Experiment set57IT011 for Escherichia coli BW25113

Compare to:

Ying_sugar7 rep B; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2904 gcvH +3.6 19.8 glycine cleavage system protein H (NCBI) compare
b2903 gcvP +3.5 33.4 glycine dehydrogenase (NCBI) compare
b2905 gcvT +3.1 23.4 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2808 gcvA +3.0 19.3 DNA-binding transcriptional dual regulator (NCBI) compare
b3181 greA +1.8 11.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b2830 nudH +1.7 4.5 dinucleoside polyphosphate hydrolase (NCBI) compare
b2947 gshB +1.6 12.5 glutathione synthetase (NCBI) compare
b2951 yggS +1.4 9.5 predicted enzyme (NCBI) compare
b0059 hepA +1.4 12.4 ATP-dependent helicase HepA (NCBI) compare
b2688 gshA +1.3 10.2 glutamate--cysteine ligase (NCBI) compare
b2829 ptsP +1.3 10.2 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b3341 rpsG +1.2 2.2 30S ribosomal protein S7 (NCBI) compare
b3778 rep +1.2 9.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4701 sokX +1.1 2.2 sok-related sRNA, function unknown (RefSeq) compare
b3206 npr +1.1 5.3 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b4203 rplI +0.9 4.7 50S ribosomal protein L9 (NCBI) compare
b4171 miaA +0.9 3.4 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0866 ybjQ +0.9 1.9 hypothetical protein (NCBI) compare
b0882 clpA +0.8 6.7 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1190 dadX +0.8 5.0 alanine racemase (NCBI) compare
b1085 b1085 +0.8 3.2 orf, hypothetical protein (VIMSS) compare
b1095 fabF +0.8 6.0 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1824 yobF +0.8 2.8 hypothetical protein (NCBI) compare
b2114 metG +0.8 1.6 methionyl-tRNA synthetase (NCBI) compare
b0949 uup +0.7 5.7 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1429 tehA +0.7 1.2 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1013 ycdC +0.7 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0232 yafN +0.7 0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1731 cedA +0.7 2.9 cell division modulator (RefSeq) compare
b0852 rimK +0.7 4.8 ribosomal protein S6 modification protein (NCBI) compare
b0381 ddlA +0.7 4.3 D-alanylalanine synthetase (NCBI) compare
b0218 yafU +0.7 3.2 predicted inner membrane protein (RefSeq) compare
b4577 sgrS +0.7 2.1 small antisense RNA (NCBI) compare
b2948 yqgE +0.7 3.1 orf, hypothetical protein (VIMSS) compare
b1159 mcrA +0.6 1.4 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b2937 speB +0.6 4.2 agmatinase (NCBI) compare
b3261 fis +0.6 2.0 DNA-binding protein Fis (NCBI) compare
b1038 csgF +0.6 3.1 predicted transport protein (NCBI) compare
b4402 yjjY +0.6 0.9 hypothetical protein (NCBI) compare
b4294 insA-7 +0.6 2.0 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b0249 ykfF +0.6 2.6 CP4-6 prophage; predicted protein (NCBI) compare
b2012 yeeD +0.6 2.0 hypothetical protein (NCBI) compare
b3616 tdh +0.6 3.3 L-threonine 3-dehydrogenase (NCBI) compare
b1593 b1593 +0.6 2.1 orf, hypothetical protein (VIMSS) compare
b1041 csgB +0.6 3.2 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b4141 yjeH +0.6 5.2 predicted transporter (NCBI) compare
b3806 cyaA +0.6 3.8 adenylate cyclase (NCBI) compare
b4163 glyV +0.6 1.8 tRNA-Gly (NCBI) compare
b1613 manA +0.6 1.8 mannose-6-phosphate isomerase (VIMSS) compare
b2258 b2258 +0.6 1.2 putative transport/receptor protein (VIMSS) compare
b2303 folX +0.6 4.9 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b0685 ybfE +0.6 3.0 orf, hypothetical protein (VIMSS) compare
b1831 proQ +0.6 2.1 putative solute/DNA competence effector (NCBI) compare
b1380 ldhA +0.6 2.1 D-lactate dehydrogenase (NCBI) compare
b1606 folM +0.6 4.1 short chain dehydrogenase (NCBI) compare
b2494 yfgC +0.6 3.7 predicted peptidase (NCBI) compare
b1155 ymfS +0.6 2.9 e14 prophage; predicted protein (NCBI) compare
b1609 rstB +0.6 2.8 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b3504 yhiS +0.6 0.5 hypothetical protein (RefSeq) compare
b1037 csgG +0.5 4.4 outer membrane lipoprotein (NCBI) compare
b4493 gapC +0.5 2.0 no description compare
b4030 yjbA +0.5 3.4 phosphate-starvation-inducible protein PsiE (NCBI) compare
b3138 agaB +0.5 2.5 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b1222 narX +0.5 3.2 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b3769 ilvM +0.5 2.2 acetolactate synthase II, small subunit (NCBI) compare
b2189 proL +0.5 1.5 tRNA-Pro (NCBI) compare
b1341 b1341 +0.5 3.2 orf, hypothetical protein (VIMSS) compare
b0783 moaC +0.5 2.6 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3676 yidH +0.5 2.0 conserved inner membrane protein (NCBI) compare
b4418 sraB +0.5 1.8 unknown RNA (NCBI) compare
b1299 puuR +0.5 2.5 DNA-binding transcriptional repressor (NCBI) compare
b3632 rfaQ +0.5 4.6 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1550 b1550 +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b2248 yfaX +0.5 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1871 yecP +0.5 2.8 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b2935 tktA +0.5 1.3 transketolase 1, thiamin-binding (NCBI) compare
b2236 yfaE +0.5 2.7 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b1823 cspC +0.5 1.4 stress protein, member of the CspA-family (NCBI) compare
b4692 oweE +0.5 2.4 no description compare
b2127 mlrA +0.5 3.0 DNA-binding transcriptional regulator (NCBI) compare
b0053 surA +0.5 3.0 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1557 cspB +0.5 0.6 Qin prophage; cold shock protein (NCBI) compare
b4391 yjjK +0.5 3.8 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0889 lrp +0.5 1.7 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b2042 galF +0.5 3.3 predicted subunit with GalU (NCBI) compare
b0545 ybcL +0.5 3.7 DLP12 prophage; predicted kinase inhibitor (NCBI) compare
b2579 yfiD +0.5 1.3 pyruvate formate lyase subunit (NCBI) compare
b1132 hflD +0.4 2.7 hypothetical protein (NCBI) compare
b2183 rsuA +0.4 2.0 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b4096 phnL +0.4 2.6 carbon-phosphorus lyase complex subunit (NCBI) compare
b0603 ybdO +0.4 0.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2642 yfjW +0.4 0.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4644 ypjI +0.4 2.0 no description compare
b0178 hlpA +0.4 1.5 periplasmic chaperone (NCBI) compare
b2506 yfgI +0.4 1.1 hypothetical protein (NCBI) compare
b4529 ydbJ +0.4 0.8 hypothetical protein (NCBI) compare
b1849 purT +0.4 2.6 phosphoribosylglycinamide formyltransferase 2 (NCBI) compare
b3755 yieP +0.4 2.7 predicted transcriptional regulator (NCBI) compare
b1482 osmC +0.4 0.9 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b2625 yfjI +0.4 1.2 CP4-57 prophage; predicted protein (NCBI) compare
b3929 rraA +0.4 3.5 ribonuclease activity regulator protein RraA (NCBI) compare
b2419 yfeK +0.4 1.4 hypothetical protein (NCBI) compare
b1279 yciS +0.4 0.7 conserved inner membrane protein (NCBI) compare
b4647 mokA +0.4 0.5 no description compare
b1273 yciN +0.4 1.1 hypothetical protein (NCBI) compare
b3706 trmE +0.4 1.7 tRNA modification GTPase (NCBI) compare
b1628 rsxB +0.4 2.1 electron transport complex protein RnfB (NCBI) compare
b1302 puuE +0.4 1.6 GABA aminotransferase, PLP-dependent (NCBI) compare
b1960 vsr +0.4 2.5 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b1333 uspE +0.4 2.6 stress-induced protein (NCBI) compare
b3194 yrbE +0.4 3.2 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3034 nudF +0.4 2.4 ADP-ribose pyrophosphatase (NCBI) compare
b4454 rdlD +0.4 2.1 sRNA antisense regulator affects LdrD translation; proposed addiction module in LDR-D repeat, with toxic peptide LdrD (RefSeq) compare
b1789 yeaL +0.4 1.7 conserved inner membrane protein (NCBI) compare
b4461 yfjD +0.4 3.2 predicted inner membrane protein (RefSeq) compare
b4225 chpB +0.4 2.4 toxin of the ChpB-ChpS toxin-antitoxin system (NCBI) compare
b0209 yafD +0.4 2.4 hypothetical protein (NCBI) compare
b4453 ldrD +0.4 1.4 toxic polypeptide, small (NCBI) compare
b4256 yjgM +0.4 3.1 predicted acetyltransferase (NCBI) compare
b4190 yjfP +0.4 2.2 predicted hydrolase (NCBI) compare
b3199 yrbK +0.4 1.7 hypothetical protein (NCBI) compare
b0627 tatE +0.4 1.0 twin arginine translocase protein E (NCBI) compare
b1243 oppA +0.4 2.5 oligopeptide transporter subunit (NCBI) compare
b1242 ychE +0.4 2.0 predicted inner membrane protein (NCBI) compare
b3934 cytR +0.4 3.1 DNA-binding transcriptional dual regulator (NCBI) compare
b1040 csgD +0.4 1.1 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1755 ynjC +0.4 2.3 fused transporter subunits of ABC superfamily: membrane components (RefSeq) compare
b2066 udk +0.4 2.2 uridine/cytidine kinase (VIMSS) compare
b1591 b1591 +0.4 1.3 putative oxidoreductase component (VIMSS) compare
b3484 yhhI +0.4 1.3 predicted transposase (NCBI) compare
b3119 tdcR +0.4 1.1 threonine dehydratase operon activator protein (VIMSS) compare
b3469 zntA +0.4 2.6 zinc, cobalt and lead efflux system (NCBI) compare
b2346 vacJ +0.4 2.7 predicted lipoprotein (NCBI) compare
b1819 manZ +0.4 2.0 mannose-specific enzyme IID component of PTS (NCBI) compare
b3096 yqjB +0.4 2.3 hypothetical protein (NCBI) compare
b4000 hupA +0.4 2.5 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b1671 ydhX +0.4 1.6 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b2706 gutM +0.4 2.1 DNA-binding transcriptional activator of glucitol operon (NCBI) compare
b1566 flxA +0.4 1.5 Qin prophage; predicted protein (NCBI) compare
b1461 ydcE +0.4 1.6 4-oxalocrotonate tautomerase (NCBI) compare
b3617 kbl +0.4 2.6 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b1692 ydiB +0.4 2.0 quinate/shikimate 5-dehydrogenase, NAD(P)-binding (NCBI) compare
b3869 glnL +0.4 2.6 sensory histidine kinase in two-component regulatory system with GlnG (NCBI) compare
b2786 barA +0.4 3.4 hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) compare
b1816 yoaE +0.4 2.3 fused predicted membrane protein/conserved protein (NCBI) compare
b3197 kdsD +0.4 2.7 D-arabinose 5-phosphate isomerase (NCBI) compare
b0998 torD +0.4 0.7 chaperone protein TorD (NCBI) compare
b1362 rzpR +0.4 1.0 putative Rac prophage endopeptidase (VIMSS) compare
b3101 yqjF +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b4135 yjdC +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b1634 tppB +0.4 2.1 putative tripeptide transporter permease (NCBI) compare
b0339 cynT +0.4 1.5 carbonic anhydrase (NCBI) compare
b3858 yihD +0.4 1.9 hypothetical protein (NCBI) compare
b3644 yicC +0.3 1.8 hypothetical protein (NCBI) compare
b2684 mprA +0.3 1.8 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1763 topB +0.3 1.7 DNA topoisomerase III (NCBI) compare
b1253 yciA +0.3 2.0 predicted hydrolase (NCBI) compare
b4452 gadY +0.3 2.5 unknown RNA (NCBI) compare
b1883 cheB +0.3 2.3 chemotaxis-specific methylesterase (NCBI) compare
b1725 yniA +0.3 2.8 predicted phosphotransferase/kinase (NCBI) compare
b2341 yfcX +0.3 2.4 fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI) compare
b0238 gpt +0.3 1.4 xanthine phosphoribosyltransferase (NCBI) compare
b3102 yqjG +0.3 2.0 predicted S-transferase (NCBI) compare
b1642 slyA +0.3 1.0 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b2726 hypA +0.3 1.8 protein involved in nickel insertion into hydrogenases 3 (NCBI) compare
b3867 hemN +0.3 2.9 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b4104 phnE +0.3 1.3 phosphonate/organophosphate ester transporter subunit (NCBI) compare
b0955 ycbZ +0.3 2.5 predicted peptidase (NCBI) compare
b3260 dusB +0.3 2.2 tRNA-dihydrouridine synthase B (NCBI) compare
b0190 yaeQ +0.3 2.7 hypothetical protein (NCBI) compare
b1961 dcm +0.3 0.7 DNA cytosine methylase (NCBI) compare
b2938 speA +0.3 2.5 arginine decarboxylase (NCBI) compare
b2052 fcl +0.3 1.5 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/ GDP-4-dehydro-6-L-deoxygalactose reductase (NCBI) compare
b4587 insN +0.3 2.1 no description compare
b2586 yfiM +0.3 1.5 predicted protein (RefSeq) compare
b1630 rsxD +0.3 1.5 electron transport complex protein RnfD (NCBI) compare
b2966 yqgA +0.3 2.3 predicted inner membrane protein (NCBI) compare
b1916 sdiA +0.3 2.6 DNA-binding transcriptional activator (NCBI) compare
b2175 spr +0.3 2.1 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b1332 ynaJ +0.3 0.4 predicted inner membrane protein (NCBI) compare
b0661 miaB +0.3 2.5 isopentenyl-adenosine A37 tRNA methylthiolase (NCBI) compare
b4522 yciX_1 +0.3 1.1 hypothetical protein (NCBI) compare
b4363 yjjB +0.3 1.4 conserved inner membrane protein (RefSeq) compare
b2646 ypjF +0.3 1.2 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b2953 yggU +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b4618 tisB +0.3 2.3 lexA-regulated toxic peptide (RefSeq) compare
b1792 yeaO +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b0696 kdpC +0.3 0.8 potassium-transporting ATPase subunit C (NCBI) compare
b3512 GadE +0.3 1.5 acid-responsive regulator of gadA and gadBC (Katherine Huang) compare
b2074 b2074 +0.3 1.8 putative membrane protein (VIMSS) compare
b1941 fliI +0.3 2.0 flagellum-specific ATP synthase (NCBI) compare
b1685 ydiH +0.3 0.7 predicted protein (RefSeq) compare
b2538 hcaE +0.3 1.4 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b1673 ydhV +0.3 1.7 predicted oxidoreductase (NCBI) compare
b0615 citF +0.3 1.7 citrate lyase, citrate-ACP transferase (alpha) subunit (NCBI) compare
b2572 rseA +0.3 1.6 anti-sigma factor (NCBI) compare
b2421 cysM +0.3 1.4 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b1487 ddpA +0.3 1.9 D-ala-D-a la transporter subunit (NCBI) compare
b2962 yggX +0.3 1.5 hypothetical protein (NCBI) compare
b1106 ycfN +0.3 1.9 thiamin kinase (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For carbon source Ying_sugar7 in Escherichia coli BW25113

For carbon source Ying_sugar7 across organisms