Experiment set57IT034 for Escherichia coli BW25113

Compare to:

Ying_Others16 rep A; time point 2

200 most detrimental genes:

  gene name fitness t score description  
b3753 rbsR +5.8 40.6 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b2127 mlrA +5.7 44.3 DNA-binding transcriptional regulator (NCBI) compare
b1341 b1341 +5.4 42.7 orf, hypothetical protein (VIMSS) compare
b1038 csgF +4.8 21.4 predicted transport protein (NCBI) compare
b1584 speG +4.8 35.5 spermidine N1-acetyltransferase (NCBI) conserved
b4172 hfq +4.7 6.6 RNA-binding protein Hfq (NCBI) compare
b3755 yieP +4.7 33.7 predicted transcriptional regulator (NCBI) compare
b1040 csgD +4.7 11.7 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b2218 rcsC +4.6 32.7 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b2903 gcvP +4.4 20.2 glycine dehydrogenase (NCBI) compare
b1037 csgG +4.4 38.4 outer membrane lipoprotein (NCBI) compare
b3398 yrfF +4.3 8.9 predicted inner membrane protein (NCBI) compare
b2741 rpoS +4.2 25.0 RNA polymerase sigma factor (NCBI) compare
b2904 gcvH +4.0 21.7 glycine cleavage system protein H (NCBI) compare
b2830 nudH +3.8 9.5 dinucleoside polyphosphate hydrolase (NCBI) compare
b1185 dsbB +3.8 11.6 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1831 proQ +3.7 13.7 putative solute/DNA competence effector (NCBI) compare
b3644 yicC +3.6 21.4 hypothetical protein (NCBI) compare
b3752 rbsK +3.5 11.6 ribokinase (NCBI) compare
b2664 ygaE +3.5 11.9 putative transcriptional regulator (VIMSS) compare
b2216 rcsD +3.4 13.1 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b2905 gcvT +3.4 16.4 glycine cleavage system aminomethyltransferase T (NCBI) compare
b0882 clpA +3.1 27.0 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1042 csgA +3.1 15.1 cryptic curlin major subunit (NCBI) compare
b1222 narX +3.1 5.0 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b2576 srmB +3.0 16.6 ATP-dependent RNA helicase (NCBI) compare
b3026 qseC +2.9 16.2 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3181 greA +2.8 14.0 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3764 yifE +2.8 18.9 hypothetical protein (NCBI) compare
b4042 dgkA +2.8 9.4 diacylglycerol kinase (NCBI) compare
b1824 yobF +2.6 8.1 hypothetical protein (NCBI) compare
b4171 miaA +2.6 8.6 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b4025 pgi +2.5 17.8 glucose-6-phosphate isomerase (NCBI) compare
b4450 arcZ +2.5 12.8 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1049 mdoH +2.5 17.3 glucosyltransferase MdoH (NCBI) compare
b3229 sspA +2.4 8.7 stringent starvation protein A (NCBI) compare
b4480 hdfR +2.4 17.0 transcriptional regulator HdfR (NCBI) compare
b3341 rpsG +2.4 3.3 30S ribosomal protein S7 (NCBI) compare
b1039 csgE +2.3 13.4 predicted transport protein (NCBI) compare
b1048 mdoG +2.2 11.0 glucan biosynthesis protein, periplasmic (NCBI) compare
b0082 mraW +2.2 10.4 S-adenosyl-methyltransferase (NCBI) compare
b1823 cspC +2.2 5.0 stress protein, member of the CspA-family (NCBI) compare
b3934 cytR +2.2 16.2 DNA-binding transcriptional dual regulator (NCBI) compare
b0385 yaiC +2.2 15.8 predicted diguanylate cyclase (NCBI) compare
b3860 dsbA +2.2 13.4 periplasmic protein disulfide isomerase I (NCBI) compare
b3706 trmE +2.1 7.8 tRNA modification GTPase (NCBI) compare
b2314 dedD +2.1 6.1 putative lipoprotein (VIMSS) compare
b0450 glnK +2.1 2.2 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b4202 rpsR +2.0 3.2 30S ribosomal protein S18 (NCBI) compare
b3504 yhiS +2.0 2.0 hypothetical protein (RefSeq) compare
b0051 ksgA +1.9 9.1 dimethyladenosine transferase (NCBI) compare
b2808 gcvA +1.9 5.5 DNA-binding transcriptional dual regulator (NCBI) compare
b3423 glpR +1.8 13.0 DNA-binding transcriptional repressor (NCBI) compare
b0232 yafN +1.8 2.0 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1041 csgB +1.8 6.9 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b3871 bipA +1.8 12.2 GTP-binding protein (NCBI) compare
b0707 ybgA +1.7 7.0 hypothetical protein (NCBI) compare
b0088 murD +1.7 1.6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b3454 livF +1.7 7.6 ATP-binding component of leucine transport (VIMSS) compare
b1144 ymfJ +1.7 1.8 orf, hypothetical protein (VIMSS) compare
b3183 obgE +1.7 3.0 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3979 thrT +1.6 1.1 tRNA-Thr (NCBI) compare
b1542 ydfI +1.6 3.3 predicted mannonate dehydrogenase (NCBI) compare
b3741 gidA +1.6 7.8 glucose-inhibited division protein A (NCBI) compare
b2911 ssrS +1.5 3.7 6S regulatory RNA (NCBI) compare
b3164 pnp +1.5 4.8 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2501 ppk +1.5 10.4 polyphosphate kinase (NCBI) compare
b0889 lrp +1.5 4.1 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b2947 gshB +1.5 5.0 glutathione synthetase (NCBI) compare
b2318 truA +1.5 5.1 tRNA pseudouridine synthase A (NCBI) compare
b1422 ydcI +1.5 6.3 putative transcriptional regulator LYSR-type (VIMSS) conserved
b1583 ynfB +1.4 1.3 hypothetical protein (NCBI) compare
b3929 rraA +1.4 9.3 ribonuclease activity regulator protein RraA (NCBI) compare
b1284 yciT +1.4 6.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b0382 yaiB +1.4 9.2 hypothetical protein (NCBI) compare
b1961 dcm +1.4 2.5 DNA cytosine methylase (NCBI) compare
b3156 yhbS +1.3 8.5 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b4375 prfC +1.3 5.8 peptide chain release factor 3 (NCBI) compare
b1236 galU +1.3 6.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2688 gshA +1.3 7.6 glutamate--cysteine ligase (NCBI) compare
b0610 rnk +1.3 5.1 nucleoside diphosphate kinase regulator (NCBI) compare
b0059 hepA +1.3 10.3 ATP-dependent helicase HepA (NCBI) compare
b0014 dnaK +1.3 2.1 molecular chaperone DnaK (NCBI) compare
b3102 yqjG +1.2 2.2 predicted S-transferase (NCBI) compare
b1830 prc +1.2 5.9 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4596 yciZ +1.2 2.8 hypothetical protein (RefSeq) compare
b3785 wzzE +1.2 9.2 putative transport protein (VIMSS) compare
b3199 yrbK +1.2 2.4 hypothetical protein (NCBI) compare
b1143 ymfI +1.2 1.2 orf, hypothetical protein (VIMSS) compare
b3649 rpoZ +1.2 2.0 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0881 clpS +1.2 2.8 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b3613 yibP +1.2 4.4 putative membrane protein (VIMSS) compare
b1095 fabF +1.2 7.1 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3933 ftsN +1.1 6.4 essential cell division protein (NCBI) compare
b0209 yafD +1.1 7.0 hypothetical protein (NCBI) compare
b1190 dadX +1.1 5.9 alanine racemase (NCBI) compare
b2136 yohD +1.1 2.1 orf, hypothetical protein (VIMSS) compare
b1553 ydfP +1.1 2.6 Qin prophage; conserved protein (NCBI) compare
b1150 ymfR +1.1 1.3 e14 prophage; predicted protein (NCBI) compare
b1960 vsr +1.1 2.4 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b0926 ycbK +1.1 5.6 hypothetical protein (NCBI) compare
b2847 yqeI +1.1 1.9 predicted transcriptional regulator (NCBI) compare
b3146 yraL +1.1 5.7 predicted methyltransferase (NCBI) compare
b4071 nrfB +1.1 1.6 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b1346 ydaQ +1.1 2.1 orf, hypothetical protein (VIMSS) compare
b0955 ycbZ +1.0 6.4 predicted peptidase (NCBI) compare
b1891 flhC +1.0 3.7 DNA-binding transcriptional dual regulator with FlhD (NCBI) compare
b4568 ytjA +1.0 2.4 predicted protein (RefSeq) compare
b1942 fliJ +1.0 2.1 flagellar biosynthesis chaperone (NCBI) compare
b2829 ptsP +1.0 7.7 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b3133 agaV +1.0 1.4 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b1743 spy +1.0 1.8 envelope stress induced periplasmic protein (NCBI) compare
b3442 yhhZ +1.0 0.4 hypothetical protein (NCBI) compare
b4155 yjeA +1.0 1.5 putative lysyl-tRNA synthetase (VIMSS) compare
b1332 ynaJ +1.0 0.6 predicted inner membrane protein (NCBI) compare
b2642 yfjW +1.0 0.8 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2262 menB +1.0 1.1 naphthoate synthase (NCBI) compare
b2742 nlpD +1.0 4.3 predicted outer membrane lipoprotein (NCBI) compare
b4570 lomR +1.0 2.2 no description compare
b3836 b3836 +1.0 2.5 orf, hypothetical protein (VIMSS) compare
b3627 rfaI +1.0 6.2 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b0542 renD +1.0 0.9 orf, hypothetical protein (VIMSS) compare
b2189 proL +1.0 2.0 tRNA-Pro (NCBI) compare
b3121 yhaC +1.0 0.5 hypothetical protein (NCBI) compare
b4462 ygaQ +0.9 3.1 hypothetical protein (RefSeq) compare
b1804 rnd +0.9 3.5 ribonuclease D (NCBI) compare
b2749 ygbE +0.9 4.0 conserved inner membrane protein (NCBI) compare
b1593 b1593 +0.9 2.1 orf, hypothetical protein (VIMSS) compare
b0234 yafP +0.9 2.4 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b3620 rfaF +0.9 3.5 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4325 yjiC +0.9 1.7 orf, hypothetical protein (VIMSS) compare
b0851 nfsA +0.9 1.5 nitroreductase A, NADPH-dependent, FMN-dependent (NCBI) compare
b3404 envZ +0.9 4.6 osmolarity sensor protein (NCBI) compare
b3842 rfaH +0.9 3.7 transcriptional activator RfaH (NCBI) compare
b4660 yhiL +0.9 0.5 no description compare
b4515 ybgT +0.9 1.7 hypothetical protein (NCBI) compare
b4646 yrdE +0.9 1.7 no description compare
b4493 gapC +0.9 1.5 no description compare
b4538 yoeF +0.9 1.8 hypothetical protein (RefSeq) compare
b0225 yafQ +0.9 2.9 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b2939 yqgB +0.9 1.7 predicted protein (RefSeq) compare
b4260 pepA +0.9 5.5 leucyl aminopeptidase (NCBI) compare
b2954 yggV +0.8 1.3 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b3625 rfaY +0.8 3.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4163 glyV +0.8 0.9 tRNA-Gly (NCBI) compare
b1269 rluB +0.8 2.3 23S rRNA pseudouridylate synthase (NCBI) compare
b1573 ydfC +0.8 0.9 Qin prophage; predicted protein (RefSeq) compare
b0339 cynT +0.8 2.6 carbonic anhydrase (NCBI) compare
b1725 yniA +0.8 2.0 predicted phosphotransferase/kinase (NCBI) compare
b1613 manA +0.8 1.7 mannose-6-phosphate isomerase (VIMSS) compare
b1306 pspC +0.8 1.7 DNA-binding transcriptional activator (NCBI) compare
b0406 tgt +0.8 3.2 queuine tRNA-ribosyltransferase (NCBI) compare
b0705 ybfL +0.8 1.1 putative receptor protein (VIMSS) compare
b1591 b1591 +0.8 1.2 putative oxidoreductase component (VIMSS) compare
b1669 ydhT +0.8 1.2 hypothetical protein (NCBI) compare
b1920 fliY +0.8 1.1 cystine transporter subunit (NCBI) compare
b1085 b1085 +0.8 1.1 orf, hypothetical protein (VIMSS) compare
b2123 yehR +0.8 1.1 orf, hypothetical protein (VIMSS) compare
b2752 cysD +0.8 3.9 sulfate adenylyltransferase subunit 2 (NCBI) compare
b0880 cspD +0.8 1.6 cold shock protein homolog (NCBI) compare
b1639 ydhA +0.8 3.1 orf, hypothetical protein (VIMSS) compare
b4603 rseX +0.8 0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3107 yhaL +0.8 1.2 orf, hypothetical protein (VIMSS) compare
b1286 rnb +0.8 2.1 exoribonuclease II (NCBI) compare
b2017 yefM +0.7 1.1 orf, hypothetical protein (VIMSS) compare
b0500 ybbD +0.7 0.3 hypothetical protein (RefSeq) compare
b0685 ybfE +0.7 2.5 orf, hypothetical protein (VIMSS) compare
b3106 yhaK +0.7 1.6 predicted pirin-related protein (NCBI) compare
b3238 yhcN +0.7 2.0 orf, hypothetical protein (VIMSS) compare
b4402 yjjY +0.7 0.9 hypothetical protein (NCBI) compare
b2948 yqgE +0.7 2.1 orf, hypothetical protein (VIMSS) compare
b2725 hycA +0.7 2.8 regulator of the transcriptional regulator FhlA (NCBI) compare
b0050 apaG +0.7 4.0 hypothetical protein (NCBI) compare
b0949 uup +0.7 4.9 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3120 yhaB +0.7 1.7 orf, hypothetical protein (VIMSS) compare
b2042 galF +0.7 4.0 predicted subunit with GalU (NCBI) compare
b0122 yacC +0.7 3.6 orf, hypothetical protein (VIMSS) compare
b3349 slyD +0.7 4.1 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b0787 ybhM +0.7 3.1 conserved inner membrane protein (NCBI) compare
b4543 ypaA +0.7 2.1 predicted protein (NCBI) compare
b0655 gltI +0.7 2.7 glutamate and aspartate transporter subunit (NCBI) compare
b2517 yfgB +0.7 3.9 predicted enzyme (NCBI) compare
b3052 rfaE +0.7 2.6 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0831 yliC +0.7 3.4 predicted peptide transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2229 b2229 +0.7 1.2 orf, hypothetical protein (VIMSS) compare
b3387 dam +0.7 5.0 DNA adenine methylase (NCBI) compare
b1370 insH-5 +0.7 1.8 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b4505 insX +0.7 1.4 predicted IS protein (RefSeq) compare
b0615 citF +0.7 1.8 citrate lyase, citrate-ACP transferase (alpha) subunit (NCBI) compare
b3740 gidB +0.7 3.8 glucose-inhibited division protein B (NCBI) compare
b4242 mgtA +0.7 4.1 magnesium transporter (NCBI) compare
b0388 aroL +0.7 2.2 shikimate kinase II (NCBI) compare
b2319 usg +0.7 1.7 hypothetical protein (NCBI) compare
b4443 gcvB +0.7 0.3 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b3784 rfe +0.7 5.0 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1540 ydfH +0.7 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b3119 tdcR +0.7 1.2 threonine dehydratase operon activator protein (VIMSS) compare
b2567 rnc +0.7 0.7 ribonuclease III (NCBI) compare
b2876 b2876 +0.7 2.7 orf, hypothetical protein (VIMSS) compare
b0556 rzpD +0.7 2.2 DLP12 prophage; predicted murein endopeptidase (NCBI) compare


Specific Phenotypes

For 24 genes in this experiment

For carbon source Ying_Others16 in Escherichia coli BW25113

For carbon source Ying_Others16 across organisms