Experiment set4IT068 for Escherichia coli BW25113

Compare to:

LB with 2,4-Dinitrophenol 1 mM

200 most important genes:

  gene name fitness t score description  
b3792 wzxE -6.2 -4.3 O-antigen translocase (NCBI) compare
b3035 tolC -5.3 -10.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b4172 hfq -4.5 -3.1 RNA-binding protein Hfq (NCBI) compare
b0053 surA -4.3 -5.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3052 rfaE -4.1 -6.2 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0222 lpcA -4.1 -4.8 phosphoheptose isomerase (NCBI) compare
b3842 rfaH -4.0 -6.7 transcriptional activator RfaH (NCBI) compare
b0630 lipB -4.0 -2.7 protein of lipoate biosynthesis (VIMSS) compare
b3619 rfaD -4.0 -4.7 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3621 rfaC -3.9 -6.9 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3884 yihW -3.7 -8.0 putative DEOR-type transcriptional regulator (VIMSS) compare
b2686 emrB -3.5 -12.4 multidrug efflux system protein (NCBI) compare
b3620 rfaF -3.5 -5.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b1236 galU -3.4 -8.2 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2685 emrA -3.4 -8.7 multidrug efflux system (NCBI) compare
b0683 fur -3.3 -3.9 ferric uptake regulator (NCBI) compare
b0200 gmhB -3.2 -2.2 hypothetical protein (NCBI) compare
b3725 pstB -3.1 -4.3 phosphate transporter subunit (NCBI) compare
b2285 nuoE -3.0 -3.6 NADH dehydrogenase subunit E (NCBI) compare
b3630 rfaP -3.0 -15.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2279 nuoK -2.8 -3.8 NADH dehydrogenase subunit K (NCBI) compare
b3631 rfaG -2.8 -19.5 glucosyltransferase I (NCBI) compare
b3183 obgE -2.8 -2.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b4375 prfC -2.8 -10.1 peptide chain release factor 3 (NCBI) compare
b3728 pstS -2.7 -8.2 phosphate transporter subunit (NCBI) compare
b2016 yeeZ -2.6 -8.3 predicted epimerase, with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b2281 nuoI -2.5 -4.8 NADH dehydrogenase subunit I (NCBI) compare
b3871 bipA -2.4 -12.2 GTP-binding protein (NCBI) compare
b2820 recB -2.4 -4.3 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3839 tatC -2.4 -11.6 TatABCE protein translocation system subunit (NCBI) compare
b3386 rpe -2.4 -2.3 ribulose-phosphate 3-epimerase (NCBI) compare
b0738 tolR -2.4 -5.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0688 pgm -2.4 -5.4 phosphoglucomutase (NCBI) compare
b3398 yrfF -2.3 -3.9 predicted inner membrane protein (NCBI) compare
b4443 gcvB -2.3 -1.6 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b3844 fre -2.2 -6.3 NAD(P)H-flavin reductase (NCBI) compare
b3226 yhcK -2.2 -7.6 putative FADA-type transcriptional regulator (VIMSS) compare
b1850 eda -2.2 -3.2 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b2276 nuoN -2.1 -7.1 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b2277 nuoM -2.1 -8.3 NADH dehydrogenase subunit M (NCBI) compare
b2284 nuoF -2.1 -6.3 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b3162 deaD -2.1 -7.8 inducible ATP-independent RNA helicase (VIMSS) compare
b0739 tolA -2.1 -5.9 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0439 lon -1.9 -6.7 DNA-binding ATP-dependent protease La (NCBI) compare
b2282 nuoH -1.9 -4.5 NADH dehydrogenase subunit H (NCBI) compare
b0145 dksA -1.9 -4.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2288 nuoA -1.9 -3.0 NADH dehydrogenase I chain A (VIMSS) compare
b0049 apaH -1.9 -6.1 diadenosinetetraphosphatase (NCBI) compare
b2287 nuoB -1.9 -4.9 NADH dehydrogenase subunit B (NCBI) compare
b0737 tolQ -1.9 -4.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3026 qseC -1.9 -6.6 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0014 dnaK -1.8 -2.7 molecular chaperone DnaK (NCBI) compare
b2283 nuoG -1.8 -8.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2894 xerD -1.8 -2.4 site-specific tyrosine recombinase XerD (NCBI) compare
b2278 nuoL -1.8 -9.3 NADH dehydrogenase subunit L (NCBI) compare
b2330 yfcB -1.7 -3.3 putative adenine-specific methylase (VIMSS) compare
b3426 glpD -1.7 -7.5 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b0740 tolB -1.7 -6.2 translocation protein TolB precursor (NCBI) compare
b3609 secB -1.7 -3.1 export protein SecB (NCBI) compare
b3741 gidA -1.6 -8.5 glucose-inhibited division protein A (NCBI) compare
b2576 srmB -1.6 -3.8 ATP-dependent RNA helicase (NCBI) compare
b3194 yrbE -1.6 -9.2 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2280 nuoJ -1.6 -5.0 NADH dehydrogenase subunit J (NCBI) compare
b1070 flgN -1.6 -1.9 export chaperone for FlgK and FlgL (NCBI) compare
b2512 yfgL -1.5 -5.9 protein assembly complex, lipoprotein component (NCBI) compare
b3193 yrbD -1.5 -7.6 predicted ABC-type organic solvent transporter (NCBI) compare
b2906 visC -1.5 -5.7 hypothetical protein (NCBI) compare
b3727 pstC -1.5 -4.9 phosphate transporter subunit (NCBI) compare
b2286 nuoC -1.5 -5.6 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b0890 ftsK -1.5 -7.6 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0471 ybaB -1.5 -3.7 hypothetical protein (NCBI) compare
b3636 rpmG -1.4 -1.7 50S ribosomal protein L33 (NCBI) compare
b1286 rnb -1.4 -3.8 exoribonuclease II (NCBI) compare
b3192 yrbC -1.4 -8.5 predicted ABC-type organic solvent transporter (NCBI) compare
b3764 yifE -1.4 -5.6 hypothetical protein (NCBI) compare
b3414 gntY -1.4 -6.3 predicted gluconate transport associated protein (NCBI) compare
b2567 rnc -1.4 -2.0 ribonuclease III (NCBI) compare
b2518 ndk -1.4 -3.2 nucleoside diphosphate kinase (NCBI) compare
b3632 rfaQ -1.3 -11.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3290 trkA -1.3 -4.3 potassium transporter peripheral membrane component (NCBI) compare
b4480 hdfR -1.3 -5.7 transcriptional regulator HdfR (NCBI) compare
b2822 recC -1.3 -5.7 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b2830 nudH -1.3 -1.7 dinucleoside polyphosphate hydrolase (NCBI) compare
b3706 trmE -1.3 -5.4 tRNA modification GTPase (NCBI) compare
b2935 tktA -1.3 -3.1 transketolase 1, thiamin-binding (NCBI) compare
b3838 tatB -1.3 -5.7 sec-independent translocase (NCBI) compare
b0726 sucA -1.3 -3.6 alpha-ketoglutarate decarboxylase (NCBI) compare
b3195 yrbF -1.3 -8.1 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2808 gcvA -1.2 -5.2 DNA-binding transcriptional dual regulator (NCBI) compare
b2528 iscA -1.2 -2.0 iron-sulfur cluster assembly protein (NCBI) compare
b0191 yaeJ -1.2 -3.8 hypothetical protein (NCBI) compare
b3390 aroK -1.2 -2.4 shikimate kinase I (NCBI) compare
b3199 yrbK -1.2 -2.0 hypothetical protein (NCBI) compare
b3237 argR -1.2 -3.9 arginine repressor (NCBI) compare
b4042 dgkA -1.2 -3.1 diacylglycerol kinase (NCBI) compare
b0949 uup -1.1 -6.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b4155 yjeA -1.1 -1.7 putative lysyl-tRNA synthetase (VIMSS) compare
b3463 ftsE -1.1 -4.2 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3164 pnp -1.1 -3.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4239 treC -1.1 -4.1 trehalose-6-P hydrolase (NCBI) compare
b4458 oxyS -1.1 -1.4 global regulatory RNA (NCBI) compare
b1124 potC -1.1 -4.8 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3811 xerC -1.1 -2.9 site-specific tyrosine recombinase XerC (NCBI) compare
b0082 mraW -1.1 -3.0 S-adenosyl-methyltransferase (NCBI) compare
b4394 yjjX -1.1 -2.5 orf, hypothetical protein (VIMSS) compare
b1125 potB -1.1 -2.4 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0431 cyoB -1.1 -6.4 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b3863 polA -1.1 -1.6 DNA polymerase I (NCBI) compare
b3261 fis -1.0 -2.9 DNA-binding protein Fis (NCBI) compare
b1984 asnW -1.0 -1.1 tRNA-Asn (NCBI) compare
b2346 vacJ -1.0 -5.6 predicted lipoprotein (NCBI) compare
b4146 yjeK -1.0 -3.3 predicted lysine aminomutase (NCBI) compare
b2168 fruK -1.0 -2.0 1-phosphofructokinase (NCBI) compare
b0428 cyoE -1.0 -4.4 protoheme IX farnesyltransferase (NCBI) compare
b3726 pstA -1.0 -4.4 phosphate transporter subunit (NCBI) compare
b0623 cspE -1.0 -2.4 cold shock protein E (NCBI) compare
b0430 cyoC -1.0 -2.8 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b0429 cyoD -1.0 -3.6 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b0118 acnB -1.0 -3.1 aconitate hydratase (NCBI) compare
b3962 udhA -1.0 -6.1 putative oxidoreductase (VIMSS) compare
b1658 purR -1.0 -4.9 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b2553 glnB -1.0 -3.6 regulatory protein P-II for glutamine synthetase (NCBI) compare
b0765 modC -1.0 -3.8 molybdate transporter subunit (NCBI) compare
b3229 sspA -0.9 -3.2 stringent starvation protein A (NCBI) compare
b0724 sdhB -0.9 -3.6 succinate dehydrogenase, FeS subunit (NCBI) compare
b0564 appY -0.9 -1.3 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2188 yejM -0.9 -4.8 predicted hydrolase, inner membrane (NCBI) compare
b4557 yidD -0.9 -3.4 hypothetical protein (NCBI) compare
b4178 yjeB -0.9 -3.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4234 yjgA -0.9 -3.6 hypothetical protein (NCBI) compare
b0767 ybhE -0.9 -3.3 6-phosphogluconolactonase (NCBI) compare
b1524 yneH -0.9 -1.4 predicted glutaminase (NCBI) compare
b2297 pta -0.9 -1.6 phosphate acetyltransferase (NCBI) compare
b1841 yobA -0.9 -1.3 hypothetical protein (NCBI) compare
b1138 ymfE -0.9 -1.4 e14 prophage; predicted inner membrane protein (NCBI) compare
b0263 afuB -0.9 -2.3 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b4685 yrbN -0.9 -1.5 expressed protein (RefSeq) compare
b2617 smpA -0.8 -2.9 small membrane protein A (VIMSS) compare
b1095 fabF -0.8 -5.0 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1248 b1248 -0.8 -1.7 orf, hypothetical protein (VIMSS) compare
b1863 ruvC -0.8 -1.9 Holliday junction resolvase (NCBI) compare
b2263 yfbB -0.8 -2.3 predicted peptidase (NCBI) compare
b1192 ldcA -0.8 -3.4 L,D-carboxypeptidase A (NCBI) compare
b1684 sufA -0.8 -1.8 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b2953 yggU -0.8 -1.4 orf, hypothetical protein (VIMSS) compare
b2531 iscR -0.8 -1.0 DNA-binding transcriptional repressor (NCBI) compare
b1134 ymfB -0.8 -1.9 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b4699 fnrS -0.8 -1.0 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b2908 pepP -0.8 -3.7 proline aminopeptidase P II (NCBI) compare
b0957 ompA -0.8 -3.2 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b1604 ydgH -0.8 -3.6 hypothetical protein (NCBI) compare
b0736 ybgC -0.8 -2.4 predicted acyl-CoA thioesterase (NCBI) compare
b2699 recA -0.8 -1.7 recombinase A (NCBI) compare
b0462 acrB -0.8 -6.5 multidrug efflux system protein (NCBI) compare
b1291 sapD -0.8 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3405 ompR -0.8 -2.9 osmolarity response regulator (NCBI) compare
b1429 tehA -0.8 -1.8 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0051 ksgA -0.8 -3.1 dimethyladenosine transferase (NCBI) compare
b4246 pyrL -0.8 -1.9 pyrBI operon leader peptide (NCBI) compare
b2424 cysU -0.8 -2.1 sulfate/thiosulfate transporter subunit (NCBI) compare
b1013 ycdC -0.8 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b4704 arrS -0.7 -1.4 Antisense sRNA ArrS, function unknown (NCBI) compare
b2569 lepA -0.7 -3.1 GTP-binding protein LepA (NCBI) compare
b0463 acrA -0.7 -4.9 multidrug efflux system (NCBI) compare
b2689 yqaA -0.7 -3.1 conserved inner membrane protein (NCBI) compare
b3963 fabR -0.7 -4.5 DNA-binding transcriptional repressor (RefSeq) compare
b0741 pal -0.7 -2.8 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1623 add -0.7 -3.2 adenosine deaminase (NCBI) compare
b3131 agaR -0.7 -2.1 DNA-binding transcriptional dual regulator (NCBI) compare
b1284 yciT -0.7 -3.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3625 rfaY -0.7 -5.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0149 mrcB -0.7 -5.2 penicillin-binding protein 1b (NCBI) compare
b1989 asnV -0.7 -1.9 tRNA-Asn (NCBI) compare
b0723 sdhA -0.7 -4.3 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b2498 upp -0.7 -2.0 uracil phosphoribosyltransferase (VIMSS) compare
b2646 ypjF -0.7 -2.0 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b0406 tgt -0.7 -4.0 queuine tRNA-ribosyltransferase (NCBI) compare
b0721 sdhC -0.7 -2.0 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0677 nagA -0.7 -3.4 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3613 yibP -0.7 -3.0 putative membrane protein (VIMSS) compare
b0008 talB -0.7 -4.2 transaldolase B (NCBI) compare
b1558 cspF -0.7 -2.0 Qin prophage; cold shock protein (NCBI) compare
b3644 yicC -0.7 -3.5 hypothetical protein (NCBI) compare
b0432 cyoA -0.7 -4.7 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b3616 tdh -0.7 -3.3 L-threonine 3-dehydrogenase (NCBI) compare
b1292 sapC -0.7 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0178 hlpA -0.7 -1.5 periplasmic chaperone (NCBI) compare
b2937 speB -0.7 -4.0 agmatinase (NCBI) compare
b2003 yeeT -0.7 -2.3 CP4-44 prophage; predicted protein (NCBI) compare
b2051 wcaH -0.6 -1.0 GDP-mannose mannosyl hydrolase (VIMSS) compare
b2340 sixA -0.6 -2.5 phosphohistidine phosphatase (NCBI) compare
b1443 ydcV -0.6 -2.1 predicted spermidine/putrescine transporter subunit (NCBI) compare
b1130 phoP -0.6 -3.9 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b0763 modA -0.6 -3.0 molybdate transporter subunit (NCBI) compare
b2325 yfcL -0.6 -2.4 hypothetical protein (NCBI) compare
b1818 manY -0.6 -1.7 mannose-specific enzyme IIC component of PTS (NCBI) compare
b3349 slyD -0.6 -3.2 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b4609 ryfD -0.6 -2.3 Novel sRNA, function unknown (RefSeq) compare
b3094 exuR -0.6 -3.1 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b3163 nlpI -0.6 -2.6 hypothetical protein (NCBI) compare


Specific Phenotypes

For 6 genes in this experiment

For stress 2,4-Dinitrophenol in Escherichia coli BW25113

For stress 2,4-Dinitrophenol across organisms