Experiment set57IT018 for Escherichia coli BW25113

Compare to:

Ying_Others16 rep C; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2903 gcvP +2.6 18.4 glycine dehydrogenase (NCBI) compare
b2904 gcvH +2.4 5.2 glycine cleavage system protein H (NCBI) compare
b2127 mlrA +2.4 14.4 DNA-binding transcriptional regulator (NCBI) compare
b4172 hfq +2.3 2.7 RNA-binding protein Hfq (NCBI) compare
b1038 csgF +2.0 8.1 predicted transport protein (NCBI) compare
b1037 csgG +1.9 15.2 outer membrane lipoprotein (NCBI) compare
b2808 gcvA +1.8 6.8 DNA-binding transcriptional dual regulator (NCBI) compare
b1341 b1341 +1.8 10.3 orf, hypothetical protein (VIMSS) compare
b4676 yoaK +1.8 0.8 expressed protein (RefSeq) compare
b2905 gcvT +1.8 9.8 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1040 csgD +1.8 3.3 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1185 dsbB +1.8 7.4 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0912 ihfB +1.8 7.6 integration host factor subunit beta (NCBI) compare
b3755 yieP +1.7 9.0 predicted transcriptional regulator (NCBI) compare
b3398 yrfF +1.6 4.4 predicted inner membrane protein (NCBI) compare
b1730 ydjO +1.5 1.9 predicted protein (RefSeq) compare
b2218 rcsC +1.4 9.9 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b0882 clpA +1.4 10.8 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1493 gadB +1.4 1.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1942 fliJ +1.4 2.8 flagellar biosynthesis chaperone (NCBI) compare
b1831 proQ +1.4 5.5 putative solute/DNA competence effector (NCBI) compare
b1712 ihfA +1.3 1.9 integration host factor subunit alpha (NCBI) compare
b4603 rseX +1.3 1.2 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1429 tehA +1.3 1.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3181 greA +1.3 5.2 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3026 qseC +1.2 5.3 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b4042 dgkA +1.2 2.4 diacylglycerol kinase (NCBI) compare
b4416 rybA +1.2 2.2 unknown RNA (NCBI) compare
b0802 ybiJ +1.2 3.4 hypothetical protein (NCBI) compare
b3860 dsbA +1.2 7.6 periplasmic protein disulfide isomerase I (NCBI) compare
b2216 rcsD +1.2 7.3 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b1039 csgE +1.2 6.5 predicted transport protein (NCBI) compare
b1041 csgB +1.1 4.8 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b1824 yobF +1.1 2.4 hypothetical protein (NCBI) compare
b2259 pmrD +1.1 1.5 polymyxin resistance protein B (VIMSS) compare
b2741 rpoS +1.1 5.6 RNA polymerase sigma factor (NCBI) compare
b1042 csgA +1.1 5.9 cryptic curlin major subunit (NCBI) compare
b3341 rpsG +1.1 1.2 30S ribosomal protein S7 (NCBI) compare
b4651 yibW +1.1 0.8 no description compare
b1332 ynaJ +1.1 0.7 predicted inner membrane protein (NCBI) compare
b2168 fruK +1.0 1.4 1-phosphofructokinase (NCBI) compare
b2664 ygaE +1.0 5.0 putative transcriptional regulator (VIMSS) compare
b1862 yebB +1.0 3.6 orf, hypothetical protein (VIMSS) compare
b1524 yneH +1.0 1.4 predicted glutaminase (NCBI) compare
b2377 yfdY +1.0 2.7 predicted inner membrane protein (NCBI) compare
b4509 ylcG +1.0 4.3 DLP12 prophage; predicted protein (NCBI) compare
b1222 narX +1.0 2.8 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1279 yciS +1.0 1.2 conserved inner membrane protein (NCBI) compare
b4025 pgi +1.0 6.6 glucose-6-phosphate isomerase (NCBI) compare
b4505 insX +1.0 1.7 predicted IS protein (RefSeq) compare
b2642 yfjW +1.0 1.1 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4701 sokX +1.0 0.7 sok-related sRNA, function unknown (RefSeq) compare
b0232 yafN +0.9 0.9 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0556 rzpD +0.9 2.2 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b0059 hepA +0.9 7.8 ATP-dependent helicase HepA (NCBI) compare
b1160 elbA +0.9 1.2 hypothetical protein (NCBI) compare
b3199 yrbK +0.9 3.0 hypothetical protein (NCBI) compare
b2911 ssrS +0.9 1.9 6S regulatory RNA (NCBI) compare
b1278 pgpB +0.9 2.2 phosphatidylglycerophosphatase B (NCBI) compare
b0889 lrp +0.9 2.1 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1159 mcrA +0.9 1.7 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b3973 birA +0.9 1.7 biotin--protein ligase (NCBI) compare
b2490 b2490 +0.9 2.5 putative protein processing element (VIMSS) compare
b1936 intG +0.9 1.1 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1179 ycgL +0.9 2.5 conserved protein (NCBI) compare
b1850 eda +0.9 2.9 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3644 yicC +0.9 3.8 hypothetical protein (NCBI) compare
b1620 malI +0.9 2.1 DNA-binding transcriptional repressor (NCBI) compare
b0429 cyoD +0.8 2.8 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b2579 yfiD +0.8 1.8 pyruvate formate lyase subunit (NCBI) compare
b1007 b1007 +0.8 1.6 orf, hypothetical protein (VIMSS) compare
b4394 yjjX +0.8 2.7 orf, hypothetical protein (VIMSS) compare
b4096 phnL +0.8 2.9 carbon-phosphorus lyase complex subunit (NCBI) compare
b4552 yrhC +0.8 0.9 no description compare
b1724 ydiZ +0.8 1.5 hypothetical protein (NCBI) compare
b1792 yeaO +0.8 1.0 orf, hypothetical protein (VIMSS) compare
b2990 hybG +0.8 2.3 hydrogenase 2 accessory protein (NCBI) compare
b4520 ymgF +0.8 1.0 hypothetical protein (NCBI) compare
b3250 mreC +0.8 1.8 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b4577 sgrS +0.8 1.8 small antisense RNA (NCBI) compare
b2114 metG +0.8 1.2 methionyl-tRNA synthetase (NCBI) compare
b1819 manZ +0.8 3.1 mannose-specific enzyme IID component of PTS (NCBI) compare
b3934 cytR +0.8 4.9 DNA-binding transcriptional dual regulator (NCBI) compare
b0247 ykfG +0.8 1.2 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b3636 rpmG +0.8 0.9 50S ribosomal protein L33 (NCBI) compare
b2829 ptsP +0.7 5.7 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b0183 rnhB +0.7 1.8 ribonuclease HII (NCBI) compare
b2749 ygbE +0.7 3.6 conserved inner membrane protein (NCBI) compare
b4201 priB +0.7 2.5 primosomal replication protein N (NCBI) compare
b2279 nuoK +0.7 1.4 NADH dehydrogenase subunit K (NCBI) compare
b2672 ygaM +0.7 4.0 orf, hypothetical protein (VIMSS) compare
b4594 ymgJ +0.7 1.6 hypothetical protein (RefSeq) compare
b2258 b2258 +0.7 1.0 putative transport/receptor protein (VIMSS) compare
b3027 ygiZ +0.7 0.5 conserved inner membrane protein (NCBI) compare
b1190 dadX +0.7 3.6 alanine racemase (NCBI) compare
b2809 b2809 +0.7 1.8 orf, hypothetical protein (VIMSS) compare
b3260 dusB +0.7 3.1 tRNA-dihydrouridine synthase B (NCBI) compare
b4436 ryeC +0.7 1.2 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b3753 rbsR +0.7 4.3 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b2083 yegZ +0.7 2.2 orf, hypothetical protein (VIMSS) compare
b2953 yggU +0.7 0.7 orf, hypothetical protein (VIMSS) compare
b2457 cchA +0.7 2.5 detox protein (VIMSS) compare
b0787 ybhM +0.6 2.5 conserved inner membrane protein (NCBI) compare
b2951 yggS +0.6 1.7 predicted enzyme (NCBI) compare
b1651 gloA +0.6 2.0 glyoxalase I, Ni-dependent (NCBI) compare
b4202 rpsR +0.6 0.7 30S ribosomal protein S18 (NCBI) compare
b2498 upp +0.6 1.4 uracil phosphoribosyltransferase (VIMSS) compare
b0840 deoR +0.6 1.9 DNA-binding transcriptional repressor (NCBI) compare
b4373 rimI +0.6 1.3 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b0550 rusA +0.6 1.1 DLP12 prophage; endonuclease RUS (NCBI) compare
b1668 ydhS +0.6 2.2 conserved protein with FAD/NAD(P)-binding domain (NCBI) compare
b3021 ygiT +0.6 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1582 ynfA +0.6 1.3 hypothetical protein (NCBI) compare
b4590 ybfK +0.6 1.5 hypothetical protein (RefSeq) compare
b0450 glnK +0.6 0.7 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b4418 sraB +0.6 0.9 unknown RNA (NCBI) compare
b1793 yoaF +0.6 1.9 conserved outer membrane protein (NCBI) compare
b4158 yjeO +0.6 1.9 conserved inner membrane protein (NCBI) compare
b2688 gshA +0.6 3.7 glutamate--cysteine ligase (NCBI) compare
b4497 yeeL +0.6 1.4 no description compare
b1707 ydiV +0.6 2.1 hypothetical protein (NCBI) compare
b1516 lsrB +0.6 2.2 AI2 transporter (NCBI) compare
b2730 hypE +0.6 3.1 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein (RefSeq) compare
b1020 phoH +0.6 2.3 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b1243 oppA +0.6 2.6 oligopeptide transporter subunit (NCBI) compare
b2187 yejL +0.6 2.0 hypothetical protein (NCBI) compare
b0714 nei +0.6 2.1 endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase (NCBI) compare
b1176 minC +0.6 1.4 septum formation inhibitor (NCBI) compare
b1584 speG +0.6 3.4 spermidine N1-acetyltransferase (NCBI) conserved
b2625 yfjI +0.6 1.5 CP4-57 prophage; predicted protein (NCBI) compare
b1526 yneJ +0.6 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2699 recA +0.6 0.8 recombinase A (NCBI) compare
b3164 pnp +0.6 1.3 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1708 nlpC +0.6 1.8 predicted lipoprotein (NCBI) compare
b1823 cspC +0.6 0.6 stress protein, member of the CspA-family (NCBI) compare
b1502 ydeQ +0.5 1.3 predicted fimbrial-like adhesin protein (NCBI) compare
b4653 yicT +0.5 1.2 no description compare
b1992 cobS +0.5 1.4 cobalamin synthase (NCBI) compare
b3280 yrdB +0.5 1.7 hypothetical protein (NCBI) compare
b1790 yeaM +0.5 2.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2325 yfcL +0.5 1.9 hypothetical protein (NCBI) compare
b1095 fabF +0.5 2.6 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2314 dedD +0.5 1.3 putative lipoprotein (VIMSS) compare
b1660 ydhC +0.5 2.0 predicted transporter (NCBI) compare
b2567 rnc +0.5 0.7 ribonuclease III (NCBI) compare
b0527 ybcI +0.5 2.4 conserved inner membrane protein (NCBI) compare
b1085 b1085 +0.5 0.9 orf, hypothetical protein (VIMSS) compare
b4541 yehK +0.5 1.6 hypothetical protein (NCBI) compare
b2175 spr +0.5 1.8 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b2528 iscA +0.5 0.6 iron-sulfur cluster assembly protein (NCBI) compare
b2319 usg +0.5 1.5 hypothetical protein (NCBI) compare
b4546 ypeB +0.5 0.7 hypothetical protein (NCBI) compare
b2481 hyfA +0.5 1.5 hydrogenase 4 Fe-S subunit (VIMSS) compare
b0613 citG +0.5 1.9 triphosphoribosyl-dephospho-CoA transferase (NCBI) compare
b3138 agaB +0.5 1.8 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b0406 tgt +0.5 2.1 queuine tRNA-ribosyltransferase (NCBI) compare
b0881 clpS +0.5 0.8 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b0751 pnuC +0.5 2.7 predicted nicotinamide mononucleotide transporter (NCBI) compare
b1006 ycdG +0.5 2.0 putative transport protein (VIMSS) compare
b0796 ybiH +0.5 2.6 putative transcriptional regulator (VIMSS) compare
b3790 rffC +0.5 2.0 TDP-fucosamine acetyltransferase (RefSeq) compare
b2521 sseA +0.5 3.7 putative thiosulfate sulfurtransferase (VIMSS) compare
b4407 thiS +0.5 0.9 sulfur carrier protein ThiS (NCBI) compare
b2553 glnB +0.5 2.0 regulatory protein P-II for glutamine synthetase (NCBI) compare
b0388 aroL +0.5 2.4 shikimate kinase II (NCBI) compare
b2427 yfeT +0.5 2.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1132 hflD +0.5 1.6 hypothetical protein (NCBI) compare
b3149 yraO +0.5 2.3 DnaA initiator-associating factor for replication initiation (NCBI) compare
b1703 ydiA +0.5 2.5 hypothetical protein (NCBI) compare
b3545 proK +0.5 0.8 tRNA-Pro (NCBI) compare
b1989 asnV +0.5 1.3 tRNA-Asn (NCBI) compare
b2229 b2229 +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b2817 b2817 +0.5 3.1 putative amidase (VIMSS) compare
b2250 b2250 +0.5 1.6 orf, hypothetical protein (VIMSS) compare
b2962 yggX +0.5 1.9 hypothetical protein (NCBI) compare
b1486 ddpB +0.5 1.2 D-ala-D-ala transporter subunit (NCBI) compare
b2225 yfaP +0.5 2.2 hypothetical protein (NCBI) compare
b0605 ahpC +0.5 1.4 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3475 acpT +0.5 2.5 holo-(acyl carrier protein) synthase 2 (NCBI) compare
b1446 ydcY +0.5 1.0 hypothetical protein (NCBI) compare
b2024 hisA +0.5 1.2 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b3929 rraA +0.5 2.7 ribonuclease activity regulator protein RraA (NCBI) compare
b3625 rfaY +0.5 1.6 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1214 ychA +0.5 2.7 predicted transcriptional regulator (NCBI) compare
b2199 ccmC +0.5 1.8 heme exporter subunit (NCBI) compare
b3842 rfaH +0.5 2.3 transcriptional activator RfaH (NCBI) compare
b0814 ompX +0.5 1.5 outer membrane protein X (NCBI) compare
b1450 b1450 +0.5 2.0 orf, hypothetical protein (VIMSS) compare
b3515 gadW +0.5 3.3 DNA-binding transcriptional activator (NCBI) compare
b4107 phnB +0.5 1.7 hypothetical protein (NCBI) compare
b1726 yniB +0.5 0.6 predicted inner membrane protein (NCBI) compare
b1427 rimL +0.5 1.0 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b1465 narV +0.5 1.2 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b2577 yfiE +0.5 1.3 putative transcriptional regulator LYSR-type (VIMSS) compare
b2948 yqgE +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b2538 hcaE +0.5 1.5 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b3844 fre +0.5 2.0 NAD(P)H-flavin reductase (NCBI) compare
b4084 alsK +0.5 2.8 D-allose kinase (NCBI) compare
b1754 b1754 +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b0109 nadC +0.5 2.2 nicotinate-nucleotide pyrophosphorylase (NCBI) compare


Specific Phenotypes

For 5 genes in this experiment

For carbon source Ying_Others16 in Escherichia coli BW25113

For carbon source Ying_Others16 across organisms