Experiment set56IT054 for Escherichia coli BW25113

Compare to:

M9 Anaerobic Capecitabine 500 uM

200 most detrimental genes:

  gene name fitness t score description  
b1493 gadB +1.8 3.2 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b4699 fnrS +1.0 1.6 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b0990 cspG +1.0 1.6 DNA-binding transcriptional regulator (NCBI) compare
b2498 upp +0.9 3.8 uracil phosphoribosyltransferase (VIMSS) compare
b2904 gcvH +0.9 2.7 glycine cleavage system protein H (NCBI) compare
b2217 rcsB +0.8 5.6 DNA-binding response regulator in two-component regulatory system with RcsC and YojN (NCBI) compare
b3636 rpmG +0.8 1.3 50S ribosomal protein L33 (NCBI) compare
b2814 metZ +0.8 2.2 tRNA-Met (NCBI) compare
b2282 nuoH +0.7 3.5 NADH dehydrogenase subunit H (NCBI) compare
b1567 intK +0.7 1.3 Qin prophage; predicted protein (RefSeq) compare
b0746 valZ +0.7 3.1 tRNA-Val (NCBI) compare
b3341 rpsG +0.7 1.5 30S ribosomal protein S7 (NCBI) compare
b1754 b1754 +0.7 2.1 orf, hypothetical protein (VIMSS) compare
b1346 ydaQ +0.7 1.5 orf, hypothetical protein (VIMSS) compare
b2285 nuoE +0.7 2.2 NADH dehydrogenase subunit E (NCBI) compare
b1476 fdnI +0.7 1.1 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b0014 dnaK +0.7 2.6 molecular chaperone DnaK (NCBI) compare
b4154 frdA +0.6 5.7 fumarate reductase (NCBI) compare
b1360 ydaV +0.6 1.1 Rac prophage; predicted DNA replication protein (NCBI) compare
b2236 yfaE +0.6 1.6 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b0858 ybjO +0.6 2.3 predicted inner membrane protein (NCBI) compare
b1257 yciE +0.6 0.4 hypothetical protein (NCBI) compare
b4406 yaeP +0.6 2.7 hypothetical protein (NCBI) compare
b4152 frdC +0.6 3.6 fumarate reductase subunit C (NCBI) compare
b1790 yeaM +0.6 3.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2279 nuoK +0.6 1.3 NADH dehydrogenase subunit K (NCBI) compare
b1429 tehA +0.6 1.2 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1518 lsrG +0.5 1.1 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b1842 holE +0.5 2.2 DNA polymerase III, theta subunit (NCBI) compare
b1400 paaY +0.5 2.3 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b1394 paaG +0.5 3.1 enoyl-CoA hydratase (NCBI) compare
b1370 insH-5 +0.5 1.6 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b3183 obgE +0.5 1.0 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0247 ykfG +0.5 1.1 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b2934 cmtB +0.5 0.7 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b3228 sspB +0.5 3.2 ClpXP protease specificity-enhancing factor (NCBI) compare
b1148 ymfM +0.5 1.7 e14 prophage; predicted protein (NCBI) compare
b1824 yobF +0.5 2.0 hypothetical protein (NCBI) compare
b1575 dicB +0.5 1.0 Qin prophage; cell division inhibition protein (NCBI) compare
b1186 nhaB +0.5 3.7 NhaB sodium/proton transporter (Katherine Huang) compare
b3926 glpK +0.5 4.1 glycerol kinase (NCBI) compare
b1187 fadR +0.5 3.6 fatty acid metabolism regulator (NCBI) compare
b2652 ileY +0.5 0.7 tRNA-Ile (NCBI) compare
b4369 leuP +0.5 0.7 tRNA-Leu (NCBI) compare
b4505 insX +0.5 1.1 predicted IS protein (RefSeq) compare
b2426 ucpA +0.4 1.8 putative oxidoreductase (VIMSS) compare
b2288 nuoA +0.4 1.6 NADH dehydrogenase I chain A (VIMSS) compare
b3779 gpp +0.4 4.0 guanosine pentaphosphatase/exopolyphosphatase (NCBI) compare
b3443 yrhA +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b2741 rpoS +0.4 2.9 RNA polymerase sigma factor (NCBI) compare
b2356 yfdM +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b1669 ydhT +0.4 1.3 hypothetical protein (NCBI) compare
b3107 yhaL +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b4570 lomR +0.4 1.4 no description compare
b2283 nuoG +0.4 3.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b4151 frdD +0.4 2.2 fumarate reductase subunit D (NCBI) compare
b3166 truB +0.4 3.1 tRNA pseudouridine synthase B (NCBI) compare
b0556 rzpD +0.4 1.7 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b2209 eco +0.4 1.7 ecotin precursor (NCBI) compare
b1492 gadC +0.4 3.0 predicted glutamate:gamma-aminobutyric acid antiporter (NCBI) compare
b3181 greA +0.4 2.4 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3884 yihW +0.4 2.7 putative DEOR-type transcriptional regulator (VIMSS) compare
b2189 proL +0.4 1.2 tRNA-Pro (NCBI) compare
b2502 ppx +0.4 3.0 exopolyphosphatase (NCBI) compare
b0977 hyaF +0.4 2.3 protein involved in nickel incorporation into hydrogenase-1 proteins (NCBI) compare
b1823 cspC +0.4 1.7 stress protein, member of the CspA-family (NCBI) compare
b2531 iscR +0.4 0.9 DNA-binding transcriptional repressor (NCBI) compare
b0191 yaeJ +0.4 2.0 hypothetical protein (NCBI) compare
b3193 yrbD +0.4 3.3 predicted ABC-type organic solvent transporter (NCBI) compare
b1156 tfaE +0.4 2.0 e14 prophage; predicted tail fiber assembly protein (NCBI) compare
b4522 yciX_1 +0.4 1.7 hypothetical protein (NCBI) compare
b3658 selC +0.4 1.5 tRNA-Sec (NCBI) compare
b2080 b2080 +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b2280 nuoJ +0.4 2.2 NADH dehydrogenase subunit J (NCBI) compare
b3512 GadE +0.4 1.5 acid-responsive regulator of gadA and gadBC (Katherine Huang) compare
b1868 yecE +0.4 1.5 hypothetical protein (NCBI) compare
b3742 mioC +0.4 2.4 flavodoxin (NCBI) compare
b4594 ymgJ +0.4 1.5 hypothetical protein (RefSeq) compare
b1343 dbpA +0.4 2.5 ATP-dependent RNA helicase, specific for 23S rRNA (NCBI) compare
b0401 brnQ +0.4 3.1 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b3745 yieM +0.4 3.4 predicted von Willibrand factor containing protein (NCBI) compare
b0435 bolA +0.4 2.5 possible regulator of murein genes (VIMSS) compare
b0955 ycbZ +0.4 2.7 predicted peptidase (NCBI) compare
b2111 yehD +0.4 1.7 predicted fimbrial-like adhesin protein (NCBI) compare
b4153 frdB +0.4 2.3 fumarate reductase (anaerobic), Fe-S subunit (NCBI) compare
b0864 artP +0.4 2.2 arginine transporter subunit (NCBI) compare
b4133 cadC +0.4 3.1 DNA-binding transcriptional activator (NCBI) compare
b1884 cheR +0.3 2.0 chemotaxis regulator, protein-glutamate methyltransferase (NCBI) compare
b1151 ymfO +0.3 1.5 e14 prophage; conserved protein (RefSeq) compare
b4232 fbp +0.3 2.8 fructose-1,6-bisphosphatase (NCBI) compare
b4630 ykgP +0.3 1.7 no description compare
b1242 ychE +0.3 1.4 predicted inner membrane protein (NCBI) compare
b1227 narI +0.3 1.9 nitrate reductase 1, gamma (cytochrome b(NR)) subunit (NCBI) compare
b0013 yaaI +0.3 1.9 hypothetical protein (NCBI) compare
b3390 aroK +0.3 0.8 shikimate kinase I (NCBI) compare
b1634 tppB +0.3 2.1 putative tripeptide transporter permease (NCBI) compare
b2291 yfbR +0.3 1.1 hypothetical protein (NCBI) compare
b1577 ydfE +0.3 2.1 Qin prophage; predicted protein (RefSeq) compare
b1523 yneG +0.3 1.0 hypothetical protein (NCBI) compare
b4557 yidD +0.3 1.3 hypothetical protein (NCBI) compare
b1034 ycdX +0.3 1.9 hypothetical protein (NCBI) compare
b4578 insP +0.3 1.5 no description compare
b2376 ypdI +0.3 1.4 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b3950 frwB +0.3 1.3 predicted enzyme IIB component of PTS (NCBI) compare
b1061 dinI +0.3 1.0 DNA damage-inducible protein I (NCBI) compare
b1667 ydhR +0.3 1.6 hypothetical protein (NCBI) compare
b3495 uspA +0.3 2.8 universal stress global response regulator (NCBI) compare
b2528 iscA +0.3 0.8 iron-sulfur cluster assembly protein (NCBI) compare
b1412 azoR +0.3 1.5 acyl carrier protein phosphodiesterase (NCBI) compare
b2743 pcm +0.3 1.5 protein-L-isoaspartate O-methyltransferase (NCBI) compare
b2435 amiA +0.3 2.2 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b0535 fimZ +0.3 1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b3816 corA +0.3 2.6 magnesium/nickel/cobalt transporter (NCBI) compare
b2419 yfeK +0.3 1.2 hypothetical protein (NCBI) compare
b4363 yjjB +0.3 1.8 conserved inner membrane protein (RefSeq) compare
b0995 torR +0.3 1.8 DNA-binding response regulator in two-component regulatory system with TorS (NCBI) compare
b0164 yaeI +0.3 1.8 orf, hypothetical protein (VIMSS) compare
b1735 chbR +0.3 1.4 DNA-binding transcriptional dual regulator (NCBI) compare
b0502 ylbG +0.3 0.9 no description compare
b1028 ymdE +0.3 1.7 orf, hypothetical protein (VIMSS) compare
b0998 torD +0.3 0.7 chaperone protein TorD (NCBI) compare
b4509 ylcG +0.3 0.7 DLP12 prophage; predicted protein (NCBI) compare
b1573 ydfC +0.3 0.5 Qin prophage; predicted protein (RefSeq) compare
b0104 guaC +0.3 2.6 guanosine 5'-monophosphate oxidoreductase (NCBI) compare
b1220 ychO +0.3 1.8 predicted invasin (RefSeq) compare
b1919 yedO +0.3 1.4 putative 1-aminocyclopropane-1-carboxylate deaminase (VIMSS) compare
b2343 b2343 +0.3 0.8 orf, hypothetical protein (VIMSS) compare
b0616 citE +0.3 1.7 citrate lyase beta chain (acyl lyase subunit) (VIMSS) compare
b1284 yciT +0.3 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2136 yohD +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b0758 galT +0.3 1.9 galactose-1-phosphate uridylyltransferase (NCBI) compare
b1172 ymgG +0.3 1.5 conserved protein, UPF0757 family (RefSeq) compare
b1306 pspC +0.3 0.7 DNA-binding transcriptional activator (NCBI) compare
b3236 mdh +0.3 2.1 malate dehydrogenase (NCBI) compare
b4135 yjdC +0.3 2.2 orf, hypothetical protein (VIMSS) compare
b3068 ygjF +0.3 1.6 G/U mismatch-specific DNA glycosylase (NCBI) compare
b1362 rzpR +0.3 1.3 putative Rac prophage endopeptidase (VIMSS) compare
b2393 nupC +0.3 1.7 nucleoside (except guanosine) transporter (NCBI) compare
b3582 sgbU +0.3 2.1 probable 3-hexulose-6-phosphate isomerase (VIMSS) compare
b3909 kdgT +0.3 1.9 2-keto-3-deoxy-D-gluconate transport system (VIMSS) compare
b1520 b1520 +0.3 1.2 orf, hypothetical protein (VIMSS) compare
b4215 ytfI +0.3 0.7 hypothetical protein (NCBI) compare
b1821 b1821 +0.3 1.5 orf, hypothetical protein (VIMSS) compare
b2646 ypjF +0.3 1.2 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b0289 yagV +0.3 1.4 orf, hypothetical protein (VIMSS) compare
b2277 nuoM +0.3 1.8 NADH dehydrogenase subunit M (NCBI) compare
b0227 yafL +0.3 1.6 predicted lipoprotein and C40 family peptidase (NCBI) compare
b4568 ytjA +0.3 0.9 predicted protein (RefSeq) compare
b4396 rob +0.3 2.1 DNA-binding transcriptional activator (NCBI) compare
b0463 acrA +0.3 2.2 multidrug efflux system (NCBI) compare
b3739 atpI +0.3 1.8 membrane-bound ATP synthase, dispensable protein, affects expression of atpB (VIMSS) compare
b2876 b2876 +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b0300 ykgA +0.3 1.4 putative ARAC-type regulatory protein (VIMSS) compare
b1648 b1648 +0.3 0.8 orf, hypothetical protein (VIMSS) compare
b2281 nuoI +0.3 1.2 NADH dehydrogenase subunit I (NCBI) compare
b1259 yciG +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b1565 ydfV +0.3 1.5 Qin prophage; predicted protein (NCBI) compare
b1968 yedV +0.3 1.1 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b0218 yafU +0.3 1.1 predicted inner membrane protein (RefSeq) compare
b1465 narV +0.3 0.6 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b1650 nemA +0.3 1.9 N-ethylmaleimide reductase, FMN-linked (NCBI) compare
b1072 flgA +0.3 1.6 flagellar basal body P-ring biosynthesis protein A (NCBI) compare
b0232 yafN +0.3 0.2 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1710 btuE +0.3 1.2 predicted glutathione peroxidase (NCBI) compare
b0384 psiF +0.3 1.5 induced by phosphate starvation (VIMSS) compare
b1075 flgD +0.3 1.2 flagellar basal body rod modification protein D (NCBI) compare
b1623 add +0.3 1.0 adenosine deaminase (NCBI) compare
b0225 yafQ +0.3 1.3 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1847 yebF +0.3 0.7 predicted protein (RefSeq) compare
b4519 icdC +0.3 1.5 no description compare
b1428 ydcK +0.3 1.7 predicted enzyme (NCBI) compare
b1143 ymfI +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b1553 ydfP +0.3 1.0 Qin prophage; conserved protein (NCBI) compare
b2421 cysM +0.3 1.2 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b1289 ycjD +0.3 1.7 hypothetical protein (NCBI) compare
b3146 yraL +0.3 1.9 predicted methyltransferase (NCBI) compare
b3259 prmA +0.3 1.4 ribosomal protein L11 methyltransferase (NCBI) compare
b1307 pspD +0.3 0.8 peripheral inner membrane phage-shock protein (NCBI) compare
b2737 ygbK +0.3 1.8 hypothetical protein (NCBI) compare
b1048 mdoG +0.3 1.4 glucan biosynthesis protein, periplasmic (NCBI) compare
b4653 yicT +0.3 0.8 no description compare
b1981 shiA +0.3 1.8 shikimate transporter (NCBI) compare
b1041 csgB +0.3 1.4 curlin nucleator protein, minor subunit in curli complex (NCBI) compare
b4387 ytjB +0.3 1.4 hypothetical protein (NCBI) compare
b1380 ldhA +0.3 0.7 D-lactate dehydrogenase (NCBI) compare
b1696 ydiP +0.3 0.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2674 nrdI +0.3 1.3 hypothetical protein (NCBI) compare
b0340 cynS +0.3 1.2 cyanate hydratase (NCBI) compare
b1904 yecR +0.3 1.1 hypothetical protein (NCBI) compare
b4277 yjgZ +0.3 1.7 KpLE2 phage-like element; predicted protein (NCBI) compare
b0843 ybjH +0.3 0.7 hypothetical protein (NCBI) compare
b3157 yhbT +0.3 1.5 predicted lipid carrier protein (NCBI) compare
b3500 gor +0.3 0.5 glutathione reductase (NCBI) compare
b0473 htpG +0.3 2.2 heat shock protein 90 (NCBI) compare
b1804 rnd +0.3 1.3 ribonuclease D (NCBI) compare
b1110 ycfJ +0.3 1.9 hypothetical protein (NCBI) compare
b3239 yhcO +0.3 1.5 predicted barnase inhibitor (NCBI) compare
b1950 fliR +0.3 1.1 flagellar biosynthesis protein R (NCBI) compare
b3501 arsR +0.3 1.4 DNA-binding transcriptional repressor (NCBI) compare
b1658 purR +0.3 1.9 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For stress Capecitabine in Escherichia coli BW25113

For stress Capecitabine across organisms