Experiment set57IT004 for Escherichia coli BW25113

Compare to:

Ying_AminoAcid20 rep A; time point 1

200 most detrimental genes:

  gene name fitness t score description  
b3261 fis +1.7 7.5 DNA-binding protein Fis (NCBI) compare
b3341 rpsG +1.6 2.4 30S ribosomal protein S7 (NCBI) compare
b4647 mokA +1.4 1.9 no description compare
b3500 gor +1.1 3.3 glutathione reductase (NCBI) compare
b3229 sspA +1.1 3.8 stringent starvation protein A (NCBI) compare
b2642 yfjW +1.0 1.9 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1823 cspC +1.0 3.0 stress protein, member of the CspA-family (NCBI) compare
b2259 pmrD +0.9 1.7 polymyxin resistance protein B (VIMSS) compare
b2741 rpoS +0.9 6.4 RNA polymerase sigma factor (NCBI) compare
b1422 ydcI +0.9 5.6 putative transcriptional regulator LYSR-type (VIMSS) compare
b0014 dnaK +0.9 2.4 molecular chaperone DnaK (NCBI) compare
b1183 umuD +0.8 1.5 DNA polymerase V, subunit D (NCBI) compare
b4585 sroB +0.8 1.8 Novel sRNA, function unknown (RefSeq) compare
b1429 tehA +0.8 0.9 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1954 dsrA +0.8 2.6 regulatory antisense RNA (NCBI) compare
b0912 ihfB +0.8 4.1 integration host factor subunit beta (NCBI) compare
b3120 yhaB +0.8 2.3 orf, hypothetical protein (VIMSS) compare
b2911 ssrS +0.7 1.7 6S regulatory RNA (NCBI) compare
b1765 ydjA +0.7 1.1 predicted oxidoreductase (NCBI) compare
b0508 hyi +0.7 3.9 hydroxypyruvate isomerase (NCBI) compare
b2814 metZ +0.7 1.9 tRNA-Met (NCBI) compare
b1476 fdnI +0.7 1.2 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1550 b1550 +0.7 1.5 orf, hypothetical protein (VIMSS) compare
b1273 yciN +0.7 1.7 hypothetical protein (NCBI) compare
b2055 wcaE +0.7 0.6 predicted glycosyl transferase (NCBI) compare
b4171 miaA +0.7 2.7 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1946 fliN +0.7 1.7 flagellar motor switch protein (NCBI) compare
b1302 puuE +0.7 2.7 GABA aminotransferase, PLP-dependent (NCBI) compare
b4128 yjdK +0.6 1.0 hypothetical protein (NCBI) compare
b4655 ythA +0.6 1.0 expressed protein (RefSeq) compare
b1739 osmE +0.6 1.9 DNA-binding transcriptional activator (NCBI) compare
b0806 ybiM +0.6 1.8 orf, hypothetical protein (VIMSS) compare
b1252 tonB +0.6 2.2 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1824 yobF +0.6 2.6 hypothetical protein (NCBI) compare
b1847 yebF +0.6 1.7 predicted protein (RefSeq) compare
b1095 fabF +0.6 4.1 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0866 ybjQ +0.6 1.2 hypothetical protein (NCBI) compare
b1351 racC +0.6 0.9 Rac prophage; predicted protein (NCBI) compare
b1557 cspB +0.6 1.6 Qin prophage; cold shock protein (NCBI) compare
b2114 metG +0.6 1.7 methionyl-tRNA synthetase (NCBI) compare
b4692 oweE +0.6 1.3 no description compare
b1380 ldhA +0.6 1.9 D-lactate dehydrogenase (NCBI) compare
b1074 flgC +0.6 2.2 flagellar basal-body rod protein C (NCBI) compare
b4450 arcZ +0.6 2.0 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1926 fliT +0.6 2.4 predicted chaperone (NCBI) compare
b1758 b1758 +0.6 1.1 putative cytochrome oxidase (VIMSS) compare
b0632 dacA +0.6 3.5 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b2376 ypdI +0.5 2.2 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b4172 hfq +0.5 0.7 RNA-binding protein Hfq (NCBI) compare
b0661 miaB +0.5 3.9 isopentenyl-adenosine A37 tRNA methylthiolase (NCBI) compare
b4522 yciX_1 +0.5 2.0 hypothetical protein (NCBI) compare
b4163 glyV +0.5 1.5 tRNA-Gly (NCBI) compare
b4596 yciZ +0.5 1.5 hypothetical protein (RefSeq) compare
b2742 nlpD +0.5 3.5 predicted outer membrane lipoprotein (NCBI) compare
b1156 tfaE +0.5 2.8 e14 prophage; predicted tail fiber assembly protein (NCBI) compare
b4594 ymgJ +0.5 1.4 hypothetical protein (RefSeq) compare
b4202 rpsR +0.5 1.0 30S ribosomal protein S18 (NCBI) compare
b3890 yiiF +0.5 2.0 orf, hypothetical protein (VIMSS) compare
b2293 yfbT +0.5 2.5 putative phosphatase (VIMSS) compare
b2058 wcaB +0.5 1.0 predicted acyl transferase (NCBI) compare
b2618 b2618 +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b2136 yohD +0.5 1.0 orf, hypothetical protein (VIMSS) compare
b1085 b1085 +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b4520 ymgF +0.5 1.1 hypothetical protein (NCBI) compare
b4426 isrA +0.5 2.0 unknown RNA (NCBI) compare
b3836 b3836 +0.5 2.1 orf, hypothetical protein (VIMSS) compare
b1629 rsxC +0.5 3.2 electron transport complex protein RnfC (NCBI) compare
b0382 yaiB +0.5 3.5 hypothetical protein (NCBI) compare
b0059 hepA +0.5 4.3 ATP-dependent helicase HepA (NCBI) compare
b0888 trxB +0.5 2.3 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1950 fliR +0.5 1.6 flagellar biosynthesis protein R (NCBI) compare
b1217 chaB +0.5 1.1 cation transport regulator (NCBI) compare
b0746 valZ +0.5 1.7 tRNA-Val (NCBI) compare
b3239 yhcO +0.5 2.2 predicted barnase inhibitor (NCBI) compare
b1006 ycdG +0.5 2.0 putative transport protein (VIMSS) compare
b1939 fliG +0.5 2.9 flagellar motor switch protein G (NCBI) compare
b1874 cutC +0.5 1.9 copper homeostasis protein (NCBI) compare
b0872 hcr +0.4 2.2 HCP oxidoreductase, NADH-dependent (NCBI) compare
b1040 csgD +0.4 1.2 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1155 ymfS +0.4 1.8 e14 prophage; predicted protein (NCBI) compare
b2829 ptsP +0.4 3.8 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b3753 rbsR +0.4 3.5 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b1604 ydgH +0.4 2.3 hypothetical protein (NCBI) compare
b4000 hupA +0.4 1.8 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b1243 oppA +0.4 2.5 oligopeptide transporter subunit (NCBI) compare
b4418 sraB +0.4 1.3 unknown RNA (NCBI) compare
b2236 yfaE +0.4 2.3 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b1513 lsrA +0.4 1.5 fused AI2 transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2935 tktA +0.4 1.2 transketolase 1, thiamin-binding (NCBI) compare
b0238 gpt +0.4 1.8 xanthine phosphoribosyltransferase (NCBI) compare
b4701 sokX +0.4 0.6 sok-related sRNA, function unknown (RefSeq) compare
b4461 yfjD +0.4 2.7 predicted inner membrane protein (RefSeq) compare
b1306 pspC +0.4 2.0 DNA-binding transcriptional activator (NCBI) compare
b3181 greA +0.4 1.9 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1583 ynfB +0.4 1.9 hypothetical protein (NCBI) compare
b0542 renD +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b0780 ybhK +0.4 3.1 predicted transferase with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b1236 galU +0.4 2.0 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1773 ydjI +0.4 1.4 predicted aldolase (NCBI) compare
b0773 ybhB +0.4 3.0 predicted kinase inhibitor (NCBI) compare
b1671 ydhX +0.4 0.8 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b1822 rrmA +0.4 1.5 23S rRNA m1G745 methyltransferase (NCBI) compare
b4217 ytfK +0.4 2.2 orf, hypothetical protein (VIMSS) compare
b3644 yicC +0.4 2.0 hypothetical protein (NCBI) compare
b0310 ykgH +0.4 1.0 predicted inner membrane protein (NCBI) compare
b4071 nrfB +0.4 1.8 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b2080 b2080 +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b2448 yffQ +0.4 1.4 CPZ-55 prophage; predicted protein (RefSeq) compare
b3183 obgE +0.4 0.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1041 csgB +0.4 1.8 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b4545 ypdJ +0.4 1.0 no description compare
b4603 rseX +0.4 0.4 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1073 flgB +0.4 2.3 flagellar basal-body rod protein B (NCBI) compare
b1920 fliY +0.4 0.7 cystine transporter subunit (NCBI) compare
b0836 yliH +0.4 2.0 hypothetical protein (NCBI) compare
b4329 yjiG +0.4 2.6 conserved inner membrane protein (NCBI) compare
b1601 ydgG +0.4 2.4 predicted inner membrane protein (NCBI) compare
b1465 narV +0.4 1.4 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b0627 tatE +0.4 0.8 twin arginine translocase protein E (NCBI) compare
b2646 ypjF +0.4 1.2 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b1644 b1644 +0.4 2.1 putative membrane protein (VIMSS) compare
b2726 hypA +0.4 1.9 protein involved in nickel insertion into hydrogenases 3 (NCBI) compare
b1731 cedA +0.4 1.3 cell division modulator (RefSeq) compare
b4642 yoeD +0.4 1.0 no description compare
b4279 yjhB +0.4 0.4 putative transport protein (VIMSS) compare
b0212 gloB +0.4 1.5 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b1566 flxA +0.4 1.4 Qin prophage; predicted protein (NCBI) compare
b2214 yojL +0.4 1.8 predicted thiamine biosynthesis lipoprotein (NCBI) compare
b2012 yeeD +0.4 1.5 hypothetical protein (NCBI) compare
b1984 asnW +0.4 0.7 tRNA-Asn (NCBI) compare
b4194 ulaB +0.4 2.2 L-ascorbate-specific enzyme IIB component of PTS (NCBI) compare
b2445 yffN +0.4 2.1 CPZ-55 prophage; predicted protein (RefSeq) compare
b4453 ldrD +0.4 1.4 toxic polypeptide, small (NCBI) compare
b1383 ydbL +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b3260 dusB +0.4 1.6 tRNA-dihydrouridine synthase B (NCBI) compare
b1591 b1591 +0.4 1.2 putative oxidoreductase component (VIMSS) compare
b3208 mtgA +0.4 2.4 monofunctional biosynthetic peptidoglycan transglycosylase (NCBI) compare
b3250 mreC +0.4 0.9 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b1628 rsxB +0.4 0.9 electron transport complex protein RnfB (NCBI) compare
b1516 lsrB +0.4 1.4 AI2 transporter (NCBI) compare
b2919 ygfG +0.4 1.7 putative enzyme (VIMSS) compare
b3405 ompR +0.4 2.0 osmolarity response regulator (NCBI) compare
b1961 dcm +0.3 0.9 DNA cytosine methylase (NCBI) compare
b4402 yjjY +0.3 0.5 hypothetical protein (NCBI) compare
b1597 asr +0.3 1.9 acid shock protein (VIMSS) compare
b0521 ybcF +0.3 1.2 predicted carbamate kinase (NCBI) compare
b4648 ysaC +0.3 1.1 no description compare
b1733 chbG +0.3 1.3 hypothetical protein (NCBI) compare
b1426 ydcH +0.3 0.9 orf, hypothetical protein (VIMSS) compare
b2502 ppx +0.3 2.1 exopolyphosphatase (NCBI) compare
b1271 yciK +0.3 1.2 short chain dehydrogenase (NCBI) compare
b4294 insA-7 +0.3 1.1 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b4646 yrdE +0.3 1.2 no description compare
b0623 cspE +0.3 1.1 cold shock protein E (NCBI) compare
b2447 yffP +0.3 1.8 CPZ-55 prophage; predicted protein (NCBI) compare
b0965 b0965 +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b4598 yncL +0.3 1.0 hypothetical protein (RefSeq) compare
b3134 agaW +0.3 0.9 N-acetylgalactosamine-specific enzyme IIC component of PTS, fragment (pseudogene) (RefSeq) compare
b4394 yjjX +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b1573 ydfC +0.3 0.7 Qin prophage; predicted protein (RefSeq) compare
b2006 yeeW +0.3 1.6 CP4-44 prophage; predicted protein (RefSeq) compare
b1540 ydfH +0.3 0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1072 flgA +0.3 1.9 flagellar basal body P-ring biosynthesis protein A (NCBI) compare
b4497 yeeL +0.3 0.7 no description compare
b0404 yajB +0.3 1.2 hypothetical protein (NCBI) compare
b1842 holE +0.3 0.6 DNA polymerase III, theta subunit (NCBI) compare
b1250 kch +0.3 2.0 voltage-gated potassium channel (NCBI) compare
b4631 ykgQ +0.3 0.8 no description compare
b2173 yeiR +0.3 2.3 predicted enzyme (NCBI) compare
b1630 rsxD +0.3 1.9 electron transport complex protein RnfD (NCBI) compare
b0296 ykgM +0.3 1.3 50S ribosomal protein L31 (NCBI) compare
b1623 add +0.3 1.5 adenosine deaminase (NCBI) compare
b4049 dusA +0.3 2.3 tRNA-dihydrouridine synthase A (RefSeq) compare
b1753 ynjA +0.3 1.1 hypothetical protein (NCBI) compare
b4451 ryhB +0.3 0.8 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b0240 crl +0.3 2.5 DNA-binding transcriptional regulator (NCBI) compare
b3999 yjaG +0.3 1.7 hypothetical protein (NCBI) compare
b0183 rnhB +0.3 1.5 ribonuclease HII (NCBI) compare
b0998 torD +0.3 0.6 chaperone protein TorD (NCBI) compare
b1679 sufE +0.3 1.3 cysteine desufuration protein SufE (NCBI) compare
b0880 cspD +0.3 0.9 cold shock protein homolog (NCBI) compare
b2492 focB +0.3 1.8 predicted formate transporter (NCBI) compare
b1489 b1489 +0.3 2.0 putative enzyme (VIMSS) compare
b1366 ydaY +0.3 1.2 Rac prophage; predicted protein (RefSeq) compare
b1790 yeaM +0.3 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0423 thiI +0.3 1.8 thiamine biosynthesis protein ThiI (NCBI) compare
b1931 yedK +0.3 1.3 hypothetical protein (NCBI) compare
b1518 lsrG +0.3 0.9 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b1820 yobD +0.3 2.2 hypothetical protein (NCBI) compare
b1621 malX +0.3 1.8 fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (NCBI) compare
b3354 yheU +0.3 1.7 hypothetical protein (NCBI) compare
b4373 rimI +0.3 1.4 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b2954 yggV +0.3 1.4 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b1977 asnT +0.3 0.9 tRNA-Asn (NCBI) compare
b1144 ymfJ +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b1453 ansP +0.3 1.6 L-asparagine permease (VIMSS) compare
b4094 phnN +0.3 1.5 ribose 1,5-bisphosphokinase (NCBI) compare
b1767 ansA +0.3 1.5 cytoplasmic asparaginase I (NCBI) compare
b1943 fliK +0.3 2.0 flagellar hook-length control protein (NCBI) compare
b1339 abgR +0.3 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in carbon source experiments

For carbon source Ying_AminoAcid20 across organisms