) compare
b4397 creA +0.7 1.5 hypothetical protein (NCBI) compare
b1070 flgN +0.7 0.9 export chaperone for FlgK and FlgL (NCBI) compare
b4443 gcvB +0.7 0.2 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b4441 glmY +0.7 1.1 sRNA activator of glmS mRNA (RefSeq) compare


Specific Phenotypes

For 19 genes in this experiment

For carbon source Ying_Others16 in Escherichia coli BW25113

For carbon source Ying_Others16 across organisms