Experiment set57IT012 for Escherichia coli BW25113

Compare to:

Ying_sugar7 rep C; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2903 gcvP +3.6 34.4 glycine dehydrogenase (NCBI) compare
b2904 gcvH +3.5 21.8 glycine cleavage system protein H (NCBI) compare
b2905 gcvT +3.2 19.4 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2808 gcvA +2.8 18.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3181 greA +1.9 16.2 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b2947 gshB +1.5 9.2 glutathione synthetase (NCBI) compare
b2688 gshA +1.4 12.2 glutamate--cysteine ligase (NCBI) compare
b2829 ptsP +1.3 10.2 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b2830 nudH +1.3 3.6 dinucleoside polyphosphate hydrolase (NCBI) compare
b0059 hepA +1.2 11.6 ATP-dependent helicase HepA (NCBI) compare
b3206 npr +1.2 7.8 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b4066 yjcF +1.2 1.5 hypothetical protein (NCBI) compare
b3778 rep +1.2 8.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2951 yggS +1.1 7.2 predicted enzyme (NCBI) compare
b4203 rplI +1.0 7.0 50S ribosomal protein L9 (NCBI) compare
b1085 b1085 +1.0 4.6 orf, hypothetical protein (VIMSS) compare
b0658 ybeX +1.0 2.7 predicteed ion transport (NCBI) compare
b2183 rsuA +1.0 5.3 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b2579 yfiD +0.9 3.9 pyruvate formate lyase subunit (NCBI) compare
b2259 pmrD +0.9 1.9 polymyxin resistance protein B (VIMSS) compare
b1824 yobF +0.9 3.3 hypothetical protein (NCBI) compare
b2642 yfjW +0.8 1.0 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0882 clpA +0.8 7.0 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1279 yciS +0.8 1.7 conserved inner membrane protein (NCBI) compare
b0889 lrp +0.8 3.0 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1095 fabF +0.8 6.5 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1038 csgF +0.8 3.3 predicted transport protein (NCBI) compare
b0949 uup +0.8 5.4 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1847 yebF +0.7 1.5 predicted protein (RefSeq) compare
b2114 metG +0.7 1.7 methionyl-tRNA synthetase (NCBI) compare
b4426 isrA +0.7 2.2 unknown RNA (NCBI) compare
b4552 yrhC +0.7 1.3 no description compare
b3977 tyrU +0.7 1.4 tRNA-Tyr (NCBI) compare
b4171 miaA +0.7 3.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0381 ddlA +0.7 4.8 D-alanylalanine synthetase (NCBI) compare
b2937 speB +0.7 5.1 agmatinase (NCBI) compare
b4699 fnrS +0.7 1.2 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1333 uspE +0.7 4.4 stress-induced protein (NCBI) compare
b4647 mokA +0.7 0.9 no description compare
b0178 hlpA +0.7 3.5 periplasmic chaperone (NCBI) compare
b1273 yciN +0.7 1.8 hypothetical protein (NCBI) compare
b1190 dadX +0.7 3.7 alanine racemase (NCBI) compare
b0852 rimK +0.7 3.0 ribosomal protein S6 modification protein (NCBI) compare
b4141 yjeH +0.6 5.7 predicted transporter (NCBI) compare
b3261 fis +0.6 2.1 DNA-binding protein Fis (NCBI) compare
b3164 pnp +0.6 1.9 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4373 rimI +0.6 3.1 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b4163 glyV +0.6 2.1 tRNA-Gly (NCBI) compare
b4701 sokX +0.6 1.1 sok-related sRNA, function unknown (RefSeq) compare
b0866 ybjQ +0.6 1.4 hypothetical protein (NCBI) compare
b1222 narX +0.6 2.8 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1346 ydaQ +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b4042 dgkA +0.6 1.6 diacylglycerol kinase (NCBI) compare
b3755 yieP +0.6 4.6 predicted transcriptional regulator (NCBI) compare
b1595 ynfL +0.6 2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b1606 folM +0.6 4.4 short chain dehydrogenase (NCBI) compare
b1493 gadB +0.6 0.8 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1823 cspC +0.6 2.0 stress protein, member of the CspA-family (NCBI) compare
b0854 potF +0.6 3.4 putrescine transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b2494 yfgC +0.5 4.0 predicted peptidase (NCBI) compare
b3443 yrhA +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b1890 motA +0.5 2.9 flagellar motor protein MotA (NCBI) compare
b0934 ycbM +0.5 2.5 putative transport system permease protein (VIMSS) compare
b3806 cyaA +0.5 2.9 adenylate cyclase (NCBI) compare
b4256 yjgM +0.5 3.9 predicted acetyltransferase (NCBI) compare
b1066 rimJ +0.5 3.3 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b1739 osmE +0.5 1.2 DNA-binding transcriptional activator (NCBI) compare
b2136 yohD +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b4135 yjdC +0.5 3.0 orf, hypothetical protein (VIMSS) compare
b2811 ygdK +0.5 3.0 predicted Fe-S metabolism protein (NCBI) compare
b2421 cysM +0.5 2.6 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b3194 yrbE +0.5 3.5 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1604 ydgH +0.5 1.7 hypothetical protein (NCBI) compare
b1482 osmC +0.5 0.7 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3632 rfaQ +0.5 4.2 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0783 moaC +0.5 2.3 molybdenum cofactor biosynthesis protein C (NCBI) compare
b1362 rzpR +0.4 1.8 putative Rac prophage endopeptidase (VIMSS) compare
b3929 rraA +0.4 3.5 ribonuclease activity regulator protein RraA (NCBI) compare
b1141 ymfG +0.4 1.2 e14 prophage; predicted excisionase (NCBI) compare
b1438 ydcQ +0.4 1.4 predicted DNA-binding transcriptional regulator (RefSeq) compare
b0605 ahpC +0.4 2.9 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b0685 ybfE +0.4 2.0 orf, hypothetical protein (VIMSS) compare
b1013 ycdC +0.4 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2896 ygfX +0.4 2.6 hypothetical protein (NCBI) compare
b2659 b2659 +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b1041 csgB +0.4 2.3 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b2303 folX +0.4 3.2 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b1164 ycgZ +0.4 1.0 hypothetical protein (NCBI) compare
b2646 ypjF +0.4 1.3 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b0527 ybcI +0.4 2.7 conserved inner membrane protein (NCBI) compare
b0714 nei +0.4 2.3 endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase (NCBI) compare
b0218 yafU +0.4 1.2 predicted inner membrane protein (RefSeq) compare
b1070 flgN +0.4 1.0 export chaperone for FlgK and FlgL (NCBI) compare
b0857 potI +0.4 2.1 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0856 potH +0.4 2.9 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1388 paaA +0.4 2.6 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b4151 frdD +0.4 2.2 fumarate reductase subunit D (NCBI) compare
b1480 sra +0.4 0.7 30S ribosomal subunit protein S22 (NCBI) compare
b3617 kbl +0.4 2.9 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b0641 rlpB +0.4 1.7 minor lipoprotein (NCBI) compare
b4603 rseX +0.4 0.5 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b4545 ypdJ +0.4 1.0 no description compare
b2572 rseA +0.4 2.6 anti-sigma factor (NCBI) compare
b1685 ydiH +0.4 0.9 predicted protein (RefSeq) compare
b0563 tfaX +0.4 2.5 DLP12 prophage; predicted protein (RefSeq) compare
b1341 b1341 +0.4 2.2 orf, hypothetical protein (VIMSS) compare
b1394 paaG +0.4 1.1 enoyl-CoA hydratase (NCBI) compare
b1528 ydeA +0.4 2.9 sugar efflux transporter (NCBI) compare
b2111 yehD +0.4 1.6 predicted fimbrial-like adhesin protein (NCBI) compare
b4511 ybdZ +0.4 1.6 hypothetical protein (NCBI) compare
b4030 yjbA +0.4 2.5 phosphate-starvation-inducible protein PsiE (NCBI) compare
b1871 yecP +0.4 1.9 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b4570 lomR +0.4 1.2 no description compare
b2587 kgtP +0.4 2.6 alpha-ketoglutarate transporter (NCBI) compare
b1366 ydaY +0.4 1.9 Rac prophage; predicted protein (RefSeq) compare
b1575 dicB +0.4 0.9 Qin prophage; cell division inhibition protein (NCBI) compare
b2341 yfcX +0.4 2.8 fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI) compare
b4504 ykfH +0.4 2.1 hypothetical protein (NCBI) compare
b1075 flgD +0.4 1.6 flagellar basal body rod modification protein D (NCBI) compare
b1573 ydfC +0.4 1.0 Qin prophage; predicted protein (RefSeq) compare
b3503 arsC +0.4 2.9 arsenate reductase (NCBI) compare
b3934 cytR +0.4 3.0 DNA-binding transcriptional dual regulator (NCBI) compare
b3769 ilvM +0.4 1.3 acetolactate synthase II, small subunit (NCBI) compare
b0556 rzpD +0.4 2.0 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b3869 glnL +0.4 2.8 sensory histidine kinase in two-component regulatory system with GlnG (NCBI) compare
b2786 barA +0.4 3.4 hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) compare
b1037 csgG +0.4 2.8 outer membrane lipoprotein (NCBI) compare
b0401 brnQ +0.4 2.9 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b4190 yjfP +0.4 2.4 predicted hydrolase (NCBI) compare
b4000 hupA +0.4 2.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b4503 yafF +0.4 0.6 no description compare
b1818 manY +0.4 1.6 mannose-specific enzyme IIC component of PTS (NCBI) compare
b3009 yghB +0.4 2.4 conserved inner membrane protein (NCBI) compare
b2061 wzb +0.4 1.3 protein-tyrosine phosphatase (NCBI) compare
b2314 dedD +0.3 1.7 putative lipoprotein (VIMSS) compare
b0456 ybaA +0.3 1.0 hypothetical protein (NCBI) compare
b4598 yncL +0.3 1.3 hypothetical protein (RefSeq) compare
b0627 tatE +0.3 1.3 twin arginine translocase protein E (NCBI) compare
b1648 b1648 +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b3867 hemN +0.3 3.0 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b1914 uvrY +0.3 2.3 response regulator (NCBI) compare
b0830 yliB +0.3 3.0 predicted peptide transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b1090 plsX +0.3 1.7 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b3351 kefG +0.3 2.3 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b4594 ymgJ +0.3 1.4 hypothetical protein (RefSeq) compare
b1634 tppB +0.3 1.9 putative tripeptide transporter permease (NCBI) compare
b1627 rsxA +0.3 1.7 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b2794 yqcD +0.3 2.3 hypothetical protein (NCBI) compare
b3675 yidG +0.3 2.4 predicted inner membrane protein (NCBI) compare
b4391 yjjK +0.3 2.7 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1383 ydbL +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b2989 b2989 +0.3 2.4 orf, hypothetical protein (VIMSS) compare
b1153 ymfQ +0.3 2.3 e14 prophage; conserved protein (NCBI) compare
b2410 yfeH +0.3 1.9 predicted inner membrane protein (NCBI) compare
b2377 yfdY +0.3 1.4 predicted inner membrane protein (NCBI) compare
b3616 tdh +0.3 2.2 L-threonine 3-dehydrogenase (NCBI) compare
b1171 b1171 +0.3 0.8 orf, hypothetical protein (VIMSS) compare
b2447 yffP +0.3 1.5 CPZ-55 prophage; predicted protein (NCBI) compare
b0249 ykfF +0.3 1.3 CP4-6 prophage; predicted protein (NCBI) compare
b0979 appB +0.3 2.0 cytochrome bd-II oxidase, subunit II (NCBI) compare
b4110 yjcZ +0.3 2.4 orf, hypothetical protein (VIMSS) compare
b0955 ycbZ +0.3 2.3 predicted peptidase (NCBI) compare
b0199 metN +0.3 2.5 DL-methionine transporter subunit (NCBI) compare
b4402 yjjY +0.3 0.5 hypothetical protein (NCBI) compare
b1916 sdiA +0.3 2.5 DNA-binding transcriptional activator (NCBI) compare
b3562 yiaA +0.3 2.8 orf, hypothetical protein (VIMSS) compare
b1642 slyA +0.3 1.0 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0686 ybfF +0.3 2.0 hypothetical protein (NCBI) compare
b3243 aaeR +0.3 1.3 predicted DNA-binding transcriptional regulator, efflux system (NCBI) compare
b1380 ldhA +0.3 0.9 D-lactate dehydrogenase (NCBI) compare
b0227 yafL +0.3 1.6 predicted lipoprotein and C40 family peptidase (NCBI) compare
b1954 dsrA +0.3 1.0 regulatory antisense RNA (NCBI) compare
b2510 b2510 +0.3 1.7 orf, hypothetical protein (VIMSS) compare
b1558 cspF +0.3 1.1 Qin prophage; cold shock protein (NCBI) compare
b2935 tktA +0.3 1.1 transketolase 1, thiamin-binding (NCBI) compare
b0855 potG +0.3 2.1 ATP-binding component of putrescine transport system (VIMSS) compare
b1755 ynjC +0.3 1.9 fused transporter subunits of ABC superfamily: membrane components (RefSeq) compare
b4631 ykgQ +0.3 0.8 no description compare
b0970 yccA +0.3 1.7 inner membrane protein (NCBI) compare
b0198 metI +0.3 2.5 DL-methionine transporter subunit (NCBI) compare
b1278 pgpB +0.3 1.3 phosphatidylglycerophosphatase B (NCBI) compare
b0991 ymcE +0.3 1.4 cold shock gene (NCBI) compare
b0339 cynT +0.3 2.0 carbonic anhydrase (NCBI) compare
b0404 yajB +0.3 1.4 hypothetical protein (NCBI) compare
b4413 sokC +0.3 0.7 regulatory antisense RNA (NCBI) compare
b1104 ycfL +0.3 1.1 hypothetical protein (NCBI) compare
b0643 ybeL +0.3 1.8 hypothetical protein (NCBI) compare
b0806 ybiM +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b4227 ytfQ +0.3 1.6 predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b3392 yrfA +0.3 2.1 orf, hypothetical protein (VIMSS) compare
b0209 yafD +0.3 2.4 hypothetical protein (NCBI) compare
b1831 proQ +0.3 1.0 putative solute/DNA competence effector (NCBI) compare
b1566 flxA +0.3 1.5 Qin prophage; predicted protein (NCBI) compare
b4232 fbp +0.3 2.5 fructose-1,6-bisphosphatase (NCBI) compare
b2175 spr +0.3 1.8 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0784 moaD +0.3 1.7 molybdopterin synthase, small subunit (NCBI) compare
b4260 pepA +0.3 2.5 leucyl aminopeptidase (NCBI) compare
b2419 yfeK +0.3 0.9 hypothetical protein (NCBI) compare
b2074 b2074 +0.3 1.9 putative membrane protein (VIMSS) compare
b3391 hofQ +0.3 2.2 predicted fimbrial transporter (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For carbon source Ying_sugar7 in Escherichia coli BW25113

For carbon source Ying_sugar7 across organisms