| | gene | name | fitness | t score | description | |
|---|
| b2838 | lysA | -6.4 | -14.9 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b2913 | serA | -5.6 | -14.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0004 | thrC | -5.5 | -15.1 | threonine synthase (NCBI) | compare |
| b4388 | serB | -5.2 | -10.4 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0907 | serC | -4.9 | -9.2 | phosphoserine aminotransferase (NCBI) | compare |
| b4005 | purD | -4.9 | -10.4 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2499 | purM | -4.9 | -5.8 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2557 | purL | -4.7 | -11.7 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2312 | purF | -4.7 | -6.4 | amidophosphoribosyltransferase (NCBI) | compare |
| b4006 | purH | -4.6 | -12.4 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2476 | purC | -4.4 | -3.6 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0522 | purK | -4.4 | -10.5 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b0003 | thrB | -4.3 | -8.6 | homoserine kinase (NCBI) | compare |
| b0957 | ompA | -4.0 | -7.6 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b2329 | aroC | -3.8 | -9.8 | chorismate synthase (NCBI) | compare |
| b3960 | argH | -3.8 | -15.8 | argininosuccinate lyase (NCBI) | compare |
| b1260 | trpA | -3.6 | -5.6 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0052 | pdxA | -3.6 | -15.3 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b1261 | trpB | -3.5 | -6.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b0523 | purE | -3.5 | -4.0 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b2320 | pdxB | -3.4 | -12.5 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b3281 | aroE | -3.3 | -17.6 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b3389 | aroB | -3.3 | -13.5 | 3-dehydroquinate synthase (NCBI) | compare |
| b2024 | hisA | -3.2 | -5.8 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2564 | pdxJ | -3.2 | -9.2 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b0908 | aroA | -3.1 | -14.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0145 | dksA | -3.1 | -3.0 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b3172 | argG | -3.1 | -18.7 | argininosuccinate synthase (NCBI) | compare |
| b0142 | folK | -3.1 | -1.3 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b1693 | aroD | -3.0 | -7.9 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0002 | thrA | -3.0 | -18.6 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0726 | sucA | -2.9 | -6.6 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3941 | metF | -2.9 | -15.2 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3829 | metE | -2.9 | -19.9 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b1185 | dsbB | -2.8 | -3.6 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b0889 | lrp | -2.8 | -3.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b1281 | pyrF | -2.7 | -2.6 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b3828 | metR | -2.6 | -17.4 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3956 | ppc | -2.6 | -20.1 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b2025 | hisF | -2.6 | -5.9 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2762 | cysH | -2.6 | -10.9 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b3860 | dsbA | -2.5 | -8.0 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b2839 | lysR | -2.5 | -6.7 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2188 | yejM | -2.5 | -11.2 | predicted hydrolase, inner membrane (NCBI) | compare |
| b1062 | pyrC | -2.4 | -5.1 | dihydroorotase (NCBI) | compare |
| b2501 | ppk | -2.4 | -12.8 | polyphosphate kinase (NCBI) | compare |
| b0632 | dacA | -2.4 | -9.3 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) | compare |
| b3870 | glnA | -2.4 | -3.5 | glutamine synthetase (NCBI) | compare |
| b3642 | pyrE | -2.3 | -2.2 | orotate phosphoribosyltransferase (NCBI) | compare |
| b1235 | rssB | -2.3 | -6.8 | response regulator of RpoS (NCBI) | compare |
| b0071 | leuD | -2.3 | -10.8 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0073 | leuB | -2.2 | -13.8 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0438 | clpX | -2.2 | -1.5 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b0072 | leuC | -2.2 | -14.6 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2600 | tyrA | -2.1 | -9.6 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b2764 | cysJ | -2.1 | -10.3 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b4245 | pyrB | -2.0 | -2.4 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2021 | hisC | -2.0 | -7.3 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3164 | pnp | -2.0 | -3.0 | polynucleotide phosphorylase/polyadenylase (RefSeq) | compare |
| b3771 | ilvD | -1.9 | -13.8 | dihydroxy-acid dehydratase (NCBI) | compare |
| b2750 | cysC | -1.9 | -9.0 | adenylylsulfate kinase (NCBI) | compare |
| b4242 | mgtA | -1.9 | -8.7 | magnesium transporter (NCBI) | compare |
| b2763 | cysI | -1.9 | -9.1 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b4171 | miaA | -1.9 | -3.7 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b3774 | ilvC | -1.9 | -14.7 | ketol-acid reductoisomerase (NCBI) | compare |
| b2414 | cysK | -1.9 | -10.0 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0032 | carA | -1.9 | -3.5 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3368 | cysG | -1.8 | -14.7 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3790 | rffC | -1.8 | -3.5 | TDP-fucosamine acetyltransferase (RefSeq) | compare |
| b3791 | rffA | -1.8 | -4.1 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b0439 | lon | -1.8 | -3.8 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b2022 | hisB | -1.8 | -8.5 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b0945 | pyrD | -1.7 | -4.1 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2313 | cvpA | -1.7 | -3.4 | membrane protein required for colicin V production (NCBI) | compare |
| b2020 | hisD | -1.7 | -10.1 | histidinol dehydrogenase (NCBI) | compare |
| b0592 | fepB | -1.7 | -11.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3916 | pfkA | -1.7 | -3.5 | 6-phosphofructokinase (NCBI) | compare |
| b2023 | hisH | -1.7 | -8.0 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b0720 | gltA | -1.7 | -8.0 | citrate synthase (NCBI) | compare |
| b4676 | yoaK | -1.7 | -1.0 | expressed protein (RefSeq) | compare |
| b0242 | proB | -1.7 | -8.9 | gamma-glutamyl kinase (NCBI) | compare |
| b0149 | mrcB | -1.6 | -9.6 | penicillin-binding protein 1b (NCBI) | compare |
| b3770 | ilvE | -1.6 | -12.7 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b0243 | proA | -1.6 | -9.8 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b1192 | ldcA | -1.6 | -3.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b1262 | trpC | -1.6 | -3.1 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b2611 | ypjD | -1.5 | -8.4 | predicted inner membrane protein (RefSeq) | compare |
| b0589 | fepG | -1.5 | -8.4 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0590 | fepD | -1.5 | -8.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b1258 | yciF | -1.5 | -1.4 | hypothetical protein (NCBI) | compare |
| b0928 | aspC | -1.5 | -6.9 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b3183 | obgE | -1.5 | -1.9 | GTPase involved in cell partioning and DNA repair (NCBI) | compare |
| b0585 | fes | -1.5 | -6.8 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b3781 | trxA | -1.5 | -5.5 | thioredoxin 1 (VIMSS) | compare |
| b0074 | leuA | -1.5 | -10.3 | 2-isopropylmalate synthase (NCBI) | compare |
| b0049 | apaH | -1.5 | -1.0 | diadenosinetetraphosphatase (NCBI) | compare |
| b0033 | carB | -1.4 | -2.7 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2912 | ygfA | -1.4 | -2.5 | putative ligase (VIMSS) | compare |
| b1176 | minC | -1.4 | -3.5 | septum formation inhibitor (NCBI) | compare |
| b0437 | clpP | -1.4 | -1.3 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b4481 | rffT | -1.4 | -3.1 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b0222 | lpcA | -1.4 | -1.8 | phosphoheptose isomerase (NCBI) | compare |
| b1291 | sapD | -1.4 | -1.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2019 | hisG | -1.4 | -6.9 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2479 | gcvR | -1.4 | -5.6 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b3204 | ptsN | -1.3 | -5.0 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b2752 | cysD | -1.3 | -5.9 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b4214 | cysQ | -1.3 | -9.3 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b3957 | argE | -1.3 | -10.8 | acetylornithine deacetylase (NCBI) | compare |
| b0200 | gmhB | -1.3 | -0.9 | hypothetical protein (NCBI) | compare |
| b3621 | rfaC | -1.3 | -1.7 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0588 | fepC | -1.3 | -6.8 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3052 | rfaE | -1.2 | -2.4 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3924 | fpr | -1.2 | -7.7 | ferredoxin-NADP reductase (NCBI) | compare |
| b0400 | phoR | -1.2 | -7.8 | sensory histidine kinase in two-component regulatory system with PhoB (NCBI) | compare |
| b3008 | metC | -1.2 | -9.3 | cystathionine beta-lyase (NCBI) | compare |
| b3630 | rfaP | -1.2 | -5.2 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b2064 | asmA | -1.2 | -6.8 | predicted assembly protein (NCBI) | compare |
| b0741 | pal | -1.2 | -1.5 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b3842 | rfaH | -1.2 | -3.4 | transcriptional activator RfaH (NCBI) | compare |
| b3493 | pitA | -1.2 | -5.8 | phosphate transporter, low-affinity (NCBI) | compare |
| b1984 | asnW | -1.2 | -1.5 | tRNA-Asn (NCBI) | compare |
| b1855 | lpxM | -1.1 | -3.7 | lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) | compare |
| b3792 | wzxE | -1.1 | -2.2 | O-antigen translocase (NCBI) | compare |
| b3849 | trkH | -1.1 | -7.8 | potassium transporter (NCBI) | compare |
| b4025 | pgi | -1.1 | -7.2 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3958 | argC | -1.1 | -8.6 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3609 | secB | -1.1 | -2.4 | export protein SecB (NCBI) | compare |
| b0926 | ycbK | -1.1 | -6.2 | hypothetical protein (NCBI) | compare |
| b0386 | proC | -1.1 | -2.5 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b3959 | argB | -1.1 | -7.9 | acetylglutamate kinase (RefSeq) | compare |
| b2751 | cysN | -1.1 | -6.1 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b2318 | truA | -1.1 | -2.5 | tRNA pseudouridine synthase A (NCBI) | compare |
| b4202 | rpsR | -1.1 | -0.7 | 30S ribosomal protein S18 (NCBI) | compare |
| b2026 | hisI | -1.1 | -5.4 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b0113 | pdhR | -1.1 | -5.1 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b4538 | yoeF | -1.0 | -2.3 | hypothetical protein (RefSeq) | compare |
| b2500 | purN | -1.0 | -5.0 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b1104 | ycfL | -1.0 | -1.8 | hypothetical protein (NCBI) | compare |
| b2818 | argA | -1.0 | -6.9 | N-acetylglutamate synthase (NCBI) | compare |
| b1290 | sapF | -1.0 | -1.5 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3794 | rffM | -1.0 | -4.5 | putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) | compare |
| b3006 | exbB | -1.0 | -5.8 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b3772 | ilvA | -1.0 | -8.0 | threonine dehydratase (NCBI) | compare |
| b3203 | yhbH | -1.0 | -3.5 | predicted ribosome-associated, sigma 54 modulation protein (NCBI) | compare |
| b2569 | lepA | -1.0 | -3.1 | GTP-binding protein LepA (NCBI) | compare |
| b2017 | yefM | -1.0 | -0.8 | orf, hypothetical protein (VIMSS) | compare |
| b2144 | sanA | -0.9 | -7.9 | hypothetical protein (NCBI) | compare |
| b1111 | ycfQ | -0.9 | -3.1 | orf, hypothetical protein (VIMSS) | compare |
| b3005 | exbD | -0.9 | -3.4 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b0912 | ihfB | -0.9 | -0.6 | integration host factor subunit beta (NCBI) | compare |
| b1175 | minD | -0.9 | -3.4 | membrane ATPase of the MinC-MinD-MinE system (NCBI) | compare |
| b1292 | sapC | -0.9 | -1.4 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3236 | mdh | -0.9 | -5.8 | malate dehydrogenase (NCBI) | compare |
| b4451 | ryhB | -0.9 | -2.1 | Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) | compare |
| b2599 | pheA | -0.9 | -5.1 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3398 | yrfF | -0.9 | -2.8 | predicted inner membrane protein (NCBI) | compare |
| b2330 | yfcB | -0.9 | -1.5 | putative adenine-specific methylase (VIMSS) | compare |
| b4551 | yheV | -0.9 | -1.7 | hypothetical protein (NCBI) | compare |
| b3169 | nusA | -0.9 | -1.5 | transcription elongation factor NusA (NCBI) | compare |
| b1865 | nudB | -0.9 | -1.3 | dATP pyrophosphohydrolase (NCBI) | compare |
| b3650 | spoT | -0.9 | -5.4 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b0434 | yajG | -0.9 | -4.7 | putative polymerase/proteinase (VIMSS) | compare |
| b0881 | clpS | -0.9 | -2.4 | ATP-dependent Clp protease adaptor protein ClpS (NCBI) | compare |
| b2784 | relA | -0.9 | -6.2 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b3939 | metB | -0.9 | -6.7 | cystathionine gamma-synthase (NCBI) | compare |
| b3375 | yhfR | -0.9 | -5.1 | putative transcriptional regulator (VIMSS) | compare |
| b1351 | racC | -0.8 | -0.6 | Rac prophage; predicted protein (NCBI) | compare |
| b3786 | rffE | -0.8 | -5.9 | UDP-N-acetyl glucosamine-2-epimerase (NCBI) | compare |
| b4436 | ryeC | -0.8 | -1.7 | Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) | compare |
| b1850 | eda | -0.8 | -1.9 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b4647 | mokA | -0.8 | -0.9 | no description | compare |
| b1264 | trpE | -0.8 | -2.0 | anthranilate synthase component I (NCBI) | compare |
| b2175 | spr | -0.8 | -1.7 | predicted peptidase, outer membrane lipoprotein (NCBI) | compare |
| b4375 | prfC | -0.8 | -4.0 | peptide chain release factor 3 (NCBI) | compare |
| b2422 | cysA | -0.8 | -5.6 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b4577 | sgrS | -0.8 | -1.9 | small antisense RNA (NCBI) | compare |
| b3527 | yhjJ | -0.8 | -7.3 | predicted zinc-dependent peptidase (NCBI) | compare |
| b1551 | b1551 | -0.8 | -0.5 | orf, hypothetical protein (VIMSS) | compare |
| b3787 | rffD | -0.8 | -5.1 | UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) | compare |
| b2601 | aroF | -0.8 | -4.9 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b3977 | tyrU | -0.8 | -0.8 | tRNA-Tyr (NCBI) | compare |
| b3838 | tatB | -0.8 | -3.8 | sec-independent translocase (NCBI) | compare |
| b0075 | leuL | -0.8 | -3.8 | leu operon leader peptide (NCBI) | compare |
| b0952 | ymbA | -0.8 | -5.8 | conserved protein (RefSeq) | compare |
| b4699 | fnrS | -0.8 | -0.9 | FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) | compare |
| b0630 | lipB | -0.8 | -1.1 | protein of lipoate biosynthesis (VIMSS) | compare |
| b3706 | trmE | -0.8 | -2.1 | tRNA modification GTPase (NCBI) | compare |
| b3545 | proK | -0.8 | -2.1 | tRNA-Pro (NCBI) | compare |
| b3994 | thiC | -0.8 | -6.6 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b4179 | vacB | -0.8 | -3.1 | putative enzyme (VIMSS) | compare |
| b1684 | sufA | -0.8 | -3.2 | iron-sulfur cluster assembly scaffold protein (NCBI) | compare |
| b2279 | nuoK | -0.8 | -1.3 | NADH dehydrogenase subunit K (NCBI) | compare |
| b3935 | priA | -0.8 | -2.4 | primosome assembly protein PriA (NCBI) | compare |
| b1438 | ydcQ | -0.7 | -1.9 | predicted DNA-binding transcriptional regulator (RefSeq) | compare |
| b2790 | yqcA | -0.7 | -4.5 | flavodoxin (NCBI) | compare |
| b0950 | pqiA | -0.7 | -4.7 | paraquat-inducible membrane protein A (NCBI) | compare |
| b0226 | dinJ | -0.7 | -2.3 | predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) | compare |
| b1874 | cutC | -0.7 | -0.6 | copper homeostasis protein (NCBI) | compare |
| b3021 | ygiT | -0.7 | -2.0 | predicted DNA-binding transcriptional regulator (NCBI) | compare |