| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -6.3 | -4.3 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0522 | purK | -5.6 | -6.6 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b0523 | purE | -5.4 | -3.7 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0004 | thrC | -5.4 | -13.0 | threonine synthase (NCBI) | compare |
| b2188 | yejM | -5.2 | -10.1 | predicted hydrolase, inner membrane (NCBI) | compare |
| b4388 | serB | -5.2 | -12.4 | 3-phosphoserine phosphatase (NCBI) | compare |
| b4005 | purD | -5.1 | -11.8 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2499 | purM | -5.0 | -4.8 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2312 | purF | -4.9 | -5.8 | amidophosphoribosyltransferase (NCBI) | compare |
| b4006 | purH | -4.8 | -12.5 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2557 | purL | -4.5 | -11.6 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2913 | serA | -4.4 | -14.8 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0907 | serC | -4.3 | -11.5 | phosphoserine aminotransferase (NCBI) | compare |
| b0003 | thrB | -4.3 | -9.5 | homoserine kinase (NCBI) | compare |
| b0463 | acrA | -4.1 | -18.3 | multidrug efflux system (NCBI) | compare |
| b3844 | fre | -4.0 | -10.5 | NAD(P)H-flavin reductase (NCBI) | compare |
| b3960 | argH | -3.9 | -18.5 | argininosuccinate lyase (NCBI) | compare |
| b0242 | proB | -3.9 | -10.3 | gamma-glutamyl kinase (NCBI) | compare |
| b0957 | ompA | -3.8 | -6.5 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b2025 | hisF | -3.6 | -8.8 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3829 | metE | -3.6 | -22.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b2741 | rpoS | -3.5 | -13.1 | RNA polymerase sigma factor (NCBI) | compare |
| b3172 | argG | -3.5 | -18.7 | argininosuccinate synthase (NCBI) | compare |
| b3941 | metF | -3.4 | -14.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3828 | metR | -3.3 | -18.2 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b2144 | sanA | -3.2 | -18.9 | hypothetical protein (NCBI) | compare |
| b2329 | aroC | -3.2 | -9.4 | chorismate synthase (NCBI) | compare |
| b2024 | hisA | -3.1 | -4.6 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b0142 | folK | -3.1 | -1.4 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0145 | dksA | -3.1 | -3.0 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0243 | proA | -3.1 | -13.2 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2686 | emrB | -2.9 | -17.5 | multidrug efflux system protein (NCBI) | compare |
| b2023 | hisH | -2.8 | -10.2 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b4480 | hdfR | -2.8 | -9.0 | transcriptional regulator HdfR (NCBI) | compare |
| b4702 | mgtL | -2.7 | -1.9 | regulatory leader peptide for mgtA (NCBI) | compare |
| b3870 | glnA | -2.7 | -3.1 | glutamine synthetase (NCBI) | compare |
| b3838 | tatB | -2.6 | -8.0 | sec-independent translocase (NCBI) | compare |
| b0908 | aroA | -2.6 | -12.7 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0632 | dacA | -2.6 | -10.0 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) | compare |
| b1865 | nudB | -2.6 | -2.4 | dATP pyrophosphohydrolase (NCBI) | compare |
| b3774 | ilvC | -2.6 | -18.4 | ketol-acid reductoisomerase (NCBI) | compare |
| b2685 | emrA | -2.6 | -11.8 | multidrug efflux system (NCBI) | compare |
| b0926 | ycbK | -2.5 | -5.1 | hypothetical protein (NCBI) | compare |
| b0222 | lpcA | -2.5 | -1.7 | phosphoheptose isomerase (NCBI) | compare |
| b2021 | hisC | -2.5 | -8.4 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3771 | ilvD | -2.5 | -18.9 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3860 | dsbA | -2.4 | -9.1 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b2022 | hisB | -2.4 | -9.3 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2020 | hisD | -2.3 | -10.3 | histidinol dehydrogenase (NCBI) | compare |
| b0889 | lrp | -2.2 | -3.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b3764 | yifE | -2.2 | -8.1 | hypothetical protein (NCBI) | compare |
| b0462 | acrB | -2.2 | -18.0 | multidrug efflux system protein (NCBI) | compare |
| b3770 | ilvE | -2.2 | -15.1 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b1185 | dsbB | -2.2 | -3.8 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b3054 | ygiF | -2.2 | -11.0 | predicted adenylate cyclase (NCBI) | compare |
| b3916 | pfkA | -2.1 | -3.5 | 6-phosphofructokinase (NCBI) | compare |
| b3163 | nlpI | -2.1 | -5.3 | hypothetical protein (NCBI) | compare |
| b4025 | pgi | -2.1 | -12.3 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3920 | yiiQ | -1.9 | -8.1 | hypothetical protein (NCBI) | compare |
| b3199 | yrbK | -1.9 | -5.8 | hypothetical protein (NCBI) | compare |
| b0438 | clpX | -1.9 | -1.8 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b0072 | leuC | -1.9 | -12.5 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2808 | gcvA | -1.9 | -5.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2762 | cysH | -1.9 | -10.9 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0071 | leuD | -1.9 | -10.2 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0073 | leuB | -1.8 | -12.0 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0074 | leuA | -1.8 | -13.6 | 2-isopropylmalate synthase (NCBI) | compare |
| b3210 | arcB | -1.8 | -9.2 | hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) | compare |
| b0014 | dnaK | -1.8 | -3.2 | molecular chaperone DnaK (NCBI) | compare |
| b0386 | proC | -1.7 | -2.6 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b1101 | ptsG | -1.7 | -11.1 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b3389 | aroB | -1.7 | -9.7 | 3-dehydroquinate synthase (NCBI) | compare |
| b3871 | bipA | -1.6 | -12.0 | GTP-binding protein (NCBI) | compare |
| b4242 | mgtA | -1.6 | -8.2 | magnesium transporter (NCBI) | compare |
| b0840 | deoR | -1.6 | -6.1 | DNA-binding transcriptional repressor (NCBI) | compare |
| b2019 | hisG | -1.5 | -6.6 | ATP phosphoribosyltransferase (NCBI) | compare |
| b3527 | yhjJ | -1.5 | -13.3 | predicted zinc-dependent peptidase (NCBI) | compare |
| b3935 | priA | -1.5 | -4.6 | primosome assembly protein PriA (NCBI) | compare |
| b0630 | lipB | -1.5 | -1.4 | protein of lipoate biosynthesis (VIMSS) | compare |
| b2838 | lysA | -1.4 | -11.0 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b2564 | pdxJ | -1.4 | -6.1 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b4381 | deoC | -1.4 | -8.3 | deoxyribose-phosphate aldolase (NCBI) | compare |
| b0052 | pdxA | -1.4 | -10.6 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b3621 | rfaC | -1.3 | -1.8 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b0605 | ahpC | -1.3 | -4.7 | alkyl hydroperoxide reductase, C22 subunit (NCBI) | compare |
| b1273 | yciN | -1.3 | -2.2 | hypothetical protein (NCBI) | compare |
| b0049 | apaH | -1.3 | -0.9 | diadenosinetetraphosphatase (NCBI) | compare |
| b4647 | mokA | -1.3 | -1.2 | no description | compare |
| b3052 | rfaE | -1.3 | -2.4 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b0431 | cyoB | -1.3 | -9.7 | cytochrome o ubiquinol oxidase subunit I (NCBI) | compare |
| b3229 | sspA | -1.3 | -4.1 | stringent starvation protein A (NCBI) | compare |
| b2320 | pdxB | -1.2 | -7.1 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b3649 | rpoZ | -1.2 | -3.3 | DNA-directed RNA polymerase subunit omega (NCBI) | compare |
| b3494 | yhiO | -1.2 | -8.6 | universal stress protein UspB (NCBI) | compare |
| b0437 | clpP | -1.2 | -1.2 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b1261 | trpB | -1.2 | -2.4 | tryptophan synthase subunit beta (NCBI) | compare |
| b2764 | cysJ | -1.2 | -6.7 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3281 | aroE | -1.2 | -9.1 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0585 | fes | -1.2 | -6.4 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b2479 | gcvR | -1.2 | -5.6 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b4048 | yjbM | -1.2 | -1.7 | hypothetical protein (NCBI) | compare |
| b0432 | cyoA | -1.2 | -8.7 | cytochrome o ubiquinol oxidase subunit II (NCBI) | compare |
| b1235 | rssB | -1.2 | -4.6 | response regulator of RpoS (NCBI) | compare |
| b1338 | ydaJ | -1.2 | -2.8 | putative aminohydrolase (EC 3.5.1.14) (VIMSS) | compare |
| b0430 | cyoC | -1.2 | -5.3 | cytochrome o ubiquinol oxidase subunit III (NCBI) | compare |
| b0002 | thrA | -1.1 | -6.4 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2512 | yfgL | -1.1 | -4.4 | protein assembly complex, lipoprotein component (NCBI) | compare |
| b0429 | cyoD | -1.1 | -5.4 | cytochrome o ubiquinol oxidase subunit IV (NCBI) | compare |
| b0240 | crl | -1.1 | -8.6 | DNA-binding transcriptional regulator (NCBI) | compare |
| b0082 | mraW | -1.1 | -3.5 | S-adenosyl-methyltransferase (NCBI) | compare |
| b3650 | spoT | -1.1 | -6.2 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b2114 | metG | -1.1 | -2.9 | methionyl-tRNA synthetase (NCBI) | compare |
| b3387 | dam | -1.1 | -5.0 | DNA adenine methylase (NCBI) | compare |
| b4179 | vacB | -1.1 | -3.9 | putative enzyme (VIMSS) | compare |
| b1914 | uvrY | -1.0 | -5.6 | response regulator (NCBI) | compare |
| b0564 | appY | -1.0 | -0.9 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b3390 | aroK | -1.0 | -1.6 | shikimate kinase I (NCBI) | compare |
| b4202 | rpsR | -1.0 | -0.7 | 30S ribosomal protein S18 (NCBI) | compare |
| b3869 | glnL | -1.0 | -5.6 | sensory histidine kinase in two-component regulatory system with GlnG (NCBI) | compare |
| b1663 | mdtK | -1.0 | -6.0 | multidrug efflux protein NorM (NCBI) | compare |
| b1693 | aroD | -1.0 | -4.5 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b4451 | ryhB | -1.0 | -2.1 | Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) | compare |
| b2285 | nuoE | -1.0 | -1.6 | NADH dehydrogenase subunit E (NCBI) | compare |
| b2494 | yfgC | -1.0 | -6.4 | predicted peptidase (NCBI) | compare |
| b4472 | yhdP | -1.0 | -8.9 | conserved membrane protein, predicted transporter (NCBI) | compare |
| b4593 | ymgI | -1.0 | -0.9 | hypothetical protein (RefSeq) | compare |
| b1233 | ychJ | -1.0 | -2.9 | hypothetical protein (NCBI) | compare |
| b2576 | srmB | -0.9 | -3.0 | ATP-dependent RNA helicase (NCBI) | compare |
| b3008 | metC | -0.9 | -6.8 | cystathionine beta-lyase (NCBI) | compare |
| b2809 | b2809 | -0.9 | -3.8 | orf, hypothetical protein (VIMSS) | compare |
| b1855 | lpxM | -0.9 | -3.3 | lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) | compare |
| b3493 | pitA | -0.9 | -5.3 | phosphate transporter, low-affinity (NCBI) | compare |
| b3956 | ppc | -0.9 | -8.0 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3652 | recG | -0.9 | -5.8 | ATP-dependent DNA helicase (NCBI) | compare |
| b0436 | tig | -0.9 | -6.1 | trigger factor (NCBI) | compare |
| b0428 | cyoE | -0.9 | -5.5 | protoheme IX farnesyltransferase (NCBI) | compare |
| b3616 | tdh | -0.9 | -5.7 | L-threonine 3-dehydrogenase (NCBI) | compare |
| b0075 | leuL | -0.9 | -4.2 | leu operon leader peptide (NCBI) | compare |
| b2313 | cvpA | -0.9 | -2.4 | membrane protein required for colicin V production (NCBI) | compare |
| b4396 | rob | -0.9 | -6.5 | DNA-binding transcriptional activator (NCBI) | compare |
| b0092 | ddlB | -0.9 | -4.4 | D-alanylalanine synthetase (NCBI) | compare |
| b1323 | tyrR | -0.9 | -5.1 | DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) | compare |
| b2168 | fruK | -0.9 | -1.0 | 1-phosphofructokinase (NCBI) | compare |
| b3465 | yhhF | -0.9 | -4.5 | predicted methyltransferase (NCBI) | compare |
| b1062 | pyrC | -0.9 | -2.9 | dihydroorotase (NCBI) | compare |
| b0726 | sucA | -0.9 | -3.2 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b2064 | asmA | -0.9 | -5.2 | predicted assembly protein (NCBI) | compare |
| b2259 | pmrD | -0.9 | -1.4 | polymyxin resistance protein B (VIMSS) | compare |
| b4214 | cysQ | -0.8 | -7.0 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b1684 | sufA | -0.8 | -3.2 | iron-sulfur cluster assembly scaffold protein (NCBI) | compare |
| b2744 | surE | -0.8 | -5.0 | acid phosphatase (NCBI) | compare |
| b2470 | acrD | -0.8 | -6.8 | aminoglycoside/multidrug efflux system (NCBI) | compare |
| b2742 | nlpD | -0.8 | -6.3 | predicted outer membrane lipoprotein (NCBI) | compare |
| b0149 | mrcB | -0.8 | -5.6 | penicillin-binding protein 1b (NCBI) | compare |
| b3993 | thiE | -0.8 | -4.6 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3926 | glpK | -0.8 | -6.8 | glycerol kinase (NCBI) | compare |
| b0033 | carB | -0.8 | -2.8 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2103 | thiD | -0.8 | -4.7 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b1260 | trpA | -0.8 | -4.6 | tryptophan synthase subunit alpha (NCBI) | compare |
| b2026 | hisI | -0.8 | -2.3 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b0720 | gltA | -0.8 | -4.1 | citrate synthase (NCBI) | compare |
| b2282 | nuoH | -0.7 | -2.2 | NADH dehydrogenase subunit H (NCBI) | compare |
| b0962 | helD | -0.7 | -4.9 | DNA helicase IV (NCBI) | compare |
| b0101 | yacG | -0.7 | -2.3 | zinc-binding protein (NCBI) | compare |
| b2829 | ptsP | -0.7 | -4.8 | fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) | compare |
| b2763 | cysI | -0.7 | -4.1 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b2553 | glnB | -0.7 | -3.0 | regulatory protein P-II for glutamine synthetase (NCBI) | compare |
| b3994 | thiC | -0.7 | -6.0 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b1823 | cspC | -0.7 | -2.0 | stress protein, member of the CspA-family (NCBI) | compare |
| b0051 | ksgA | -0.7 | -2.9 | dimethyladenosine transferase (NCBI) | compare |
| b0721 | sdhC | -0.7 | -2.9 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b0623 | cspE | -0.7 | -1.0 | cold shock protein E (NCBI) | compare |
| b2939 | yqgB | -0.7 | -1.2 | predicted protein (RefSeq) | compare |
| b1686 | ydiI | -0.7 | -2.1 | hypothetical protein (NCBI) | compare |
| b1609 | rstB | -0.7 | -3.3 | sensory histidine kinase in two-component regulatory system with RstA (NCBI) | compare |
| b4178 | yjeB | -0.7 | -3.1 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3973 | birA | -0.7 | -2.8 | biotin--protein ligase (NCBI) | compare |
| b2600 | tyrA | -0.7 | -3.4 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b1882 | cheY | -0.7 | -0.6 | chemotaxis regulator transmitting signal to flagellar motor component (NCBI) | compare |
| b2611 | ypjD | -0.7 | -4.3 | predicted inner membrane protein (RefSeq) | compare |
| b2281 | nuoI | -0.7 | -1.9 | NADH dehydrogenase subunit I (NCBI) | compare |
| b1109 | ndh | -0.7 | -2.3 | respiratory NADH dehydrogenase 2/cupric reductase (NCBI) | compare |
| b0588 | fepC | -0.7 | -4.1 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3468 | yhhN | -0.7 | -5.3 | conserved inner membrane protein (NCBI) | compare |
| b1105 | ycfM | -0.7 | -2.0 | predicted outer membrane lipoprotein (NCBI) | compare |
| b1677 | lpp | -0.7 | -0.8 | murein lipoprotein (NCBI) | compare |
| b2317 | dedA | -0.7 | -1.8 | conserved inner membrane protein (NCBI) | compare |
| b3931 | hslU | -0.6 | -5.6 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b2786 | barA | -0.6 | -6.1 | hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) | compare |
| b0590 | fepD | -0.6 | -4.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b4000 | hupA | -0.6 | -2.8 | HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) | compare |
| b3226 | yhcK | -0.6 | -2.9 | putative FADA-type transcriptional regulator (VIMSS) | compare |
| b0078 | ilvH | -0.6 | -4.6 | acetolactate synthase small subunit (NCBI) | compare |
| b2277 | nuoM | -0.6 | -3.2 | NADH dehydrogenase subunit M (NCBI) | compare |
| b0937 | ssuE | -0.6 | -1.5 | NAD(P)H-dependent FMN reductase (NCBI) | compare |
| b2038 | rfbC | -0.6 | -3.9 | dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) | compare |
| b1370 | insH-5 | -0.6 | -1.7 | Rac prophage; IS5 transposase and trans-activator (NCBI) | compare |
| b4533 | ynfO | -0.6 | -1.9 | Qin prophage; predicted protein (NCBI) | compare |
| b3739 | atpI | -0.6 | -3.5 | membrane-bound ATP synthase, dispensable protein, affects expression of atpB (VIMSS) | compare |
| b1423 | ydcJ | -0.6 | -2.2 | hypothetical protein (NCBI) | compare |