Experiment set52IT048 for Escherichia coli BW25113

Compare to:

Carbon source D-Mannitol 5 mM

200 most detrimental genes:

  gene name fitness t score description  
b2904 gcvH +2.1 9.4 glycine cleavage system protein H (NCBI) compare
b2903 gcvP +1.9 17.5 glycine dehydrogenase (NCBI) compare
b1361 ydaW +1.7 1.4 orf, hypothetical protein (VIMSS) compare
b2905 gcvT +1.7 13.4 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1161 ycgX +1.7 1.7 hypothetical protein (NCBI) compare
b4676 yoaK +1.5 1.9 expressed protein (RefSeq) compare
b1506 yneL +1.3 2.9 predicted transcriptional regulator (NCBI) compare
b2808 gcvA +1.2 7.4 DNA-binding transcriptional dual regulator (NCBI) compare
b0059 hepA +1.1 10.3 ATP-dependent helicase HepA (NCBI) compare
b0232 yafN +1.1 0.9 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b4402 yjjY +1.1 2.3 hypothetical protein (NCBI) compare
b4203 rplI +1.1 6.8 50S ribosomal protein L9 (NCBI) compare
b3206 npr +1.0 7.3 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b2829 ptsP +1.0 7.8 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b3977 tyrU +0.9 1.8 tRNA-Tyr (NCBI) compare
b2504 yfgG +0.9 2.3 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b3806 cyaA +0.9 4.8 adenylate cyclase (NCBI) compare
b0784 moaD +0.8 3.1 molybdopterin synthase, small subunit (NCBI) compare
b0990 cspG +0.8 1.4 DNA-binding transcriptional regulator (NCBI) compare
b4701 sokX +0.8 1.0 sok-related sRNA, function unknown (RefSeq) compare
b4048 yjbM +0.7 1.7 hypothetical protein (NCBI) compare
b2587 kgtP +0.7 5.9 alpha-ketoglutarate transporter (NCBI) compare
b1575 dicB +0.7 1.6 Qin prophage; cell division inhibition protein (NCBI) compare
b2947 gshB +0.7 4.7 glutathione synthetase (NCBI) compare
b1656 sodB +0.7 3.0 superoxide dismutase, Fe (NCBI) compare
b4406 yaeP +0.7 2.0 hypothetical protein (NCBI) compare
b3181 greA +0.7 4.8 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1418 cybB +0.7 2.8 cytochrome b(561) (VIMSS) compare
b1823 cspC +0.7 2.0 stress protein, member of the CspA-family (NCBI) compare
b1563 relE +0.7 2.2 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b3164 pnp +0.7 3.0 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b3842 rfaH +0.7 4.5 transcriptional activator RfaH (NCBI) compare
b4416 rybA +0.7 1.8 unknown RNA (NCBI) compare
b1567 intK +0.6 2.2 Qin prophage; predicted protein (RefSeq) compare
b1438 ydcQ +0.6 2.2 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1066 rimJ +0.6 4.2 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b3643 rph +0.6 1.9 ribonuclease PH (NCBI) compare
b1095 fabF +0.6 3.6 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b4453 ldrD +0.6 2.2 toxic polypeptide, small (NCBI) compare
b2356 yfdM +0.6 1.0 orf, hypothetical protein (VIMSS) compare
b4215 ytfI +0.6 1.6 hypothetical protein (NCBI) compare
b2688 gshA +0.6 4.0 glutamate--cysteine ligase (NCBI) compare
b1258 yciF +0.5 0.9 hypothetical protein (NCBI) compare
b1634 tppB +0.5 3.2 putative tripeptide transporter permease (NCBI) compare
b1138 ymfE +0.5 1.3 e14 prophage; predicted inner membrane protein (NCBI) compare
b0082 mraW +0.5 2.4 S-adenosyl-methyltransferase (NCBI) compare
b4653 yicT +0.5 1.5 no description compare
b1334 fnr +0.5 1.3 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1818 manY +0.5 1.9 mannose-specific enzyme IIC component of PTS (NCBI) compare
b1222 narX +0.5 2.9 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b0550 rusA +0.5 1.7 DLP12 prophage; endonuclease RUS (NCBI) compare
b4155 yjeA +0.5 0.6 putative lysyl-tRNA synthetase (VIMSS) compare
b1676 pykF +0.5 2.9 pyruvate kinase (NCBI) compare
b2783 chpR +0.5 2.0 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b2702 srlA +0.5 2.8 glucitol/sorbitol-specific enzyme IIC component of PTS (NCBI) compare
b2618 b2618 +0.5 3.0 orf, hypothetical protein (VIMSS) compare
b4598 yncL +0.5 1.4 hypothetical protein (RefSeq) compare
b1038 csgF +0.5 1.6 predicted transport protein (NCBI) compare
b2444 yffM +0.5 1.8 CPZ-55 prophage; predicted protein (NCBI) compare
b1855 lpxM +0.5 2.4 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2141 yohJ +0.5 1.7 hypothetical protein (NCBI) compare
b1792 yeaO +0.5 2.1 orf, hypothetical protein (VIMSS) compare
b1362 rzpR +0.5 1.9 putative Rac prophage endopeptidase (VIMSS) compare
b2136 yohD +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b3928 yiiU +0.4 2.7 hypothetical protein (NCBI) compare
b1727 yniC +0.4 1.8 predicted hydrolase (NCBI) compare
b1486 ddpB +0.4 1.9 D-ala-D-ala transporter subunit (NCBI) compare
b2236 yfaE +0.4 1.9 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b4545 ypdJ +0.4 1.2 no description compare
b2951 yggS +0.4 2.5 predicted enzyme (NCBI) compare
b4369 leuP +0.4 1.5 tRNA-Leu (NCBI) compare
b4413 sokC +0.4 1.2 regulatory antisense RNA (NCBI) compare
b0381 ddlA +0.4 3.1 D-alanylalanine synthetase (NCBI) compare
b4441 glmY +0.4 1.3 sRNA activator of glmS mRNA (RefSeq) compare
b1426 ydcH +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b1141 ymfG +0.4 2.3 e14 prophage; predicted excisionase (NCBI) compare
b3632 rfaQ +0.4 4.0 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1703 ydiA +0.4 1.9 hypothetical protein (NCBI) compare
b1305 pspB +0.4 1.9 phage shock protein B (NCBI) compare
b2679 proX +0.4 2.7 glycine betaine transporter subunit (NCBI) compare
b2939 yqgB +0.4 0.7 predicted protein (RefSeq) compare
b2175 spr +0.4 2.2 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0051 ksgA +0.4 2.0 dimethyladenosine transferase (NCBI) compare
b4546 ypeB +0.4 0.8 hypothetical protein (NCBI) compare
b1627 rsxA +0.4 1.2 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b4141 yjeH +0.4 3.5 predicted transporter (NCBI) compare
b4062 soxS +0.4 1.6 DNA-binding transcriptional dual regulator (NCBI) compare
b1183 umuD +0.4 1.3 DNA polymerase V, subunit D (NCBI) compare
b1726 yniB +0.4 0.9 predicted inner membrane protein (NCBI) compare
b2341 yfcX +0.4 3.0 fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI) compare
b4135 yjdC +0.4 3.3 orf, hypothetical protein (VIMSS) compare
b3082 ygjM +0.4 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b3043 ygiL +0.4 2.1 predicted fimbrial-like adhesin protein (NCBI) compare
b1090 plsX +0.4 2.3 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b2170 setB +0.4 1.9 lactose/glucose efflux system (NCBI) compare
b2134 pbpG +0.4 2.4 penicillin-binding protein 7 (VIMSS) compare
b1562 hokD +0.4 1.4 Qin prophage; small toxic polypeptide (NCBI) compare
b2266 elaB +0.4 2.5 hypothetical protein (NCBI) compare
b3766 ilvL +0.4 1.1 ilvG operon leader peptide (NCBI) compare
b3630 rfaP +0.4 3.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2897 ygfY +0.4 1.0 hypothetical protein (NCBI) compare
b3098 yqjD +0.4 1.5 hypothetical protein (NCBI) compare
b1812 pabB +0.4 1.7 para-aminobenzoate synthase component I (NCBI) compare
b1278 pgpB +0.4 1.4 phosphatidylglycerophosphatase B (NCBI) compare
b2768 ygcP +0.4 1.8 predicted anti-terminator regulatory protein (NCBI) compare
b3890 yiiF +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b1013 ycdC +0.4 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1504 ydeS +0.4 1.6 predicted fimbrial-like adhesin protein (NCBI) compare
b2910 zapA +0.4 2.5 protein that localizes to the cytokinetic ring (NCBI) compare
b1679 sufE +0.4 1.6 cysteine desufuration protein SufE (NCBI) compare
b2248 yfaX +0.4 1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1485 ddpC +0.4 1.9 D-ala-D-ala transporter subunit (NCBI) compare
b1660 ydhC +0.4 1.5 predicted transporter (NCBI) compare
b1752 ydjZ +0.4 0.9 conserved inner membrane protein (NCBI) compare
b2774 ygcW +0.4 2.0 putative oxidoreductase (VIMSS) compare
b1218 chaC +0.4 1.3 regulatory protein for cation transport (RefSeq) compare
b0190 yaeQ +0.4 2.3 hypothetical protein (NCBI) compare
b1791 yeaN +0.4 1.7 predicted transporter (NCBI) compare
b2419 yfeK +0.4 0.7 hypothetical protein (NCBI) compare
b3350 kefB +0.4 3.3 glutathione-regulated potassium-efflux system protein (NCBI) compare
b4655 ythA +0.4 0.6 expressed protein (RefSeq) compare
b0129 yadI +0.4 2.8 predicted PTS Enzyme IIA (NCBI) compare
b4461 yfjD +0.4 2.7 predicted inner membrane protein (RefSeq) compare
b3628 rfaB +0.4 2.9 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b1685 ydiH +0.4 0.8 predicted protein (RefSeq) compare
b1914 uvrY +0.4 2.1 response regulator (NCBI) compare
b4511 ybdZ +0.4 1.7 hypothetical protein (NCBI) compare
b2521 sseA +0.4 2.8 putative thiosulfate sulfurtransferase (VIMSS) compare
b0711 ybgJ +0.4 2.4 predicted enzyme subunit (NCBI) compare
b1446 ydcY +0.3 1.2 hypothetical protein (NCBI) compare
b3351 kefG +0.3 2.4 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b2343 b2343 +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b4378 yjjV +0.3 2.3 predicted DNase (NCBI) compare
b1247 oppF +0.3 1.3 oligopeptide transporter subunit (NCBI) compare
b3101 yqjF +0.3 1.4 orf, hypothetical protein (VIMSS) compare
b1390 paaC +0.3 1.4 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b3086 ygjQ +0.3 2.2 predicted thioredoxin-like (NCBI) compare
b2399 yfeD +0.3 2.0 predicted DNA-binding transcriptional regulator (RefSeq) compare
b0759 galE +0.3 2.1 UDP-galactose-4-epimerase (VIMSS) compare
b0852 rimK +0.3 1.8 ribosomal protein S6 modification protein (NCBI) compare
b4041 plsB +0.3 1.1 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1589 ynfG +0.3 1.0 oxidoreductase, Fe-S subunit (NCBI) compare
b1359 ydaU +0.3 1.5 Rac prophage; conserved protein (NCBI) compare
b1821 b1821 +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b0865 ybjP +0.3 1.8 predicted lipoprotein (NCBI) compare
b3199 yrbK +0.3 1.1 hypothetical protein (NCBI) compare
b3557 insJ +0.3 2.3 IS150 protein InsA (NCBI) compare
b1123 potD +0.3 1.8 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1335 ogt +0.3 1.3 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b0751 pnuC +0.3 2.0 predicted nicotinamide mononucleotide transporter (NCBI) compare
b2058 wcaB +0.3 0.7 predicted acyl transferase (NCBI) compare
b0989 cspH +0.3 1.0 stress protein, member of the CspA-family (NCBI) compare
b1650 nemA +0.3 1.6 N-ethylmaleimide reductase, FMN-linked (NCBI) compare
b0926 ycbK +0.3 1.7 hypothetical protein (NCBI) compare
b3836 b3836 +0.3 1.5 orf, hypothetical protein (VIMSS) compare
b4174 hflK +0.3 2.6 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b4533 ynfO +0.3 0.6 Qin prophage; predicted protein (NCBI) compare
b1187 fadR +0.3 2.2 fatty acid metabolism regulator (NCBI) compare
b0792 ybhR +0.3 1.6 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3929 rraA +0.3 2.5 ribonuclease activity regulator protein RraA (NCBI) compare
b1647 ydhF +0.3 1.2 predicted oxidoreductase (NCBI) compare
b1597 asr +0.3 1.1 acid shock protein (VIMSS) compare
b1122 ymfA +0.3 2.2 orf, hypothetical protein (VIMSS) compare
b3033 yqiB +0.3 2.2 predicted dehydrogenase (NCBI) compare
b0219 yafV +0.3 1.8 predicted C-N hydrolase family amidase, NAD(P)-binding (NCBI) compare
b4660 yhiL +0.3 0.2 no description compare
b1617 uidA +0.3 1.7 beta-D-glucuronidase (NCBI) compare
b3780 rhlB +0.3 2.5 ATP-dependent RNA helicase (NCBI) compare
b4345 mcrC +0.3 0.5 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b0856 potH +0.3 1.4 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1819 manZ +0.3 1.8 mannose-specific enzyme IID component of PTS (NCBI) compare
b4631 ykgQ +0.3 1.1 no description compare
b4371 rsmC +0.3 2.3 16S ribosomal RNA m2G1207 methyltransferase (NCBI) compare
b1111 ycfQ +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b3627 rfaI +0.3 2.4 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b0955 ycbZ +0.3 2.5 predicted peptidase (NCBI) compare
b0545 ybcL +0.3 2.4 DLP12 prophage; predicted kinase inhibitor (NCBI) compare
b3009 yghB +0.3 2.2 conserved inner membrane protein (NCBI) compare
b1035 ycdY +0.3 2.3 hypothetical protein (NCBI) compare
b4543 ypaA +0.3 1.7 predicted protein (NCBI) compare
b1751 ydjY +0.3 1.4 orf, hypothetical protein (VIMSS) compare
b0502 ylbG +0.3 1.3 no description compare
b2099 yegU +0.3 1.8 predicted hydrolase (NCBI) compare
b3631 rfaG +0.3 2.7 glucosyltransferase I (NCBI) compare
b1085 b1085 +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b0849 grxA +0.3 0.8 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b1621 malX +0.3 1.7 fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (NCBI) compare
b0405 queA +0.3 2.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (NCBI) compare
b1199 dhaL +0.3 1.1 dihydroxyacetone kinase, C-terminal domain (NCBI) compare
b3545 proK +0.3 0.9 tRNA-Pro (NCBI) compare
b0197 metQ +0.3 2.0 DL-methionine transporter subunit (NCBI) compare
b1433 b1433 +0.3 1.5 putative membrane transport protein (VIMSS) compare
b1922 fliA +0.3 1.9 flagellar biosynthesis; alternative sigma factor 28; regulation of flagellar operons (VIMSS) compare
b1739 osmE +0.3 1.1 DNA-binding transcriptional activator (NCBI) compare
b2346 vacJ +0.3 2.3 predicted lipoprotein (NCBI) compare
b1322 ycjF +0.3 1.8 hypothetical protein (NCBI) compare
b3152 yraR +0.3 1.7 orf, hypothetical protein (VIMSS) compare
b2151 galS +0.3 1.7 DNA-binding transcriptional repressor (NCBI) compare
b1618 uidR +0.3 0.9 DNA-binding transcriptional repressor (NCBI) compare
b4521 ycgI +0.3 1.1 hypothetical protein (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For carbon source D-Mannitol in Escherichia coli BW25113

For carbon source D-Mannitol across organisms