Experiment set52IT047 for Escherichia coli BW25113

Compare to:

Carbon source D-Mannitol 10 mM

200 most detrimental genes:

  gene name fitness t score description  
b2904 gcvH +1.9 9.5 glycine cleavage system protein H (NCBI) compare
b2903 gcvP +1.9 17.5 glycine dehydrogenase (NCBI) compare
b2905 gcvT +1.5 10.9 glycine cleavage system aminomethyltransferase T (NCBI) compare
b4701 sokX +1.5 2.3 sok-related sRNA, function unknown (RefSeq) compare
b2808 gcvA +1.3 7.4 DNA-binding transcriptional dual regulator (NCBI) compare
b3977 tyrU +1.2 2.3 tRNA-Tyr (NCBI) compare
b0059 hepA +1.2 11.1 ATP-dependent helicase HepA (NCBI) compare
b3181 greA +1.1 5.1 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b4203 rplI +1.0 6.3 50S ribosomal protein L9 (NCBI) compare
b2829 ptsP +1.0 7.8 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b4647 mokA +1.0 1.2 no description compare
b4503 yafF +0.9 0.9 no description compare
b3206 npr +0.8 4.5 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b4533 ynfO +0.8 1.9 Qin prophage; predicted protein (NCBI) compare
b2587 kgtP +0.8 5.9 alpha-ketoglutarate transporter (NCBI) compare
b4698 mgrR +0.8 2.8 sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq) compare
b1334 fnr +0.8 2.6 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1438 ydcQ +0.8 3.2 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1667 ydhR +0.7 1.3 hypothetical protein (NCBI) compare
b4172 hfq +0.7 1.1 RNA-binding protein Hfq (NCBI) compare
b3806 cyaA +0.7 3.7 adenylate cyclase (NCBI) compare
b3504 yhiS +0.7 0.7 hypothetical protein (RefSeq) compare
b0303 ykgI +0.7 1.1 orf, hypothetical protein (VIMSS) compare
b2688 gshA +0.7 4.4 glutamate--cysteine ligase (NCBI) compare
b2236 yfaE +0.7 3.2 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b4373 rimI +0.7 3.8 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b4535 yniD +0.7 1.2 predicted protein (RefSeq) compare
b3164 pnp +0.7 2.9 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0989 cspH +0.7 2.2 stress protein, member of the CspA-family (NCBI) compare
b2951 yggS +0.6 3.6 predicted enzyme (NCBI) compare
b2804 fucU +0.6 3.0 L-fucose mutarotase (NCBI) compare
b2444 yffM +0.6 1.6 CPZ-55 prophage; predicted protein (NCBI) compare
b0784 moaD +0.6 2.7 molybdopterin synthase, small subunit (NCBI) compare
b1095 fabF +0.6 3.9 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1669 ydhT +0.6 1.7 hypothetical protein (NCBI) compare
b4546 ypeB +0.6 1.2 hypothetical protein (NCBI) compare
b0219 yafV +0.6 2.5 predicted C-N hydrolase family amidase, NAD(P)-binding (NCBI) compare
b3443 yrhA +0.6 1.6 orf, hypothetical protein (VIMSS) compare
b3341 rpsG +0.5 1.4 30S ribosomal protein S7 (NCBI) compare
b1752 ydjZ +0.5 1.6 conserved inner membrane protein (NCBI) compare
b2506 yfgI +0.5 1.7 hypothetical protein (NCBI) compare
b2783 chpR +0.5 2.2 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b2947 gshB +0.5 3.0 glutathione synthetase (NCBI) compare
b3068 ygjF +0.5 1.2 G/U mismatch-specific DNA glycosylase (NCBI) compare
b0627 tatE +0.5 1.3 twin arginine translocase protein E (NCBI) compare
b2934 cmtB +0.5 0.6 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b2939 yqgB +0.5 1.4 predicted protein (RefSeq) compare
b3643 rph +0.5 1.6 ribonuclease PH (NCBI) compare
b1758 b1758 +0.5 1.0 putative cytochrome oxidase (VIMSS) compare
b2659 b2659 +0.5 2.1 orf, hypothetical protein (VIMSS) compare
b1160 elbA +0.5 0.8 hypothetical protein (NCBI) compare
b3979 thrT +0.5 0.5 tRNA-Thr (NCBI) compare
b1360 ydaV +0.5 0.7 Rac prophage; predicted DNA replication protein (NCBI) compare
b1742 b1742 +0.5 1.5 orf, hypothetical protein (VIMSS) compare
b4418 sraB +0.5 1.0 unknown RNA (NCBI) compare
b0610 rnk +0.5 2.2 nucleoside diphosphate kinase regulator (NCBI) compare
b4406 yaeP +0.5 1.5 hypothetical protein (NCBI) compare
b1400 paaY +0.5 1.8 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b4345 mcrC +0.5 0.9 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b4215 ytfI +0.5 1.2 hypothetical protein (NCBI) compare
b1607 ydgC +0.5 1.0 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b0998 torD +0.4 0.9 chaperone protein TorD (NCBI) compare
b4012 yjaB +0.4 1.4 predicted acetyltransferase (NCBI) compare
b2823 ppdC +0.4 2.5 hypothetical protein (NCBI) compare
b2366 dsdA +0.4 2.8 D-serine dehydratase (NCBI) compare
b1697 ydiQ +0.4 2.2 hypothetical protein (NCBI) compare
b0661 miaB +0.4 3.7 isopentenyl-adenosine A37 tRNA methylthiolase (NCBI) compare
b1642 slyA +0.4 1.4 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0051 ksgA +0.4 2.5 dimethyladenosine transferase (NCBI) compare
b2521 sseA +0.4 3.6 putative thiosulfate sulfurtransferase (VIMSS) compare
b3632 rfaQ +0.4 4.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1597 asr +0.4 1.9 acid shock protein (VIMSS) compare
b3630 rfaP +0.4 3.6 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b0759 galE +0.4 2.9 UDP-galactose-4-epimerase (VIMSS) compare
b0232 yafN +0.4 0.4 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3842 rfaH +0.4 3.1 transcriptional activator RfaH (NCBI) compare
b4141 yjeH +0.4 3.6 predicted transporter (NCBI) compare
b1739 osmE +0.4 1.6 DNA-binding transcriptional activator (NCBI) compare
b4603 rseX +0.4 0.5 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2830 nudH +0.4 1.1 dinucleoside polyphosphate hydrolase (NCBI) compare
b1849 purT +0.4 2.5 phosphoribosylglycinamide formyltransferase 2 (NCBI) compare
b0249 ykfF +0.4 1.8 CP4-6 prophage; predicted protein (NCBI) compare
b1868 yecE +0.4 1.2 hypothetical protein (NCBI) compare
b2237 inaA +0.4 1.2 hypothetical protein (NCBI) compare
b4369 leuP +0.4 1.1 tRNA-Leu (NCBI) compare
b2356 yfdM +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b2198 ccmD +0.4 1.9 cytochrome c biogenesis protein (NCBI) compare
b1567 intK +0.4 1.2 Qin prophage; predicted protein (RefSeq) compare
b4135 yjdC +0.4 2.9 orf, hypothetical protein (VIMSS) compare
b3199 yrbK +0.4 1.5 hypothetical protein (NCBI) compare
b0852 rimK +0.4 2.2 ribosomal protein S6 modification protein (NCBI) compare
b4294 insA-7 +0.4 1.5 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b1461 ydcE +0.4 1.2 4-oxalocrotonate tautomerase (NCBI) compare
b1855 lpxM +0.4 2.2 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2376 ypdI +0.4 1.7 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b1630 rsxD +0.4 2.3 electron transport complex protein RnfD (NCBI) compare
b3043 ygiL +0.4 2.2 predicted fimbrial-like adhesin protein (NCBI) compare
b0502 ylbG +0.4 1.2 no description compare
b1282 yciH +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b2082 ogrK +0.4 1.4 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b0190 yaeQ +0.4 2.3 hypothetical protein (NCBI) compare
b1671 ydhX +0.4 0.8 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b1125 potB +0.4 2.1 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b4692 oweE +0.4 1.4 no description compare
b2684 mprA +0.4 2.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b4050 yjbO +0.4 2.4 orf, hypothetical protein (VIMSS) compare
b1618 uidR +0.4 1.2 DNA-binding transcriptional repressor (NCBI) compare
b1589 ynfG +0.4 1.1 oxidoreductase, Fe-S subunit (NCBI) compare
b1548 nohA +0.4 1.0 Qin prophage; predicted packaging protein (RefSeq) compare
b1253 yciA +0.4 1.2 predicted hydrolase (NCBI) compare
b1380 ldhA +0.4 0.9 D-lactate dehydrogenase (NCBI) compare
b2726 hypA +0.4 2.5 protein involved in nickel insertion into hydrogenases 3 (NCBI) compare
b3780 rhlB +0.4 3.0 ATP-dependent RNA helicase (NCBI) compare
b1793 yoaF +0.4 1.4 conserved outer membrane protein (NCBI) compare
b0580 ybdJ +0.4 1.4 predicted inner membrane protein (NCBI) compare
b4523 yciX +0.4 1.8 hypothetical protein (RefSeq) compare
b1199 dhaL +0.4 1.6 dihydroxyacetone kinase, C-terminal domain (NCBI) compare
b1141 ymfG +0.4 1.6 e14 prophage; predicted excisionase (NCBI) compare
b0696 kdpC +0.3 1.9 potassium-transporting ATPase subunit C (NCBI) compare
b1854 pykA +0.3 2.4 pyruvate kinase (NCBI) compare
b3769 ilvM +0.3 1.4 acetolactate synthase II, small subunit (NCBI) compare
b2735 ygbI +0.3 1.8 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2646 ypjF +0.3 1.4 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b4695 ykgT +0.3 1.3 no description compare
b2707 srlR +0.3 2.1 DNA-bindng transcriptional repressor (NCBI) compare
b2007 yeeX +0.3 1.5 conserved protein (RefSeq) compare
b3351 kefG +0.3 2.6 glutathione-regulated potassium-efflux system ancillary protein (NCBI) compare
b0550 rusA +0.3 0.8 DLP12 prophage; endonuclease RUS (NCBI) compare
b4030 yjbA +0.3 1.6 phosphate-starvation-inducible protein PsiE (NCBI) compare
b2114 metG +0.3 1.1 methionyl-tRNA synthetase (NCBI) compare
b3009 yghB +0.3 2.5 conserved inner membrane protein (NCBI) compare
b3002 yqhA +0.3 0.6 hypothetical protein (NCBI) compare
b4363 yjjB +0.3 1.3 conserved inner membrane protein (RefSeq) compare
b0881 clpS +0.3 1.1 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b3929 rraA +0.3 2.6 ribonuclease activity regulator protein RraA (NCBI) compare
b3292 zntR +0.3 1.4 zinc-responsive transcriptional regulator (NCBI) compare
b3350 kefB +0.3 3.1 glutathione-regulated potassium-efflux system protein (NCBI) compare
b4582 yoeA +0.3 1.6 no description compare
b1302 puuE +0.3 1.4 GABA aminotransferase, PLP-dependent (NCBI) compare
b1904 yecR +0.3 1.2 hypothetical protein (NCBI) compare
b1823 cspC +0.3 1.1 stress protein, member of the CspA-family (NCBI) compare
b2579 yfiD +0.3 1.2 pyruvate formate lyase subunit (NCBI) compare
b1394 paaG +0.3 1.5 enoyl-CoA hydratase (NCBI) compare
b2910 zapA +0.3 1.0 protein that localizes to the cytokinetic ring (NCBI) compare
b1575 dicB +0.3 0.7 Qin prophage; cell division inhibition protein (NCBI) compare
b0796 ybiH +0.3 1.9 putative transcriptional regulator (VIMSS) compare
b1273 yciN +0.3 0.8 hypothetical protein (NCBI) compare
b3601 mtlR +0.3 2.1 DNA-binding repressor (NCBI) compare
b1139 lit +0.3 1.8 e14 prophage; cell death peptidase, inhibitor of T4 late gene expression (NCBI) compare
b1751 ydjY +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b1953 b1953 +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b1609 rstB +0.3 1.8 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b1222 narX +0.3 1.7 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b0195 yaeB +0.3 2.5 hypothetical protein (NCBI) compare
b1148 ymfM +0.3 1.5 e14 prophage; predicted protein (NCBI) compare
b3423 glpR +0.3 2.5 DNA-binding transcriptional repressor (NCBI) compare
b0178 hlpA +0.3 1.9 periplasmic chaperone (NCBI) compare
b2103 thiD +0.3 2.1 phosphomethylpyrimidine kinase (NCBI) compare
b1395 paaH +0.3 2.1 3-hydroxybutyryl-CoA dehydrogenase (NCBI) compare
b2134 pbpG +0.3 1.5 penicillin-binding protein 7 (VIMSS) compare
b1824 yobF +0.3 1.5 hypothetical protein (NCBI) compare
b0197 metQ +0.3 2.4 DL-methionine transporter subunit (NCBI) compare
b0955 ycbZ +0.3 2.3 predicted peptidase (NCBI) compare
b1519 tam +0.3 1.7 trans-aconitate 2-methyltransferase (NCBI) compare
b3484 yhhI +0.3 1.2 predicted transposase (NCBI) compare
b1755 ynjC +0.3 1.8 fused transporter subunits of ABC superfamily: membrane components (RefSeq) compare
b1692 ydiB +0.3 1.3 quinate/shikimate 5-dehydrogenase, NAD(P)-binding (NCBI) compare
b0791 ybhQ +0.3 1.6 predicted inner membrane protein (NCBI) compare
b4521 ycgI +0.3 1.4 hypothetical protein (NCBI) compare
b3469 zntA +0.3 2.2 zinc, cobalt and lead efflux system (NCBI) compare
b1278 pgpB +0.3 0.9 phosphatidylglycerophosphatase B (NCBI) compare
b1231 tyrT +0.3 0.5 tRNA-Tyr (NCBI) compare
b0469 apt +0.3 2.2 adenine phosphoribosyltransferase (NCBI) compare
b0225 yafQ +0.3 1.4 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1632 rsxE +0.3 2.1 NADH-ubiquinone oxidoreductase (NCBI) compare
b0934 ycbM +0.3 1.3 putative transport system permease protein (VIMSS) compare
b4461 yfjD +0.3 2.5 predicted inner membrane protein (RefSeq) compare
b1307 pspD +0.3 0.8 peripheral inner membrane phage-shock protein (NCBI) compare
b3034 nudF +0.3 1.8 ADP-ribose pyrophosphatase (NCBI) compare
b4048 yjbM +0.3 0.6 hypothetical protein (NCBI) compare
b2889 idi +0.3 1.8 isopentenyl-diphosphate delta-isomerase (NCBI) compare
b1727 yniC +0.3 1.1 predicted hydrolase (NCBI) compare
b4041 plsB +0.3 0.9 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4581 ybeM +0.3 1.8 no description compare
b3631 rfaG +0.3 2.6 glucosyltransferase I (NCBI) compare
b3627 rfaI +0.3 2.3 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b1486 ddpB +0.3 0.9 D-ala-D-ala transporter subunit (NCBI) compare
b0751 pnuC +0.3 1.9 predicted nicotinamide mononucleotide transporter (NCBI) compare
b0678 nagB +0.3 1.2 glucosamine-6-phosphate deaminase (NCBI) compare
b1676 pykF +0.3 1.3 pyruvate kinase (NCBI) compare
b4699 fnrS +0.3 0.4 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b2168 fruK +0.3 0.7 1-phosphofructokinase (NCBI) compare
b4527 b1354 +0.3 1.6 orf, hypothetical protein (VIMSS) compare
b3446 yrhB +0.3 1.6 hypothetical protein (NCBI) compare
b4545 ypdJ +0.3 1.0 no description compare
b2702 srlA +0.3 2.1 glucitol/sorbitol-specific enzyme IIC component of PTS (NCBI) compare
b4675 yoaJ +0.3 1.4 expressed protein (RefSeq) compare
b1767 ansA +0.3 1.9 cytoplasmic asparaginase I (NCBI) compare
b0809 glnQ +0.3 1.6 glutamine ABC transporter ATP-binding protein (NCBI) compare
b1075 flgD +0.3 1.3 flagellar basal body rod modification protein D (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For carbon source D-Mannitol in Escherichia coli BW25113

For carbon source D-Mannitol across organisms