Experiment set57IT006 for Escherichia coli BW25113

Compare to:

Ying_AminoAcid20 rep C; time point 1

200 most important genes:

  gene name fitness t score description  
b2499 purM -4.2 -6.2 phosphoribosylaminoimidazole synthetase (NCBI) compare
b0726 sucA -4.0 -7.7 alpha-ketoglutarate decarboxylase (NCBI) compare
b0522 purK -3.8 -10.9 phosphoribosylaminoimidazole carboxylase (NCBI) compare
b2557 purL -3.7 -13.4 phosphoribosylformylglycinamidine synthase (NCBI) compare
b4006 purH -3.6 -15.5 bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) compare
b3642 pyrE -3.6 -6.1 orotate phosphoribosyltransferase (NCBI) compare
b4232 fbp -3.4 -13.9 fructose-1,6-bisphosphatase (NCBI) compare
b0523 purE -3.4 -5.5 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b0945 pyrD -3.3 -13.5 dihydroorotate dehydrogenase (NCBI) compare
b1192 ldcA -3.1 -6.8 L,D-carboxypeptidase A (NCBI) compare
b1281 pyrF -3.1 -5.0 orotidine 5'-phosphate decarboxylase (NCBI) compare
b1062 pyrC -3.0 -10.4 dihydroorotase (NCBI) compare
b2312 purF -3.0 -6.5 amidophosphoribosyltransferase (NCBI) compare
b4005 purD -2.9 -8.0 phosphoribosylamine--glycine ligase (NCBI) compare
b4245 pyrB -2.8 -12.4 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b0564 appY -2.8 -1.2 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b0033 carB -2.6 -14.8 carbamoyl-phosphate synthase large subunit (NCBI) compare
b2282 nuoH -2.6 -3.7 NADH dehydrogenase subunit H (NCBI) compare
b0739 tolA -2.6 -6.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2476 purC -2.6 -3.4 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b4676 yoaK -2.5 -1.2 expressed protein (RefSeq) compare
b2276 nuoN -2.3 -7.1 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1291 sapD -2.3 -4.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0738 tolR -2.2 -5.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0114 aceE -2.2 -2.5 pyruvate dehydrogenase subunit E1 (NCBI) compare
b4146 yjeK -2.2 -4.8 predicted lysine aminomutase (NCBI) compare
b0032 carA -2.1 -6.9 carbamoyl-phosphate synthase small subunit (NCBI) compare
b2500 purN -2.1 -6.7 phosphoribosylglycinamide formyltransferase (NCBI) compare
b1130 phoP -2.1 -3.6 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1551 b1551 -2.0 -1.3 orf, hypothetical protein (VIMSS) compare
b2518 ndk -2.0 -3.5 nucleoside diphosphate kinase (NCBI) compare
b0729 sucD -2.0 -5.0 succinyl-CoA synthetase subunit alpha (NCBI) compare
b4177 purA -2.0 -1.4 adenylosuccinate synthetase (NCBI) compare
b4139 aspA -1.9 -9.8 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b2277 nuoM -1.9 -6.2 NADH dehydrogenase subunit M (NCBI) compare
b2278 nuoL -1.9 -10.2 NADH dehydrogenase subunit L (NCBI) compare
b0200 gmhB -1.9 -3.0 hypothetical protein (NCBI) compare
b3082 ygjM -1.9 -2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1058 yceO -1.9 -0.9 hypothetical protein (NCBI) compare
b1332 ynaJ -1.9 -1.3 predicted inner membrane protein (NCBI) compare
b1346 ydaQ -1.8 -2.7 orf, hypothetical protein (VIMSS) compare
b0728 sucC -1.7 -8.6 succinyl-CoA synthetase subunit beta (NCBI) compare
b2283 nuoG -1.7 -8.1 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2281 nuoI -1.7 -3.0 NADH dehydrogenase subunit I (NCBI) compare
b2853 ygeI -1.7 -1.0 hypothetical protein (NCBI) compare
b3021 ygiT -1.7 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3236 mdh -1.7 -9.5 malate dehydrogenase (NCBI) compare
b2287 nuoB -1.7 -3.4 NADH dehydrogenase subunit B (NCBI) compare
b1545 pinQ -1.6 -0.5 Qin prophage; predicted site-specific recombinase (NCBI) compare
b2284 nuoF -1.6 -5.7 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b4155 yjeA -1.6 -1.9 putative lysyl-tRNA synthetase (VIMSS) compare
b3806 cyaA -1.6 -5.6 adenylate cyclase (NCBI) compare
b1182 hlyE -1.6 -1.1 hemolysin E (VIMSS) compare
b0437 clpP -1.6 -6.8 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b2286 nuoC -1.6 -5.6 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b3027 ygiZ -1.6 -1.0 conserved inner membrane protein (NCBI) compare
b3443 yrhA -1.5 -2.8 orf, hypothetical protein (VIMSS) compare
b1165 ymgA -1.5 -1.0 hypothetical protein (NCBI) compare
b2350 yfdG -1.5 -5.9 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b0303 ykgI -1.4 -1.0 orf, hypothetical protein (VIMSS) compare
b3792 wzxE -1.4 -6.5 O-antigen translocase (NCBI) compare
b3839 tatC -1.4 -6.1 TatABCE protein translocation system subunit (NCBI) compare
b0741 pal -1.4 -5.1 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b2285 nuoE -1.4 -2.7 NADH dehydrogenase subunit E (NCBI) compare
b3725 pstB -1.3 -0.9 phosphate transporter subunit (NCBI) compare
b4042 dgkA -1.3 -2.5 diacylglycerol kinase (NCBI) compare
b0730 mngR -1.3 -2.3 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0737 tolQ -1.3 -2.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2859 ygeO -1.3 -3.3 hypothetical protein (RefSeq) compare
b2279 nuoK -1.3 -2.0 NADH dehydrogenase subunit K (NCBI) compare
b3500 gor -1.3 -2.0 glutathione reductase (NCBI) compare
b2280 nuoJ -1.3 -5.2 NADH dehydrogenase subunit J (NCBI) compare
b2652 ileY -1.3 -1.4 tRNA-Ile (NCBI) compare
b0890 ftsK -1.2 -5.9 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2329 aroC -1.2 -4.7 chorismate synthase (NCBI) compare
b0740 tolB -1.2 -4.9 translocation protein TolB precursor (NCBI) compare
b2288 nuoA -1.2 -2.6 NADH dehydrogenase I chain A (VIMSS) compare
b0724 sdhB -1.2 -5.7 succinate dehydrogenase, FeS subunit (NCBI) compare
b3764 yifE -1.2 -4.2 hypothetical protein (NCBI) compare
b0630 lipB -1.2 -1.8 protein of lipoate biosynthesis (VIMSS) compare
b4066 yjcF -1.2 -0.8 hypothetical protein (NCBI) compare
b0928 aspC -1.1 -6.0 aspartate aminotransferase, PLP-dependent (NCBI) compare
b0723 sdhA -1.1 -6.9 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b4505 insX -1.1 -2.1 predicted IS protein (RefSeq) compare
b0817 mntR -1.1 -4.1 DNA-binding transcriptional regulator of mntH (NCBI) compare
b4647 mokA -1.1 -1.0 no description compare
b0438 clpX -1.1 -6.7 ATP-dependent protease ATP-binding subunit (NCBI) compare
b2504 yfgG -1.1 -2.0 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b3977 tyrU -1.1 -1.2 tRNA-Tyr (NCBI) compare
b4593 ymgI -1.1 -0.9 hypothetical protein (RefSeq) compare
b2935 tktA -1.0 -2.7 transketolase 1, thiamin-binding (NCBI) compare
b4128 yjdK -1.0 -0.7 hypothetical protein (NCBI) compare
b0722 sdhD -1.0 -3.0 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b0720 gltA -1.0 -4.6 citrate synthase (NCBI) compare
b4590 ybfK -1.0 -1.1 hypothetical protein (RefSeq) compare
b1235 rssB -1.0 -6.0 response regulator of RpoS (NCBI) compare
b2318 truA -1.0 -2.9 tRNA pseudouridine synthase A (NCBI) compare
b1084 rne -0.9 -4.2 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b3624 rfaZ -0.9 -2.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1347 ydaC -0.9 -0.5 Rac prophage; predicted protein (NCBI) compare
b1785 yeaI -0.9 -3.3 predicted diguanylate cyclase (NCBI) compare
b2567 rnc -0.9 -1.1 ribonuclease III (NCBI) compare
b0088 murD -0.9 -2.2 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0401 brnQ -0.9 -5.6 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b2313 cvpA -0.9 -3.6 membrane protein required for colicin V production (NCBI) compare
b3238 yhcN -0.9 -2.5 orf, hypothetical protein (VIMSS) compare
b0242 proB -0.9 -4.1 gamma-glutamyl kinase (NCBI) compare
b2528 iscA -0.9 -1.8 iron-sulfur cluster assembly protein (NCBI) compare
b0721 sdhC -0.9 -5.3 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b2501 ppk -0.9 -5.7 polyphosphate kinase (NCBI) compare
b1506 yneL -0.9 -1.2 predicted transcriptional regulator (NCBI) compare
b0439 lon -0.9 -3.5 DNA-binding ATP-dependent protease La (NCBI) compare
b0750 nadA -0.8 -4.6 quinolinate synthetase (NCBI) compare
b2297 pta -0.8 -0.6 phosphate acetyltransferase (NCBI) compare
b1984 asnW -0.8 -1.2 tRNA-Asn (NCBI) compare
b3205 yhbJ -0.8 -3.0 hypothetical protein (NCBI) compare
b1778 yeaA -0.8 -1.8 methionine sulfoxide reductase B (NCBI) compare
b4451 ryhB -0.8 -0.6 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b2340 sixA -0.8 -3.1 phosphohistidine phosphatase (NCBI) compare
b4535 yniD -0.8 -1.1 predicted protein (RefSeq) compare
b0705 ybfL -0.8 -0.5 putative receptor protein (VIMSS) compare
b2830 nudH -0.8 -1.0 dinucleoside polyphosphate hydrolase (NCBI) compare
b3169 nusA -0.8 -2.7 transcription elongation factor NusA (NCBI) compare
b1190 dadX -0.8 -3.7 alanine racemase (NCBI) compare
b4435 isrC -0.8 -1.7 unknown RNA (NCBI) compare
b1257 yciE -0.8 -0.5 hypothetical protein (NCBI) compare
b1292 sapC -0.8 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1951 rcsA -0.8 -1.6 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b2820 recB -0.8 -1.5 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b4313 fimE -0.8 -4.6 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b1151 ymfO -0.8 -3.8 e14 prophage; conserved protein (RefSeq) compare
b1290 sapF -0.8 -1.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4596 yciZ -0.7 -1.2 hypothetical protein (RefSeq) compare
b4215 ytfI -0.7 -1.8 hypothetical protein (NCBI) compare
b0149 mrcB -0.7 -5.7 penicillin-binding protein 1b (NCBI) compare
b3414 gntY -0.7 -3.8 predicted gluconate transport associated protein (NCBI) compare
b3237 argR -0.7 -2.9 arginine repressor (NCBI) compare
b2025 hisF -0.7 -3.0 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b1187 fadR -0.7 -2.0 fatty acid metabolism regulator (NCBI) compare
b1524 yneH -0.7 -0.9 predicted glutaminase (NCBI) compare
b4375 prfC -0.7 -3.0 peptide chain release factor 3 (NCBI) compare
b2584 yfiQ -0.7 -5.0 fused predicted acyl-CoA synthetase: NAD(P)-binding subunit/ATP-binding subunit (NCBI) compare
b4208 cycA -0.7 -4.9 D-alanine/D-serine/glycine transporter (NCBI) compare
b4179 vacB -0.7 -3.7 putative enzyme (VIMSS) compare
b1121 ycfZ -0.7 -1.6 predicted inner membrane protein (NCBI) compare
b3290 trkA -0.7 -1.8 potassium transporter peripheral membrane component (NCBI) compare
b4481 rffT -0.7 -3.2 4-alpha-L-fucosyltransferase (NCBI) compare
b4039 ubiC -0.7 -4.2 chorismate lyase (VIMSS) compare
b1293 sapB -0.7 -1.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1863 ruvC -0.7 -1.4 Holliday junction resolvase (NCBI) compare
b1503 ydeR -0.7 -2.6 predicted fimbrial-like adhesin protein (NCBI) compare
b4480 hdfR -0.7 -2.8 transcriptional regulator HdfR (NCBI) compare
b3204 ptsN -0.7 -2.8 sugar-specific enzyme IIA component of PTS (NCBI) compare
b1109 ndh -0.7 -3.1 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b4651 yibW -0.7 -0.4 no description compare
b1502 ydeQ -0.7 -1.6 predicted fimbrial-like adhesin protein (NCBI) compare
b0658 ybeX -0.7 -1.4 predicteed ion transport (NCBI) compare
b2822 recC -0.6 -2.9 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b0428 cyoE -0.6 -3.2 protoheme IX farnesyltransferase (NCBI) compare
b0585 fes -0.6 -3.2 enterobactin/ferric enterobactin esterase (NCBI) compare
b1576 ydfD -0.6 -0.4 Qin prophage; predicted protein (NCBI) compare
b3281 aroE -0.6 -5.1 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b0908 aroA -0.6 -3.9 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b3728 pstS -0.6 -2.1 phosphate transporter subunit (NCBI) compare
b1847 yebF -0.6 -0.7 predicted protein (RefSeq) compare
b4191 ulaR -0.6 -2.1 DNA-binding transcriptional dual regulator (NCBI) compare
b4552 yrhC -0.6 -0.6 no description compare
b0243 proA -0.6 -4.1 gamma-glutamyl phosphate reductase (NCBI) compare
b0688 pgm -0.6 -2.7 phosphoglucomutase (NCBI) compare
b4246 pyrL -0.6 -1.0 pyrBI operon leader peptide (NCBI) compare
b0109 nadC -0.6 -3.6 nicotinate-nucleotide pyrophosphorylase (NCBI) compare
b2912 ygfA -0.6 -1.7 putative ligase (VIMSS) compare
b3623 rfaK -0.6 -1.8 lipopolysaccharide core biosynthesis (NCBI) compare
b0707 ybgA -0.6 -1.2 hypothetical protein (NCBI) compare
b2684 mprA -0.6 -3.0 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b3390 aroK -0.6 -1.4 shikimate kinase I (NCBI) compare
b1936 intG -0.6 -0.7 predicted defective phage integrase (pseudogene) (RefSeq) compare
b3232 yhcM -0.6 -3.9 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b2939 yqgB -0.6 -0.9 predicted protein (RefSeq) compare
b3621 rfaC -0.6 -2.9 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b2168 fruK -0.6 -0.9 1-phosphofructokinase (NCBI) compare
b3389 aroB -0.6 -4.1 3-dehydroquinate synthase (NCBI) compare
b3863 polA -0.6 -0.8 DNA polymerase I (NCBI) compare
b4546 ypeB -0.6 -0.9 hypothetical protein (NCBI) compare
b0990 cspG -0.6 -0.6 DNA-binding transcriptional regulator (NCBI) compare
b4551 yheV -0.6 -1.2 hypothetical protein (NCBI) compare
b4431 rprA -0.6 -1.3 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b3860 dsbA -0.6 -3.8 periplasmic protein disulfide isomerase I (NCBI) compare
b2699 recA -0.6 -0.9 recombinase A (NCBI) compare
b0957 ompA -0.6 -1.8 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b0080 fruR -0.5 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b3844 fre -0.5 -2.7 NAD(P)H-flavin reductase (NCBI) compare
b3811 xerC -0.5 -1.1 site-specific tyrosine recombinase XerC (NCBI) compare
b3062 ttdB -0.5 -2.6 L(+)-tartrate dehydratase (NCBI) compare
b0588 fepC -0.5 -3.6 iron-enterobactin transporter subunit (NCBI) compare
b1499 ydeO -0.5 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b1304 pspA -0.5 -1.4 regulatory protein for phage-shock-protein operon (NCBI) compare
b1696 ydiP -0.5 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1129 phoQ -0.5 -1.4 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b2426 ucpA -0.5 -1.2 putative oxidoreductase (VIMSS) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in carbon source experiments

For carbon source Ying_AminoAcid20 across organisms