Experiment set57IT009 for Escherichia coli BW25113

Compare to:

Ying_OrganicAcid7 rep C; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2808 gcvA +2.8 17.3 DNA-binding transcriptional dual regulator (NCBI) compare
b2903 gcvP +2.3 21.6 glycine dehydrogenase (NCBI) compare
b2904 gcvH +2.2 13.9 glycine cleavage system protein H (NCBI) compare
b2905 gcvT +2.1 16.7 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2741 rpoS +1.9 13.9 RNA polymerase sigma factor (NCBI) compare
b2951 yggS +1.9 14.3 predicted enzyme (NCBI) compare
b4172 hfq +1.6 2.9 RNA-binding protein Hfq (NCBI) compare
b3164 pnp +1.5 6.8 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0889 lrp +1.3 7.6 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1095 fabF +1.3 10.5 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b4203 rplI +1.2 7.9 50S ribosomal protein L9 (NCBI) compare
b2688 gshA +1.2 10.1 glutamate--cysteine ligase (NCBI) compare
b1085 b1085 +1.2 3.5 orf, hypothetical protein (VIMSS) compare
b1190 dadX +1.1 5.3 alanine racemase (NCBI) compare
b4402 yjjY +1.0 2.6 hypothetical protein (NCBI) compare
b0059 hepA +1.0 9.8 ATP-dependent helicase HepA (NCBI) compare
b2947 gshB +1.0 4.9 glutathione synthetase (NCBI) compare
b3341 rpsG +1.0 1.7 30S ribosomal protein S7 (NCBI) compare
b1824 yobF +0.9 4.0 hypothetical protein (NCBI) compare
b1236 galU +0.9 5.6 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3741 gidA +0.9 5.9 glucose-inhibited division protein A (NCBI) compare
b2846 yqeH +0.9 1.0 orf, hypothetical protein (VIMSS) compare
b4030 yjbA +0.9 6.9 phosphate-starvation-inducible protein PsiE (NCBI) compare
b2937 speB +0.9 6.6 agmatinase (NCBI) compare
b2830 nudH +0.9 1.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b1855 lpxM +0.9 5.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2259 pmrD +0.8 1.9 polymyxin resistance protein B (VIMSS) compare
b1765 ydjA +0.8 1.4 predicted oxidoreductase (NCBI) compare
b2829 ptsP +0.8 6.7 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b0232 yafN +0.8 1.1 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1831 proQ +0.8 3.2 putative solute/DNA competence effector (NCBI) compare
b1823 cspC +0.7 1.9 stress protein, member of the CspA-family (NCBI) compare
b1731 cedA +0.7 4.3 cell division modulator (RefSeq) compare
b2258 b2258 +0.7 1.7 putative transport/receptor protein (VIMSS) compare
b3194 yrbE +0.7 5.6 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3706 trmE +0.7 3.9 tRNA modification GTPase (NCBI) compare
b1159 mcrA +0.7 1.6 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b0955 ycbZ +0.7 5.4 predicted peptidase (NCBI) compare
b1273 yciN +0.7 1.9 hypothetical protein (NCBI) compare
b3778 rep +0.7 5.1 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1758 b1758 +0.7 1.6 putative cytochrome oxidase (VIMSS) compare
b2659 b2659 +0.7 1.2 orf, hypothetical protein (VIMSS) compare
b1294 sapA +0.6 4.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1524 yneH +0.6 1.3 predicted glutaminase (NCBI) compare
b0471 ybaB +0.6 3.3 hypothetical protein (NCBI) compare
b3616 tdh +0.6 4.0 L-threonine 3-dehydrogenase (NCBI) compare
b1634 tppB +0.6 4.4 putative tripeptide transporter permease (NCBI) compare
b1595 ynfL +0.6 2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b3632 rfaQ +0.6 5.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4660 yhiL +0.6 0.5 no description compare
b0882 clpA +0.6 4.8 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b1299 puuR +0.6 3.1 DNA-binding transcriptional repressor (NCBI) compare
b3454 livF +0.6 3.6 ATP-binding component of leucine transport (VIMSS) compare
b3780 rhlB +0.6 5.2 ATP-dependent RNA helicase (NCBI) compare
b1916 sdiA +0.6 4.3 DNA-binding transcriptional activator (NCBI) compare
b0381 ddlA +0.6 4.2 D-alanylalanine synthetase (NCBI) compare
b1548 nohA +0.5 2.0 Qin prophage; predicted packaging protein (RefSeq) compare
b1191 b1191 +0.5 3.9 orf, hypothetical protein (VIMSS) compare
b4436 ryeC +0.5 1.8 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1333 uspE +0.5 3.2 stress-induced protein (NCBI) compare
b0998 torD +0.5 1.3 chaperone protein TorD (NCBI) compare
b3181 greA +0.5 3.0 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3753 rbsR +0.5 4.6 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b4000 hupA +0.5 3.5 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b3842 rfaH +0.5 4.1 transcriptional activator RfaH (NCBI) compare
b3138 agaB +0.5 2.4 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b1187 fadR +0.5 3.7 fatty acid metabolism regulator (NCBI) compare
b1667 ydhR +0.5 1.9 hypothetical protein (NCBI) compare
b2576 srmB +0.5 2.6 ATP-dependent RNA helicase (NCBI) compare
b3867 hemN +0.5 4.6 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b0624 crcB +0.5 2.9 camphor resistance protein CrcB (NCBI) compare
b3977 tyrU +0.5 1.0 tRNA-Tyr (NCBI) compare
b1550 b1550 +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b1708 nlpC +0.5 1.8 predicted lipoprotein (NCBI) compare
b1725 yniA +0.5 2.4 predicted phosphotransferase/kinase (NCBI) compare
b3979 thrT +0.5 0.5 tRNA-Thr (NCBI) compare
b3624 rfaZ +0.5 1.8 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3644 yicC +0.5 3.0 hypothetical protein (NCBI) compare
b1279 yciS +0.5 0.9 conserved inner membrane protein (NCBI) compare
b3468 yhhN +0.5 4.2 conserved inner membrane protein (NCBI) compare
b2962 yggX +0.5 2.5 hypothetical protein (NCBI) compare
b1961 dcm +0.5 1.6 DNA cytosine methylase (NCBI) compare
b4603 rseX +0.5 0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3630 rfaP +0.5 4.1 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3658 selC +0.5 2.2 tRNA-Sec (NCBI) compare
b3387 dam +0.5 4.2 DNA adenine methylase (NCBI) compare
b3469 zntA +0.5 3.5 zinc, cobalt and lead efflux system (NCBI) compare
b1295 ymjA +0.5 2.3 hypothetical protein (NCBI) compare
b1040 csgD +0.5 1.3 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b3292 zntR +0.5 1.8 zinc-responsive transcriptional regulator (NCBI) compare
b1038 csgF +0.5 2.2 predicted transport protein (NCBI) compare
b4066 yjcF +0.5 0.5 hypothetical protein (NCBI) compare
b3195 yrbF +0.5 3.9 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1164 ycgZ +0.5 1.1 hypothetical protein (NCBI) compare
b1422 ydcI +0.5 3.0 putative transcriptional regulator LYSR-type (VIMSS) compare
b3293 yhdN +0.5 1.9 hypothetical protein (NCBI) compare
b1739 osmE +0.4 1.0 DNA-binding transcriptional activator (NCBI) compare
b1606 folM +0.4 3.8 short chain dehydrogenase (NCBI) compare
b1730 ydjO +0.4 0.9 predicted protein (RefSeq) compare
b3346 yheO +0.4 3.4 orf, hypothetical protein (VIMSS) compare
b3752 rbsK +0.4 3.7 ribokinase (NCBI) compare
b2156 lysP +0.4 3.7 lysine transporter (NCBI) compare
b1090 plsX +0.4 2.9 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b0949 uup +0.4 3.5 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2817 b2817 +0.4 2.9 putative amidase (VIMSS) compare
b1253 yciA +0.4 1.5 predicted hydrolase (NCBI) compare
b3929 rraA +0.4 3.5 ribonuclease activity regulator protein RraA (NCBI) compare
b1271 yciK +0.4 1.7 short chain dehydrogenase (NCBI) compare
b2494 yfgC +0.4 3.0 predicted peptidase (NCBI) compare
b2910 zapA +0.4 2.8 protein that localizes to the cytokinetic ring (NCBI) compare
b1954 dsrA +0.4 1.5 regulatory antisense RNA (NCBI) compare
b1438 ydcQ +0.4 1.7 predicted DNA-binding transcriptional regulator (RefSeq) compare
b0082 mraW +0.4 2.4 S-adenosyl-methyltransferase (NCBI) compare
b3803 hemX +0.4 3.5 predicted uroporphyrinogen III methylase (NCBI) compare
b0685 ybfE +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b3670 ilvN +0.4 3.0 acetolactate synthase small subunit (NCBI) compare
b1429 tehA +0.4 0.8 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3149 yraO +0.4 3.0 DnaA initiator-associating factor for replication initiation (NCBI) compare
b2742 nlpD +0.4 3.2 predicted outer membrane lipoprotein (NCBI) compare
b3456 livM +0.4 3.4 leucine/isoleucine/valine transporter subunit (NCBI) compare
b0852 rimK +0.4 2.3 ribosomal protein S6 modification protein (NCBI) compare
b1593 b1593 +0.4 1.9 orf, hypothetical protein (VIMSS) compare
b3107 yhaL +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b3631 rfaG +0.4 3.7 glucosyltransferase I (NCBI) compare
b4443 gcvB +0.4 0.3 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b2346 vacJ +0.4 3.0 predicted lipoprotein (NCBI) compare
b1890 motA +0.4 2.6 flagellar motor protein MotA (NCBI) compare
b4071 nrfB +0.4 1.1 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b2318 truA +0.4 1.4 tRNA pseudouridine synthase A (NCBI) compare
b1194 ycgR +0.4 1.6 protein involved in flagellar function (NCBI) compare
b1329 b1329 +0.4 2.5 putative transport periplasmic protein (VIMSS) compare
b4529 ydbJ +0.4 0.8 hypothetical protein (NCBI) compare
b0814 ompX +0.4 1.7 outer membrane protein X (NCBI) compare
b4158 yjeO +0.4 1.1 conserved inner membrane protein (NCBI) compare
b1952 dsrB +0.4 2.1 hypothetical protein (NCBI) compare
b0830 yliB +0.4 3.0 predicted peptide transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b2421 cysM +0.4 1.7 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b2661 gabD +0.4 2.8 succinate-semialdehyde dehydrogenase I, NADP-dependent (NCBI) compare
b4224 chpS +0.4 2.1 suppressor of inhibitory function of ChpB, PemI-like, autoregulated (VIMSS) compare
b1874 cutC +0.4 1.5 copper homeostasis protein (NCBI) compare
b4545 ypdJ +0.4 1.0 no description compare
b1433 b1433 +0.4 2.6 putative membrane transport protein (VIMSS) compare
b3146 yraL +0.4 2.9 predicted methyltransferase (NCBI) compare
b0605 ahpC +0.4 2.2 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3229 sspA +0.4 1.8 stringent starvation protein A (NCBI) compare
b0782 moaB +0.4 1.4 molybdopterin biosynthesis protein B (NCBI) compare
b1434 ydcN +0.4 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1418 cybB +0.4 1.3 cytochrome b(561) (VIMSS) compare
b4163 glyV +0.4 1.2 tRNA-Gly (NCBI) compare
b4450 arcZ +0.4 1.7 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b0219 yafV +0.4 2.3 predicted C-N hydrolase family amidase, NAD(P)-binding (NCBI) compare
b2189 proL +0.4 1.2 tRNA-Pro (NCBI) compare
b2944 sprT +0.4 1.9 hypothetical protein (NCBI) compare
b3102 yqjG +0.4 2.0 predicted S-transferase (NCBI) compare
b2474 ypfI +0.4 2.7 predicted hydrolase (NCBI) compare
b4461 yfjD +0.4 2.9 predicted inner membrane protein (RefSeq) compare
b0791 ybhQ +0.4 0.9 predicted inner membrane protein (NCBI) compare
b4373 rimI +0.4 1.9 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b4630 ykgP +0.4 1.3 no description compare
b1358 ydaT +0.4 0.8 Rac prophage; predicted protein (NCBI) compare
b2611 ypjD +0.4 2.5 predicted inner membrane protein (RefSeq) compare
b3617 kbl +0.4 2.6 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b4011 yjaA +0.4 1.7 hypothetical protein (NCBI) compare
b4594 ymgJ +0.4 1.2 hypothetical protein (RefSeq) compare
b1390 paaC +0.4 1.9 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b3455 livG +0.4 2.2 leucine/isoleucine/valine transporter subunit (NCBI) compare
b3071 yqjI +0.3 1.7 predicted transcriptional regulator (NCBI) compare
b3686 ibpB +0.3 2.0 heat shock chaperone (NCBI) compare
b0190 yaeQ +0.3 2.4 hypothetical protein (NCBI) compare
b1992 cobS +0.3 1.4 cobalamin synthase (NCBI) compare
b2175 spr +0.3 1.3 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b3928 yiiU +0.3 2.0 hypothetical protein (NCBI) compare
b1248 b1248 +0.3 1.5 orf, hypothetical protein (VIMSS) compare
b4256 yjgM +0.3 2.8 predicted acetyltransferase (NCBI) compare
b2605 yfiB +0.3 1.8 predicted outer membrane lipoprotein (NCBI) compare
b2127 mlrA +0.3 2.3 DNA-binding transcriptional regulator (NCBI) compare
b4570 lomR +0.3 0.9 no description compare
b3515 gadW +0.3 3.0 DNA-binding transcriptional activator (NCBI) compare
b1475 fdnH +0.3 2.1 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible (NCBI) compare
b1743 spy +0.3 1.4 envelope stress induced periplasmic protein (NCBI) compare
b3625 rfaY +0.3 2.0 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2579 yfiD +0.3 1.0 pyruvate formate lyase subunit (NCBI) compare
b1189 dadA +0.3 2.0 D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) compare
b2572 rseA +0.3 1.4 anti-sigma factor (NCBI) compare
b2061 wzb +0.3 1.2 protein-tyrosine phosphatase (NCBI) compare
b3213 gltD +0.3 2.3 glutamate synthase, 4Fe-4S protein, small subunit (NCBI) compare
b2409 yfeR +0.3 2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b4137 cutA +0.3 2.4 copper binding protein, copper sensitivity (NCBI) compare
b1914 uvrY +0.3 2.0 response regulator (NCBI) compare
b1790 yeaM +0.3 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3457 livH +0.3 2.5 leucine/isoleucine/valine transporter subunit (NCBI) compare
b3934 cytR +0.3 2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b1037 csgG +0.3 2.5 outer membrane lipoprotein (NCBI) compare
b3166 truB +0.3 2.1 tRNA pseudouridine synthase B (NCBI) compare
b2262 menB +0.3 1.2 naphthoate synthase (NCBI) compare
b4538 yoeF +0.3 1.0 hypothetical protein (RefSeq) compare
b3627 rfaI +0.3 2.5 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b2319 usg +0.3 1.8 hypothetical protein (NCBI) compare
b2948 yqgE +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b1485 ddpC +0.3 1.6 D-ala-D-ala transporter subunit (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For carbon source Ying_OrganicAcid7 in Escherichia coli BW25113

For carbon source Ying_OrganicAcid7 across organisms