Experiment set4IT069 for Escherichia coli BW25113

Compare to:

LB with capsaicin 2 mM

200 most important genes:

  gene name fitness t score description  
b0463 acrA -7.0 -6.8 multidrug efflux system (NCBI) compare
b0462 acrB -7.0 -11.7 multidrug efflux system protein (NCBI) compare
b3035 tolC -5.0 -11.7 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3792 wzxE -4.3 -13.7 O-antigen translocase (NCBI) compare
b3390 aroK -3.7 -4.3 shikimate kinase I (NCBI) compare
b2820 recB -3.6 -4.3 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3621 rfaC -3.4 -7.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b2285 nuoE -3.1 -4.7 NADH dehydrogenase subunit E (NCBI) compare
b3619 rfaD -3.1 -6.3 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0630 lipB -3.1 -3.6 protein of lipoate biosynthesis (VIMSS) compare
b3052 rfaE -2.9 -7.6 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0200 gmhB -2.9 -2.8 hypothetical protein (NCBI) compare
b0222 lpcA -2.8 -5.0 phosphoheptose isomerase (NCBI) compare
b1236 galU -2.8 -7.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b0118 acnB -2.7 -5.5 aconitate hydratase (NCBI) compare
b0053 surA -2.5 -7.8 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b4172 hfq -2.3 -3.2 RNA-binding protein Hfq (NCBI) compare
b3811 xerC -2.3 -4.6 site-specific tyrosine recombinase XerC (NCBI) compare
b0737 tolQ -2.3 -5.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3620 rfaF -2.2 -6.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2281 nuoI -2.1 -3.9 NADH dehydrogenase subunit I (NCBI) compare
b2699 recA -2.1 -3.4 recombinase A (NCBI) compare
b4577 sgrS -2.0 -3.1 small antisense RNA (NCBI) compare
b0739 tolA -2.0 -5.5 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2567 rnc -1.9 -2.6 ribonuclease III (NCBI) compare
b0890 ftsK -1.9 -9.6 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3386 rpe -1.8 -2.5 ribulose-phosphate 3-epimerase (NCBI) compare
b2330 yfcB -1.7 -3.4 putative adenine-specific methylase (VIMSS) compare
b0740 tolB -1.7 -6.0 translocation protein TolB precursor (NCBI) compare
b0683 fur -1.7 -2.8 ferric uptake regulator (NCBI) compare
b2935 tktA -1.7 -4.2 transketolase 1, thiamin-binding (NCBI) compare
b3229 sspA -1.7 -4.6 stringent starvation protein A (NCBI) compare
b4177 purA -1.6 -4.4 adenylosuccinate synthetase (NCBI) compare
b2576 srmB -1.6 -4.5 ATP-dependent RNA helicase (NCBI) compare
b3162 deaD -1.6 -6.6 inducible ATP-independent RNA helicase (VIMSS) compare
b2297 pta -1.6 -2.5 phosphate acetyltransferase (NCBI) compare
b2822 recC -1.5 -5.9 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b3198 kdsC -1.5 -4.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3414 gntY -1.5 -6.4 predicted gluconate transport associated protein (NCBI) compare
b3839 tatC -1.5 -7.4 TatABCE protein translocation system subunit (NCBI) compare
b0232 yafN -1.5 -1.3 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3631 rfaG -1.5 -11.6 glucosyltransferase I (NCBI) compare
b3630 rfaP -1.5 -9.9 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2284 nuoF -1.5 -5.7 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b2282 nuoH -1.5 -3.9 NADH dehydrogenase subunit H (NCBI) compare
b3728 pstS -1.4 -5.7 phosphate transporter subunit (NCBI) compare
b3725 pstB -1.3 -3.2 phosphate transporter subunit (NCBI) compare
b1095 fabF -1.3 -6.3 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0149 mrcB -1.3 -9.3 penicillin-binding protein 1b (NCBI) compare
b1861 ruvA -1.2 -2.8 Holliday junction DNA helicase motor protein (NCBI) compare
b3290 trkA -1.2 -3.9 potassium transporter peripheral membrane component (NCBI) compare
b0114 aceE -1.2 -2.9 pyruvate dehydrogenase subunit E1 (NCBI) compare
b1863 ruvC -1.2 -3.7 Holliday junction resolvase (NCBI) compare
b1709 btuD -1.2 -1.7 vitamin B12-transporter ATPase (NCBI) compare
b3609 secB -1.2 -3.1 export protein SecB (NCBI) compare
b2279 nuoK -1.1 -2.4 NADH dehydrogenase subunit K (NCBI) compare
b3842 rfaH -1.1 -3.6 transcriptional activator RfaH (NCBI) compare
b1290 sapF -1.1 -2.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4146 yjeK -1.1 -3.6 predicted lysine aminomutase (NCBI) compare
b1514 lsrC -1.1 -2.1 AI2 transporter (NCBI) compare
b3426 glpD -1.1 -5.4 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b3463 ftsE -1.1 -3.9 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0738 tolR -1.1 -3.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3940 metL -1.1 -5.4 bifunctional aspartate kinase II/homoserine dehydrogenase II (NCBI) compare
b1830 prc -1.1 -4.7 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4402 yjjY -1.0 -1.7 hypothetical protein (NCBI) compare
b0014 dnaK -1.0 -2.2 molecular chaperone DnaK (NCBI) compare
b2286 nuoC -1.0 -4.6 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b3237 argR -1.0 -4.1 arginine repressor (NCBI) compare
b0439 lon -1.0 -4.5 DNA-binding ATP-dependent protease La (NCBI) compare
b0357 yaiN -1.0 -2.4 putative alpha helix chain (VIMSS) compare
b1677 lpp -1.0 -1.9 murein lipoprotein (NCBI) compare
b1434 ydcN -1.0 -2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3613 yibP -1.0 -4.7 putative membrane protein (VIMSS) compare
b2277 nuoM -1.0 -4.7 NADH dehydrogenase subunit M (NCBI) compare
b4647 mokA -1.0 -1.8 no description compare
b2531 iscR -1.0 -0.9 DNA-binding transcriptional repressor (NCBI) compare
b3871 bipA -1.0 -6.4 GTP-binding protein (NCBI) compare
b2479 gcvR -1.0 -3.9 transcriptional regulation of gcv operon (VIMSS) compare
b3493 pitA -1.0 -6.1 phosphate transporter, low-affinity (NCBI) compare
b3778 rep -1.0 -6.0 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2784 relA -0.9 -6.5 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b1865 nudB -0.9 -1.9 dATP pyrophosphohydrolase (NCBI) compare
b3706 trmE -0.9 -4.4 tRNA modification GTPase (NCBI) compare
b2512 yfgL -0.9 -4.3 protein assembly complex, lipoprotein component (NCBI) compare
b3164 pnp -0.9 -1.7 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b3462 ftsX -0.9 -4.4 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2283 nuoG -0.9 -5.4 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3636 rpmG -0.9 -1.8 50S ribosomal protein L33 (NCBI) compare
b2287 nuoB -0.9 -2.5 NADH dehydrogenase subunit B (NCBI) compare
b1048 mdoG -0.9 -5.0 glucan biosynthesis protein, periplasmic (NCBI) compare
b0247 ykfG -0.9 -1.2 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b3838 tatB -0.9 -4.6 sec-independent translocase (NCBI) compare
b1848 yebG -0.9 -1.4 conserved protein regulated by LexA (NCBI) compare
b3026 qseC -0.9 -3.5 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0688 pgm -0.9 -3.2 phosphoglucomutase (NCBI) compare
b4025 pgi -0.9 -5.4 glucose-6-phosphate isomerase (NCBI) compare
b3616 tdh -0.9 -4.2 L-threonine 3-dehydrogenase (NCBI) compare
b4155 yjeA -0.9 -1.5 putative lysyl-tRNA synthetase (VIMSS) compare
b2278 nuoL -0.8 -5.5 NADH dehydrogenase subunit L (NCBI) compare
b3398 yrfF -0.8 -1.6 predicted inner membrane protein (NCBI) compare
b0437 clpP -0.8 -5.3 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b0082 mraW -0.8 -3.2 S-adenosyl-methyltransferase (NCBI) compare
b1358 ydaT -0.8 -1.4 Rac prophage; predicted protein (NCBI) compare
b4163 glyV -0.8 -1.7 tRNA-Gly (NCBI) compare
b2288 nuoA -0.8 -2.6 NADH dehydrogenase I chain A (VIMSS) compare
b2280 nuoJ -0.8 -3.6 NADH dehydrogenase subunit J (NCBI) compare
b4551 yheV -0.8 -2.0 hypothetical protein (NCBI) compare
b2276 nuoN -0.8 -3.5 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b4513 kdpF -0.8 -2.3 potassium ion accessory transporter subunit (NCBI) compare
b1231 tyrT -0.8 -1.1 tRNA-Tyr (NCBI) compare
b3979 thrT -0.8 -1.0 tRNA-Thr (NCBI) compare
b3726 pstA -0.8 -3.4 phosphate transporter subunit (NCBI) compare
b2198 ccmD -0.8 -2.4 cytochrome c biogenesis protein (NCBI) compare
b1105 ycfM -0.8 -2.5 predicted outer membrane lipoprotein (NCBI) compare
b2528 iscA -0.8 -1.4 iron-sulfur cluster assembly protein (NCBI) compare
b4585 sroB -0.8 -1.1 Novel sRNA, function unknown (RefSeq) compare
b2579 yfiD -0.8 -1.9 pyruvate formate lyase subunit (NCBI) compare
b3183 obgE -0.7 -1.3 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0049 apaH -0.7 -3.3 diadenosinetetraphosphatase (NCBI) compare
b1676 pykF -0.7 -3.2 pyruvate kinase (NCBI) compare
b4685 yrbN -0.7 -1.6 expressed protein (RefSeq) compare
b2363 yfdT -0.7 -1.8 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b4426 isrA -0.7 -1.3 unknown RNA (NCBI) compare
b3617 kbl -0.7 -4.1 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b3727 pstC -0.7 -3.4 phosphate transporter subunit (NCBI) compare
b1124 potC -0.7 -3.8 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3210 arcB -0.7 -4.0 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b3741 gidA -0.7 -4.2 glucose-inhibited division protein A (NCBI) compare
b0677 nagA -0.7 -3.0 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0438 clpX -0.7 -3.8 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3082 ygjM -0.7 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2569 lepA -0.7 -2.9 GTP-binding protein LepA (NCBI) compare
b2058 wcaB -0.7 -0.9 predicted acyl transferase (NCBI) compare
b2325 yfcL -0.6 -2.5 hypothetical protein (NCBI) compare
b1144 ymfJ -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b1658 purR -0.6 -2.8 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b4381 deoC -0.6 -2.8 deoxyribose-phosphate aldolase (NCBI) compare
b2017 yefM -0.6 -1.9 orf, hypothetical protein (VIMSS) compare
b1292 sapC -0.6 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3863 polA -0.6 -1.1 DNA polymerase I (NCBI) compare
b0726 sucA -0.6 -2.2 alpha-ketoglutarate decarboxylase (NCBI) compare
b0145 dksA -0.6 -2.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3163 nlpI -0.6 -2.1 hypothetical protein (NCBI) compare
b2258 b2258 -0.6 -1.1 putative transport/receptor protein (VIMSS) compare
b1572 ydfB -0.6 -1.1 orf, hypothetical protein (VIMSS) compare
b3632 rfaQ -0.6 -5.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1955 yedP -0.6 -2.0 hypothetical protein (NCBI) compare
b0627 tatE -0.6 -1.1 twin arginine translocase protein E (NCBI) compare
b2617 smpA -0.6 -2.3 small membrane protein A (VIMSS) compare
b1049 mdoH -0.6 -4.2 glucosyltransferase MdoH (NCBI) compare
b4104 phnE -0.6 -1.7 phosphonate/organophosphate ester transporter subunit (NCBI) compare
b3962 udhA -0.6 -4.3 putative oxidoreductase (VIMSS) compare
b2895 fldB -0.6 -2.0 flavodoxin 2 (NCBI) compare
b1793 yoaF -0.6 -1.9 conserved outer membrane protein (NCBI) compare
b4201 priB -0.6 -1.6 primosomal replication protein N (NCBI) compare
b1765 ydjA -0.6 -0.9 predicted oxidoreductase (NCBI) compare
b0912 ihfB -0.6 -1.5 integration host factor subunit beta (NCBI) compare
b1317 ycjU -0.6 -2.5 predicted beta-phosphoglucomutase (NCBI) compare
b3916 pfkA -0.6 -2.0 6-phosphofructokinase (NCBI) compare
b0189 yaeO -0.6 -2.7 orf, hypothetical protein (VIMSS) compare
b4041 plsB -0.6 -1.3 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4695 ykgT -0.6 -1.2 no description compare
b3649 rpoZ -0.6 -1.9 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0113 pdhR -0.6 -2.1 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b0605 ahpC -0.6 -2.1 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b0720 gltA -0.6 -2.9 citrate synthase (NCBI) compare
b0756 galM -0.6 -2.4 galactose-1-epimerase (mutarotase) (NCBI) compare
b2498 upp -0.6 -1.7 uracil phosphoribosyltransferase (VIMSS) compare
b1855 lpxM -0.5 -2.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3405 ompR -0.5 -2.6 osmolarity response regulator (NCBI) compare
b2359 yfdP -0.5 -2.8 CPS-53 (KpLE1) prophage; predicted protein (RefSeq) compare
b1594 dgsA -0.5 -2.6 DNA-binding transcriptional repressor (NCBI) compare
b1394 paaG -0.5 -1.5 enoyl-CoA hydratase (NCBI) compare
b0843 ybjH -0.5 -1.7 hypothetical protein (NCBI) compare
b1192 ldcA -0.5 -2.4 L,D-carboxypeptidase A (NCBI) compare
b1989 asnV -0.5 -1.6 tRNA-Asn (NCBI) compare
b0028 fkpB -0.5 -1.7 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b0759 galE -0.5 -2.4 UDP-galactose-4-epimerase (VIMSS) compare
b1831 proQ -0.5 -2.2 putative solute/DNA competence effector (NCBI) compare
b4042 dgkA -0.5 -1.7 diacylglycerol kinase (NCBI) compare
b0767 ybhE -0.5 -1.8 6-phosphogluconolactonase (NCBI) compare
b0406 tgt -0.5 -2.6 queuine tRNA-ribosyltransferase (NCBI) compare
b0696 kdpC -0.5 -1.7 potassium-transporting ATPase subunit C (NCBI) compare
b4191 ulaR -0.5 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b1841 yobA -0.5 -1.2 hypothetical protein (NCBI) compare
b0741 pal -0.5 -1.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b2340 sixA -0.5 -2.1 phosphohistidine phosphatase (NCBI) compare
b2937 speB -0.5 -3.2 agmatinase (NCBI) compare
b3781 trxA -0.5 -2.0 thioredoxin 1 (VIMSS) compare
b1278 pgpB -0.5 -1.3 phosphatidylglycerophosphatase B (NCBI) compare
b2900 yqfB -0.5 -1.2 hypothetical protein (NCBI) compare
b1286 rnb -0.5 -1.8 exoribonuclease II (NCBI) compare
b4045 yjbJ -0.5 -1.4 predicted stress response protein (NCBI) compare
b1123 potD -0.5 -2.0 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b0212 gloB -0.5 -1.5 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b2141 yohJ -0.5 -1.7 hypothetical protein (NCBI) compare
b0685 ybfE -0.5 -1.5 orf, hypothetical protein (VIMSS) compare
b4101 phnG -0.5 -2.0 carbon-phosphorus lyase complex subunit (NCBI) compare
b0131 panD -0.5 -1.9 aspartate 1-decarboxylase precursor (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress capsaicin across organisms