Experiment set57IT031 for Escherichia coli BW25113

Compare to:

Ying_Nucleobase14 rep A; time point 2

200 most detrimental genes:

  gene name fitness t score description  
b2830 nudH +3.9 14.8 dinucleoside polyphosphate hydrolase (NCBI) compare
b2688 gshA +3.2 24.4 glutamate--cysteine ligase (NCBI) compare
b2101 yegW +3.1 23.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3934 cytR +3.1 28.4 DNA-binding transcriptional dual regulator (NCBI) conserved
b1236 galU +3.0 23.4 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2947 gshB +2.8 18.4 glutathione synthetase (NCBI) compare
b2903 gcvP +2.5 23.8 glycine dehydrogenase (NCBI) compare
b0840 deoR +2.3 13.2 DNA-binding transcriptional repressor (NCBI) compare
b3181 greA +2.3 17.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1190 dadX +2.3 16.7 alanine racemase (NCBI) compare
b1095 fabF +2.3 18.5 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2904 gcvH +2.2 9.4 glycine cleavage system protein H (NCBI) compare
b1824 yobF +2.0 2.9 hypothetical protein (NCBI) compare
b4260 pepA +1.8 16.0 leucyl aminopeptidase (NCBI) compare
b3706 trmE +1.7 7.7 tRNA modification GTPase (NCBI) compare
b3977 tyrU +1.7 3.9 tRNA-Tyr (NCBI) compare
b1663 mdtK +1.6 8.4 multidrug efflux protein NorM (NCBI) compare
b2829 ptsP +1.6 12.6 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b0059 hepA +1.5 14.2 ATP-dependent helicase HepA (NCBI) compare
b4450 arcZ +1.5 9.6 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1823 cspC +1.5 3.1 stress protein, member of the CspA-family (NCBI) compare
b3199 yrbK +1.4 4.7 hypothetical protein (NCBI) compare
b3620 rfaF +1.4 9.8 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4381 deoC +1.4 5.2 deoxyribose-phosphate aldolase (NCBI) compare
b3741 gidA +1.4 10.0 glucose-inhibited division protein A (NCBI) compare
b2808 gcvA +1.4 7.2 DNA-binding transcriptional dual regulator (NCBI) compare
b3164 pnp +1.4 7.7 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1273 yciN +1.3 3.0 hypothetical protein (NCBI) compare
b1085 b1085 +1.3 3.4 orf, hypothetical protein (VIMSS) compare
b0688 pgm +1.2 6.4 phosphoglucomutase (NCBI) compare
b3341 rpsG +1.2 1.7 30S ribosomal protein S7 (NCBI) compare
b3842 rfaH +1.2 9.6 transcriptional activator RfaH (NCBI) compare
b1038 csgF +1.2 5.9 predicted transport protein (NCBI) compare
b0852 rimK +1.2 5.9 ribosomal protein S6 modification protein (NCBI) compare
b1341 b1341 +1.2 7.4 orf, hypothetical protein (VIMSS) compare
b0438 clpX +1.1 7.9 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3405 ompR +1.1 6.7 osmolarity response regulator (NCBI) compare
b3630 rfaP +1.1 9.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3387 dam +1.1 10.0 DNA adenine methylase (NCBI) compare
b0437 clpP +1.1 7.3 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b3404 envZ +1.1 7.5 osmolarity sensor protein (NCBI) compare
b4373 rimI +1.1 4.0 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1233 ychJ +1.1 1.0 hypothetical protein (NCBI) compare
b3929 rraA +1.1 9.7 ribonuclease activity regulator protein RraA (NCBI) compare
b3755 yieP +1.1 8.7 predicted transcriptional regulator (NCBI) compare
b3644 yicC +1.1 7.3 hypothetical protein (NCBI) compare
b1294 sapA +1.1 5.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2127 mlrA +1.1 6.6 DNA-binding transcriptional regulator (NCBI) compare
b4391 yjjK +1.0 8.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1235 rssB +1.0 7.4 response regulator of RpoS (NCBI) compare
b4380 yjjI +1.0 5.5 hypothetical protein (NCBI) compare
b2948 yqgE +1.0 4.6 orf, hypothetical protein (VIMSS) compare
b0053 surA +1.0 7.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0556 rzpD +1.0 1.6 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b2042 galF +1.0 8.0 predicted subunit with GalU (NCBI) compare
b3052 rfaE +1.0 6.3 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1831 proQ +0.9 5.7 putative solute/DNA competence effector (NCBI) compare
b2421 cysM +0.9 4.9 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b3631 rfaG +0.9 8.5 glucosyltransferase I (NCBI) compare
b4256 yjgM +0.9 7.8 predicted acetyltransferase (NCBI) compare
b4558 yifL +0.9 2.9 predicted lipoprotein (NCBI) compare
b2258 b2258 +0.9 2.0 putative transport/receptor protein (VIMSS) compare
b4135 yjdC +0.9 7.0 orf, hypothetical protein (VIMSS) compare
b3261 fis +0.9 3.0 DNA-binding protein Fis (NCBI) compare
b1222 narX +0.9 5.8 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1187 fadR +0.9 5.8 fatty acid metabolism regulator (NCBI) compare
b4110 yjcZ +0.9 6.5 orf, hypothetical protein (VIMSS) compare
b0949 uup +0.8 6.6 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0222 lpcA +0.8 3.4 phosphoheptose isomerase (NCBI) compare
b2576 srmB +0.8 3.9 ATP-dependent RNA helicase (NCBI) compare
b2175 spr +0.8 4.1 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b1853 yebK +0.8 3.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b4239 treC +0.8 3.2 trehalose-6-P hydrolase (NCBI) compare
b1606 folM +0.8 6.0 short chain dehydrogenase (NCBI) compare
b0926 ycbK +0.8 5.8 hypothetical protein (NCBI) compare
b3769 ilvM +0.8 2.5 acetolactate synthase II, small subunit (NCBI) compare
b2067 yegE +0.8 6.6 predicted diguanylate cyclase, GGDEF domain signalling protein (NCBI) compare
b0178 hlpA +0.8 4.5 periplasmic chaperone (NCBI) compare
b1482 osmC +0.8 1.6 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b2572 rseA +0.8 2.5 anti-sigma factor (NCBI) compare
b2749 ygbE +0.8 5.2 conserved inner membrane protein (NCBI) compare
b2303 folX +0.8 6.6 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b3621 rfaC +0.8 5.4 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1332 ynaJ +0.8 1.1 predicted inner membrane protein (NCBI) compare
b3351 kefG +0.8 3.9 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b1284 yciT +0.8 5.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b2218 rcsC +0.8 6.6 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b2642 yfjW +0.8 1.3 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4190 yjfP +0.8 5.3 predicted hydrolase (NCBI) compare
b0955 ycbZ +0.8 5.7 predicted peptidase (NCBI) compare
b2517 yfgB +0.7 5.4 predicted enzyme (NCBI) compare
b1042 csgA +0.7 4.7 cryptic curlin major subunit (NCBI) compare
b2007 yeeX +0.7 2.6 conserved protein (RefSeq) compare
b0866 ybjQ +0.7 1.6 hypothetical protein (NCBI) compare
b4647 mokA +0.7 0.9 no description compare
b1642 slyA +0.7 2.4 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0381 ddlA +0.7 5.1 D-alanylalanine synthetase (NCBI) compare
b4416 rybA +0.7 1.9 unknown RNA (NCBI) compare
b0564 appY +0.7 1.1 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b1037 csgG +0.7 5.9 outer membrane lipoprotein (NCBI) compare
b3350 kefB +0.7 6.6 glutathione-regulated potassium-efflux system protein (NCBI) compare
b2189 proL +0.7 2.2 tRNA-Pro (NCBI) compare
b2183 rsuA +0.7 3.7 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b2512 yfgL +0.7 4.7 protein assembly complex, lipoprotein component (NCBI) compare
b4520 ymgF +0.7 2.4 hypothetical protein (NCBI) compare
b3973 birA +0.7 2.8 biotin--protein ligase (NCBI) compare
b3676 yidH +0.7 4.6 conserved inner membrane protein (NCBI) compare
b0610 rnk +0.7 3.5 nucleoside diphosphate kinase regulator (NCBI) compare
b4109 yjdA +0.7 5.9 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b3206 npr +0.7 2.6 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b1634 tppB +0.7 4.5 putative tripeptide transporter permease (NCBI) compare
b1349 recT +0.7 3.3 Rac prophage; recombination and repair protein (NCBI) compare
b3752 rbsK +0.7 5.8 ribokinase (NCBI) compare
b2324 b2324 +0.7 4.8 putative peptidase (VIMSS) compare
b2314 dedD +0.6 2.6 putative lipoprotein (VIMSS) compare
b3753 rbsR +0.6 4.5 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b1329 b1329 +0.6 4.4 putative transport periplasmic protein (VIMSS) compare
b1696 ydiP +0.6 3.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0051 ksgA +0.6 4.2 dimethyladenosine transferase (NCBI) compare
b2951 yggS +0.6 4.3 predicted enzyme (NCBI) compare
b1607 ydgC +0.6 1.3 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b2516 yfgA +0.6 4.7 hypothetical protein (NCBI) compare
b1804 rnd +0.6 3.6 ribonuclease D (NCBI) compare
b0685 ybfE +0.6 3.3 orf, hypothetical protein (VIMSS) compare
b3238 yhcN +0.6 1.2 orf, hypothetical protein (VIMSS) compare
b3784 rfe +0.6 5.0 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b3889 yiiE +0.6 2.7 predicted transcriptional regulator (RefSeq) compare
b1758 b1758 +0.6 1.2 putative cytochrome oxidase (VIMSS) compare
b4596 yciZ +0.6 1.9 hypothetical protein (RefSeq) compare
b4390 nadR +0.6 4.7 probable nadAB transcriptional regulator (VIMSS) compare
b0221 yafH +0.6 5.3 putative acyl-CoA dehydrogenase (EC 1.3.99.-) (VIMSS) compare
b3197 kdsD +0.6 3.9 D-arabinose 5-phosphate isomerase (NCBI) compare
b4141 yjeH +0.6 5.2 predicted transporter (NCBI) compare
b2313 cvpA +0.6 2.6 membrane protein required for colicin V production (NCBI) compare
b4375 prfC +0.6 3.4 peptide chain release factor 3 (NCBI) compare
b1765 ydjA +0.6 0.8 predicted oxidoreductase (NCBI) compare
b0779 uvrB +0.6 4.7 excinuclease ABC subunit B (NCBI) compare
b1090 plsX +0.6 3.4 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b4592 yccB +0.6 1.0 hypothetical protein (RefSeq) compare
b1891 flhC +0.6 3.2 DNA-binding transcriptional dual regulator with FlhD (NCBI) compare
b2518 ndk +0.6 2.4 nucleoside diphosphate kinase (NCBI) compare
b4533 ynfO +0.6 2.4 Qin prophage; predicted protein (NCBI) compare
b0385 yaiC +0.6 3.2 predicted diguanylate cyclase (NCBI) compare
b0197 metQ +0.6 4.3 DL-methionine transporter subunit (NCBI) compare
b2521 sseA +0.6 4.2 putative thiosulfate sulfurtransferase (VIMSS) compare
b1217 chaB +0.6 1.5 cation transport regulator (NCBI) compare
b4461 yfjD +0.5 4.2 predicted inner membrane protein (RefSeq) compare
b2698 recX +0.5 1.4 RecA regulator RecX (NCBI) compare
b1514 lsrC +0.5 2.2 AI2 transporter (NCBI) compare
b1871 yecP +0.5 3.1 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b3466 yhhL +0.5 2.7 conserved inner membrane protein (NCBI) compare
b4551 yheV +0.5 1.3 hypothetical protein (NCBI) compare
b0632 dacA +0.5 3.8 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b0212 gloB +0.5 1.8 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b1041 csgB +0.5 2.3 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b0167 glnD +0.5 1.1 PII uridylyl-transferase (NCBI) compare
b4058 uvrA +0.5 4.5 excinuclease ABC subunit A (NCBI) compare
b1450 b1450 +0.5 3.2 orf, hypothetical protein (VIMSS) compare
b2962 yggX +0.5 2.8 hypothetical protein (NCBI) compare
b1513 lsrA +0.5 3.4 fused AI2 transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3150 yraP +0.5 3.6 hypothetical protein (NCBI) compare
b1106 ycfN +0.5 2.7 thiamin kinase (NCBI) compare
b2352 yfdI +0.5 0.9 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b3146 yraL +0.5 3.3 predicted methyltransferase (NCBI) compare
b1819 manZ +0.5 2.5 mannose-specific enzyme IID component of PTS (NCBI) compare
b3617 kbl +0.5 3.5 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b1108 ycfP +0.5 1.5 orf, hypothetical protein (VIMSS) compare
b2114 metG +0.5 1.1 methionyl-tRNA synthetase (NCBI) compare
b1493 gadB +0.5 0.6 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b4409 blr +0.5 3.2 beta-lactam resistance membrane protein (NCBI) compare
b0998 torD +0.5 1.0 chaperone protein TorD (NCBI) compare
b1952 dsrB +0.5 2.5 hypothetical protein (NCBI) compare
b3465 yhhF +0.5 3.6 predicted methyltransferase (NCBI) compare
b3766 ilvL +0.5 2.5 ilvG operon leader peptide (NCBI) compare
b0935 ssuD +0.5 1.4 alkanesulfonate monooxygenase (NCBI) compare
b2946 yggJ +0.5 2.3 orf, hypothetical protein (VIMSS) compare
b0710 ybgI +0.5 2.8 conserved metal-binding protein (NCBI) compare
b2066 udk +0.5 3.0 uridine/cytidine kinase (VIMSS) compare
b3786 rffE +0.5 3.9 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b4413 sokC +0.5 1.0 regulatory antisense RNA (NCBI) compare
b2538 hcaE +0.5 1.4 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b3156 yhbS +0.4 3.5 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b3632 rfaQ +0.4 4.2 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2786 barA +0.4 4.3 hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) compare
b1685 ydiH +0.4 0.9 predicted protein (RefSeq) compare
b3787 rffD +0.4 3.5 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b1542 ydfI +0.4 1.6 predicted mannonate dehydrogenase (NCBI) compare
b2553 glnB +0.4 3.2 regulatory protein P-II for glutamine synthetase (NCBI) compare
b4028 yjbG +0.4 1.4 hypothetical protein (NCBI) compare
b4345 mcrC +0.4 0.9 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b2536 hcaT +0.4 3.3 predicted 3-phenylpropionic transporter (NCBI) compare
b1603 pntA +0.4 2.8 NAD(P) transhydrogenase subunit alpha (NCBI) compare
b3293 yhdN +0.4 0.9 hypothetical protein (NCBI) compare
b1667 ydhR +0.4 1.1 hypothetical protein (NCBI) compare
b1553 ydfP +0.4 1.1 Qin prophage; conserved protein (NCBI) compare
b3740 gidB +0.4 1.7 glucose-inhibited division protein B (NCBI) compare
b1040 csgD +0.4 1.2 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1485 ddpC +0.4 2.1 D-ala-D-ala transporter subunit (NCBI) compare
b0461 ybaJ +0.4 2.5 hypothetical protein (NCBI) compare
b3388 damX +0.4 3.6 hypothetical protein (NCBI) compare


Specific Phenotypes

For 28 genes in this experiment

For carbon source Ying_Nucleobase14 in Escherichia coli BW25113

For carbon source Ying_Nucleobase14 across organisms