Experiment set4IT036 for Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Compare to:

LB_plus_SM_buffer with FelixO1_phage (wt new) 0.0075 MOI

200 most detrimental genes:

  gene name fitness t score description  
GFF388 +2.5 17.5 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase (EC 2.4.1.56) compare
GFF3669 +2.3 8.8 Integration host factor beta subunit compare
GFF3528 +2.3 8.8 Integration host factor alpha subunit compare
GFF387 +2.0 3.2 Lipopolysaccharide core biosynthesis protein RfaZ compare
GFF2341 +1.7 15.4 UPF0141 membrane protein YijP possibly required for phosphoethanolamine modification of lipopolysaccharide compare
GFF1690 +1.7 6.9 RNA polymerase sigma factor for flagellar operon compare
GFF383 +1.7 3.7 Lipopolysaccharide 1,6-galactosyltransferase (EC 2.4.1.-) compare
GFF4010 +1.6 3.6 Flagellar motor switch protein FliN compare
GFF4158 +1.6 4.8 tmRNA-binding protein SmpB compare
GFF4008 +1.4 5.7 Flagellar biosynthesis protein FliP compare
GFF4018 +1.4 5.4 Flagellar M-ring protein FliF compare
GFF2436 +1.4 4.9 Iron-sulfur cluster regulator IscR compare
GFF3567 +1.3 8.1 Pyruvate kinase (EC 2.7.1.40) compare
GFF1673 +1.3 5.4 Flagellar transcriptional activator FlhD compare
GFF3329 +1.3 10.6 Glucans biosynthesis glucosyltransferase H (EC 2.4.1.-) compare
GFF614 +1.3 7.7 Osmolarity sensory histidine kinase EnvZ compare
GFF4011 +1.3 9.3 Flagellar motor switch protein FliM compare
GFF4906 +1.3 10.0 Virulence factor VirK compare
GFF3357 +1.3 10.2 Flagellar hook protein FlgE compare
GFF3414 +1.3 10.4 Sensor protein PhoQ (EC 2.7.13.3) compare
GFF3328 +1.3 10.4 Glucans biosynthesis protein G precursor compare
GFF1631 +1.2 6.7 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) compare
GFF1983 +1.2 7.5 tRNA-Arg-CCT compare
GFF613 +1.2 7.6 Two-component system response regulator OmpR compare
GFF2455 +1.2 8.9 Putative sensory histidine kinase YfhA compare
GFF3415 +1.2 8.6 Transcriptional regulatory protein PhoP compare
GFF2045 +1.2 4.4 hypothetical protein compare
GFF3358 +1.2 7.9 Flagellar basal-body rod protein FlgF compare
GFF2213 +1.2 6.7 Periplasmic thiol:disulfide interchange protein DsbA compare
GFF1059 +1.2 9.6 ABC transporter, ATP-binding protein compare
GFF4006 +1.2 3.3 Flagellar biosynthesis protein FliR compare
GFF2456 +1.2 6.3 putative alpha helix protein compare
GFF3355 +1.2 4.4 Flagellar basal-body rod protein FlgC compare
GFF3360 +1.2 7.4 Flagellar L-ring protein FlgH compare
GFF2892 +1.2 7.1 ATP-dependent RNA helicase RhlB compare
GFF1671 +1.1 6.4 Flagellar motor rotation protein MotA compare
GFF2457 +1.1 9.7 Putative sensor-like histidine kinase YfhK compare
GFF1500 +1.1 8.6 tRNA pseudouridine synthase B (EC 4.2.1.70) compare
GFF3359 +1.1 7.0 Flagellar basal-body rod protein FlgG compare
GFF4029 +1.1 7.2 Flagellar biosynthesis protein FliC compare
GFF4015 +1.1 4.8 Flagellum-specific ATP synthase FliI compare
GFF4013 +1.1 9.1 Flagellar hook-length control protein FliK compare
GFF573 +1.1 2.2 FIG01046423: hypothetical protein compare
GFF652 +1.1 2.6 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) / UDP-glucose 4-epimerase (EC 5.1.3.2) compare
GFF3353 +1.1 7.1 Flagellar basal-body P-ring formation protein FlgA compare
GFF3362 +1.1 5.2 Flagellar protein FlgJ [peptidoglycan hydrolase] (EC 3.2.1.-) compare
GFF1691 +1.1 5.7 Flagellar biosynthesis protein FliZ compare
GFF2893 +1.0 8.2 'Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) @ Exopolyphosphatase (EC 3.6.1.11)' transl_table=11 compare
GFF110 +1.0 5.6 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) compare
GFF2454 +1.0 4.3 Nitrogen regulatory protein P-II compare
GFF2307 +1.0 8.1 Glycerol kinase (EC 2.7.1.30) compare
GFF1597 +1.0 9.2 Glutamate--cysteine ligase (EC 6.3.2.2) compare
GFF2806 +1.0 3.0 Transcriptional regulator for fatty acid degradation FadR, GntR family compare
GFF4017 +1.0 7.0 Flagellar motor switch protein FliG compare
GFF1661 +1.0 8.6 Flagellar biosynthesis protein FlhB compare
GFF384 +1.0 2.1 UDP-glucose:(glucosyl)lipopolysaccharide alpha-1,3-glucosyltransferase WaaO (EC 2.4.1.-) compare
GFF2942 +1.0 5.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (EC 3.1.3.45) compare
GFF1411 +1.0 5.5 Diacylglycerol kinase (EC 2.7.1.107) compare
GFF2308 +1.0 5.8 Glycerol uptake facilitator protein compare
GFF4020 +1.0 2.7 Flagellar hook-basal body complex protein FliE compare
GFF619 +1.0 6.2 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) compare
GFF2954 +1.0 8.0 Aerobic respiration control sensor protein arcB (EC 2.7.3.-) compare
GFF103 +1.0 6.8 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) compare
GFF2283 +1.0 7.6 6-phosphofructokinase (EC 2.7.1.11) compare
GFF3028 +1.0 8.3 Transketolase (EC 2.2.1.1) compare
GFF1264 +0.9 1.5 putative cytoplasmic protein compare
GFF4012 +0.9 4.6 Flagellar biosynthesis protein FliL compare
GFF267 +0.9 3.9 Transcriptional activator RfaH compare
GFF3354 +0.9 6.1 Flagellar basal-body rod protein FlgB compare
GFF2776 +0.9 3.7 hypothetical protein compare
GFF4549 +0.9 4.6 LSU m3Psi1915 methyltransferase RlmH compare
GFF777 +0.9 2.5 COG0419: ATPase involved in DNA repair compare
GFF2133 +0.9 7.4 RNase E specificity factor CsrD compare
GFF1035 +0.9 7.1 Peptide chain release factor 3 compare
GFF2941 +0.9 3.2 Arabinose 5-phosphate isomerase (EC 5.3.1.13) compare
GFF2409 +0.9 5.1 Outer membrane protein YfgL, lipoprotein component of the protein assembly complex (forms a complex with YaeT, YfiO, and NlpB) compare
GFF522 +0.9 5.7 Low-affinity inorganic phosphate transporter compare
GFF2280 +0.9 4.4 Copper-sensing two-component system response regulator CpxR compare
GFF2841 +0.9 2.2 putative exported protein compare
GFF1660 +0.9 3.6 Flagellar biosynthesis protein FlhA compare
GFF2171 +0.9 6.6 Uracil phosphoribosyltransferase (EC 2.4.2.9) compare
GFF4322 +0.9 5.6 Phosphatidylglycerophosphatase A (EC 3.1.3.27) compare
GFF2612 +0.9 6.4 Glucans biosynthesis protein D precursor compare
GFF3356 +0.9 4.1 Flagellar basal-body rod modification protein FlgD compare
GFF3363 +0.8 5.6 Flagellar hook-associated protein FlgK compare
GFF2867 +0.8 1.0 hypothetical protein compare
GFF3052 +0.8 6.2 Transcriptional regulator, IclR family compare
GFF578 +0.8 6.9 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) compare
GFF1813 +0.8 2.6 Cnu protein compare
GFF3049 +0.8 4.7 Glutathione synthetase (EC 6.3.2.3) compare
GFF4007 +0.8 3.4 Flagellar biosynthesis protein FliQ compare
GFF3419 +0.8 1.6 Nudix-like NDP and NTP phosphohydrolase YmfB compare
GFF1553 +0.8 1.1 FIG01046564: hypothetical protein compare
GFF83 +0.8 6.6 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) compare
GFF4615 +0.8 1.4 FIG137478: Hypothetical protein YbgI compare
GFF4623 +0.8 3.2 UDP-galactopyranose mutase (EC 5.4.99.9) compare
GFF2138 +0.8 5.9 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) compare
GFF4161 +0.8 5.0 Outer membrane lipoprotein SmpA, a component of the essential YaeT outer-membrane protein assembly complex compare
GFF2753 +0.8 6.1 Hnr protein compare
GFF3863 +0.8 5.0 A/G-specific adenine glycosylase (EC 3.2.2.-) compare
GFF227 +0.8 5.0 Homolog of E. coli HemX protein compare
GFF987 +0.8 1.4 FIG00637915: hypothetical protein compare
GFF249 +0.8 1.4 L-lysine permease compare
GFF265 +0.8 4.9 Twin-arginine translocation protein TatC compare
GFF3700 +0.8 1.7 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
GFF4218 +0.8 1.2 hypothetical protein compare
GFF3361 +0.8 4.3 Flagellar P-ring protein FlgI compare
GFF2758 +0.8 1.5 FIG01045187: hypothetical protein compare
GFF1672 +0.7 3.5 Flagellar transcriptional activator FlhC compare
GFF3695 +0.7 5.0 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) compare
GFF3007 +0.7 5.4 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (EC 1.14.13.-) compare
GFF2992 +0.7 5.4 Flavodoxin 2 compare
GFF3985 +0.7 1.0 Integrase compare
GFF1084 +0.7 3.8 Molybdopterin biosynthesis molybdochelatase MogA compare
GFF2754 +0.7 4.0 UPF0028 protein YchK compare
GFF4790 +0.7 1.1 FIG01047833: hypothetical protein compare
GFF2410 +0.7 3.6 Mlr7403 protein compare
GFF2689 +0.7 2.8 Peptide transport system permease protein SapB compare
GFF191 +0.7 1.9 ApaG protein compare
GFF1828 +0.7 4.9 Thiamin biosynthesis lipoprotein ApbE compare
GFF1037 +0.7 2.6 Osmotically inducible protein OsmY compare
GFF2640 +0.7 1.5 probable lipoprotein YPO2331 compare
GFF400 +0.7 1.4 Glutaredoxin 3 (Grx3) compare
GFF2534 +0.7 4.7 Transcriptional regulator, MarR family compare
GFF2888 +0.7 5.1 regulator of length of O-antigen component of lipopolysaccharide chains compare
GFF3388 +0.7 3.6 Lipoprotein YcfM, part of a salvage pathway of unknown substrate compare
GFF82 +0.7 1.7 hypothetical protein compare
GFF226 +0.7 4.0 Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) compare
GFF2501 +0.7 1.1 FIG00638667: hypothetical protein compare
GFF3086 +0.7 1.7 hypothetical protein compare
GFF2221 +0.7 4.9 Nitrogen regulation protein NtrB (EC 2.7.13.3) compare
GFF513 +0.7 5.2 Glutathione reductase (EC 1.8.1.7) compare
GFF2688 +0.7 3.7 Peptide transport periplasmic protein SapA compare
GFF2635 +0.7 1.4 Putative uncharacterized protein ydbL, may be related to amine metabolism compare
GFF3884 +0.6 3.1 Colanic acid biosynthesis glycosyl transferase WcaL compare
GFF2220 +0.6 4.5 Nitrogen regulation protein NR(I) compare
GFF1865 +0.6 3.4 Polymyxin resistance protein PmrD compare
GFF1785 +0.6 3.5 Mlc, transcriptional repressor of MalT (the transcriptional activator of maltose regulon) and manXYZ operon compare
GFF1321 +0.6 3.6 Galactose operon repressor, GalR-LacI family of transcriptional regulators compare
GFF3548 +0.6 3.2 3-dehydroquinate dehydratase I (EC 4.2.1.10) compare
GFF4384 +0.6 3.9 Putative inner membrane protein compare
GFF917 +0.6 2.0 RelE/StbE replicon stabilization toxin compare
GFF4385 +0.6 2.2 Primosomal replication protein N prime prime compare
GFF1921 +0.6 1.7 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) compare
GFF4701 +0.6 3.7 Glucitol operon repressor compare
GFF188 +0.6 3.1 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) compare
GFF3761 +0.6 3.2 Lipoprotein spr precursor compare
GFF4305 +0.6 2.2 tRNA-guanine transglycosylase (EC 2.4.2.29) compare
GFF2990 +0.6 3.7 Thiol:disulfide interchange protein DsbC compare
GFF3883 +0.6 2.4 Colanic acid biosysnthesis protein WcaK compare
GFF2349 +0.6 3.4 Unsaturated fatty acid biosythesis repressor FabR, TetR family compare
GFF2993 +0.6 2.9 FIG00731769: possible membrane protein compare
GFF1901 +0.6 3.6 Phosphate acetyltransferase (EC 2.3.1.8) compare
GFF3377 +0.6 3.2 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41) compare
GFF4182 +0.6 3.4 Ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70) compare
GFF1792 +0.6 1.7 Spermidine export protein MdtJ compare
GFF684 +0.6 2.4 Putative membrane protein compare
GFF3123 +0.6 1.2 hypothetical protein compare
GFF1505 +0.6 3.4 Tryptophan-specific transport protein compare
GFF1670 +0.6 2.7 Flagellar motor rotation protein MotB compare
GFF1497 +0.6 1.7 Transcription termination protein NusA compare
GFF648 +0.6 3.5 Phosphoglycerate mutase (EC 5.4.2.1) compare
GFF4243 +0.6 0.8 Probable secreted protein compare
GFF2634 +0.6 1.4 Gfa-like protein compare
GFF1390 +0.6 1.7 Phage protein compare
GFF4365 +0.6 4.8 ATP-binding component compare
GFF4364 +0.6 2.7 Putative HTH-type transcriptional regulator ybaO compare
GFF4892 +0.6 1.9 Thioredoxin reductase (EC 1.8.1.9) compare
GFF725 +0.6 4.5 Molybdopterin biosynthesis protein MoeA compare
GFF3027 +0.6 1.5 ATPase component STY3233 of energizing module of queuosine-regulated ECF transporter compare
GFF2137 +0.6 2.9 Septum formation protein Maf compare
GFF420 +0.6 4.5 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) compare
GFF2593 +0.6 1.8 FIG00639831: hypothetical protein compare
GFF678 +0.6 3.3 Molybdenum cofactor biosynthesis protein MoaA compare
GFF4208 +0.6 1.2 FIG01046757: hypothetical protein compare
GFF2715 +0.6 2.4 FIG00948954: hypothetical protein YciN compare
GFF2852 +0.6 2.2 FIG00638105: hypothetical protein compare
GFF218 +0.6 1.8 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC 2.7.7.61) compare
GFF2794 +0.6 3.6 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) compare
GFF2808 +0.6 3.1 Periplasmic thiol:disulfide oxidoreductase DsbB, required for DsbA reoxidation compare
GFF2049 +0.6 0.8 FIG01045978: hypothetical protein compare
GFF2193 +0.5 3.3 FIG01200701: possible membrane protein compare
GFF3940 +0.5 0.9 Propanediol utilization polyhedral body protein PduJ compare
GFF3064 +0.5 2.9 tRNA (guanine46-N7-)-methyltransferase (EC 2.1.1.33) compare
GFF2223 +0.5 3.1 GTP-binding protein TypA/BipA compare
GFF587 +0.5 1.6 Aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) compare
GFF3621 +0.5 2.8 Glutaredoxin-related protein compare
GFF2648 +0.5 3.0 tRNA(Cytosine32)-2-thiocytidine synthetase compare
GFF2585 +0.5 4.5 SrfB compare
GFF3039 +0.5 2.1 Putative outer membrane lipoprotein compare
GFF2801 +0.5 1.8 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) compare
GFF125 +0.5 1.4 hypothetical protein compare
GFF3193 +0.5 2.8 Uncharacterized protein YqjB compare
GFF1784 +0.5 1.5 Dethiobiotin synthetase (EC 6.3.3.3) compare
GFF655 +0.5 3.3 DNA-binding domain of ModE / Molybdate-binding domain of ModE compare
GFF2012 +0.5 2.1 FxsA protein compare
GFF261 +0.5 1.3 Protein YigP (COG3165) clustered with ubiquinone biosynthetic genes compare
GFF1710 +0.5 4.6 Kup system potassium uptake protein compare
GFF1079 +0.5 0.9 Homoserine kinase (EC 2.7.1.39) compare
GFF333 +0.5 1.7 hypothetical protein compare


Specific Phenotypes

None in this experiment

For Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 in phage experiments

For phage FelixO1_phage (wt new) across organisms