Experiment set56IT080 for Escherichia coli BW25113

Compare to:

LB Anaerobic Sulfasalazine 250 uM

200 most important genes:

  gene name fitness t score description  
b1334 fnr -3.9 -5.7 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4237 nrdG -3.4 -14.6 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4238 nrdD -3.2 -20.9 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b1830 prc -3.1 -2.2 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b2808 gcvA -3.0 -5.7 DNA-binding transcriptional dual regulator (NCBI) compare
b4218 ytfL -3.0 -11.8 predicted inner membrane protein (NCBI) compare
b4171 miaA -3.0 -2.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0688 pgm -2.8 -3.3 phosphoglucomutase (NCBI) compare
b2318 truA -2.7 -3.7 tRNA pseudouridine synthase A (NCBI) compare
b0049 apaH -2.7 -1.9 diadenosinetetraphosphatase (NCBI) compare
b3842 rfaH -2.7 -5.0 transcriptional activator RfaH (NCBI) compare
b4242 mgtA -2.5 -6.9 magnesium transporter (NCBI) compare
b0145 dksA -2.5 -4.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2017 yefM -2.5 -1.6 orf, hypothetical protein (VIMSS) compare
b0051 ksgA -2.5 -6.5 dimethyladenosine transferase (NCBI) compare
b3052 rfaE -2.5 -1.7 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3620 rfaF -2.4 -1.7 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0222 lpcA -2.4 -2.3 phosphoheptose isomerase (NCBI) compare
b0632 dacA -2.3 -9.6 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b3630 rfaP -2.2 -4.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2912 ygfA -2.2 -2.6 putative ligase (VIMSS) compare
b4375 prfC -2.2 -5.2 peptide chain release factor 3 (NCBI) compare
b4702 mgtL -2.2 -1.5 regulatory leader peptide for mgtA (NCBI) compare
b2501 ppk -2.1 -10.7 polyphosphate kinase (NCBI) compare
b0908 aroA -2.1 -11.8 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b3237 argR -2.0 -5.4 arginine repressor (NCBI) compare
b3621 rfaC -2.0 -1.3 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0386 proC -1.9 -3.7 pyrroline-5-carboxylate reductase (NCBI) compare
b2330 yfcB -1.9 -2.5 putative adenine-specific methylase (VIMSS) compare
b4146 yjeK -1.8 -1.3 predicted lysine aminomutase (NCBI) compare
b0902 pflA -1.8 -9.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b3469 zntA -1.8 -9.2 zinc, cobalt and lead efflux system (NCBI) compare
b0926 ycbK -1.8 -8.8 hypothetical protein (NCBI) compare
b4025 pgi -1.8 -9.8 glucose-6-phosphate isomerase (NCBI) compare
b4174 hflK -1.7 -11.0 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b4647 mokA -1.7 -1.5 no description compare
b3021 ygiT -1.7 -3.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b4245 pyrB -1.7 -3.7 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b1192 ldcA -1.7 -3.2 L,D-carboxypeptidase A (NCBI) compare
b4481 rffT -1.7 -4.3 4-alpha-L-fucosyltransferase (NCBI) compare
b3977 tyrU -1.6 -1.2 tRNA-Tyr (NCBI) compare
b1438 ydcQ -1.6 -2.9 predicted DNA-binding transcriptional regulator (RefSeq) compare
b0903 pflB -1.6 -11.4 pyruvate formate lyase I (NCBI) compare
b1290 sapF -1.6 -2.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3790 rffC -1.5 -3.6 TDP-fucosamine acetyltransferase (RefSeq) compare
b2329 aroC -1.5 -4.3 chorismate synthase (NCBI) compare
b4179 vacB -1.5 -4.9 putative enzyme (VIMSS) compare
b3631 rfaG -1.5 -8.4 glucosyltransferase I (NCBI) compare
b3836 b3836 -1.5 -5.9 orf, hypothetical protein (VIMSS) compare
b4175 hflC -1.5 -8.6 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b3838 tatB -1.5 -7.0 sec-independent translocase (NCBI) compare
b3916 pfkA -1.5 -2.9 6-phosphofructokinase (NCBI) compare
b3792 wzxE -1.5 -1.4 O-antigen translocase (NCBI) compare
b1584 speG -1.5 -8.4 spermidine N1-acetyltransferase (NCBI) compare
b1286 rnb -1.5 -2.4 exoribonuclease II (NCBI) compare
b0142 folK -1.5 -0.9 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b4593 ymgI -1.4 -1.0 hypothetical protein (RefSeq) compare
b0400 phoR -1.4 -7.6 sensory histidine kinase in two-component regulatory system with PhoB (NCBI) compare
b3706 trmE -1.4 -2.3 tRNA modification GTPase (NCBI) compare
b0677 nagA -1.4 -5.5 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b1281 pyrF -1.4 -2.4 orotidine 5'-phosphate decarboxylase (NCBI) compare
b2832 ygdQ -1.4 -6.7 predicted inner membrane protein (NCBI) compare
b4414 tff -1.4 -1.7 unknown RNA (NCBI) compare
b0232 yafN -1.4 -0.8 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3619 rfaD -1.4 -0.9 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0439 lon -1.4 -3.4 DNA-binding ATP-dependent protease La (NCBI) compare
b3082 ygjM -1.3 -0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b1236 galU -1.3 -1.3 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3786 rffE -1.3 -8.5 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b0764 modB -1.3 -5.0 molybdate ABC transporter permease protein (NCBI) compare
b3791 rffA -1.3 -4.1 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b4698 mgrR -1.3 -3.2 sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq) compare
b3787 rffD -1.3 -6.9 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3741 gidA -1.3 -1.2 glucose-inhibited division protein A (NCBI) compare
b1850 eda -1.3 -2.5 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1241 adhE -1.2 -8.9 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b0730 mngR -1.2 -1.9 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1506 yneL -1.2 -2.0 predicted transcriptional regulator (NCBI) compare
b4053 alr -1.2 -7.7 alanine racemase (NCBI) compare
b1523 yneG -1.2 -2.9 hypothetical protein (NCBI) compare
b3613 yibP -1.2 -0.8 putative membrane protein (VIMSS) compare
b3839 tatC -1.2 -1.4 TatABCE protein translocation system subunit (NCBI) compare
b0949 uup -1.2 -6.8 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2567 rnc -1.2 -0.8 ribonuclease III (NCBI) compare
b0032 carA -1.2 -3.4 carbamoyl-phosphate synthase small subunit (NCBI) compare
b4203 rplI -1.2 -4.8 50S ribosomal protein L9 (NCBI) compare
b0685 ybfE -1.2 -3.8 orf, hypothetical protein (VIMSS) compare
b1591 b1591 -1.2 -2.8 putative oxidoreductase component (VIMSS) compare
b3387 dam -1.2 -5.4 DNA adenine methylase (NCBI) compare
b3426 glpD -1.2 -0.8 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b0765 modC -1.2 -6.0 molybdate transporter subunit (NCBI) compare
b2620 smpB -1.1 -1.2 SsrA-binding protein (NCBI) compare
b3611 yibN -1.1 -3.6 predicted rhodanese-related sulfurtransferase (NCBI) compare
b0200 gmhB -1.1 -0.7 hypothetical protein (NCBI) compare
b0009 mog -1.1 -6.4 molybdenum cofactor biosynthesis protein (NCBI) compare
b0437 clpP -1.1 -0.8 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1291 sapD -1.1 -1.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2071 yegJ -1.1 -2.1 hypothetical protein (NCBI) compare
b1095 fabF -1.1 -5.2 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0149 mrcB -1.1 -7.0 penicillin-binding protein 1b (NCBI) compare
b1126 potA -1.1 -6.2 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b1613 manA -1.1 -2.0 mannose-6-phosphate isomerase (VIMSS) compare
b3930 menA -1.1 -9.4 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3261 fis -1.1 -1.2 DNA-binding protein Fis (NCBI) compare
b4545 ypdJ -1.1 -1.2 no description compare
b2576 srmB -1.1 -3.1 ATP-dependent RNA helicase (NCBI) compare
b0783 moaC -1.1 -4.1 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3289 rsmB -1.1 -7.9 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent (NCBI) compare
b4202 rpsR -1.0 -0.7 30S ribosomal protein S18 (NCBI) compare
b0999 cbpM -1.0 -3.8 modulator of CbpA co-chaperone (NCBI) compare
b1175 minD -1.0 -3.6 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b1235 rssB -1.0 -3.9 response regulator of RpoS (NCBI) compare
b0781 moaA -1.0 -5.6 molybdenum cofactor biosynthesis protein A (NCBI) compare
b0826 moeB -1.0 -4.7 molybdopterin biosynthesis protein MoeB (NCBI) compare
b0752 zitB -1.0 -5.2 zinc transporter ZitB (NCBI) compare
b0053 surA -1.0 -2.9 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1304 pspA -1.0 -3.4 regulatory protein for phage-shock-protein operon (NCBI) compare
b3932 hslV -1.0 -6.5 ATP-dependent protease peptidase subunit (NCBI) compare
b0033 carB -1.0 -3.4 carbamoyl-phosphate synthase large subunit (NCBI) compare
b3247 cafA -1.0 -6.4 bundles of cytoplasmic filaments (VIMSS) compare
b4246 pyrL -1.0 -1.2 pyrBI operon leader peptide (NCBI) compare
b0407 yajC -1.0 -2.5 preprotein translocase subunit YajC (NCBI) compare
b0785 moaE -1.0 -5.8 molybdopterin synthase, large subunit (NCBI) compare
b2809 b2809 -1.0 -2.5 orf, hypothetical protein (VIMSS) compare
b4655 ythA -0.9 -1.0 expressed protein (RefSeq) compare
b0438 clpX -0.9 -2.2 ATP-dependent protease ATP-binding subunit (NCBI) compare
b2168 fruK -0.9 -0.8 1-phosphofructokinase (NCBI) compare
b3494 yhiO -0.9 -5.7 universal stress protein UspB (NCBI) compare
b2683 ygaH -0.9 -2.5 predicted inner membrane protein (NCBI) compare
b0784 moaD -0.9 -2.3 molybdopterin synthase, small subunit (NCBI) compare
b0143 pcnB -0.9 -3.2 poly(A) polymerase I (VIMSS) compare
b4243 yjgF -0.9 -4.1 orf, hypothetical protein (VIMSS) compare
b3404 envZ -0.9 -6.0 osmolarity sensor protein (NCBI) compare
b1123 potD -0.9 -5.2 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1124 potC -0.9 -4.2 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3784 rfe -0.9 -5.7 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b3281 aroE -0.9 -6.5 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b0912 ihfB -0.9 -0.6 integration host factor subunit beta (NCBI) compare
b3857 mobA -0.9 -5.2 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b1084 rne -0.9 -2.7 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b2175 spr -0.9 -1.6 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b3912 cpxR -0.9 -5.5 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b3673 emrD -0.9 -6.8 2-module integral membrane pump; multidrug resistance (VIMSS) compare
b2516 yfgA -0.9 -4.2 hypothetical protein (NCBI) compare
b1107 nagZ -0.9 -3.8 beta-hexosaminidase (NCBI) compare
b3642 pyrE -0.9 -1.7 orotate phosphoribosyltransferase (NCBI) compare
b4533 ynfO -0.8 -1.7 Qin prophage; predicted protein (NCBI) compare
b3204 ptsN -0.8 -3.8 sugar-specific enzyme IIA component of PTS (NCBI) compare
b3825 pldB -0.8 -7.3 lysophospholipase L(2) (NCBI) compare
b1871 yecP -0.8 -3.6 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b0763 modA -0.8 -3.6 molybdate transporter subunit (NCBI) compare
b3601 mtlR -0.8 -5.1 DNA-binding repressor (NCBI) compare
b0080 fruR -0.8 -3.9 DNA-binding transcriptional dual regulator (NCBI) compare
b2493 yfgO -0.8 -5.9 predicted inner membrane protein (NCBI) compare
b2935 tktA -0.8 -1.4 transketolase 1, thiamin-binding (NCBI) compare
b4390 nadR -0.8 -5.7 probable nadAB transcriptional regulator (VIMSS) compare
b0729 sucD -0.8 -1.9 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1831 proQ -0.8 -3.4 putative solute/DNA competence effector (NCBI) compare
b3728 pstS -0.8 -2.6 phosphate transporter subunit (NCBI) compare
b1160 elbA -0.8 -0.7 hypothetical protein (NCBI) compare
b3726 pstA -0.8 -3.8 phosphate transporter subunit (NCBI) compare
b3409 feoB -0.8 -7.3 ferrous iron transport protein B (NCBI) compare
b1659 ydhB -0.8 -2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0767 ybhE -0.8 -3.2 6-phosphogluconolactonase (NCBI) compare
b1954 dsrA -0.8 -2.1 regulatory antisense RNA (NCBI) compare
b1677 lpp -0.8 -1.4 murein lipoprotein (NCBI) compare
b0728 sucC -0.8 -4.1 succinyl-CoA synthetase subunit beta (NCBI) compare
b4470 yhaM -0.8 -4.2 hypothetical protein (NCBI) compare
b3162 deaD -0.8 -3.0 inducible ATP-independent RNA helicase (VIMSS) compare
b0055 djlA -0.8 -5.2 Dna-J like membrane chaperone protein (NCBI) compare
b4180 rlmB -0.8 -3.9 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b1693 aroD -0.8 -3.8 3-dehydroquinate dehydratase (NCBI) compare
b0178 hlpA -0.8 -2.2 periplasmic chaperone (NCBI) compare
b4373 rimI -0.7 -1.9 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1855 lpxM -0.7 -3.0 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3055 htrG -0.7 -4.6 predicted signal transduction protein (SH3 domain) (NCBI) compare
b3479 nikD -0.7 -5.5 nickel transporter subunit (NCBI) compare
b0015 dnaJ -0.7 -4.3 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b0827 moeA -0.7 -3.9 molybdopterin biosynthesis protein (NCBI) compare
b2188 yejM -0.7 -4.8 predicted hydrolase, inner membrane (NCBI) compare
b3408 feoA -0.7 -5.8 ferrous iron transport protein A (NCBI) compare
b3761 trpT -0.7 -1.4 tRNA-Trp (NCBI) compare
b1125 potB -0.7 -1.9 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3931 hslU -0.7 -5.6 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1429 tehA -0.7 -1.1 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1085 b1085 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b3465 yhhF -0.7 -4.0 predicted methyltransferase (NCBI) compare
b0237 pepD -0.7 -4.5 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b3149 yraO -0.7 -4.1 DnaA initiator-associating factor for replication initiation (NCBI) compare
b1273 yciN -0.7 -1.5 hypothetical protein (NCBI) compare
b0761 modE -0.7 -3.9 DNA-binding transcriptional dual regulator (NCBI) compare
b2141 yohJ -0.7 -2.9 hypothetical protein (NCBI) compare
b1685 ydiH -0.7 -1.3 predicted protein (RefSeq) compare
b1434 ydcN -0.7 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b3252 yhdA -0.7 -5.5 conserved inner membrane protein (NCBI) compare
b3438 gntR -0.7 -3.8 DNA-binding transcriptional repressor (NCBI) compare
b3476 nikA -0.7 -4.6 nickel transporter subunit (NCBI) compare
b0547 ybcN -0.7 -3.1 DLP12 prophage; predicted protein (NCBI) compare
b2553 glnB -0.7 -3.0 regulatory protein P-II for glutamine synthetase (NCBI) compare
b2215 ompC -0.6 -0.4 outer membrane porin protein C (NCBI) compare


Specific Phenotypes

For 3 genes in this experiment

For stress Sulfasalazine in Escherichia coli BW25113

For stress Sulfasalazine across organisms