| Pathway | #Steps | #Present | #Specific |
|---|
| L-tryptophan degradation II (via pyruvate) | 3 | 3 | 3 |
| glutathionylspermidine biosynthesis | 1 | 1 | 1 |
| D-serine degradation | 3 | 3 | 2 |
| L-serine degradation | 3 | 3 | 2 |
| L-cysteine degradation II | 3 | 2 | 2 |
| siroheme biosynthesis | 4 | 4 | 2 |
| dTDP-N-acetylthomosamine biosynthesis | 4 | 4 | 2 |
| polyphosphate metabolism | 2 | 2 | 1 |
| pseudouridine degradation | 2 | 2 | 1 |
| acetoacetate degradation (to acetyl CoA) | 2 | 2 | 1 |
| ribose phosphorylation | 2 | 2 | 1 |
| dTDP-N-acetylviosamine biosynthesis | 4 | 2 | 2 |
| dTDP-β-D-fucofuranose biosynthesis | 4 | 2 | 2 |
| dTDP-6-deoxy-α-D-allose biosynthesis | 4 | 2 | 2 |
| dTDP-β-L-rhamnose biosynthesis | 5 | 5 | 2 |
| 5,6-dehydrokavain biosynthesis (engineered) | 10 | 8 | 4 |
| dTDP-4-O-demethyl-β-L-noviose biosynthesis | 5 | 3 | 2 |
| dTDP-α-D-mycaminose biosynthesis | 5 | 2 | 2 |
| felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis | 5 | 2 | 2 |
| dTDP-3-acetamido-α-D-fucose biosynthesis | 5 | 2 | 2 |
| dTDP-3-acetamido-3,6-dideoxy-α-D-glucose biosynthesis | 5 | 2 | 2 |
| benzoyl-CoA biosynthesis | 3 | 3 | 1 |
| 2-deoxy-D-ribose degradation I | 3 | 3 | 1 |
| L-methionine biosynthesis II | 6 | 5 | 2 |
| ketolysis | 3 | 2 | 1 |
| polyhydroxybutanoate biosynthesis | 3 | 2 | 1 |
| dTDP-sibirosamine biosynthesis | 6 | 3 | 2 |
| dTDP-L-daunosamine biosynthesis | 6 | 3 | 2 |
| dTDP-D-desosamine biosynthesis | 6 | 2 | 2 |
| dTDP-α-D-ravidosamine and dTDP-4-acetyl-α-D-ravidosamine biosynthesis | 6 | 2 | 2 |
| microcin B17 biosynthesis | 3 | 1 | 1 |
| glycine betaine degradation III | 7 | 4 | 2 |
| dTDP-β-L-digitoxose biosynthesis | 7 | 3 | 2 |
| factor 430 biosynthesis | 7 | 3 | 2 |
| dTDP-β-L-olivose biosynthesis | 7 | 3 | 2 |
| dTDP-β-L-mycarose biosynthesis | 7 | 2 | 2 |
| heme b biosynthesis I (aerobic) | 4 | 4 | 1 |
| heme b biosynthesis V (aerobic) | 4 | 4 | 1 |
| L-mimosine degradation | 8 | 4 | 2 |
| glycine betaine degradation I | 8 | 4 | 2 |
| (2S)-ethylmalonyl-CoA biosynthesis | 4 | 2 | 1 |
| dTDP-β-L-4-epi-vancosamine biosynthesis | 8 | 3 | 2 |
| glutathione-mediated detoxification I | 8 | 3 | 2 |
| dTDP-β-L-megosamine biosynthesis | 8 | 3 | 2 |
| oleate β-oxidation | 35 | 32 | 8 |
| valproate β-oxidation | 9 | 5 | 2 |
| dTDP-α-D-olivose, dTDP-α-D-oliose and dTDP-α-D-mycarose biosynthesis | 9 | 3 | 2 |
| dTDP-α-D-forosamine biosynthesis | 9 | 3 | 2 |
| superpathway of glyoxylate cycle and fatty acid degradation | 14 | 11 | 3 |
| 2-methyl-branched fatty acid β-oxidation | 14 | 9 | 3 |
| CMP-3-deoxy-D-manno-octulosonate biosynthesis | 5 | 5 | 1 |
| superpathway of enterobacterial common antigen biosynthesis | 10 | 9 | 2 |
| (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) | 5 | 4 | 1 |
| pyruvate fermentation to acetone | 5 | 3 | 1 |
| glutaryl-CoA degradation | 5 | 3 | 1 |
| NAD salvage pathway V (PNC V cycle) | 5 | 3 | 1 |
| fatty acid β-oxidation II (plant peroxisome) | 5 | 3 | 1 |
| 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) | 10 | 4 | 2 |
| 4-hydroxybenzoate biosynthesis III (plants) | 5 | 2 | 1 |
| isopropanol biosynthesis (engineered) | 5 | 2 | 1 |
| ketogenesis | 5 | 2 | 1 |
| ethylbenzene degradation (anaerobic) | 5 | 1 | 1 |
| fatty acid β-oxidation VII (yeast peroxisome) | 5 | 1 | 1 |
| O-antigen building blocks biosynthesis (E. coli) | 11 | 11 | 2 |
| pyruvate fermentation to hexanol (engineered) | 11 | 8 | 2 |
| ppGpp metabolism | 6 | 6 | 1 |
| superpathway of heme b biosynthesis from uroporphyrinogen-III | 6 | 6 | 1 |
| fatty acid salvage | 6 | 5 | 1 |
| TCA cycle VIII (Chlamydia) | 6 | 5 | 1 |
| pyruvate fermentation to butanol II (engineered) | 6 | 4 | 1 |
| L-isoleucine degradation I | 6 | 4 | 1 |
| propanoate fermentation to 2-methylbutanoate | 6 | 3 | 1 |
| 10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast) | 6 | 1 | 1 |
| hydrogen sulfide biosynthesis II (mammalian) | 6 | 1 | 1 |
| 4-ethylphenol degradation (anaerobic) | 6 | 1 | 1 |
| jasmonic acid biosynthesis | 19 | 4 | 3 |
| cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) | 13 | 2 | 2 |
| fatty acid β-oxidation I (generic) | 7 | 6 | 1 |
| acetyl-CoA fermentation to butanoate | 7 | 5 | 1 |
| incomplete reductive TCA cycle | 7 | 5 | 1 |
| pyruvate fermentation to propanoate I | 7 | 5 | 1 |
| anaerobic energy metabolism (invertebrates, cytosol) | 7 | 5 | 1 |
| NAD salvage pathway I (PNC VI cycle) | 7 | 5 | 1 |
| pyruvate fermentation to butanoate | 7 | 4 | 1 |
| CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis | 7 | 4 | 1 |
| fatty acid β-oxidation VI (mammalian peroxisome) | 7 | 3 | 1 |
| mevalonate pathway II (haloarchaea) | 7 | 2 | 1 |
| mevalonate pathway I (eukaryotes and bacteria) | 7 | 2 | 1 |
| superpathway of L-lysine, L-threonine and L-methionine biosynthesis II | 15 | 13 | 2 |
| cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) | 15 | 3 | 2 |
| mixed acid fermentation | 16 | 16 | 2 |
| superpathway of heme b biosynthesis from glycine | 8 | 7 | 1 |
| partial TCA cycle (obligate autotrophs) | 8 | 7 | 1 |
| glycerol degradation to butanol | 16 | 11 | 2 |
| pyruvate fermentation to butanol I | 8 | 4 | 1 |
| 2-deoxy-D-ribose degradation II | 8 | 3 | 1 |
| isoprene biosynthesis II (engineered) | 8 | 2 | 1 |
| mevalonate pathway IV (archaea) | 8 | 2 | 1 |
| 2-methylpropene degradation | 8 | 2 | 1 |
| mevalonate pathway III (Thermoplasma) | 8 | 2 | 1 |
| androstenedione degradation I (aerobic) | 25 | 6 | 3 |
| superpathway of anaerobic energy metabolism (invertebrates) | 17 | 12 | 2 |
| Entner-Doudoroff pathway I | 9 | 9 | 1 |
| TCA cycle IV (2-oxoglutarate decarboxylase) | 9 | 7 | 1 |
| TCA cycle II (plants and fungi) | 9 | 7 | 1 |
| TCA cycle V (2-oxoglutarate synthase) | 9 | 7 | 1 |
| TCA cycle VI (Helicobacter) | 9 | 7 | 1 |
| superpathway of Clostridium acetobutylicum acidogenic fermentation | 9 | 6 | 1 |
| TCA cycle VII (acetate-producers) | 9 | 6 | 1 |
| Entner-Doudoroff pathway II (non-phosphorylative) | 9 | 6 | 1 |
| Entner-Doudoroff pathway III (semi-phosphorylative) | 9 | 6 | 1 |
| benzoate biosynthesis I (CoA-dependent, β-oxidative) | 9 | 4 | 1 |
| 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) | 9 | 3 | 1 |
| 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) | 9 | 3 | 1 |
| 4-oxopentanoate degradation | 9 | 1 | 1 |
| superpathway of testosterone and androsterone degradation | 28 | 6 | 3 |
| superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis | 19 | 7 | 2 |
| superpathway of novobiocin biosynthesis | 19 | 4 | 2 |
| superpathway of erythromycin biosynthesis | 19 | 2 | 2 |
| superpathway of heme b biosynthesis from glutamate | 10 | 10 | 1 |
| Rubisco shunt | 10 | 9 | 1 |
| NiFe(CO)(CN)2 cofactor biosynthesis | 10 | 9 | 1 |
| TCA cycle I (prokaryotic) | 10 | 9 | 1 |
| lipid A-core biosynthesis (E. coli K-12) | 10 | 9 | 1 |
| glycolysis IV | 10 | 8 | 1 |
| TCA cycle III (animals) | 10 | 8 | 1 |
| anaerobic energy metabolism (invertebrates, mitochondrial) | 10 | 7 | 1 |
| glycolysis V (Pyrococcus) | 10 | 7 | 1 |
| L-glutamate degradation V (via hydroxyglutarate) | 10 | 5 | 1 |
| 3-phenylpropanoate degradation | 10 | 4 | 1 |
| superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | 10 | 4 | 1 |
| L-lysine fermentation to acetate and butanoate | 10 | 3 | 1 |
| methyl tert-butyl ether degradation | 10 | 2 | 1 |
| superpathway of cholesterol degradation I (cholesterol oxidase) | 42 | 8 | 4 |
| glycolysis II (from fructose 6-phosphate) | 11 | 11 | 1 |
| glycolysis III (from glucose) | 11 | 11 | 1 |
| superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle | 22 | 18 | 2 |
| reductive TCA cycle I | 11 | 8 | 1 |
| glycolysis VI (from fructose) | 11 | 8 | 1 |
| NAD salvage (plants) | 11 | 5 | 1 |
| (8E,10E)-dodeca-8,10-dienol biosynthesis | 11 | 5 | 1 |
| L-glutamate degradation VIII (to propanoate) | 11 | 5 | 1 |
| ethylmalonyl-CoA pathway | 11 | 2 | 1 |
| superpathway of megalomicin A biosynthesis | 22 | 3 | 2 |
| superpathway of dTDP-glucose-derived antibiotic building blocks biosynthesis | 23 | 3 | 2 |
| superpathway of cholesterol degradation II (cholesterol dehydrogenase) | 47 | 8 | 4 |
| homolactic fermentation | 12 | 12 | 1 |
| superpathway of glyoxylate bypass and TCA | 12 | 11 | 1 |
| purine nucleobases degradation II (anaerobic) | 24 | 17 | 2 |
| reductive TCA cycle II | 12 | 8 | 1 |
| L-glutamate degradation VII (to butanoate) | 12 | 5 | 1 |
| 10-cis-heptadecenoyl-CoA degradation (yeast) | 12 | 2 | 1 |
| 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) | 12 | 2 | 1 |
| superpathway of Kdo2-lipid A biosynthesis | 25 | 24 | 2 |
| gluconeogenesis I | 13 | 13 | 1 |
| glycolysis I (from glucose 6-phosphate) | 13 | 13 | 1 |
| superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass | 26 | 25 | 2 |
| (S)-lactate fermentation to propanoate, acetate and hydrogen | 13 | 10 | 1 |
| photosynthetic 3-hydroxybutanoate biosynthesis (engineered) | 26 | 19 | 2 |
| superpathway of Clostridium acetobutylicum solventogenic fermentation | 13 | 7 | 1 |
| (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) | 13 | 2 | 1 |
| 1-butanol autotrophic biosynthesis (engineered) | 27 | 19 | 2 |
| androstenedione degradation II (anaerobic) | 27 | 4 | 2 |
| C4 photosynthetic carbon assimilation cycle, PEPCK type | 14 | 9 | 1 |
| superpathway of NAD biosynthesis in eukaryotes | 14 | 7 | 1 |
| docosahexaenoate biosynthesis III (6-desaturase, mammals) | 14 | 2 | 1 |
| Bifidobacterium shunt | 15 | 13 | 1 |
| L-tryptophan degradation III (eukaryotic) | 15 | 3 | 1 |
| crotonate fermentation (to acetate and cyclohexane carboxylate) | 16 | 3 | 1 |
| adenosylcobalamin biosynthesis II (aerobic) | 33 | 17 | 2 |
| superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis | 33 | 14 | 2 |
| superpathway of glucose and xylose degradation | 17 | 17 | 1 |
| superpathway of (Kdo)2-lipid A biosynthesis | 17 | 17 | 1 |
| superpathway of glycolysis and the Entner-Doudoroff pathway | 17 | 17 | 1 |
| superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation | 17 | 9 | 1 |
| benzoate fermentation (to acetate and cyclohexane carboxylate) | 17 | 3 | 1 |
| cholesterol degradation to androstenedione I (cholesterol oxidase) | 17 | 2 | 1 |
| superpathway of hexitol degradation (bacteria) | 18 | 18 | 1 |
| heterolactic fermentation | 18 | 16 | 1 |
| 3-hydroxypropanoate/4-hydroxybutanate cycle | 18 | 10 | 1 |
| adenosylcobalamin biosynthesis I (anaerobic) | 36 | 16 | 2 |
| toluene degradation VI (anaerobic) | 18 | 3 | 1 |
| sitosterol degradation to androstenedione | 18 | 1 | 1 |
| hexitol fermentation to lactate, formate, ethanol and acetate | 19 | 19 | 1 |
| superpathway of anaerobic sucrose degradation | 19 | 17 | 1 |
| methylaspartate cycle | 19 | 9 | 1 |
| superpathway of N-acetylneuraminate degradation | 22 | 22 | 1 |
| cholesterol degradation to androstenedione II (cholesterol dehydrogenase) | 22 | 2 | 1 |
| superpathway of cholesterol degradation III (oxidase) | 49 | 4 | 2 |
| platensimycin biosynthesis | 26 | 6 | 1 |
| superpathway of ergosterol biosynthesis I | 26 | 4 | 1 |
| Methanobacterium thermoautotrophicum biosynthetic metabolism | 56 | 22 | 2 |
| superpathway of cholesterol biosynthesis | 38 | 4 | 1 |
| superpathway of L-lysine degradation | 43 | 14 | 1 |