Experiment set55IT055 for Escherichia coli BW25113

Compare to:

Fr_1000_F3

200 most detrimental genes:

  gene name fitness t score description  
b3418 malT +6.6 54.1 transcriptional regulator MalT (NCBI) compare
b4036 lamB +6.5 43.3 maltoporin precursor (NCBI) compare
b1620 malI +5.1 9.2 DNA-binding transcriptional repressor (NCBI) compare
b3620 rfaF +3.4 19.1 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4313 fimE +3.2 18.7 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b3052 rfaE +2.5 15.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3619 rfaD +2.4 12.4 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3649 rpoZ +2.3 3.0 DNA-directed RNA polymerase subunit omega (NCBI) compare
b4035 malK +2.2 3.3 fused maltose transport subunit, ATP-binding component of ABC superfamily/regulatory protein (NCBI) compare
b2285 nuoE +2.1 3.0 NADH dehydrogenase subunit E (NCBI) compare
b3621 rfaC +2.0 12.7 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0222 lpcA +1.9 9.3 phosphoheptose isomerase (NCBI) compare
b2282 nuoH +1.9 8.5 NADH dehydrogenase subunit H (NCBI) compare
b3229 sspA +1.9 4.8 stringent starvation protein A (NCBI) compare
b3398 yrfF +1.8 7.0 predicted inner membrane protein (NCBI) compare
b2280 nuoJ +1.8 7.1 NADH dehydrogenase subunit J (NCBI) compare
b2287 nuoB +1.8 5.5 NADH dehydrogenase subunit B (NCBI) compare
b2278 nuoL +1.8 12.6 NADH dehydrogenase subunit L (NCBI) compare
b1936 intG +1.8 2.3 predicted defective phage integrase (pseudogene) (RefSeq) compare
b2277 nuoM +1.8 8.9 NADH dehydrogenase subunit M (NCBI) compare
b2279 nuoK +1.7 3.7 NADH dehydrogenase subunit K (NCBI) compare
b2286 nuoC +1.7 8.9 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2283 nuoG +1.7 11.1 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3405 ompR +1.7 8.7 osmolarity response regulator (NCBI) compare
b2284 nuoF +1.6 7.5 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b1236 galU +1.6 8.8 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1607 ydgC +1.6 1.7 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1257 yciE +1.6 1.0 hypothetical protein (NCBI) compare
b0726 sucA +1.6 7.3 alpha-ketoglutarate decarboxylase (NCBI) compare
b2281 nuoI +1.5 6.4 NADH dehydrogenase subunit I (NCBI) compare
b1205 ychH +1.4 4.1 predicted inner membrane protein (NCBI) compare
b1085 b1085 +1.4 3.9 orf, hypothetical protein (VIMSS) compare
b1160 elbA +1.3 0.8 hypothetical protein (NCBI) compare
b3375 yhfR +1.3 8.7 putative transcriptional regulator (VIMSS) compare
b4701 sokX +1.3 1.1 sok-related sRNA, function unknown (RefSeq) compare
b1823 cspC +1.3 2.6 stress protein, member of the CspA-family (NCBI) compare
b3082 ygjM +1.3 3.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b4535 yniD +1.3 1.6 predicted protein (RefSeq) compare
b3631 rfaG +1.3 11.1 glucosyltransferase I (NCBI) compare
b2288 nuoA +1.3 3.0 NADH dehydrogenase I chain A (VIMSS) compare
b2276 nuoN +1.3 6.6 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2531 iscR +1.2 2.0 DNA-binding transcriptional repressor (NCBI) compare
b3806 cyaA +1.2 6.6 adenylate cyclase (NCBI) compare
b1595 ynfL +1.2 2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b3842 rfaH +1.2 7.8 transcriptional activator RfaH (NCBI) compare
b1594 dgsA +1.2 4.0 DNA-binding transcriptional repressor (NCBI) compare
b2114 metG +1.2 2.1 methionyl-tRNA synthetase (NCBI) compare
b1831 proQ +1.2 3.7 putative solute/DNA competence effector (NCBI) compare
b1752 ydjZ +1.2 1.2 conserved inner membrane protein (NCBI) compare
b1476 fdnI +1.1 1.1 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1007 b1007 +1.1 2.3 orf, hypothetical protein (VIMSS) compare
b4239 treC +1.1 2.7 trehalose-6-P hydrolase (NCBI) compare
b1548 nohA +1.1 1.6 Qin prophage; predicted packaging protein (RefSeq) compare
b3630 rfaP +1.0 8.4 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2540 hcaC +1.0 2.4 3-phenylpropionate dioxygenase, predicted ferredoxin subunit (NCBI) compare
b4345 mcrC +1.0 1.3 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b0688 pgm +1.0 4.6 phosphoglucomutase (NCBI) compare
b4194 ulaB +1.0 2.6 L-ascorbate-specific enzyme IIB component of PTS (NCBI) compare
b0200 gmhB +1.0 2.3 hypothetical protein (NCBI) compare
b1132 hflD +0.9 4.0 hypothetical protein (NCBI) compare
b3290 trkA +0.9 2.8 potassium transporter peripheral membrane component (NCBI) compare
b1531 marA +0.9 2.5 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1842 holE +0.9 1.5 DNA polymerase III, theta subunit (NCBI) compare
b0097 yacA +0.9 2.2 orf, hypothetical protein (VIMSS) compare
b4240 treB +0.9 6.1 fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component (NCBI) compare
b4630 ykgP +0.9 2.5 no description compare
b2017 yefM +0.9 1.1 orf, hypothetical protein (VIMSS) compare
b1950 fliR +0.9 2.8 flagellar biosynthesis protein R (NCBI) compare
b0990 cspG +0.8 0.9 DNA-binding transcriptional regulator (NCBI) compare
b2808 gcvA +0.8 3.7 DNA-binding transcriptional dual regulator (NCBI) compare
b4642 yoeD +0.8 2.6 no description compare
b1332 ynaJ +0.8 0.4 predicted inner membrane protein (NCBI) compare
b1382 ynbE +0.8 1.3 predicted lipoprotein (NCBI) compare
b1573 ydfC +0.8 0.9 Qin prophage; predicted protein (RefSeq) compare
b1150 ymfR +0.8 0.7 e14 prophage; predicted protein (NCBI) compare
b1819 manZ +0.8 3.1 mannose-specific enzyme IID component of PTS (NCBI) compare
b4546 ypeB +0.8 1.1 hypothetical protein (NCBI) compare
b3601 mtlR +0.8 5.3 DNA-binding repressor (NCBI) compare
b1931 yedK +0.8 3.7 hypothetical protein (NCBI) compare
b2637 yfjT +0.8 1.7 CP4-57 prophage; predicted protein (NCBI) compare
b1677 lpp +0.8 1.2 murein lipoprotein (NCBI) compare
b1235 rssB +0.8 4.7 response regulator of RpoS (NCBI) compare
b4012 yjaB +0.7 2.1 predicted acetyltransferase (NCBI) compare
b3755 yieP +0.7 3.6 predicted transcriptional regulator (NCBI) compare
b0730 mngR +0.7 1.3 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1233 ychJ +0.7 3.8 hypothetical protein (NCBI) compare
b2111 yehD +0.7 2.3 predicted fimbrial-like adhesin protein (NCBI) compare
b1837 yebW +0.7 2.2 orf, hypothetical protein (VIMSS) compare
b0310 ykgH +0.7 1.0 predicted inner membrane protein (NCBI) compare
b1305 pspB +0.7 2.6 phage shock protein B (NCBI) compare
b2672 ygaM +0.7 3.2 orf, hypothetical protein (VIMSS) compare
b4472 yhdP +0.7 6.5 conserved membrane protein, predicted transporter (NCBI) compare
b4653 yicT +0.7 1.7 no description compare
b4066 yjcF +0.7 0.9 hypothetical protein (NCBI) compare
b1709 btuD +0.7 0.6 vitamin B12-transporter ATPase (NCBI) compare
b2735 ygbI +0.7 2.5 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2456 cchB +0.7 3.1 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b0303 ykgI +0.7 0.6 orf, hypothetical protein (VIMSS) compare
b0080 fruR +0.7 4.5 DNA-binding transcriptional dual regulator (NCBI) compare
b4533 ynfO +0.7 2.1 Qin prophage; predicted protein (NCBI) compare
b3867 hemN +0.7 6.2 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b0279 yagM +0.7 0.6 CP4-6 prophage; predicted protein (NCBI) compare
b4045 yjbJ +0.7 1.3 predicted stress response protein (NCBI) compare
b3194 yrbE +0.7 4.1 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1486 ddpB +0.7 2.1 D-ala-D-ala transporter subunit (NCBI) compare
b2262 menB +0.7 2.3 naphthoate synthase (NCBI) compare
b1877 yecT +0.7 1.5 orf, hypothetical protein (VIMSS) compare
b4032 malG +0.7 4.4 maltose transporter subunit (NCBI) compare
b1361 ydaW +0.7 0.4 orf, hypothetical protein (VIMSS) compare
b1185 dsbB +0.7 2.3 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2754 ygbF +0.7 2.4 orf, hypothetical protein (VIMSS) compare
b1196 ycgY +0.7 1.8 hypothetical protein (NCBI) compare
b3341 rpsG +0.7 0.7 30S ribosomal protein S7 (NCBI) compare
b0242 proB +0.7 3.3 gamma-glutamyl kinase (NCBI) compare
b1412 azoR +0.7 1.1 acyl carrier protein phosphodiesterase (NCBI) compare
b4679 yohP +0.7 2.4 expressed protein (RefSeq) compare
b4151 frdD +0.6 2.5 fumarate reductase subunit D (NCBI) compare
b2969 yghE +0.6 1.6 predicted secretion pathway protein, L-type protein (pseudogene) (RefSeq) compare
b2457 cchA +0.6 2.8 detox protein (VIMSS) compare
b1344 ydaO +0.6 1.9 predicted C32 tRNA thiolase (NCBI) compare
b1339 abgR +0.6 2.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b2741 rpoS +0.6 2.4 RNA polymerase sigma factor (NCBI) compare
b0623 cspE +0.6 1.3 cold shock protein E (NCBI) compare
b1591 b1591 +0.6 1.2 putative oxidoreductase component (VIMSS) compare
b1278 pgpB +0.6 1.7 phosphatidylglycerophosphatase B (NCBI) compare
b4694 yagP +0.6 2.3 no description compare
b4480 hdfR +0.6 3.3 transcriptional regulator HdfR (NCBI) compare
b1588 ynfF +0.6 2.2 oxidoreductase subunit (RefSeq) compare
b1040 csgD +0.6 1.0 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1325 ycjG +0.6 1.8 putative muconate cycloisomerase I (EC 5.5.-.-) (VIMSS) compare
b1566 flxA +0.6 2.4 Qin prophage; predicted protein (NCBI) compare
b4532 yncN +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b2506 yfgI +0.6 1.4 hypothetical protein (NCBI) compare
b2455 eutE +0.6 2.5 predicted aldehyde dehydrogenase, ethanolamine utilization protein (NCBI) compare
b2264 menD +0.6 3.4 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase (NCBI) compare
b2652 ileY +0.6 0.6 tRNA-Ile (NCBI) compare
b2044 wcaL +0.6 1.8 predicted glycosyl transferase (NCBI) compare
b4093 phnO +0.6 1.9 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b2009 sbmC +0.6 2.1 DNA gyrase inhibitor (NCBI) compare
b0217 yafT +0.6 2.9 predicted aminopeptidase (NCBI) compare
b4104 phnE +0.6 2.0 phosphonate/organophosphate ester transporter subunit (NCBI) compare
b1668 ydhS +0.6 2.6 conserved protein with FAD/NAD(P)-binding domain (NCBI) compare
b2004 yeeU +0.6 1.0 CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b4613 dinQ +0.6 1.0 Damage inducible, function unknown (RefSeq) compare
b3163 nlpI +0.6 2.5 hypothetical protein (NCBI) compare
b4603 rseX +0.6 0.4 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b4529 ydbJ +0.6 0.6 hypothetical protein (NCBI) compare
b4177 purA +0.6 1.0 adenylosuccinate synthetase (NCBI) compare
b3504 yhiS +0.6 0.3 hypothetical protein (RefSeq) compare
b1523 yneG +0.6 0.8 hypothetical protein (NCBI) compare
b2051 wcaH +0.6 1.2 GDP-mannose mannosyl hydrolase (VIMSS) compare
b0720 gltA +0.6 3.4 citrate synthase (NCBI) compare
b0792 ybhR +0.6 1.7 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0798 ybiA +0.6 1.1 hypothetical protein (NCBI) compare
b4660 yhiL +0.6 0.3 no description compare
b4651 yibW +0.6 0.3 no description compare
b3442 yhhZ +0.6 0.3 hypothetical protein (NCBI) compare
b0768 ybhD +0.6 1.8 predicted DNA-binding transcriptional regulator (RefSeq) compare
b3728 pstS +0.6 1.9 phosphate transporter subunit (NCBI) compare
b4702 mgtL +0.6 1.0 regulatory leader peptide for mgtA (NCBI) compare
b4655 ythA +0.5 0.9 expressed protein (RefSeq) compare
b0246 yafW +0.5 1.8 CP4-6 prophage; antitoxin of the YkfI-YafW toxin-antitoxin system (NCBI) compare
b0234 yafP +0.5 1.1 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b1613 manA +0.5 1.1 mannose-6-phosphate isomerase (VIMSS) compare
b3075 ebgR +0.5 2.7 DNA-binding transcriptional repressor (NCBI) compare
b2266 elaB +0.5 1.2 hypothetical protein (NCBI) compare
b2977 glcG +0.5 2.6 hypothetical protein (NCBI) compare
b1315 ycjS +0.5 2.1 predicted oxidoreductase, NADH-binding (NCBI) compare
b2023 hisH +0.5 2.2 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b3121 yhaC +0.5 0.3 hypothetical protein (NCBI) compare
b4458 oxyS +0.5 0.9 global regulatory RNA (NCBI) compare
b0209 yafD +0.5 2.1 hypothetical protein (NCBI) compare
b4063 soxR +0.5 2.0 DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing (NCBI) compare
b0530 sfmA +0.5 1.9 putative fimbrial-like protein (VIMSS) compare
b3027 ygiZ +0.5 0.3 conserved inner membrane protein (NCBI) compare
b1183 umuD +0.5 1.0 DNA polymerase V, subunit D (NCBI) compare
b2728 hypC +0.5 2.0 protein required for maturation of hydrogenases 1 and 3 (NCBI) compare
b1830 prc +0.5 2.6 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1971 yedY +0.5 2.2 hypothetical protein (NCBI) compare
b3021 ygiT +0.5 1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3624 rfaZ +0.5 1.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3622 rfaL +0.5 1.9 O-antigen ligase (NCBI) compare
b2778 ygcG +0.5 2.6 orf, hypothetical protein (VIMSS) compare
b4370 leuQ +0.5 1.5 tRNA-Leu (NCBI) compare
b4443 gcvB +0.5 0.2 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b1955 yedP +0.5 1.8 hypothetical protein (NCBI) compare
b2853 ygeI +0.5 0.2 hypothetical protein (NCBI) compare
b3676 yidH +0.5 0.9 conserved inner membrane protein (NCBI) compare
b4191 ulaR +0.5 1.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3811 xerC +0.5 1.1 site-specific tyrosine recombinase XerC (NCBI) compare
b2635 ypjK +0.5 1.5 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0957 ompA +0.5 1.6 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2659 b2659 +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b2300 yfcE +0.5 2.2 orf, hypothetical protein (VIMSS) compare
b1263 trpD +0.5 0.8 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b3725 pstB +0.5 0.4 phosphate transporter subunit (NCBI) compare
b2742 nlpD +0.5 3.0 predicted outer membrane lipoprotein (NCBI) compare
b4294 insA-7 +0.5 1.3 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b2911 ssrS +0.5 0.8 6S regulatory RNA (NCBI) compare
b0781 moaA +0.5 2.7 molybdenum cofactor biosynthesis protein A (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For fr_1000_f3 Fr_1000_F3 in Escherichia coli BW25113

For fr_1000_f3 Fr_1000_F3 across organisms