Experiment set56IT068 for Escherichia coli BW25113

Compare to:

M9 Aerobic 5'-Deoxy-5-fluorocytidine 500 uM

200 most important genes:

  gene name fitness t score description  
b4374 yjjG -4.5 -8.6 nucleotidase (NCBI) compare
b2188 yejM -3.3 -10.3 predicted hydrolase, inner membrane (NCBI) compare
b1105 ycfM -2.5 -2.6 predicted outer membrane lipoprotein (NCBI) compare
b0142 folK -2.5 -1.0 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b4025 pgi -2.1 -9.8 glucose-6-phosphate isomerase (NCBI) compare
b4246 pyrL -2.0 -1.3 pyrBI operon leader peptide (NCBI) compare
b1361 ydaW -2.0 -0.8 orf, hypothetical protein (VIMSS) compare
b0222 lpcA -1.9 -1.3 phosphoheptose isomerase (NCBI) compare
b1192 ldcA -1.9 -1.3 L,D-carboxypeptidase A (NCBI) compare
b3849 trkH -1.8 -9.1 potassium transporter (NCBI) compare
b3642 pyrE -1.7 -1.2 orotate phosphoribosyltransferase (NCBI) compare
b0149 mrcB -1.7 -7.6 penicillin-binding protein 1b (NCBI) compare
b1290 sapF -1.7 -1.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3169 nusA -1.6 -1.6 transcription elongation factor NusA (NCBI) compare
b1882 cheY -1.6 -0.6 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3787 rffD -1.5 -6.8 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3790 rffC -1.5 -2.3 TDP-fucosamine acetyltransferase (RefSeq) compare
b2038 rfbC -1.5 -5.5 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b2912 ygfA -1.5 -1.0 putative ligase (VIMSS) compare
b2017 yefM -1.5 -0.9 orf, hypothetical protein (VIMSS) compare
b4000 hupA -1.4 -6.2 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b3860 dsbA -1.4 -5.8 periplasmic protein disulfide isomerase I (NCBI) compare
b3960 argH -1.4 -8.3 argininosuccinate lyase (NCBI) compare
b0632 dacA -1.4 -5.8 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b2497 uraA -1.4 -6.6 uracil transporter (NCBI) compare
b0080 fruR -1.4 -4.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3205 yhbJ -1.3 -2.9 hypothetical protein (NCBI) compare
b3469 zntA -1.3 -6.1 zinc, cobalt and lead efflux system (NCBI) compare
b1709 btuD -1.3 -1.1 vitamin B12-transporter ATPase (NCBI) compare
b3172 argG -1.3 -7.2 argininosuccinate synthase (NCBI) compare
b4481 rffT -1.3 -2.7 4-alpha-L-fucosyltransferase (NCBI) compare
b1620 malI -1.3 -2.9 DNA-binding transcriptional repressor (NCBI) compare
b1062 pyrC -1.2 -2.7 dihydroorotase (NCBI) compare
b3791 rffA -1.2 -2.4 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3761 trpT -1.2 -1.6 tRNA-Trp (NCBI) compare
b2330 yfcB -1.2 -1.2 putative adenine-specific methylase (VIMSS) compare
b4218 ytfL -1.2 -5.6 predicted inner membrane protein (NCBI) compare
b4201 priB -1.2 -2.3 primosomal replication protein N (NCBI) compare
b3934 cytR -1.2 -8.7 DNA-binding transcriptional dual regulator (NCBI) compare
b0051 ksgA -1.2 -3.7 dimethyladenosine transferase (NCBI) compare
b0523 purE -1.2 -3.6 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b3794 rffM -1.2 -4.0 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b1830 prc -1.2 -1.8 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3052 rfaE -1.2 -0.8 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1176 minC -1.2 -1.2 septum formation inhibitor (NCBI) compare
b3500 gor -1.2 -1.5 glutathione reductase (NCBI) compare
b0088 murD -1.2 -2.3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b2258 b2258 -1.1 -1.3 putative transport/receptor protein (VIMSS) compare
b3867 hemN -1.1 -5.9 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b1185 dsbB -1.1 -2.0 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0866 ybjQ -1.1 -1.3 hypothetical protein (NCBI) compare
b3649 rpoZ -1.1 -2.2 DNA-directed RNA polymerase subunit omega (NCBI) compare
b3164 pnp -1.1 -2.2 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1231 tyrT -1.1 -1.0 tRNA-Tyr (NCBI) compare
b3620 rfaF -1.1 -0.7 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0015 dnaJ -1.1 -6.2 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b1217 chaB -1.1 -1.2 cation transport regulator (NCBI) compare
b4431 rprA -1.1 -2.0 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b1304 pspA -1.0 -2.8 regulatory protein for phage-shock-protein operon (NCBI) compare
b3204 ptsN -1.0 -3.3 sugar-specific enzyme IIA component of PTS (NCBI) compare
b2040 rfbD -1.0 -5.7 dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase (NCBI) compare
b2343 b2343 -1.0 -1.1 orf, hypothetical protein (VIMSS) compare
b3784 rfe -1.0 -5.9 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1362 rzpR -1.0 -1.3 putative Rac prophage endopeptidase (VIMSS) compare
b4702 mgtL -1.0 -0.7 regulatory leader peptide for mgtA (NCBI) compare
b2490 b2490 -1.0 -3.2 putative protein processing element (VIMSS) compare
b4655 ythA -1.0 -1.3 expressed protein (RefSeq) compare
b1358 ydaT -1.0 -1.4 Rac prophage; predicted protein (NCBI) compare
b3281 aroE -1.0 -6.3 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b0212 gloB -1.0 -1.5 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b0767 ybhE -1.0 -2.8 6-phosphogluconolactonase (NCBI) compare
b1583 ynfB -1.0 -2.0 hypothetical protein (NCBI) compare
b1279 yciS -1.0 -1.2 conserved inner membrane protein (NCBI) compare
b2832 ygdQ -1.0 -5.1 predicted inner membrane protein (NCBI) compare
b1269 rluB -0.9 -2.7 23S rRNA pseudouridylate synthase (NCBI) compare
b1281 pyrF -0.9 -1.4 orotidine 5'-phosphate decarboxylase (NCBI) compare
b0567 ybcH -0.9 -5.4 hypothetical protein (NCBI) compare
b3289 rsmB -0.9 -6.3 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent (NCBI) compare
b0957 ompA -0.9 -2.3 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b4508 peaD -0.9 -2.2 putative sensory transduction regulator (VIMSS) compare
b0585 fes -0.9 -3.9 enterobactin/ferric enterobactin esterase (NCBI) compare
b4533 ynfO -0.9 -1.5 Qin prophage; predicted protein (NCBI) compare
b1942 fliJ -0.9 -1.0 flagellar biosynthesis chaperone (NCBI) compare
b3438 gntR -0.9 -3.9 DNA-binding transcriptional repressor (NCBI) compare
b1613 manA -0.9 -1.2 mannose-6-phosphate isomerase (VIMSS) compare
b0907 serC -0.9 -4.0 phosphoserine aminotransferase (NCBI) compare
b0232 yafN -0.8 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b4394 yjjX -0.8 -2.1 orf, hypothetical protein (VIMSS) compare
b2837 galR -0.8 -3.9 DNA-binding transcriptional repressor (NCBI) compare
b3786 rffE -0.8 -4.7 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b1271 yciK -0.8 -2.3 short chain dehydrogenase (NCBI) compare
b3755 yieP -0.8 -3.7 predicted transcriptional regulator (NCBI) compare
b1848 yebG -0.8 -1.2 conserved protein regulated by LexA (NCBI) compare
b2207 napD -0.8 -2.4 assembly protein for periplasmic nitrate reductase (NCBI) compare
b1138 ymfE -0.8 -1.2 e14 prophage; predicted inner membrane protein (NCBI) compare
b1835 yebU -0.8 -2.3 putative nucleolar proteins (VIMSS) compare
b4245 pyrB -0.8 -1.5 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b4203 rplI -0.8 -2.3 50S ribosomal protein L9 (NCBI) compare
b1671 ydhX -0.8 -1.8 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b0145 dksA -0.8 -1.7 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3404 envZ -0.8 -4.8 osmolarity sensor protein (NCBI) compare
b2007 yeeX -0.8 -2.0 conserved protein (RefSeq) compare
b1685 ydiH -0.8 -1.0 predicted protein (RefSeq) compare
b2444 yffM -0.8 -1.7 CPZ-55 prophage; predicted protein (NCBI) compare
b1642 slyA -0.8 -1.1 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b3162 deaD -0.8 -2.2 inducible ATP-independent RNA helicase (VIMSS) compare
b0049 apaH -0.7 -1.2 diadenosinetetraphosphatase (NCBI) compare
b1143 ymfI -0.7 -1.5 orf, hypothetical protein (VIMSS) compare
b3764 yifE -0.7 -2.2 hypothetical protein (NCBI) compare
b4407 thiS -0.7 -1.4 sulfur carrier protein ThiS (NCBI) compare
b4178 yjeB -0.7 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2082 ogrK -0.7 -1.8 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b0814 ompX -0.7 -2.7 outer membrane protein X (NCBI) compare
b1805 fadD -0.7 -4.3 acyl-CoA synthase (NCBI) compare
b4180 rlmB -0.7 -4.2 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b2071 yegJ -0.7 -1.0 hypothetical protein (NCBI) compare
b4171 miaA -0.7 -1.1 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1670 ydhU -0.7 -2.2 predicted cytochrome (NCBI) compare
b0004 thrC -0.7 -4.8 threonine synthase (NCBI) compare
b2025 hisF -0.7 -2.4 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b3149 yraO -0.7 -3.3 DnaA initiator-associating factor for replication initiation (NCBI) compare
b1253 yciA -0.7 -2.0 predicted hydrolase (NCBI) compare
b1853 yebK -0.7 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1758 b1758 -0.7 -0.8 putative cytochrome oxidase (VIMSS) compare
b0522 purK -0.7 -3.8 phosphoribosylaminoimidazole carboxylase (NCBI) compare
b2100 yegV -0.7 -3.3 predicted kinase (NCBI) compare
b3098 yqjD -0.7 -2.5 hypothetical protein (NCBI) compare
b2493 yfgO -0.7 -3.4 predicted inner membrane protein (NCBI) compare
b0926 ycbK -0.7 -3.0 hypothetical protein (NCBI) compare
b3237 argR -0.7 -1.9 arginine repressor (NCBI) compare
b1548 nohA -0.7 -1.4 Qin prophage; predicted packaging protein (RefSeq) compare
b1936 intG -0.7 -0.6 predicted defective phage integrase (pseudogene) (RefSeq) compare
b2248 yfaX -0.7 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b4472 yhdP -0.7 -5.8 conserved membrane protein, predicted transporter (NCBI) compare
b4480 hdfR -0.7 -2.5 transcriptional regulator HdfR (NCBI) compare
b2569 lepA -0.7 -1.4 GTP-binding protein LepA (NCBI) compare
b1293 sapB -0.7 -0.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0002 thrA -0.7 -4.9 bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) compare
b0101 yacG -0.6 -1.5 zinc-binding protein (NCBI) compare
b4697 yrdF -0.6 -2.9 no description compare
b3979 thrT -0.6 -0.2 tRNA-Thr (NCBI) compare
b2783 chpR -0.6 -1.7 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b2344 fadL -0.6 -3.9 long-chain fatty acid outer membrane transporter (RefSeq) compare
b2329 aroC -0.6 -2.2 chorismate synthase (NCBI) compare
b3375 yhfR -0.6 -3.6 putative transcriptional regulator (VIMSS) compare
b3472 b3472 -0.6 -3.0 orf, hypothetical protein (VIMSS) compare
b2144 sanA -0.6 -4.1 hypothetical protein (NCBI) compare
b2506 yfgI -0.6 -1.3 hypothetical protein (NCBI) compare
b1791 yeaN -0.6 -3.2 predicted transporter (NCBI) compare
b4596 yciZ -0.6 -1.3 hypothetical protein (RefSeq) compare
b3644 yicC -0.6 -2.7 hypothetical protein (NCBI) compare
b1553 ydfP -0.6 -0.9 Qin prophage; conserved protein (NCBI) compare
b3838 tatB -0.6 -2.6 sec-independent translocase (NCBI) compare
b3621 rfaC -0.6 -0.4 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0434 yajG -0.6 -3.4 putative polymerase/proteinase (VIMSS) compare
b3497 yhiQ -0.6 -3.7 predicted SAM-dependent methyltransferase (NCBI) compare
b3387 dam -0.6 -2.4 DNA adenine methylase (NCBI) compare
b2445 yffN -0.6 -1.1 CPZ-55 prophage; predicted protein (RefSeq) compare
b1108 ycfP -0.6 -1.7 orf, hypothetical protein (VIMSS) compare
b1266 yciV -0.6 -1.8 hypothetical protein (NCBI) compare
b0730 mngR -0.6 -0.8 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0033 carB -0.6 -1.6 carbamoyl-phosphate synthase large subunit (NCBI) compare
b3601 mtlR -0.6 -2.5 DNA-binding repressor (NCBI) compare
b1179 ycgL -0.6 -1.4 conserved protein (NCBI) compare
b3602 yibL -0.6 -2.8 hypothetical protein (NCBI) compare
b1656 sodB -0.6 -1.2 superoxide dismutase, Fe (NCBI) compare
b4538 yoeF -0.6 -1.1 hypothetical protein (RefSeq) compare
b1939 fliG -0.6 -1.5 flagellar motor switch protein G (NCBI) compare
b1960 vsr -0.6 -1.7 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b2237 inaA -0.6 -1.3 hypothetical protein (NCBI) compare
b1147 ymfL -0.6 -1.8 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b2281 nuoI -0.6 -1.4 NADH dehydrogenase subunit I (NCBI) compare
b1842 holE -0.6 -1.0 DNA polymerase III, theta subunit (NCBI) compare
b4242 mgtA -0.5 -2.5 magnesium transporter (NCBI) compare
b2818 argA -0.5 -2.7 N-acetylglutamate synthase (NCBI) compare
b3247 cafA -0.5 -3.4 bundles of cytoplasmic filaments (VIMSS) compare
b4174 hflK -0.5 -3.7 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1412 azoR -0.5 -1.4 acyl carrier protein phosphodiesterase (NCBI) compare
b1992 cobS -0.5 -1.1 cobalamin synthase (NCBI) compare
b3163 nlpI -0.5 -1.3 hypothetical protein (NCBI) compare
b2564 pdxJ -0.5 -2.1 pyridoxal phosphate biosynthetic protein (NCBI) compare
b4648 ysaC -0.5 -0.8 no description compare
b3409 feoB -0.5 -4.6 ferrous iron transport protein B (NCBI) compare
b4158 yjeO -0.5 -1.5 conserved inner membrane protein (NCBI) compare
b2259 pmrD -0.5 -0.6 polymyxin resistance protein B (VIMSS) compare
b2750 cysC -0.5 -2.4 adenylylsulfate kinase (NCBI) compare
b2423 cysW -0.5 -2.0 sulfate/thiosulfate transporter subunit (NCBI) compare
b3259 prmA -0.5 -1.6 ribosomal protein L11 methyltransferase (NCBI) compare
b2350 yfdG -0.5 -2.7 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b2125 yehT -0.5 -2.2 orf, hypothetical protein (VIMSS) compare
b4402 yjjY -0.5 -0.5 hypothetical protein (NCBI) compare
b0003 thrB -0.5 -2.2 homoserine kinase (NCBI) compare
b3465 yhhF -0.5 -2.4 predicted methyltransferase (NCBI) compare
b1540 ydfH -0.5 -1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b4436 ryeC -0.5 -0.7 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b2295 yfbV -0.5 -2.7 hypothetical protein (NCBI) compare
b3977 tyrU -0.5 -0.4 tRNA-Tyr (NCBI) compare
b2024 hisA -0.5 -0.8 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b1007 b1007 -0.5 -0.9 orf, hypothetical protein (VIMSS) compare
b4676 yoaK -0.5 -0.3 expressed protein (RefSeq) compare


Specific Phenotypes

For 3 genes in this experiment

For stress 5'-Deoxy-5-fluorocytidine in Escherichia coli BW25113

For stress 5'-Deoxy-5-fluorocytidine across organisms