| | gene | name | fitness | t score | description | |
|---|
| b2476 | purC | -7.1 | -6.1 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1192 | ldcA | -6.6 | -6.4 | L,D-carboxypeptidase A (NCBI) | compare |
| b0243 | proA | -6.1 | -16.5 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3770 | ilvE | -5.9 | -20.3 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2838 | lysA | -5.9 | -17.4 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3960 | argH | -5.8 | -19.8 | argininosuccinate lyase (NCBI) | compare |
| b2312 | purF | -5.8 | -11.5 | amidophosphoribosyltransferase (NCBI) | compare |
| b1260 | trpA | -5.7 | -9.4 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3389 | aroB | -5.6 | -19.7 | 3-dehydroquinate synthase (NCBI) | compare |
| b2021 | hisC | -5.6 | -9.8 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3600 | mtlD | -5.6 | -18.9 | mannitol-1-phosphate 5-dehydrogenase (NCBI) | compare |
| b0004 | thrC | -5.6 | -14.8 | threonine synthase (NCBI) | compare |
| b1261 | trpB | -5.5 | -5.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b3772 | ilvA | -5.5 | -20.0 | threonine dehydratase (NCBI) | compare |
| b3956 | ppc | -5.5 | -25.1 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3281 | aroE | -5.5 | -25.6 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b2023 | hisH | -5.3 | -9.6 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b1281 | pyrF | -5.3 | -6.2 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b4388 | serB | -5.3 | -12.3 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0071 | leuD | -5.3 | -13.6 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0002 | thrA | -5.3 | -20.0 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b4005 | purD | -5.2 | -13.7 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b3771 | ilvD | -5.2 | -21.5 | dihydroxy-acid dehydratase (NCBI) | compare |
| b4006 | purH | -5.1 | -20.0 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b3774 | ilvC | -5.1 | -21.5 | ketol-acid reductoisomerase (NCBI) | compare |
| b0074 | leuA | -5.1 | -16.9 | 2-isopropylmalate synthase (NCBI) | compare |
| b0072 | leuC | -5.1 | -16.8 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b3941 | metF | -5.1 | -15.5 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b1693 | aroD | -5.1 | -10.2 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0073 | leuB | -5.0 | -15.9 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b3642 | pyrE | -5.0 | -9.6 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0720 | gltA | -5.0 | -12.1 | citrate synthase (NCBI) | compare |
| b2022 | hisB | -5.0 | -12.1 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2839 | lysR | -4.8 | -9.6 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2020 | hisD | -4.8 | -12.9 | histidinol dehydrogenase (NCBI) | compare |
| b0386 | proC | -4.8 | -10.6 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b0032 | carA | -4.8 | -9.5 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0242 | proB | -4.7 | -9.8 | gamma-glutamyl kinase (NCBI) | compare |
| b2026 | hisI | -4.7 | -11.0 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3172 | argG | -4.6 | -16.7 | argininosuccinate synthase (NCBI) | compare |
| b2557 | purL | -4.6 | -17.2 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0145 | dksA | -4.6 | -6.9 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b1062 | pyrC | -4.6 | -15.3 | dihydroorotase (NCBI) | compare |
| b0908 | aroA | -4.6 | -14.0 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0726 | sucA | -4.5 | -6.2 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b2499 | purM | -4.5 | -8.9 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2479 | gcvR | -4.4 | -8.9 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b3957 | argE | -4.4 | -20.0 | acetylornithine deacetylase (NCBI) | compare |
| b3959 | argB | -4.4 | -15.6 | acetylglutamate kinase (RefSeq) | compare |
| b2784 | relA | -4.4 | -17.8 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b2025 | hisF | -4.4 | -6.0 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3958 | argC | -4.3 | -19.5 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b0003 | thrB | -4.3 | -8.4 | homoserine kinase (NCBI) | compare |
| b0907 | serC | -4.3 | -9.4 | phosphoserine aminotransferase (NCBI) | compare |
| b0522 | purK | -4.2 | -13.4 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3939 | metB | -4.2 | -17.7 | cystathionine gamma-synthase (NCBI) | compare |
| b2024 | hisA | -4.2 | -3.9 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2913 | serA | -4.2 | -14.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0033 | carB | -4.1 | -20.6 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b0523 | purE | -4.0 | -6.8 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b2762 | cysH | -3.9 | -13.8 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b2329 | aroC | -3.9 | -9.6 | chorismate synthase (NCBI) | compare |
| b2600 | tyrA | -3.9 | -7.8 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3008 | metC | -3.9 | -14.8 | cystathionine beta-lyase (NCBI) | compare |
| b3870 | glnA | -3.8 | -4.5 | glutamine synthetase (NCBI) | compare |
| b0945 | pyrD | -3.8 | -16.7 | dihydroorotate dehydrogenase (NCBI) | compare |
| b4013 | metA | -3.8 | -9.2 | homoserine O-succinyltransferase (NCBI) | compare |
| b3773 | ilvY | -3.7 | -10.4 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2818 | argA | -3.7 | -11.0 | N-acetylglutamate synthase (NCBI) | compare |
| b2019 | hisG | -3.7 | -6.0 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2750 | cysC | -3.6 | -14.5 | adenylylsulfate kinase (NCBI) | compare |
| b2764 | cysJ | -3.5 | -16.4 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2414 | cysK | -3.4 | -19.5 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3916 | pfkA | -3.2 | -4.8 | 6-phosphofructokinase (NCBI) | compare |
| b3368 | cysG | -3.2 | -22.3 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b2763 | cysI | -3.2 | -13.5 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0113 | pdhR | -3.2 | -8.8 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b1263 | trpD | -2.9 | -4.7 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0200 | gmhB | -2.9 | -2.7 | hypothetical protein (NCBI) | compare |
| b2500 | purN | -2.8 | -7.4 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b0740 | tolB | -2.7 | -9.5 | translocation protein TolB precursor (NCBI) | compare |
| b0739 | tolA | -2.7 | -7.2 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b0564 | appY | -2.6 | -1.2 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b1262 | trpC | -2.5 | -4.1 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b2599 | pheA | -2.5 | -4.8 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b1712 | ihfA | -2.5 | -3.3 | integration host factor subunit alpha (NCBI) | compare |
| b3764 | yifE | -2.5 | -10.4 | hypothetical protein (NCBI) | compare |
| b4245 | pyrB | -2.4 | -14.5 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b4480 | hdfR | -2.3 | -10.3 | transcriptional regulator HdfR (NCBI) | compare |
| b3390 | aroK | -2.3 | -3.9 | shikimate kinase I (NCBI) | compare |
| b4214 | cysQ | -2.3 | -16.0 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b3237 | argR | -2.1 | -8.4 | arginine repressor (NCBI) | compare |
| b2501 | ppk | -2.1 | -12.6 | polyphosphate kinase (NCBI) | compare |
| b3053 | glnE | -2.1 | -9.7 | fused deadenylyltransferase/adenylyltransferase for glutamine synthetase (NCBI) | compare |
| b1361 | ydaW | -2.0 | -0.8 | orf, hypothetical protein (VIMSS) | compare |
| b3781 | trxA | -2.0 | -5.7 | thioredoxin 1 (VIMSS) | compare |
| b4593 | ymgI | -2.0 | -1.8 | hypothetical protein (RefSeq) | compare |
| b0912 | ihfB | -2.0 | -4.7 | integration host factor subunit beta (NCBI) | compare |
| b2313 | cvpA | -2.0 | -3.6 | membrane protein required for colicin V production (NCBI) | compare |
| b4171 | miaA | -2.0 | -5.6 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0738 | tolR | -2.0 | -5.2 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2699 | recA | -1.9 | -2.2 | recombinase A (NCBI) | compare |
| b1860 | ruvB | -1.9 | -2.1 | Holliday junction DNA helicase B (NCBI) | compare |
| b0741 | pal | -1.9 | -6.8 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b1830 | prc | -1.9 | -8.3 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b3236 | mdh | -1.8 | -10.1 | malate dehydrogenase (NCBI) | compare |
| b4177 | purA | -1.8 | -1.7 | adenylosuccinate synthetase (NCBI) | compare |
| b1677 | lpp | -1.8 | -2.5 | murein lipoprotein (NCBI) | compare |
| b3163 | nlpI | -1.8 | -5.9 | hypothetical protein (NCBI) | compare |
| b1865 | nudB | -1.7 | -3.1 | dATP pyrophosphohydrolase (NCBI) | compare |
| b1551 | b1551 | -1.7 | -1.1 | orf, hypothetical protein (VIMSS) | compare |
| b3169 | nusA | -1.6 | -5.1 | transcription elongation factor NusA (NCBI) | compare |
| b1264 | trpE | -1.6 | -2.8 | anthranilate synthase component I (NCBI) | compare |
| b1730 | ydjO | -1.6 | -1.4 | predicted protein (RefSeq) | compare |
| b0737 | tolQ | -1.6 | -4.8 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2330 | yfcB | -1.5 | -2.2 | putative adenine-specific methylase (VIMSS) | compare |
| b0817 | mntR | -1.5 | -4.6 | DNA-binding transcriptional regulator of mntH (NCBI) | compare |
| b4375 | prfC | -1.5 | -5.3 | peptide chain release factor 3 (NCBI) | compare |
| b0075 | leuL | -1.5 | -3.9 | leu operon leader peptide (NCBI) | compare |
| b3429 | glgA | -1.5 | -11.2 | glycogen synthase (NCBI) | compare |
| b3026 | qseC | -1.5 | -6.0 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b1286 | rnb | -1.4 | -3.8 | exoribonuclease II (NCBI) | compare |
| b3213 | gltD | -1.4 | -10.1 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b2642 | yfjW | -1.4 | -1.8 | CP4-57 prophage; predicted inner membrane protein (NCBI) | compare |
| b1217 | chaB | -1.4 | -2.7 | cation transport regulator (NCBI) | compare |
| b3204 | ptsN | -1.4 | -5.3 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0439 | lon | -1.4 | -5.4 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b2518 | ndk | -1.3 | -3.9 | nucleoside diphosphate kinase (NCBI) | compare |
| b3725 | pstB | -1.3 | -1.2 | phosphate transporter subunit (NCBI) | compare |
| b2188 | yejM | -1.3 | -8.8 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2846 | yqeH | -1.3 | -1.2 | orf, hypothetical protein (VIMSS) | compare |
| b0088 | murD | -1.3 | -3.5 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b3386 | rpe | -1.3 | -0.9 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b2751 | cysN | -1.3 | -8.6 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b3027 | ygiZ | -1.3 | -0.8 | conserved inner membrane protein (NCBI) | compare |
| b3212 | gltB | -1.3 | -11.3 | glutamate synthase, large subunit (NCBI) | compare |
| b2752 | cysD | -1.2 | -7.3 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3599 | mtlA | -1.2 | -10.6 | Mannitol phosphotransferase system, IIA/IIB/IIC components (EC 2.7.1.197) (from data) | conserved |
| b2741 | rpoS | -1.2 | -5.8 | RNA polymerase sigma factor (NCBI) | compare |
| b0928 | aspC | -1.2 | -6.1 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b1882 | cheY | -1.2 | -1.0 | chemotaxis regulator transmitting signal to flagellar motor component (NCBI) | compare |
| b4594 | ymgJ | -1.2 | -3.3 | hypothetical protein (RefSeq) | compare |
| b3811 | xerC | -1.2 | -2.5 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b3790 | rffC | -1.2 | -5.6 | TDP-fucosamine acetyltransferase (RefSeq) | compare |
| b3728 | pstS | -1.2 | -3.2 | phosphate transporter subunit (NCBI) | compare |
| b0890 | ftsK | -1.1 | -4.8 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b4066 | yjcF | -1.1 | -0.7 | hypothetical protein (NCBI) | compare |
| b0722 | sdhD | -1.1 | -4.2 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b3671 | ilvB | -1.1 | -9.0 | acetolactate synthase large subunit (NCBI) | compare |
| b3792 | wzxE | -1.1 | -6.9 | O-antigen translocase (NCBI) | compare |
| b2297 | pta | -1.1 | -0.7 | phosphate acetyltransferase (NCBI) | compare |
| b3650 | spoT | -1.1 | -5.9 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b2567 | rnc | -1.1 | -1.5 | ribonuclease III (NCBI) | compare |
| b2689 | yqaA | -1.1 | -3.1 | conserved inner membrane protein (NCBI) | compare |
| b3791 | rffA | -1.1 | -6.4 | TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) | compare |
| b4481 | rffT | -1.1 | -4.8 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b1499 | ydeO | -1.1 | -0.7 | predicted DNA-binding transcriptional acfivator (NCBI) | compare |
| b1269 | rluB | -1.1 | -3.5 | 23S rRNA pseudouridylate synthase (NCBI) | compare |
| b2894 | xerD | -1.1 | -1.2 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b4042 | dgkA | -1.0 | -2.4 | diacylglycerol kinase (NCBI) | compare |
| b2282 | nuoH | -1.0 | -4.0 | NADH dehydrogenase subunit H (NCBI) | compare |
| b1232 | purU | -1.0 | -4.9 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b0500 | ybbD | -1.0 | -0.6 | hypothetical protein (RefSeq) | compare |
| b0149 | mrcB | -1.0 | -8.7 | penicillin-binding protein 1b (NCBI) | compare |
| b2822 | recC | -1.0 | -4.9 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b2601 | aroF | -1.0 | -3.7 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b0142 | folK | -1.0 | -0.8 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0755 | gpmA | -1.0 | -6.2 | phosphoglyceromutase (NCBI) | compare |
| b2820 | recB | -1.0 | -1.2 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b2284 | nuoF | -0.9 | -4.5 | NADH:ubiquinone oxidoreductase, chain F (NCBI) | compare |
| b1861 | ruvA | -0.9 | -1.7 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b2286 | nuoC | -0.9 | -5.2 | NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) | compare |
| b3205 | yhbJ | -0.9 | -3.1 | hypothetical protein (NCBI) | compare |
| b2912 | ygfA | -0.9 | -3.0 | putative ligase (VIMSS) | compare |
| b0724 | sdhB | -0.9 | -4.5 | succinate dehydrogenase, FeS subunit (NCBI) | compare |
| b2340 | sixA | -0.9 | -4.0 | phosphohistidine phosphatase (NCBI) | compare |
| b3726 | pstA | -0.9 | -4.9 | phosphate transporter subunit (NCBI) | compare |
| b1409 | ynbB | -0.9 | -1.1 | predicted CDP-diglyceride synthase (NCBI) | compare |
| b0721 | sdhC | -0.9 | -4.1 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b1347 | ydaC | -0.9 | -0.5 | Rac prophage; predicted protein (NCBI) | compare |
| b3839 | tatC | -0.9 | -5.2 | TatABCE protein translocation system subunit (NCBI) | compare |
| b0889 | lrp | -0.9 | -3.6 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0049 | apaH | -0.9 | -2.7 | diadenosinetetraphosphatase (NCBI) | compare |
| b2935 | tktA | -0.9 | -2.4 | transketolase 1, thiamin-binding (NCBI) | compare |
| b0723 | sdhA | -0.9 | -7.0 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b1536 | ydeI | -0.8 | -1.1 | hypothetical protein (NCBI) | compare |
| b0957 | ompA | -0.8 | -2.6 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b1497 | b1497 | -0.8 | -0.5 | putative enzyme (VIMSS) | compare |
| b2287 | nuoB | -0.8 | -3.6 | NADH dehydrogenase subunit B (NCBI) | compare |
| b0767 | ybhE | -0.8 | -3.2 | 6-phosphogluconolactonase (NCBI) | compare |
| b0437 | clpP | -0.8 | -5.0 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b1129 | phoQ | -0.8 | -1.7 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b1480 | sra | -0.8 | -1.1 | 30S ribosomal subunit protein S22 (NCBI) | compare |
| b1060 | yceP | -0.8 | -4.2 | orf, hypothetical protein (VIMSS) | compare |
| b2290 | yfbQ | -0.8 | -6.8 | aspartate aminotransferase (NCBI) | compare |
| b1358 | ydaT | -0.8 | -1.6 | Rac prophage; predicted protein (NCBI) | compare |
| b2911 | ssrS | -0.8 | -1.8 | 6S regulatory RNA (NCBI) | compare |
| b2283 | nuoG | -0.8 | -5.6 | NADH:ubiquinone oxidoreductase, chain G (RefSeq) | compare |
| b1185 | dsbB | -0.8 | -2.1 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b1600 | mdtJ | -0.8 | -1.5 | multidrug efflux system transporter (NCBI) | compare |