Experiment set57IT007 for Escherichia coli BW25113

Compare to:

Ying_OrganicAcid7 rep A; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b2808 gcvA +2.6 15.3 DNA-binding transcriptional dual regulator (NCBI) compare
b2903 gcvP +2.4 22.2 glycine dehydrogenase (NCBI) compare
b2904 gcvH +2.3 13.0 glycine cleavage system protein H (NCBI) compare
b2905 gcvT +2.2 18.2 glycine cleavage system aminomethyltransferase T (NCBI) compare
b2741 rpoS +2.0 15.3 RNA polymerase sigma factor (NCBI) compare
b2951 yggS +2.0 13.6 predicted enzyme (NCBI) compare
b4402 yjjY +1.5 2.0 hypothetical protein (NCBI) compare
b3979 thrT +1.4 1.6 tRNA-Thr (NCBI) compare
b4172 hfq +1.4 2.4 RNA-binding protein Hfq (NCBI) compare
b1095 fabF +1.4 12.3 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3164 pnp +1.3 7.7 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2688 gshA +1.2 10.0 glutamate--cysteine ligase (NCBI) compare
b2947 gshB +1.2 8.2 glutathione synthetase (NCBI) compare
b1831 proQ +1.2 4.2 putative solute/DNA competence effector (NCBI) compare
b0059 hepA +1.1 10.4 ATP-dependent helicase HepA (NCBI) compare
b4203 rplI +1.1 7.1 50S ribosomal protein L9 (NCBI) compare
b4030 yjbA +1.0 6.7 phosphate-starvation-inducible protein PsiE (NCBI) compare
b2829 ptsP +1.0 8.5 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1190 dadX +1.0 5.5 alanine racemase (NCBI) compare
b2642 yfjW +0.9 1.0 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b3341 rpsG +0.9 2.0 30S ribosomal protein S7 (NCBI) compare
b3181 greA +0.9 6.4 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1085 b1085 +0.8 2.2 orf, hypothetical protein (VIMSS) compare
b2937 speB +0.8 6.1 agmatinase (NCBI) compare
b3741 gidA +0.8 5.3 glucose-inhibited division protein A (NCBI) compare
b0882 clpA +0.8 7.1 ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity (NCBI) compare
b3842 rfaH +0.8 5.2 transcriptional activator RfaH (NCBI) compare
b1855 lpxM +0.8 5.7 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b1294 sapA +0.8 5.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1422 ydcI +0.8 5.5 putative transcriptional regulator LYSR-type (VIMSS) compare
b1429 tehA +0.8 1.5 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1236 galU +0.8 4.7 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2114 metG +0.8 1.5 methionyl-tRNA synthetase (NCBI) compare
b0503 ybbB +0.8 3.5 tRNA 2-selenouridine synthase, selenophosphate-dependent (NCBI) compare
b0889 lrp +0.8 3.1 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b3658 selC +0.7 3.5 tRNA-Sec (NCBI) compare
b0082 mraW +0.7 3.0 S-adenosyl-methyltransferase (NCBI) compare
b1191 b1191 +0.7 5.4 orf, hypothetical protein (VIMSS) compare
b1824 yobF +0.7 3.7 hypothetical protein (NCBI) compare
b0955 ycbZ +0.7 5.8 predicted peptidase (NCBI) compare
b1582 ynfA +0.7 2.0 hypothetical protein (NCBI) compare
b4552 yrhC +0.7 1.1 no description compare
b3778 rep +0.7 4.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1765 ydjA +0.6 1.0 predicted oxidoreductase (NCBI) compare
b1961 dcm +0.6 2.0 DNA cytosine methylase (NCBI) compare
b1438 ydcQ +0.6 2.3 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2659 b2659 +0.6 2.0 orf, hypothetical protein (VIMSS) compare
b1465 narV +0.6 2.3 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b0605 ahpC +0.6 2.9 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4655 ythA +0.6 0.9 expressed protein (RefSeq) compare
b3194 yrbE +0.6 4.6 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b4614 sokA +0.6 1.9 no description compare
b3752 rbsK +0.6 4.9 ribokinase (NCBI) compare
b3454 livF +0.6 3.3 ATP-binding component of leucine transport (VIMSS) compare
b1793 yoaF +0.6 1.5 conserved outer membrane protein (NCBI) compare
b1334 fnr +0.6 2.0 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4570 lomR +0.6 1.4 no description compare
b1382 ynbE +0.6 1.5 predicted lipoprotein (NCBI) compare
b1450 b1450 +0.6 3.0 orf, hypothetical protein (VIMSS) compare
b0542 renD +0.6 1.6 orf, hypothetical protein (VIMSS) compare
b1134 ymfB +0.6 2.0 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b1222 narX +0.6 3.7 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b4000 hupA +0.6 2.7 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b3616 tdh +0.5 3.0 L-threonine 3-dehydrogenase (NCBI) compare
b3780 rhlB +0.5 5.0 ATP-dependent RNA helicase (NCBI) compare
b1822 rrmA +0.5 2.0 23S rRNA m1G745 methyltransferase (NCBI) compare
b1916 sdiA +0.5 4.4 DNA-binding transcriptional activator (NCBI) compare
b3632 rfaQ +0.5 5.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4522 yciX_1 +0.5 1.3 hypothetical protein (NCBI) compare
b3753 rbsR +0.5 4.5 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b3455 livG +0.5 3.4 leucine/isoleucine/valine transporter subunit (NCBI) compare
b1725 yniA +0.5 2.4 predicted phosphotransferase/kinase (NCBI) compare
b2209 eco +0.5 1.7 ecotin precursor (NCBI) compare
b1874 cutC +0.5 1.5 copper homeostasis protein (NCBI) compare
b1557 cspB +0.5 1.3 Qin prophage; cold shock protein (NCBI) compare
b1350 recE +0.5 3.3 Rac prophage; exonuclease VIII, 5' -> 3' specific dsDNA exonuclease (NCBI) compare
b0783 moaC +0.5 3.3 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3102 yqjG +0.5 2.5 predicted S-transferase (NCBI) compare
b0471 ybaB +0.5 2.3 hypothetical protein (NCBI) compare
b1634 tppB +0.5 3.2 putative tripeptide transporter permease (NCBI) compare
b3468 yhhN +0.5 4.4 conserved inner membrane protein (NCBI) compare
b1607 ydgC +0.5 1.2 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b0696 kdpC +0.5 1.6 potassium-transporting ATPase subunit C (NCBI) compare
b3523 yhjE +0.5 4.3 predicted transporter (NCBI) compare
b2620 smpB +0.5 1.1 SsrA-binding protein (NCBI) compare
b0685 ybfE +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b1333 uspE +0.5 1.8 stress-induced protein (NCBI) compare
b2576 srmB +0.5 2.0 ATP-dependent RNA helicase (NCBI) compare
b3934 cytR +0.5 4.1 DNA-binding transcriptional dual regulator (NCBI) compare
b0995 torR +0.5 2.0 DNA-binding response regulator in two-component regulatory system with TorS (NCBI) compare
b2007 yeeX +0.5 0.9 conserved protein (RefSeq) compare
b0381 ddlA +0.5 3.3 D-alanylalanine synthetase (NCBI) compare
b2579 yfiD +0.5 2.0 pyruvate formate lyase subunit (NCBI) compare
b3387 dam +0.5 4.2 DNA adenine methylase (NCBI) compare
b1914 uvrY +0.5 3.5 response regulator (NCBI) compare
b0785 moaE +0.5 3.0 molybdopterin synthase, large subunit (NCBI) compare
b3644 yicC +0.5 3.3 hypothetical protein (NCBI) compare
b0099 mutT +0.5 2.7 nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP (NCBI) compare
b3195 yrbF +0.5 4.2 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0178 hlpA +0.5 3.2 periplasmic chaperone (NCBI) compare
b3630 rfaP +0.5 4.0 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1821 b1821 +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b3197 kdsD +0.5 3.7 D-arabinose 5-phosphate isomerase (NCBI) compare
b2698 recX +0.5 1.7 RecA regulator RecX (NCBI) compare
b1575 dicB +0.5 1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b4503 yafF +0.5 0.7 no description compare
b1558 cspF +0.5 1.5 Qin prophage; cold shock protein (NCBI) compare
b2183 rsuA +0.5 1.8 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b3206 npr +0.5 3.2 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b2494 yfgC +0.5 3.1 predicted peptidase (NCBI) compare
b1189 dadA +0.4 3.5 D-amino acid dehydrogenase (quinone) DadA (EC 1.4.5.1) (from data) compare
b4202 rpsR +0.4 0.9 30S ribosomal protein S18 (NCBI) compare
b3706 trmE +0.4 2.5 tRNA modification GTPase (NCBI) compare
b1984 asnW +0.4 0.9 tRNA-Asn (NCBI) compare
b4613 dinQ +0.4 1.2 Damage inducible, function unknown (RefSeq) compare
b3911 cpxA +0.4 3.6 two-component sensor protein (NCBI) compare
b1591 b1591 +0.4 1.6 putative oxidoreductase component (VIMSS) compare
b1341 b1341 +0.4 2.9 orf, hypothetical protein (VIMSS) compare
b0580 ybdJ +0.4 1.5 predicted inner membrane protein (NCBI) compare
b3229 sspA +0.4 2.0 stringent starvation protein A (NCBI) compare
b4653 yicT +0.4 1.0 no description compare
b2572 rseA +0.4 2.1 anti-sigma factor (NCBI) compare
b1602 pntB +0.4 3.1 pyridine nucleotide transhydrogenase (NCBI) compare
b2005 yeeV +0.4 2.6 CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b2156 lysP +0.4 3.6 lysine transporter (NCBI) compare
b2474 ypfI +0.4 3.2 predicted hydrolase (NCBI) compare
b2538 hcaE +0.4 2.2 3-phenylpropionate dioxygenase, large (alpha) subunit (NCBI) compare
b4260 pepA +0.4 3.6 leucyl aminopeptidase (NCBI) compare
b4450 arcZ +0.4 2.1 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b0238 gpt +0.4 1.7 xanthine phosphoribosyltransferase (NCBI) compare
b3929 rraA +0.4 3.0 ribonuclease activity regulator protein RraA (NCBI) compare
b2565 recO +0.4 2.6 DNA repair protein RecO (NCBI) compare
b2521 sseA +0.4 3.3 putative thiosulfate sulfurtransferase (VIMSS) compare
b4436 ryeC +0.4 1.2 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b3933 ftsN +0.4 3.5 essential cell division protein (NCBI) compare
b0295 ykgL +0.4 2.8 hypothetical protein (NCBI) compare
b1176 minC +0.4 1.1 septum formation inhibitor (NCBI) compare
b2199 ccmC +0.4 1.5 heme exporter subunit (NCBI) compare
b3192 yrbC +0.4 3.2 predicted ABC-type organic solvent transporter (NCBI) compare
b1955 yedP +0.4 1.7 hypothetical protein (NCBI) compare
b1485 ddpC +0.4 2.2 D-ala-D-ala transporter subunit (NCBI) compare
b2450 yffS +0.4 1.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b2017 yefM +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b1946 fliN +0.4 1.6 flagellar motor switch protein (NCBI) compare
b1253 yciA +0.4 1.4 predicted hydrolase (NCBI) compare
b1153 ymfQ +0.4 1.1 e14 prophage; conserved protein (NCBI) compare
b3672 ivbL +0.4 0.9 ilvB operon leader peptide (NCBI) compare
b2935 tktA +0.4 1.3 transketolase 1, thiamin-binding (NCBI) compare
b1302 puuE +0.4 1.8 GABA aminotransferase, PLP-dependent (NCBI) compare
b3627 rfaI +0.4 3.2 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b4094 phnN +0.4 1.8 ribose 1,5-bisphosphokinase (NCBI) compare
b2954 yggV +0.4 1.1 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b1883 cheB +0.4 2.1 chemotaxis-specific methylesterase (NCBI) compare
b3193 yrbD +0.4 3.2 predicted ABC-type organic solvent transporter (NCBI) compare
b1406 ydbC +0.4 2.1 predicted oxidoreductase, NAD(P)-binding (NCBI) compare
b2643 yfjX +0.4 1.3 CP4-57 prophage; predicted antirestriction protein (NCBI) compare
b2428 yfeU +0.4 1.9 N-acetylmuramic acid-6-phosphate etherase (NCBI) compare
b3456 livM +0.4 3.2 leucine/isoleucine/valine transporter subunit (NCBI) compare
b3243 aaeR +0.4 2.2 predicted DNA-binding transcriptional regulator, efflux system (NCBI) compare
b3867 hemN +0.4 3.4 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b3191 yrbB +0.4 3.2 orf, hypothetical protein (VIMSS) compare
b2303 folX +0.4 3.0 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b1329 b1329 +0.4 2.6 putative transport periplasmic protein (VIMSS) compare
b4158 yjeO +0.4 1.5 conserved inner membrane protein (NCBI) compare
b4353 yjiX +0.4 2.3 hypothetical protein (NCBI) compare
b0058 rluA +0.4 2.4 pseudouridine synthase for 23S rRNA (position 746) and tRNAphe(position 32) (NCBI) compare
b1286 rnb +0.4 1.7 exoribonuclease II (NCBI) compare
b4695 ykgT +0.4 1.3 no description compare
b4294 insA-7 +0.4 1.3 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b3133 agaV +0.4 1.5 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b3803 hemX +0.4 3.1 predicted uroporphyrinogen III methylase (NCBI) compare
b0862 artQ +0.4 1.0 arginine transporter subunit (NCBI) compare
b0469 apt +0.4 2.7 adenine phosphoribosyltransferase (NCBI) compare
b3280 yrdB +0.4 1.3 hypothetical protein (NCBI) compare
b2754 ygbF +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b4558 yifL +0.4 1.8 predicted lipoprotein (NCBI) compare
b3469 zntA +0.4 2.5 zinc, cobalt and lead efflux system (NCBI) compare
b0352 mhpE +0.4 2.2 4-hydroxy-2-ketovalerate aldolase (NCBI) compare
b1610 tus +0.4 1.8 DNA replication terminus site-binding protein (NCBI) compare
b1038 csgF +0.4 1.4 predicted transport protein (NCBI) compare
b1399 paaX +0.4 1.9 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b1823 cspC +0.4 0.8 stress protein, member of the CspA-family (NCBI) compare
b0183 rnhB +0.4 1.0 ribonuclease HII (NCBI) compare
b0880 cspD +0.4 0.9 cold shock protein homolog (NCBI) compare
b1819 manZ +0.4 1.6 mannose-specific enzyme IID component of PTS (NCBI) compare
b2101 yegW +0.4 1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4045 yjbJ +0.4 1.3 predicted stress response protein (NCBI) compare
b0443 ybaW +0.4 2.6 hypothetical protein (NCBI) compare
b2262 menB +0.4 1.6 naphthoate synthase (NCBI) compare
b2318 truA +0.4 1.4 tRNA pseudouridine synthase A (NCBI) compare
b1130 phoP +0.4 0.9 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b0852 rimK +0.4 2.3 ribosomal protein S6 modification protein (NCBI) compare
b3293 yhdN +0.4 1.3 hypothetical protein (NCBI) compare
b1187 fadR +0.3 1.8 fatty acid metabolism regulator (NCBI) compare
b2906 visC +0.3 2.4 hypothetical protein (NCBI) compare
b1613 manA +0.3 1.0 mannose-6-phosphate isomerase (VIMSS) compare
b2440 eutC +0.3 2.4 ethanolamine ammonia-lyase small subunit (NCBI) compare
b1418 cybB +0.3 1.3 cytochrome b(561) (VIMSS) compare
b1684 sufA +0.3 1.0 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b3146 yraL +0.3 2.6 predicted methyltransferase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in carbon source experiments

For carbon source Ying_OrganicAcid7 across organisms