Experiment set57IT017 for Escherichia coli BW25113

Compare to:

Ying_Others16 rep B; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2903 gcvP +2.4 17.0 glycine dehydrogenase (NCBI) compare
b2904 gcvH +2.3 10.6 glycine cleavage system protein H (NCBI) compare
b2808 gcvA +2.1 8.6 DNA-binding transcriptional dual regulator (NCBI) compare
b3341 rpsG +2.1 3.4 30S ribosomal protein S7 (NCBI) compare
b2127 mlrA +2.0 10.5 DNA-binding transcriptional regulator (NCBI) compare
b1341 b1341 +1.8 11.4 orf, hypothetical protein (VIMSS) compare
b1429 tehA +1.8 3.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0912 ihfB +1.7 6.5 integration host factor subunit beta (NCBI) compare
b2905 gcvT +1.7 10.9 glycine cleavage system aminomethyltransferase T (NCBI) compare
b3755 yieP +1.6 12.2 predicted transcriptional regulator (NCBI) compare
b1038 csgF +1.6 6.3 predicted transport protein (NCBI) compare
b2830 nudH +1.6 2.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b1831 proQ +1.5 6.4 putative solute/DNA competence effector (NCBI) compare
b0882 clpA +1.5 11.7 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b2846 yqeH +1.5 1.0 orf, hypothetical protein (VIMSS) compare
b1185 dsbB +1.5 4.8 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b3199 yrbK +1.4 2.8 hypothetical protein (NCBI) compare
b1037 csgG +1.4 10.4 outer membrane lipoprotein (NCBI) compare
b1362 rzpR +1.4 1.6 putative Rac prophage endopeptidase (VIMSS) compare
b2218 rcsC +1.4 11.0 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b1041 csgB +1.4 5.8 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b1040 csgD +1.4 3.6 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1222 narX +1.3 5.0 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b2664 ygaE +1.2 6.3 putative transcriptional regulator (VIMSS) compare
b3398 yrfF +1.1 4.6 predicted inner membrane protein (NCBI) compare
b2216 rcsD +1.1 7.9 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b3181 greA +1.1 4.7 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1360 ydaV +1.1 1.6 Rac prophage; predicted DNA replication protein (NCBI) compare
b1823 cspC +1.1 1.8 stress protein, member of the CspA-family (NCBI) compare
b1042 csgA +1.0 5.2 cryptic curlin major subunit (NCBI) compare
b3644 yicC +1.0 6.1 hypothetical protein (NCBI) compare
b2504 yfgG +1.0 2.3 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b1273 yciN +1.0 2.1 hypothetical protein (NCBI) compare
b1217 chaB +1.0 2.2 cation transport regulator (NCBI) compare
b0889 lrp +0.9 2.8 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b4699 fnrS +0.9 1.2 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1558 cspF +0.9 2.7 Qin prophage; cold shock protein (NCBI) compare
b1039 csgE +0.9 5.5 predicted transport protein (NCBI) compare
b1824 yobF +0.9 2.3 hypothetical protein (NCBI) compare
b3860 dsbA +0.9 5.2 periplasmic protein disulfide isomerase I (NCBI) compare
b4025 pgi +0.9 5.8 glucose-6-phosphate isomerase (NCBI) compare
b1572 ydfB +0.9 2.1 orf, hypothetical protein (VIMSS) compare
b0232 yafN +0.9 0.8 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b4515 ybgT +0.9 1.9 hypothetical protein (NCBI) compare
b0014 dnaK +0.9 1.4 molecular chaperone DnaK (NCBI) compare
b4373 rimI +0.8 3.0 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b2314 dedD +0.8 3.4 putative lipoprotein (VIMSS) compare
b1306 pspC +0.8 2.0 DNA-binding transcriptional activator (NCBI) compare
b4503 yafF +0.8 0.4 no description compare
b0627 tatE +0.8 1.5 twin arginine translocase protein E (NCBI) compare
b0059 hepA +0.8 7.0 ATP-dependent helicase HepA (NCBI) compare
b3934 cytR +0.8 5.6 DNA-binding transcriptional dual regulator (NCBI) compare
b4655 ythA +0.8 1.1 expressed protein (RefSeq) compare
b2579 yfiD +0.8 2.0 pyruvate formate lyase subunit (NCBI) compare
b1284 yciT +0.8 4.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2110 yehC +0.8 1.7 predicted periplasmic pilin chaperone (NCBI) compare
b3026 qseC +0.8 2.8 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2111 yehD +0.8 2.3 predicted fimbrial-like adhesin protein (NCBI) compare
b0082 mraW +0.8 2.3 S-adenosyl-methyltransferase (NCBI) compare
b4410 ecnA +0.8 1.4 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b1302 puuE +0.8 2.6 GABA aminotransferase, PLP-dependent (NCBI) compare
b2741 rpoS +0.8 3.5 RNA polymerase sigma factor (NCBI) compare
b3753 rbsR +0.7 4.9 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b1286 rnb +0.7 2.1 exoribonuclease II (NCBI) compare
b0865 ybjP +0.7 2.3 predicted lipoprotein (NCBI) compare
b3133 agaV +0.7 2.4 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b1600 mdtJ +0.7 1.6 multidrug efflux system transporter (NCBI) compare
b1758 b1758 +0.7 1.2 putative cytochrome oxidase (VIMSS) compare
b1712 ihfA +0.7 1.1 integration host factor subunit alpha (NCBI) compare
b4066 yjcF +0.7 0.5 hypothetical protein (NCBI) compare
b4413 sokC +0.7 1.3 regulatory antisense RNA (NCBI) compare
b4345 mcrC +0.7 1.4 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b0685 ybfE +0.7 1.5 orf, hypothetical protein (VIMSS) compare
b3706 trmE +0.7 2.0 tRNA modification GTPase (NCBI) compare
b2659 b2659 +0.7 1.0 orf, hypothetical protein (VIMSS) compare
b0858 ybjO +0.7 1.0 predicted inner membrane protein (NCBI) compare
b1795 yeaQ +0.7 2.1 conserved inner membrane protein (NCBI) compare
b1584 speG +0.7 4.0 spermidine N1-acetyltransferase (NCBI) conserved
b1547 stfQ +0.7 2.5 Qin prophage; predicted side tail fibre assembly protein (NCBI) compare
b4246 pyrL +0.7 1.6 pyrBI operon leader peptide (NCBI) compare
b4676 yoaK +0.7 0.5 expressed protein (RefSeq) compare
b1427 rimL +0.7 2.7 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b4453 ldrD +0.6 1.4 toxic polypeptide, small (NCBI) compare
b1067 yceH +0.6 2.5 hypothetical protein (NCBI) compare
b2829 ptsP +0.6 5.2 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1085 b1085 +0.6 1.0 orf, hypothetical protein (VIMSS) compare
b3929 rraA +0.6 3.9 ribonuclease activity regulator protein RraA (NCBI) compare
b0710 ybgI +0.6 2.4 conserved metal-binding protein (NCBI) compare
b4694 yagP +0.6 1.8 no description compare
b2948 yqgE +0.6 1.8 orf, hypothetical protein (VIMSS) compare
b2175 spr +0.6 2.4 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0051 ksgA +0.6 2.4 dimethyladenosine transferase (NCBI) compare
b3183 obgE +0.6 0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3264 envR +0.6 2.3 DNA-binding transcriptional regulator (NCBI) compare
b2749 ygbE +0.6 3.2 conserved inner membrane protein (NCBI) compare
b0364 yaiS +0.6 2.1 orf, hypothetical protein (VIMSS) compare
b1270 btuR +0.6 2.0 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) compare
b3120 yhaB +0.6 1.3 orf, hypothetical protein (VIMSS) compare
b1418 cybB +0.6 1.2 cytochrome b(561) (VIMSS) compare
b1557 cspB +0.6 0.8 Qin prophage; cold shock protein (NCBI) compare
b1317 ycjU +0.6 1.9 predicted beta-phosphoglucomutase (NCBI) compare
b0010 yaaH +0.6 2.8 conserved inner membrane protein associated with acetate transport (NCBI) compare
b1621 malX +0.6 3.6 fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (NCBI) compare
b3871 bipA +0.6 4.2 GTP-binding protein (NCBI) compare
b4406 yaeP +0.6 0.8 hypothetical protein (NCBI) compare
b2141 yohJ +0.6 2.4 hypothetical protein (NCBI) compare
b1575 dicB +0.6 0.9 Qin prophage; cell division inhibition protein (NCBI) compare
b1955 yedP +0.6 1.5 hypothetical protein (NCBI) compare
b0843 ybjH +0.6 1.8 hypothetical protein (NCBI) compare
b1992 cobS +0.6 1.4 cobalamin synthase (NCBI) compare
b0999 cbpM +0.6 1.6 modulator of CbpA co-chaperone (NCBI) compare
b1370 insH-5 +0.6 1.2 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b4062 soxS +0.5 2.3 DNA-binding transcriptional dual regulator (NCBI) compare
b1818 manY +0.5 1.5 mannose-specific enzyme IIC component of PTS (NCBI) compare
b1573 ydfC +0.5 0.6 Qin prophage; predicted protein (RefSeq) compare
b0974 hyaC +0.5 2.3 hydrogenase 1, b-type cytochrome subunit (NCBI) compare
b4493 gapC +0.5 1.1 no description compare
b2618 b2618 +0.5 1.6 orf, hypothetical protein (VIMSS) compare
b4363 yjjB +0.5 1.9 conserved inner membrane protein (RefSeq) compare
b1671 ydhX +0.5 1.8 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b1430 tehB +0.5 2.4 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b3146 yraL +0.5 3.1 predicted methyltransferase (NCBI) compare
b1916 sdiA +0.5 3.4 DNA-binding transcriptional activator (NCBI) compare
b1326 mpaA +0.5 2.1 murein peptide amidase A (RefSeq) compare
b0655 gltI +0.5 2.0 glutamate and aspartate transporter subunit (NCBI) compare
b4644 ypjI +0.5 2.4 no description compare
b4042 dgkA +0.5 1.1 diacylglycerol kinase (NCBI) compare
b0798 ybiA +0.5 1.8 hypothetical protein (NCBI) compare
b2989 b2989 +0.5 2.8 orf, hypothetical protein (VIMSS) compare
b4245 pyrB +0.5 3.9 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b2582 trxC +0.5 1.7 thioredoxin 2 (NCBI) compare
b2309 hisJ +0.5 1.3 histidine/lysine/arginine/ornithine transporter subunit (NCBI) compare
b2977 glcG +0.5 2.1 hypothetical protein (NCBI) compare
b1850 eda +0.5 1.0 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b0450 glnK +0.5 1.1 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b0955 ycbZ +0.5 2.7 predicted peptidase (NCBI) compare
b3752 rbsK +0.5 3.2 ribokinase (NCBI) compare
b2518 ndk +0.5 0.9 nucleoside diphosphate kinase (NCBI) compare
b0560 nohB +0.5 1.2 DLP12 prophage; DNA packaging protein (NCBI) compare
b4450 arcZ +0.5 1.3 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b2262 menB +0.5 1.7 naphthoate synthase (NCBI) compare
b2962 yggX +0.5 1.8 hypothetical protein (NCBI) compare
b0471 ybaB +0.5 0.8 hypothetical protein (NCBI) compare
b0303 ykgI +0.5 0.5 orf, hypothetical protein (VIMSS) compare
b1358 ydaT +0.5 0.7 Rac prophage; predicted protein (NCBI) compare
b1931 yedK +0.5 1.2 hypothetical protein (NCBI) compare
b0404 yajB +0.5 1.8 hypothetical protein (NCBI) compare
b1121 ycfZ +0.5 1.6 predicted inner membrane protein (NCBI) compare
b1633 nth +0.5 1.4 DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) (NCBI) compare
b1862 yebB +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b4369 leuP +0.5 1.1 tRNA-Leu (NCBI) compare
b4172 hfq +0.5 0.5 RNA-binding protein Hfq (NCBI) compare
b1408 b1408 +0.5 1.9 probable enzyme (VIMSS) compare
b4096 phnL +0.5 1.2 carbon-phosphorus lyase complex subunit (NCBI) compare
b2445 yffN +0.4 1.6 CPZ-55 prophage; predicted protein (RefSeq) compare
b1689 b1689 +0.4 1.3 orf, hypothetical protein (VIMSS) compare
b1221 narL +0.4 2.9 DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) (NCBI) compare
b0217 yafT +0.4 2.2 predicted aminopeptidase (NCBI) compare
b2080 b2080 +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b2051 wcaH +0.4 0.5 GDP-mannose mannosyl hydrolase (VIMSS) compare
b4403 yjtD +0.4 1.7 predicted rRNA methyltransferase (NCBI) compare
b2703 srlE +0.4 1.9 glucitol/sorbitol-specific enzyme IIB component of PTS (NCBI) compare
b4634 ylcF +0.4 1.3 no description compare
b0212 gloB +0.4 0.8 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b3156 yhbS +0.4 2.1 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b1889 motB +0.4 2.2 flagellar motor protein MotB (NCBI) compare
b3973 birA +0.4 1.4 biotin--protein ligase (NCBI) compare
b2229 b2229 +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b3242 yhcR +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b4242 mgtA +0.4 2.7 magnesium transporter (NCBI) compare
b1095 fabF +0.4 2.7 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b4071 nrfB +0.4 2.0 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b3206 npr +0.4 1.6 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b1465 narV +0.4 0.6 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b1269 rluB +0.4 1.4 23S rRNA pseudouridylate synthase (NCBI) compare
b1926 fliT +0.4 2.0 predicted chaperone (NCBI) compare
b2199 ccmC +0.4 2.0 heme exporter subunit (NCBI) compare
b4596 yciZ +0.4 0.8 hypothetical protein (RefSeq) compare
b2951 yggS +0.4 1.7 predicted enzyme (NCBI) compare
b0872 hcr +0.4 1.0 HCP oxidoreductase, NADH-dependent (NCBI) compare
b1847 yebF +0.4 0.6 predicted protein (RefSeq) compare
b0949 uup +0.4 2.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2935 tktA +0.4 0.9 transketolase 1, thiamin-binding (NCBI) compare
b2576 srmB +0.4 1.0 ATP-dependent RNA helicase (NCBI) compare
b3119 tdcR +0.4 0.5 threonine dehydratase operon activator protein (VIMSS) compare
b2204 napH +0.4 1.9 quinol dehydrogenase membrane component (NCBI) compare
b3977 tyrU +0.4 0.5 tRNA-Tyr (NCBI) compare
b1921 fliZ +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b2436 hemF +0.4 1.9 coproporphyrinogen III oxidase (NCBI) compare
b3602 yibL +0.4 2.5 hypothetical protein (NCBI) compare
b1874 cutC +0.4 1.0 copper homeostasis protein (NCBI) compare
b1061 dinI +0.4 1.7 DNA damage-inducible protein I (NCBI) compare
b2243 glpC +0.4 2.5 sn-glycerol-3-phosphate dehydrogenase (anaerobic), small subunit (NCBI) compare
b1201 b1201 +0.4 1.8 putative sensor-type regulator (VIMSS) compare
b1422 ydcI +0.4 1.3 putative transcriptional regulator LYSR-type (VIMSS) conserved
b1819 manZ +0.4 1.5 mannose-specific enzyme IID component of PTS (NCBI) compare
b1739 osmE +0.4 0.9 DNA-binding transcriptional activator (NCBI) compare
b4557 yidD +0.4 1.6 hypothetical protein (NCBI) compare
b1634 tppB +0.4 2.0 putative tripeptide transporter permease (NCBI) compare
b1920 fliY +0.4 0.9 cystine transporter subunit (NCBI) compare


Specific Phenotypes

For 7 genes in this experiment

For carbon source Ying_Others16 in Escherichia coli BW25113

For carbon source Ying_Others16 across organisms