Experiment set57IT032 for Escherichia coli BW25113

Compare to:

Ying_Nucleobase14 rep B; time point 2

200 most detrimental genes:

  gene name fitness t score description  
b2830 nudH +4.4 14.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b2688 gshA +3.1 21.8 glutamate--cysteine ligase (NCBI) compare
b3934 cytR +3.0 27.0 DNA-binding transcriptional dual regulator (NCBI) conserved
b2101 yegW +3.0 19.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1236 galU +2.9 19.7 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2947 gshB +2.7 17.1 glutathione synthetase (NCBI) compare
b0840 deoR +2.6 19.4 DNA-binding transcriptional repressor (NCBI) compare
b2904 gcvH +2.5 15.4 glycine cleavage system protein H (NCBI) compare
b2903 gcvP +2.4 22.5 glycine dehydrogenase (NCBI) compare
b1190 dadX +2.4 15.4 alanine racemase (NCBI) compare
b1095 fabF +2.3 19.0 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3181 greA +2.2 11.0 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1824 yobF +2.1 3.2 hypothetical protein (NCBI) compare
b4260 pepA +1.7 15.6 leucyl aminopeptidase (NCBI) compare
b2829 ptsP +1.7 13.9 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1663 mdtK +1.7 8.0 multidrug efflux protein NorM (NCBI) compare
b2808 gcvA +1.6 8.4 DNA-binding transcriptional dual regulator (NCBI) compare
b3706 trmE +1.6 6.3 tRNA modification GTPase (NCBI) compare
b0059 hepA +1.5 14.4 ATP-dependent helicase HepA (NCBI) compare
b3979 thrT +1.5 1.5 tRNA-Thr (NCBI) compare
b3620 rfaF +1.5 10.4 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3863 polA +1.5 2.7 DNA polymerase I (NCBI) compare
b3199 yrbK +1.5 4.5 hypothetical protein (NCBI) compare
b0688 pgm +1.5 9.1 phosphoglucomutase (NCBI) compare
b3741 gidA +1.4 9.5 glucose-inhibited division protein A (NCBI) compare
b3164 pnp +1.4 4.7 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b3405 ompR +1.4 8.7 osmolarity response regulator (NCBI) compare
b1823 cspC +1.3 4.6 stress protein, member of the CspA-family (NCBI) compare
b0437 clpP +1.3 8.5 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1233 ychJ +1.2 1.0 hypothetical protein (NCBI) compare
b3630 rfaP +1.2 10.1 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b4381 deoC +1.2 3.3 deoxyribose-phosphate aldolase (NCBI) compare
b3644 yicC +1.2 8.0 hypothetical protein (NCBI) compare
b1831 proQ +1.2 5.1 putative solute/DNA competence effector (NCBI) compare
b1341 b1341 +1.2 8.1 orf, hypothetical protein (VIMSS) compare
b0852 rimK +1.1 8.9 ribosomal protein S6 modification protein (NCBI) compare
b4647 mokA +1.1 1.5 no description compare
b3387 dam +1.1 9.7 DNA adenine methylase (NCBI) compare
b1038 csgF +1.1 4.7 predicted transport protein (NCBI) compare
b2189 proL +1.1 3.6 tRNA-Pro (NCBI) compare
b4391 yjjK +1.1 9.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3755 yieP +1.1 7.5 predicted transcriptional regulator (NCBI) compare
b1235 rssB +1.1 8.1 response regulator of RpoS (NCBI) compare
b4443 gcvB +1.1 0.6 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b2127 mlrA +1.1 6.2 DNA-binding transcriptional regulator (NCBI) compare
b4450 arcZ +1.1 3.9 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b3052 rfaE +1.1 6.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0556 rzpD +1.1 1.9 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b3929 rraA +1.1 7.8 ribonuclease activity regulator protein RraA (NCBI) compare
b2421 cysM +1.0 5.1 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b0222 lpcA +1.0 3.5 phosphoheptose isomerase (NCBI) compare
b1085 b1085 +1.0 3.4 orf, hypothetical protein (VIMSS) compare
b2642 yfjW +1.0 1.2 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4380 yjjI +1.0 5.2 hypothetical protein (NCBI) compare
b2114 metG +1.0 2.3 methionyl-tRNA synthetase (NCBI) compare
b4558 yifL +1.0 2.9 predicted lipoprotein (NCBI) compare
b2518 ndk +1.0 3.1 nucleoside diphosphate kinase (NCBI) compare
b3842 rfaH +1.0 5.8 transcriptional activator RfaH (NCBI) compare
b4256 yjgM +0.9 7.9 predicted acetyltransferase (NCBI) compare
b4190 yjfP +0.9 7.4 predicted hydrolase (NCBI) compare
b1222 narX +0.9 5.7 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b4375 prfC +0.9 5.5 peptide chain release factor 3 (NCBI) compare
b0053 surA +0.9 5.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3404 envZ +0.9 5.8 osmolarity sensor protein (NCBI) compare
b4373 rimI +0.9 3.1 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1294 sapA +0.9 4.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4402 yjjY +0.9 1.5 hypothetical protein (NCBI) compare
b3769 ilvM +0.9 2.9 acetolactate synthase II, small subunit (NCBI) compare
b2067 yegE +0.9 7.3 predicted diguanylate cyclase, GGDEF domain signalling protein (NCBI) compare
b2175 spr +0.9 4.4 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b4702 mgtL +0.9 1.9 regulatory leader peptide for mgtA (NCBI) compare
b1349 recT +0.9 5.3 Rac prophage; recombination and repair protein (NCBI) compare
b1187 fadR +0.9 5.1 fatty acid metabolism regulator (NCBI) compare
b1284 yciT +0.9 5.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b2042 galF +0.9 6.2 predicted subunit with GalU (NCBI) compare
b1037 csgG +0.9 6.3 outer membrane lipoprotein (NCBI) compare
b2218 rcsC +0.8 7.4 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b4135 yjdC +0.8 5.3 orf, hypothetical protein (VIMSS) compare
b3977 tyrU +0.8 1.5 tRNA-Tyr (NCBI) compare
b1150 ymfR +0.8 1.4 e14 prophage; predicted protein (NCBI) compare
b0438 clpX +0.8 5.2 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3631 rfaG +0.8 7.5 glucosyltransferase I (NCBI) compare
b1480 sra +0.8 1.4 30S ribosomal subunit protein S22 (NCBI) compare
b1542 ydfI +0.8 2.1 predicted mannonate dehydrogenase (NCBI) compare
b0564 appY +0.8 1.2 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2576 srmB +0.8 2.7 ATP-dependent RNA helicase (NCBI) compare
b4110 yjcZ +0.8 5.6 orf, hypothetical protein (VIMSS) compare
b1348 lar +0.8 3.2 Rac prophage; restriction alleviation protein (NCBI) compare
b0082 mraW +0.8 3.6 S-adenosyl-methyltransferase (NCBI) compare
b3621 rfaC +0.8 4.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1042 csgA +0.8 4.6 cryptic curlin major subunit (NCBI) compare
b3350 kefB +0.8 7.0 glutathione-regulated potassium-efflux system protein (NCBI) compare
b3676 yidH +0.7 4.5 conserved inner membrane protein (NCBI) compare
b2303 folX +0.7 5.3 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b3351 kefG +0.7 3.8 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b1731 cedA +0.7 3.6 cell division modulator (RefSeq) compare
b1281 pyrF +0.7 3.0 orotidine 5'-phosphate decarboxylase (NCBI) compare
b1804 rnd +0.7 4.3 ribonuclease D (NCBI) compare
b1279 yciS +0.7 1.3 conserved inner membrane protein (NCBI) compare
b4048 yjbM +0.7 1.8 hypothetical protein (NCBI) compare
b1482 osmC +0.7 1.7 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b1871 yecP +0.7 4.0 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b0949 uup +0.7 4.2 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1160 elbA +0.7 1.5 hypothetical protein (NCBI) compare
b1329 b1329 +0.7 4.7 putative transport periplasmic protein (VIMSS) compare
b1164 ycgZ +0.7 1.6 hypothetical protein (NCBI) compare
b3261 fis +0.7 1.9 DNA-binding protein Fis (NCBI) compare
b1606 folM +0.7 4.5 short chain dehydrogenase (NCBI) compare
b0051 ksgA +0.7 3.2 dimethyladenosine transferase (NCBI) compare
b2749 ygbE +0.7 4.4 conserved inner membrane protein (NCBI) compare
b0381 ddlA +0.7 3.9 D-alanylalanine synthetase (NCBI) compare
b0461 ybaJ +0.7 3.9 hypothetical protein (NCBI) compare
b0610 rnk +0.7 3.3 nucleoside diphosphate kinase regulator (NCBI) compare
b1273 yciN +0.7 1.6 hypothetical protein (NCBI) compare
b0685 ybfE +0.6 2.6 orf, hypothetical protein (VIMSS) compare
b0221 yafH +0.6 5.3 putative acyl-CoA dehydrogenase (EC 1.3.99.-) (VIMSS) compare
b2314 dedD +0.6 3.5 putative lipoprotein (VIMSS) compare
b4109 yjdA +0.6 5.6 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b2911 ssrS +0.6 1.9 6S regulatory RNA (NCBI) compare
b0339 cynT +0.6 3.3 carbonic anhydrase (NCBI) compare
b2946 yggJ +0.6 3.3 orf, hypothetical protein (VIMSS) compare
b4655 ythA +0.6 1.1 expressed protein (RefSeq) compare
b4596 yciZ +0.6 1.6 hypothetical protein (RefSeq) compare
b0955 ycbZ +0.6 4.9 predicted peptidase (NCBI) compare
b4409 blr +0.6 3.9 beta-lactam resistance membrane protein (NCBI) compare
b1686 ydiI +0.6 2.0 hypothetical protein (NCBI) compare
b2516 yfgA +0.6 4.0 hypothetical protein (NCBI) compare
b4653 yicT +0.6 1.2 no description compare
b4570 lomR +0.6 1.9 no description compare
b1144 ymfJ +0.6 1.5 orf, hypothetical protein (VIMSS) compare
b1134 ymfB +0.6 1.8 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b0746 valZ +0.6 2.5 tRNA-Val (NCBI) compare
b3250 mreC +0.6 1.1 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b3206 npr +0.6 4.1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b4533 ynfO +0.6 1.2 Qin prophage; predicted protein (NCBI) compare
b3197 kdsD +0.6 3.2 D-arabinose 5-phosphate isomerase (NCBI) compare
b4141 yjeH +0.6 4.9 predicted transporter (NCBI) compare
b2521 sseA +0.6 3.8 putative thiosulfate sulfurtransferase (VIMSS) compare
b1040 csgD +0.6 1.7 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b2258 b2258 +0.6 1.1 putative transport/receptor protein (VIMSS) compare
b1041 csgB +0.6 2.1 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b2419 yfeK +0.6 2.2 hypothetical protein (NCBI) compare
b2513 yfgM +0.6 1.4 hypothetical protein (NCBI) compare
b1090 plsX +0.6 3.7 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b0310 ykgH +0.6 1.5 predicted inner membrane protein (NCBI) compare
b4390 nadR +0.6 4.4 probable nadAB transcriptional regulator (VIMSS) compare
b2948 yqgE +0.5 2.7 orf, hypothetical protein (VIMSS) compare
b3466 yhhL +0.5 3.0 conserved inner membrane protein (NCBI) compare
b0545 ybcL +0.5 4.0 DLP12 prophage; predicted kinase inhibitor (NCBI) compare
b4504 ykfH +0.5 3.0 hypothetical protein (NCBI) compare
b4042 dgkA +0.5 1.8 diacylglycerol kinase (NCBI) compare
b4522 yciX_1 +0.5 1.0 hypothetical protein (NCBI) compare
b2111 yehD +0.5 2.2 predicted fimbrial-like adhesin protein (NCBI) compare
b1423 ydcJ +0.5 2.9 hypothetical protein (NCBI) compare
b0779 uvrB +0.5 4.2 excinuclease ABC subunit B (NCBI) compare
b2183 rsuA +0.5 2.6 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b1920 fliY +0.5 1.7 cystine transporter subunit (NCBI) compare
b4028 yjbG +0.5 1.5 hypothetical protein (NCBI) compare
b2951 yggS +0.5 2.6 predicted enzyme (NCBI) compare
b1159 mcrA +0.5 1.1 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b4382 deoA +0.5 1.7 thymidine phosphorylase (NCBI) compare
b4058 uvrA +0.5 4.3 excinuclease ABC subunit A (NCBI) compare
b0340 cynS +0.5 2.8 cyanate hydratase (NCBI) compare
b2847 yqeI +0.5 0.9 predicted transcriptional regulator (NCBI) compare
b0197 metQ +0.5 3.8 DL-methionine transporter subunit (NCBI) compare
b0926 ycbK +0.5 2.5 hypothetical protein (NCBI) compare
b2058 wcaB +0.5 1.0 predicted acyl transferase (NCBI) compare
b1558 cspF +0.5 1.2 Qin prophage; cold shock protein (NCBI) compare
b3026 qseC +0.5 2.5 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2143 cdd +0.5 2.5 cytidine deaminase (NCBI) compare
b2052 fcl +0.5 1.3 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/ GDP-4-dehydro-6-L-deoxygalactose reductase (NCBI) compare
b0998 torD +0.5 1.0 chaperone protein TorD (NCBI) compare
b2538 hcaE +0.5 1.4 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b2572 rseA +0.5 1.8 anti-sigma factor (NCBI) compare
b1673 ydhV +0.5 2.9 predicted oxidoreductase (NCBI) compare
b4505 insX +0.5 1.2 predicted IS protein (RefSeq) compare
b3632 rfaQ +0.5 4.2 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2216 rcsD +0.5 3.6 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b1189 dadA +0.5 2.8 D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) compare
b4171 miaA +0.5 1.8 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0965 b0965 +0.5 1.5 orf, hypothetical protein (VIMSS) compare
b1397 paaJ +0.5 3.2 acetyl-CoA acetyltransferase (NCBI) compare
b4246 pyrL +0.5 2.2 pyrBI operon leader peptide (NCBI) compare
b2517 yfgB +0.5 3.0 predicted enzyme (NCBI) compare
b4461 yfjD +0.5 3.4 predicted inner membrane protein (RefSeq) compare
b1847 yebF +0.5 0.6 predicted protein (RefSeq) compare
b3787 rffD +0.5 3.6 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3753 rbsR +0.4 3.0 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b4174 hflK +0.4 2.9 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b3156 yhbS +0.4 3.4 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b3784 rfe +0.4 3.6 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b4325 yjiC +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b3871 bipA +0.4 3.7 GTP-binding protein (NCBI) compare
b1642 slyA +0.4 0.9 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b4066 yjcF +0.4 0.5 hypothetical protein (NCBI) compare
b0542 renD +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b0856 potH +0.4 2.9 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1961 dcm +0.4 0.9 DNA cytosine methylase (NCBI) compare
b2587 kgtP +0.4 2.7 alpha-ketoglutarate transporter (NCBI) compare
b0979 appB +0.4 2.0 cytochrome bd-II oxidase, subunit II (NCBI) compare


Specific Phenotypes

For 28 genes in this experiment

For carbon source Ying_Nucleobase14 in Escherichia coli BW25113

For carbon source Ying_Nucleobase14 across organisms