Experiment set57IT016 for Escherichia coli BW25113

Compare to:

Ying_Others16 rep A; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2904 gcvH +2.5 11.5 glycine cleavage system protein H (NCBI) compare
b2903 gcvP +2.5 18.0 glycine dehydrogenase (NCBI) compare
b3341 rpsG +1.9 2.6 30S ribosomal protein S7 (NCBI) compare
b1038 csgF +1.8 7.4 predicted transport protein (NCBI) compare
b2905 gcvT +1.7 9.2 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1540 ydfH +1.7 4.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1185 dsbB +1.6 5.7 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2127 mlrA +1.6 8.1 DNA-binding transcriptional regulator (NCBI) compare
b1341 b1341 +1.5 8.3 orf, hypothetical protein (VIMSS) compare
b1831 proQ +1.5 6.0 putative solute/DNA competence effector (NCBI) compare
b1823 cspC +1.4 2.7 stress protein, member of the CspA-family (NCBI) compare
b3755 yieP +1.4 10.4 predicted transcriptional regulator (NCBI) compare
b0882 clpA +1.4 9.6 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b3181 greA +1.4 7.9 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1217 chaB +1.3 2.1 cation transport regulator (NCBI) compare
b1573 ydfC +1.3 2.3 Qin prophage; predicted protein (RefSeq) compare
b2699 recA +1.3 2.1 recombinase A (NCBI) compare
b2218 rcsC +1.3 9.3 hybrid sensory kinase in two-component regulatory system with RcsB and YojN (RefSeq) compare
b1037 csgG +1.3 9.9 outer membrane lipoprotein (NCBI) compare
b2664 ygaE +1.2 6.5 putative transcriptional regulator (VIMSS) compare
b1712 ihfA +1.2 2.2 integration host factor subunit alpha (NCBI) compare
b0912 ihfB +1.1 2.9 integration host factor subunit beta (NCBI) compare
b1231 tyrT +1.1 1.6 tRNA-Tyr (NCBI) compare
b0247 ykfG +1.1 2.3 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b4660 yhiL +1.1 1.1 no description compare
b4647 mokA +1.1 1.2 no description compare
b2808 gcvA +1.1 4.1 DNA-binding transcriptional dual regulator (NCBI) compare
b0450 glnK +1.1 2.2 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b3398 yrfF +1.1 2.9 predicted inner membrane protein (NCBI) compare
b1222 narX +1.0 3.2 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b0802 ybiJ +1.0 2.6 hypothetical protein (NCBI) compare
b1334 fnr +1.0 2.9 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0082 mraW +0.9 3.3 S-adenosyl-methyltransferase (NCBI) compare
b1584 speG +0.9 4.7 spermidine N1-acetyltransferase (NCBI) conserved
b2614 grpE +0.9 2.0 heat shock protein (NCBI) compare
b4042 dgkA +0.9 1.8 diacylglycerol kinase (NCBI) compare
b1257 yciE +0.9 0.7 hypothetical protein (NCBI) compare
b3183 obgE +0.9 1.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3644 yicC +0.9 4.5 hypothetical protein (NCBI) compare
b3860 dsbA +0.9 5.3 periplasmic protein disulfide isomerase I (NCBI) compare
b2741 rpoS +0.9 4.1 RNA polymerase sigma factor (NCBI) compare
b3753 rbsR +0.9 5.9 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b2216 rcsD +0.8 5.4 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b4546 ypeB +0.8 1.4 hypothetical protein (NCBI) compare
b3504 yhiS +0.8 0.8 hypothetical protein (RefSeq) compare
b0059 hepA +0.8 7.3 ATP-dependent helicase HepA (NCBI) compare
b3164 pnp +0.8 2.4 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2136 yohD +0.8 1.9 orf, hypothetical protein (VIMSS) compare
b1824 yobF +0.8 2.9 hypothetical protein (NCBI) compare
b1039 csgE +0.8 4.2 predicted transport protein (NCBI) compare
b0018 mokC +0.8 1.4 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b2259 pmrD +0.8 1.1 polymyxin resistance protein B (VIMSS) compare
b1161 ycgX +0.8 1.3 hypothetical protein (NCBI) compare
b0889 lrp +0.8 2.6 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b2579 yfiD +0.8 2.1 pyruvate formate lyase subunit (NCBI) compare
b3026 qseC +0.8 3.0 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0843 ybjH +0.7 1.9 hypothetical protein (NCBI) compare
b1412 azoR +0.7 2.7 acyl carrier protein phosphodiesterase (NCBI) compare
b3229 sspA +0.7 2.1 stringent starvation protein A (NCBI) compare
b1085 b1085 +0.7 1.7 orf, hypothetical protein (VIMSS) compare
b1731 cedA +0.7 2.1 cell division modulator (RefSeq) compare
b1159 mcrA +0.7 1.2 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b1366 ydaY +0.7 1.8 Rac prophage; predicted protein (RefSeq) compare
b4171 miaA +0.7 1.8 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1835 yebU +0.7 1.9 putative nucleolar proteins (VIMSS) compare
b4603 rseX +0.7 0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2911 ssrS +0.7 1.0 6S regulatory RNA (NCBI) compare
b1503 ydeR +0.7 1.8 predicted fimbrial-like adhesin protein (NCBI) compare
b4631 ykgQ +0.7 1.4 no description compare
b2830 nudH +0.6 0.8 dinucleoside polyphosphate hydrolase (NCBI) compare
b1493 gadB +0.6 0.6 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1273 yciN +0.6 1.3 hypothetical protein (NCBI) compare
b2829 ptsP +0.6 4.8 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1042 csgA +0.6 3.0 cryptic curlin major subunit (NCBI) compare
b0782 moaB +0.6 1.5 molybdopterin biosynthesis protein B (NCBI) compare
b0610 rnk +0.6 2.4 nucleoside diphosphate kinase regulator (NCBI) compare
b1255 yciC +0.6 2.5 hypothetical protein (NCBI) compare
b3706 trmE +0.6 1.8 tRNA modification GTPase (NCBI) compare
b0542 renD +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b1095 fabF +0.6 3.4 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1954 dsrA +0.6 1.6 regulatory antisense RNA (NCBI) compare
b1644 b1644 +0.6 2.6 putative membrane protein (VIMSS) compare
b2248 yfaX +0.6 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2948 yqgE +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b1485 ddpC +0.6 1.3 D-ala-D-ala transporter subunit (NCBI) compare
b3934 cytR +0.6 4.4 DNA-binding transcriptional dual regulator (NCBI) compare
b2017 yefM +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b1013 ycdC +0.6 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b4451 ryhB +0.6 0.9 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b4025 pgi +0.6 3.4 glucose-6-phosphate isomerase (NCBI) compare
b4450 arcZ +0.6 2.2 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1819 manZ +0.6 3.3 mannose-specific enzyme IID component of PTS (NCBI) compare
b2688 gshA +0.6 2.9 glutamate--cysteine ligase (NCBI) compare
b1382 ynbE +0.6 1.1 predicted lipoprotein (NCBI) compare
b4692 oweE +0.6 1.4 no description compare
b4511 ybdZ +0.6 1.5 hypothetical protein (NCBI) compare
b0976 hyaE +0.6 1.9 protein involved in processing of HyaA and HyaB proteins (NCBI) compare
b0596 entA +0.6 3.1 2,3-dihydroxybenzoate-2,3-dehydrogenase (NCBI) compare
b1916 sdiA +0.6 3.6 DNA-binding transcriptional activator (NCBI) compare
b2947 gshB +0.5 2.4 glutathione synthetase (NCBI) compare
b1942 fliJ +0.5 0.8 flagellar biosynthesis chaperone (NCBI) compare
b3146 yraL +0.5 3.4 predicted methyltransferase (NCBI) compare
b1949 fliQ +0.5 1.5 flagellar biosynthesis protein Q (NCBI) compare
b3029 ygiN +0.5 1.0 quinol monooxygenase (NCBI) compare
b0881 clpS +0.5 1.4 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b2427 yfeT +0.5 2.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b3199 yrbK +0.5 0.8 hypothetical protein (NCBI) compare
b1550 b1550 +0.5 0.8 orf, hypothetical protein (VIMSS) compare
b1850 eda +0.5 1.3 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3752 rbsK +0.5 3.6 ribokinase (NCBI) compare
b2293 yfbT +0.5 1.1 putative phosphatase (VIMSS) compare
b1921 fliZ +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b2939 yqgB +0.5 0.8 predicted protein (RefSeq) compare
b0527 ybcI +0.5 2.9 conserved inner membrane protein (NCBI) compare
b0949 uup +0.5 2.8 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1111 ycfQ +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b1446 ydcY +0.5 1.6 hypothetical protein (NCBI) compare
b0268 yagE +0.5 2.4 2-keto-3-deoxy gluconate (KDG) aldolase; CP4-6 prophage (NCBI) compare
b4608 ryfC +0.5 1.4 Novel sRNA, function unknown (RefSeq) compare
b1842 holE +0.5 0.8 DNA polymerase III, theta subunit (NCBI) compare
b1614 ydgA +0.5 1.6 hypothetical protein (NCBI) compare
b4686 yshB +0.5 1.8 expressed protein (RefSeq) compare
b2959 yggL +0.5 2.5 orf, hypothetical protein (VIMSS) compare
b4416 rybA +0.5 0.9 unknown RNA (NCBI) compare
b4299 yjhI +0.5 2.4 KpLE2 phage-like element; predicted DNA-binding transcriptional regulator (NCBI) compare
b2093 gatB +0.5 1.6 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b4598 yncL +0.5 1.2 hypothetical protein (RefSeq) compare
b3042 b3042 +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b0974 hyaC +0.5 1.4 hydrogenase 1, b-type cytochrome subunit (NCBI) compare
b2895 fldB +0.5 1.7 flavodoxin 2 (NCBI) compare
b3062 ttdB +0.5 3.0 L(+)-tartrate dehydratase (NCBI) compare
b0920 ycbC +0.5 2.3 conserved inner membrane protein (NCBI) compare
b1874 cutC +0.5 0.8 copper homeostasis protein (NCBI) compare
b1848 yebG +0.5 0.9 conserved protein regulated by LexA (NCBI) compare
b4402 yjjY +0.5 0.4 hypothetical protein (NCBI) compare
b3207 yrbL +0.5 1.9 hypothetical protein (NCBI) compare
b1359 ydaU +0.5 1.9 Rac prophage; conserved protein (NCBI) compare
b1422 ydcI +0.5 1.8 putative transcriptional regulator LYSR-type (VIMSS) conserved
b2266 elaB +0.5 1.6 hypothetical protein (NCBI) compare
b2998 yghW +0.5 2.3 hypothetical protein (NCBI) compare
b4203 rplI +0.5 1.9 50S ribosomal protein L9 (NCBI) compare
b2576 srmB +0.5 1.6 ATP-dependent RNA helicase (NCBI) compare
b4554 yibT +0.5 1.8 hypothetical protein (NCBI) compare
b1333 uspE +0.5 1.6 stress-induced protein (NCBI) compare
b2480 bcp +0.5 1.9 thioredoxin-dependent thiol peroxidase (NCBI) compare
b2012 yeeD +0.5 1.8 hypothetical protein (NCBI) compare
b1287 yciW +0.5 1.8 putative oxidoreductase (VIMSS) compare
b1522 yneF +0.5 1.3 predicted diguanylate cyclase (NCBI) compare
b1286 rnb +0.5 1.4 exoribonuclease II (NCBI) compare
b1450 b1450 +0.5 1.5 orf, hypothetical protein (VIMSS) compare
b1765 ydjA +0.5 0.5 predicted oxidoreductase (NCBI) compare
b3868 glnG +0.5 1.8 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b2310 argT +0.5 2.4 lysine/arginine/ornithine transporter subunit (NCBI) compare
b3260 dusB +0.5 2.3 tRNA-dihydrouridine synthase B (NCBI) compare
b2768 ygcP +0.5 1.5 predicted anti-terminator regulatory protein (NCBI) compare
b3293 yhdN +0.5 1.4 hypothetical protein (NCBI) compare
b2634 yfjR +0.5 1.8 CP4-57 prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b1593 b1593 +0.5 0.9 orf, hypothetical protein (VIMSS) compare
b0943 b0943 +0.5 1.9 putative fimbrial-like protein (VIMSS) compare
b0814 ompX +0.5 1.4 outer membrane protein X (NCBI) compare
b0213 yafS +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b1421 trg +0.5 1.6 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor (NCBI) compare
b1372 b1372 +0.5 2.5 putative membrane protein (VIMSS) compare
b1108 ycfP +0.4 1.3 orf, hypothetical protein (VIMSS) compare
b4097 phnK +0.4 1.9 carbon-phosphorus lyase complex subunit (NCBI) compare
b1107 nagZ +0.4 1.4 beta-hexosaminidase (NCBI) compare
b1482 osmC +0.4 0.7 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b2027 wzzB +0.4 1.8 regulator of length of O-antigen component of lipopolysaccharide chains (VIMSS) compare
b3834 yigP +0.4 2.3 hypothetical protein (NCBI) compare
b4642 yoeD +0.4 0.8 no description compare
b2758 ygcJ +0.4 2.0 hypothetical protein (NCBI) compare
b1760 ynjH +0.4 1.7 hypothetical protein (NCBI) compare
b4438 cyaR +0.4 1.0 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b3636 rpmG +0.4 0.8 50S ribosomal protein L33 (NCBI) compare
b3387 dam +0.4 3.2 DNA adenine methylase (NCBI) compare
b2074 b2074 +0.4 2.7 putative membrane protein (VIMSS) compare
b0624 crcB +0.4 2.1 camphor resistance protein CrcB (NCBI) compare
b1821 b1821 +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b1299 puuR +0.4 1.1 DNA-binding transcriptional repressor (NCBI) compare
b1083 flgL +0.4 1.5 flagellar hook-associated protein L (NCBI) compare
b1423 ydcJ +0.4 1.8 hypothetical protein (NCBI) compare
b1926 fliT +0.4 0.8 predicted chaperone (NCBI) compare
b3888 yiiD +0.4 3.1 predicted acetyltransferase (NCBI) compare
b3741 gidA +0.4 2.0 glucose-inhibited division protein A (NCBI) compare
b0381 ddlA +0.4 2.2 D-alanylalanine synthetase (NCBI) compare
b3102 yqjG +0.4 1.6 predicted S-transferase (NCBI) compare
b1945 fliM +0.4 2.3 flagellar motor switch protein M (NCBI) compare
b1335 ogt +0.4 1.2 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b4453 ldrD +0.4 0.6 toxic polypeptide, small (NCBI) compare
b2390 ypeC +0.4 1.6 hypothetical protein (NCBI) compare
b1847 yebF +0.4 0.6 predicted protein (RefSeq) compare
b2157 yeiE +0.4 2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b4623 insO +0.4 1.8 no description compare
b3658 selC +0.4 0.9 tRNA-Sec (NCBI) compare
b3778 rep +0.4 2.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1041 csgB +0.4 1.7 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b4375 prfC +0.4 1.7 peptide chain release factor 3 (NCBI) compare
b3071 yqjI +0.4 1.0 predicted transcriptional regulator (NCBI) compare
b1778 yeaA +0.4 1.0 methionine sulfoxide reductase B (NCBI) compare
b3836 b3836 +0.4 1.4 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 5 genes in this experiment

For carbon source Ying_Others16 in Escherichia coli BW25113

For carbon source Ying_Others16 across organisms