Experiment set57IT010 for Escherichia coli BW25113

Compare to:

Ying_sugar7 rep A; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2903 gcvP +3.5 33.4 glycine dehydrogenase (NCBI) compare
b2904 gcvH +3.4 21.0 glycine cleavage system protein H (NCBI) compare
b2905 gcvT +3.1 19.6 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2808 gcvA +2.8 18.2 DNA-binding transcriptional dual regulator (NCBI) compare
b3181 greA +1.8 10.6 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b2947 gshB +1.6 11.3 glutathione synthetase (NCBI) compare
b2830 nudH +1.5 4.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b2688 gshA +1.4 11.2 glutamate--cysteine ligase (NCBI) compare
b3206 npr +1.3 9.1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b0059 hepA +1.3 12.4 ATP-dependent helicase HepA (NCBI) compare
b2829 ptsP +1.3 10.4 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b2951 yggS +1.3 9.8 predicted enzyme (NCBI) compare
b3778 rep +1.0 8.8 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4203 rplI +1.0 7.1 50S ribosomal protein L9 (NCBI) compare
b0705 ybfL +0.9 1.8 putative receptor protein (VIMSS) compare
b2937 speB +0.9 6.7 agmatinase (NCBI) compare
b0882 clpA +0.9 7.5 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1429 tehA +0.9 1.8 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1095 fabF +0.8 6.3 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3806 cyaA +0.8 4.9 adenylate cyclase (NCBI) compare
b1038 csgF +0.8 4.4 predicted transport protein (NCBI) compare
b1273 yciN +0.8 2.1 hypothetical protein (NCBI) compare
b1361 ydaW +0.8 0.9 orf, hypothetical protein (VIMSS) compare
b0949 uup +0.7 6.0 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0852 rimK +0.7 5.7 ribosomal protein S6 modification protein (NCBI) compare
b1824 yobF +0.7 2.5 hypothetical protein (NCBI) compare
b4171 miaA +0.7 4.1 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0381 ddlA +0.7 5.9 D-alanylalanine synthetase (NCBI) compare
b4042 dgkA +0.7 2.2 diacylglycerol kinase (NCBI) compare
b0232 yafN +0.7 0.8 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b4141 yjeH +0.7 5.7 predicted transporter (NCBI) compare
b1299 puuR +0.7 3.4 DNA-binding transcriptional repressor (NCBI) compare
b1085 b1085 +0.7 3.0 orf, hypothetical protein (VIMSS) compare
b4172 hfq +0.6 1.0 RNA-binding protein Hfq (NCBI) compare
b1190 dadX +0.6 3.6 alanine racemase (NCBI) compare
b1823 cspC +0.6 1.2 stress protein, member of the CspA-family (NCBI) compare
b1685 ydiH +0.6 1.5 predicted protein (RefSeq) compare
b2494 yfgC +0.6 4.5 predicted peptidase (NCBI) compare
b1333 uspE +0.6 2.4 stress-induced protein (NCBI) compare
b3706 trmE +0.6 3.1 tRNA modification GTPase (NCBI) compare
b4653 yicT +0.6 1.8 no description compare
b4522 yciX_1 +0.6 2.0 hypothetical protein (NCBI) compare
b2058 wcaB +0.6 1.3 predicted acyl transferase (NCBI) compare
b2768 ygcP +0.5 2.4 predicted anti-terminator regulatory protein (NCBI) compare
b3616 tdh +0.5 3.4 L-threonine 3-dehydrogenase (NCBI) compare
b0178 hlpA +0.5 3.5 periplasmic chaperone (NCBI) compare
b1992 cobS +0.5 2.1 cobalamin synthase (NCBI) compare
b1259 yciG +0.5 1.0 orf, hypothetical protein (VIMSS) compare
b3341 rpsG +0.5 0.7 30S ribosomal protein S7 (NCBI) compare
b3929 rraA +0.5 4.4 ribonuclease activity regulator protein RraA (NCBI) compare
b2145 yeiS +0.5 2.6 predicted inner membrane protein (NCBI) compare
b2114 metG +0.5 1.9 methionyl-tRNA synthetase (NCBI) compare
b0556 rzpD +0.5 2.3 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b1524 yneH +0.5 1.1 predicted glutaminase (NCBI) compare
b2303 folX +0.5 4.0 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b2127 mlrA +0.5 3.1 DNA-binding transcriptional regulator (NCBI) compare
b2421 cysM +0.5 3.5 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b3755 yieP +0.5 3.4 predicted transcriptional regulator (NCBI) compare
b3504 yhiS +0.5 0.5 hypothetical protein (RefSeq) compare
b1961 dcm +0.5 1.8 DNA cytosine methylase (NCBI) compare
b1731 cedA +0.5 2.9 cell division modulator (RefSeq) compare
b1607 ydgC +0.5 1.6 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1667 ydhR +0.5 2.4 hypothetical protein (NCBI) compare
b1604 ydgH +0.5 2.9 hypothetical protein (NCBI) compare
b0471 ybaB +0.5 3.1 hypothetical protein (NCBI) compare
b1236 galU +0.5 3.0 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2962 yggX +0.5 2.5 hypothetical protein (NCBI) compare
b4135 yjdC +0.5 3.3 orf, hypothetical protein (VIMSS) compare
b1642 slyA +0.5 1.4 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0843 ybjH +0.5 1.7 hypothetical protein (NCBI) compare
b4394 yjjX +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b4461 yfjD +0.5 3.8 predicted inner membrane protein (RefSeq) compare
b2419 yfeK +0.5 1.9 hypothetical protein (NCBI) compare
b0889 lrp +0.5 1.6 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1758 b1758 +0.5 1.1 putative cytochrome oxidase (VIMSS) compare
b1418 cybB +0.5 2.3 cytochrome b(561) (VIMSS) compare
b1606 folM +0.5 3.5 short chain dehydrogenase (NCBI) compare
b0830 yliB +0.5 3.3 predicted peptide transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b2183 rsuA +0.5 2.4 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b2017 yefM +0.5 1.6 orf, hypothetical protein (VIMSS) compare
b3632 rfaQ +0.5 4.3 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1890 motA +0.5 2.9 flagellar motor protein MotA (NCBI) compare
b1222 narX +0.5 2.9 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b0946 ycbW +0.5 2.3 orf, hypothetical protein (VIMSS) compare
b4256 yjgM +0.5 3.9 predicted acetyltransferase (NCBI) compare
b2749 ygbE +0.4 3.2 conserved inner membrane protein (NCBI) compare
b0686 ybfF +0.4 3.3 hypothetical protein (NCBI) compare
b1446 ydcY +0.4 1.9 hypothetical protein (NCBI) compare
b1037 csgG +0.4 3.5 outer membrane lipoprotein (NCBI) compare
b3101 yqjF +0.4 1.9 orf, hypothetical protein (VIMSS) compare
b4030 yjbA +0.4 3.2 phosphate-starvation-inducible protein PsiE (NCBI) compare
b3194 yrbE +0.4 3.6 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0051 ksgA +0.4 2.5 dimethyladenosine transferase (NCBI) compare
b4000 hupA +0.4 2.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b1582 ynfA +0.4 2.4 hypothetical protein (NCBI) compare
b3617 kbl +0.4 3.0 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b4190 yjfP +0.4 2.9 predicted hydrolase (NCBI) compare
b3934 cytR +0.4 3.6 DNA-binding transcriptional dual regulator (NCBI) compare
b3867 hemN +0.4 3.6 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b3563 yiaB +0.4 2.2 orf, hypothetical protein (VIMSS) compare
b2369 evgA +0.4 1.9 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b4570 lomR +0.4 1.1 no description compare
b1041 csgB +0.4 2.6 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b1306 pspC +0.4 2.3 DNA-binding transcriptional activator (NCBI) compare
b1597 asr +0.4 2.0 acid shock protein (VIMSS) compare
b2204 napH +0.4 1.8 quinol dehydrogenase membrane component (NCBI) compare
b1336 ydaH +0.4 2.4 putative pump protein (transport) (VIMSS) compare
b3769 ilvM +0.4 1.3 acetolactate synthase II, small subunit (NCBI) compare
b2605 yfiB +0.4 2.1 predicted outer membrane lipoprotein (NCBI) compare
b2096 gatY +0.4 2.6 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b4391 yjjK +0.4 2.9 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2935 tktA +0.4 1.1 transketolase 1, thiamin-binding (NCBI) compare
b1341 b1341 +0.4 2.6 orf, hypothetical protein (VIMSS) compare
b1819 manZ +0.4 1.6 mannose-specific enzyme IID component of PTS (NCBI) compare
b3183 obgE +0.4 0.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b4503 yafF +0.4 0.6 no description compare
b2066 udk +0.4 2.1 uridine/cytidine kinase (VIMSS) compare
b2642 yfjW +0.4 0.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0053 surA +0.4 2.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0209 yafD +0.4 2.8 hypothetical protein (NCBI) compare
b2309 hisJ +0.4 2.0 histidine/lysine/arginine/ornithine transporter subunit (NCBI) compare
b1634 tppB +0.4 2.5 putative tripeptide transporter permease (NCBI) compare
b0955 ycbZ +0.4 3.0 predicted peptidase (NCBI) compare
b4546 ypeB +0.4 0.9 hypothetical protein (NCBI) compare
b2786 barA +0.4 3.5 hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) compare
b1871 yecP +0.4 1.8 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b0508 hyi +0.4 1.8 hydroxypyruvate isomerase (NCBI) compare
b2538 hcaE +0.4 1.7 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b3869 glnL +0.4 2.7 sensory histidine kinase in two-component regulatory system with GlnG (NCBI) compare
b2042 galF +0.4 2.8 predicted subunit with GalU (NCBI) compare
b1630 rsxD +0.4 1.7 electron transport complex protein RnfD (NCBI) compare
b1918 yecS +0.4 1.3 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1242 ychE +0.4 2.4 predicted inner membrane protein (NCBI) compare
b1335 ogt +0.4 2.1 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b1217 chaB +0.4 0.9 cation transport regulator (NCBI) compare
b4515 ybgT +0.4 1.1 hypothetical protein (NCBI) compare
b1854 pykA +0.4 2.2 pyruvate kinase (NCBI) compare
b1150 ymfR +0.3 0.6 e14 prophage; predicted protein (NCBI) compare
b4260 pepA +0.3 2.9 leucyl aminopeptidase (NCBI) compare
b2314 dedD +0.3 1.9 putative lipoprotein (VIMSS) compare
b2341 yfcX +0.3 2.6 fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI) compare
b2794 yqcD +0.3 2.3 hypothetical protein (NCBI) compare
b1860 ruvB +0.3 0.5 Holliday junction DNA helicase B (NCBI) compare
b2428 yfeU +0.3 2.5 N-acetylmuramic acid-6-phosphate etherase (NCBI) compare
b4041 plsB +0.3 1.1 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1556 b1556 +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b1035 ycdY +0.3 2.3 hypothetical protein (NCBI) compare
b4066 yjcF +0.3 0.4 hypothetical protein (NCBI) compare
b0979 appB +0.3 2.2 cytochrome bd-II oxidase, subunit II (NCBI) compare
b3197 kdsD +0.3 2.5 D-arabinose 5-phosphate isomerase (NCBI) compare
b0853 ybjN +0.3 1.7 predicted oxidoreductase (NCBI) compare
b1194 ycgR +0.3 2.2 protein involved in flagellar function (NCBI) compare
b0545 ybcL +0.3 2.6 DLP12 prophage; predicted kinase inhibitor (NCBI) compare
b1648 b1648 +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b1609 rstB +0.3 1.8 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b4158 yjeO +0.3 1.1 conserved inner membrane protein (NCBI) compare
b3469 zntA +0.3 2.5 zinc, cobalt and lead efflux system (NCBI) compare
b4232 fbp +0.3 2.6 fructose-1,6-bisphosphatase (NCBI) compare
b1583 ynfB +0.3 0.8 hypothetical protein (NCBI) compare
b2521 sseA +0.3 2.6 putative thiosulfate sulfurtransferase (VIMSS) compare
b1689 b1689 +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b0605 ahpC +0.3 1.7 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b1831 proQ +0.3 1.4 putative solute/DNA competence effector (NCBI) compare
b0367 tauC +0.3 1.2 taurine transporter subunit (NCBI) compare
b1042 csgA +0.3 2.4 cryptic curlin major subunit (NCBI) compare
b1621 malX +0.3 2.3 fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (NCBI) compare
b4543 ypaA +0.3 1.8 predicted protein (NCBI) compare
b2474 ypfI +0.3 2.4 predicted hydrolase (NCBI) compare
b4578 insP +0.3 1.8 no description compare
b2698 recX +0.3 1.1 RecA regulator RecX (NCBI) compare
b3766 ilvL +0.3 1.2 ilvG operon leader peptide (NCBI) compare
b1073 flgB +0.3 1.6 flagellar basal-body rod protein B (NCBI) compare
b0339 cynT +0.3 2.2 carbonic anhydrase (NCBI) compare
b3644 yicC +0.3 2.3 hypothetical protein (NCBI) compare
b0412 yajI +0.3 1.8 orf, hypothetical protein (VIMSS) compare
b1765 ydjA +0.3 0.5 predicted oxidoreductase (NCBI) compare
b1703 ydiA +0.3 2.4 hypothetical protein (NCBI) compare
b0197 metQ +0.3 2.4 DL-methionine transporter subunit (NCBI) compare
b1919 yedO +0.3 1.1 putative 1-aminocyclopropane-1-carboxylate deaminase (VIMSS) compare
b2342 yfcY +0.3 1.7 acetyl-CoA acetyltransferase (NCBI) compare
b1486 ddpB +0.3 1.2 D-ala-D-ala transporter subunit (NCBI) compare
b1070 flgN +0.3 0.8 export chaperone for FlgK and FlgL (NCBI) compare
b3466 yhhL +0.3 1.4 conserved inner membrane protein (NCBI) compare
b1793 yoaF +0.3 1.5 conserved outer membrane protein (NCBI) compare
b0163 yaeH +0.3 2.0 hypothetical protein (NCBI) compare
b2684 mprA +0.3 1.4 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b0685 ybfE +0.3 0.9 orf, hypothetical protein (VIMSS) compare
b1141 ymfG +0.3 1.4 e14 prophage; predicted excisionase (NCBI) compare
b1547 stfQ +0.3 1.3 Qin prophage; predicted side tail fibre assembly protein (NCBI) compare
b1159 mcrA +0.3 0.6 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b3562 yiaA +0.3 2.6 orf, hypothetical protein (VIMSS) compare
b1438 ydcQ +0.3 1.3 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2485 hyfE +0.3 1.6 hydrogenase 4, membrane subunit (NCBI) compare
b0469 apt +0.3 2.2 adenine phosphoribosyltransferase (NCBI) compare
b3503 arsC +0.3 1.5 arsenate reductase (NCBI) compare
b4594 ymgJ +0.3 1.0 hypothetical protein (RefSeq) compare
b1127 pepT +0.3 2.1 peptidase T (NCBI) compare
b4656 yjhY +0.3 1.8 no description compare
b1820 yobD +0.3 1.9 hypothetical protein (NCBI) compare
b2938 speA +0.3 2.1 arginine decarboxylase (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For carbon source Ying_sugar7 in Escherichia coli BW25113

For carbon source Ying_sugar7 across organisms