Experiment set43IT031 for Escherichia coli BW25113

Compare to:

R2_N4_T2_phage10

200 most important genes:

  gene name fitness t score description  
b1279 yciS -4.6 -0.9 conserved inner membrane protein (NCBI) compare
b1346 ydaQ -4.1 -1.3 orf, hypothetical protein (VIMSS) compare
b1550 b1550 -4.0 -1.1 orf, hypothetical protein (VIMSS) compare
b1293 sapB -3.9 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1176 minC -3.6 -2.2 septum formation inhibitor (NCBI) compare
b3860 dsbA -3.5 -13.3 periplasmic protein disulfide isomerase I (NCBI) compare
b0683 fur -3.5 -1.1 ferric uptake regulator (NCBI) compare
b4685 yrbN -3.4 -1.9 expressed protein (RefSeq) compare
b2363 yfdT -3.4 -3.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2501 ppk -3.3 -11.4 polyphosphate kinase (NCBI) compare
b0998 torD -3.3 -1.0 chaperone protein TorD (NCBI) compare
b0888 trxB -2.9 -4.0 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1524 yneH -2.9 -0.9 predicted glutaminase (NCBI) compare
b1882 cheY -2.8 -0.5 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b1290 sapF -2.7 -2.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3790 rffC -2.6 -5.1 TDP-fucosamine acetyltransferase (RefSeq) compare
b2282 nuoH -2.5 -4.2 NADH dehydrogenase subunit H (NCBI) compare
b1185 dsbB -2.4 -3.9 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1291 sapD -2.4 -1.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1958 yedI -2.4 -6.2 conserved inner membrane protein (NCBI) compare
b3787 rffD -2.3 -9.6 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b0439 lon -2.3 -4.5 DNA-binding ATP-dependent protease La (NCBI) compare
b3236 mdh -2.3 -8.6 malate dehydrogenase (NCBI) compare
b4535 yniD -2.2 -0.9 predicted protein (RefSeq) compare
b3839 tatC -2.2 -7.9 TatABCE protein translocation system subunit (NCBI) compare
b4614 sokA -2.2 -4.1 no description compare
b0721 sdhC -2.2 -6.0 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b3784 rfe -2.2 -9.4 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b0142 folK -2.1 -0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1429 tehA -2.1 -0.6 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2531 iscR -2.1 -0.7 DNA-binding transcriptional repressor (NCBI) compare
b1861 ruvA -2.1 -0.8 Holliday junction DNA helicase motor protein (NCBI) compare
b2808 gcvA -2.1 -4.2 DNA-binding transcriptional dual regulator (NCBI) compare
b1175 minD -2.0 -4.5 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0145 dksA -2.0 -3.3 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2906 visC -2.0 -7.0 hypothetical protein (NCBI) compare
b0389 yaiA -2.0 -2.3 hypothetical protein (NCBI) compare
b1523 yneG -2.0 -1.6 hypothetical protein (NCBI) compare
b0222 lpcA -1.9 -2.8 phosphoheptose isomerase (NCBI) compare
b4458 oxyS -1.9 -0.5 global regulatory RNA (NCBI) compare
b2432 yfeY -1.9 -1.1 hypothetical protein (NCBI) compare
b1696 ydiP -1.9 -3.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0741 pal -1.9 -2.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3341 rpsG -1.9 -1.2 30S ribosomal protein S7 (NCBI) compare
b0843 ybjH -1.8 -1.9 hypothetical protein (NCBI) compare
b1187 fadR -1.8 -3.0 fatty acid metabolism regulator (NCBI) compare
b0696 kdpC -1.8 -2.6 potassium-transporting ATPase subunit C (NCBI) compare
b2280 nuoJ -1.7 -5.1 NADH dehydrogenase subunit J (NCBI) compare
b1332 ynaJ -1.7 -0.4 predicted inner membrane protein (NCBI) compare
b3761 trpT -1.7 -1.0 tRNA-Trp (NCBI) compare
b0722 sdhD -1.7 -3.9 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b0723 sdhA -1.7 -8.1 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b1179 ycgL -1.7 -2.1 conserved protein (NCBI) compare
b3791 rffA -1.7 -5.3 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b1556 b1556 -1.7 -2.4 orf, hypothetical protein (VIMSS) compare
b3844 fre -1.6 -4.2 NAD(P)H-flavin reductase (NCBI) compare
b4191 ulaR -1.6 -2.9 DNA-binding transcriptional dual regulator (NCBI) compare
b0178 hlpA -1.6 -2.6 periplasmic chaperone (NCBI) compare
b3162 deaD -1.6 -4.9 inducible ATP-independent RNA helicase (VIMSS) compare
b2287 nuoB -1.5 -3.2 NADH dehydrogenase subunit B (NCBI) compare
b2586 yfiM -1.5 -2.8 predicted protein (RefSeq) compare
b2276 nuoN -1.5 -3.6 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1709 btuD -1.5 -0.8 vitamin B12-transporter ATPase (NCBI) compare
b1129 phoQ -1.5 -2.6 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b3071 yqjI -1.5 -3.3 predicted transcriptional regulator (NCBI) compare
b3816 corA -1.5 -5.8 magnesium/nickel/cobalt transporter (NCBI) compare
b3871 bipA -1.5 -6.6 GTP-binding protein (NCBI) compare
b2446 yffO -1.5 -1.5 CPZ-55 prophage; predicted protein (NCBI) compare
b0920 ycbC -1.5 -2.8 conserved inner membrane protein (NCBI) compare
b0113 pdhR -1.5 -3.0 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b0014 dnaK -1.5 -1.4 molecular chaperone DnaK (NCBI) compare
b2168 fruK -1.5 -1.4 1-phosphofructokinase (NCBI) compare
b3169 nusA -1.4 -1.7 transcription elongation factor NusA (NCBI) compare
b1361 ydaW -1.4 -0.2 orf, hypothetical protein (VIMSS) compare
b2617 smpA -1.4 -1.7 small membrane protein A (VIMSS) compare
b0937 ssuE -1.4 -1.9 NAD(P)H-dependent FMN reductase (NCBI) compare
b2603 yfiR -1.4 -2.7 hypothetical protein (NCBI) compare
b3529 yhjK -1.4 -8.9 predicted diguanylate cyclase (RefSeq) compare
b1765 ydjA -1.4 -0.6 predicted oxidoreductase (NCBI) compare
b1426 ydcH -1.4 -1.3 orf, hypothetical protein (VIMSS) compare
b0724 sdhB -1.4 -5.6 succinate dehydrogenase, FeS subunit (NCBI) compare
b3794 rffM -1.4 -4.2 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b4676 yoaK -1.4 -0.3 expressed protein (RefSeq) compare
b2278 nuoL -1.4 -6.6 NADH dehydrogenase subunit L (NCBI) compare
b4139 aspA -1.4 -5.7 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b2912 ygfA -1.4 -2.0 putative ligase (VIMSS) compare
b0015 dnaJ -1.3 -5.7 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b4503 yafF -1.3 -0.3 no description compare
b2217 rcsB -1.3 -2.8 DNA-binding response regulator in two-component regulatory system with RcsC and YojN (NCBI) compare
b1931 yedK -1.3 -3.7 hypothetical protein (NCBI) compare
b0928 aspC -1.3 -4.8 aspartate aminotransferase, PLP-dependent (NCBI) compare
b2684 mprA -1.3 -3.3 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1357 ydaS -1.3 -1.3 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b0726 sucA -1.3 -2.6 alpha-ketoglutarate decarboxylase (NCBI) compare
b2283 nuoG -1.3 -5.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b0737 tolQ -1.3 -1.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1855 lpxM -1.3 -3.4 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2894 xerD -1.3 -0.5 site-specific tyrosine recombinase XerD (NCBI) compare
b2897 ygfY -1.3 -1.3 hypothetical protein (NCBI) compare
b2277 nuoM -1.3 -4.6 NADH dehydrogenase subunit M (NCBI) compare
b3107 yhaL -1.3 -0.7 orf, hypothetical protein (VIMSS) compare
b3838 tatB -1.2 -4.2 sec-independent translocase (NCBI) compare
b1518 lsrG -1.2 -1.2 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b3101 yqjF -1.2 -2.2 orf, hypothetical protein (VIMSS) compare
b0589 fepG -1.2 -3.9 iron-enterobactin transporter subunit (NCBI) compare
b2846 yqeH -1.2 -0.4 orf, hypothetical protein (VIMSS) compare
b0385 yaiC -1.2 -3.8 predicted diguanylate cyclase (NCBI) compare
b4481 rffT -1.2 -3.3 4-alpha-L-fucosyltransferase (NCBI) compare
b3237 argR -1.2 -2.4 arginine repressor (NCBI) compare
b0957 ompA -1.2 -2.0 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b1850 eda -1.2 -1.0 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b4655 ythA -1.2 -0.9 expressed protein (RefSeq) compare
b3961 oxyR -1.2 -5.1 DNA-binding transcriptional dual regulator (NCBI) compare
b2285 nuoE -1.1 -1.4 NADH dehydrogenase subunit E (NCBI) compare
b1739 osmE -1.1 -1.5 DNA-binding transcriptional activator (NCBI) compare
b2017 yefM -1.1 -1.2 orf, hypothetical protein (VIMSS) compare
b1842 holE -1.1 -1.1 DNA polymerase III, theta subunit (NCBI) compare
b1595 ynfL -1.1 -2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b1130 phoP -1.1 -2.2 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1506 yneL -1.1 -0.9 predicted transcriptional regulator (NCBI) compare
b0728 sucC -1.1 -4.4 succinyl-CoA synthetase subunit beta (NCBI) compare
b3781 trxA -1.1 -2.2 thioredoxin 1 (VIMSS) compare
b2859 ygeO -1.1 -0.5 hypothetical protein (RefSeq) compare
b1252 tonB -1.1 -2.0 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1874 cutC -1.1 -1.9 copper homeostasis protein (NCBI) compare
b2532 yfhQ -1.1 -3.5 predicted methyltransferase (NCBI) compare
b0542 renD -1.1 -1.4 orf, hypothetical protein (VIMSS) compare
b0218 yafU -1.1 -2.5 predicted inner membrane protein (RefSeq) compare
b1542 ydfI -1.1 -2.6 predicted mannonate dehydrogenase (NCBI) compare
b2288 nuoA -1.1 -1.9 NADH dehydrogenase I chain A (VIMSS) compare
b0471 ybaB -1.1 -2.5 hypothetical protein (NCBI) compare
b1907 tyrP -1.1 -3.6 tyrosine transporter (NCBI) compare
b2284 nuoF -1.1 -2.6 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b1583 ynfB -1.1 -2.2 hypothetical protein (NCBI) compare
b1730 ydjO -1.1 -0.4 predicted protein (RefSeq) compare
b4108 phnA -1.1 -1.6 hypothetical protein (NCBI) compare
b0549 ybcO -1.1 -1.1 DLP12 prophage; predicted protein (NCBI) compare
b2571 rseB -1.1 -3.1 periplasmic negative regulator of sigmaE (NCBI) compare
b4325 yjiC -1.0 -2.4 orf, hypothetical protein (VIMSS) compare
b1503 ydeR -1.0 -2.3 predicted fimbrial-like adhesin protein (NCBI) compare
b1904 yecR -1.0 -1.7 hypothetical protein (NCBI) compare
b1161 ycgX -1.0 -0.3 hypothetical protein (NCBI) compare
b3017 sufI -1.0 -4.9 repressor protein for FtsI (NCBI) compare
b1689 b1689 -1.0 -2.6 orf, hypothetical protein (VIMSS) compare
b2576 srmB -1.0 -2.0 ATP-dependent RNA helicase (NCBI) compare
b1261 trpB -1.0 -1.4 tryptophan synthase subunit beta (NCBI) compare
b3281 aroE -1.0 -6.0 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b2263 yfbB -1.0 -1.4 predicted peptidase (NCBI) compare
b2248 yfaX -1.0 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b3834 yigP -1.0 -2.7 hypothetical protein (NCBI) compare
b3210 arcB -1.0 -4.4 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b3858 yihD -1.0 -1.4 hypothetical protein (NCBI) compare
b1222 narX -1.0 -2.7 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b2175 spr -1.0 -1.9 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0216 aspV -1.0 -2.7 tRNA-Asp (NCBI) compare
b1575 dicB -1.0 -0.7 Qin prophage; cell division inhibition protein (NCBI) compare
b3933 ftsN -1.0 -5.1 essential cell division protein (NCBI) compare
b3029 ygiN -0.9 -1.4 quinol monooxygenase (NCBI) compare
b2951 yggS -0.9 -1.9 predicted enzyme (NCBI) compare
b1269 rluB -0.9 -1.3 23S rRNA pseudouridylate synthase (NCBI) compare
b1643 ydhI -0.9 -2.8 predicted inner membrane protein (NCBI) compare
b3928 yiiU -0.9 -3.0 hypothetical protein (NCBI) compare
b0437 clpP -0.9 -2.5 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b0564 appY -0.9 -0.6 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2101 yegW -0.9 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2620 smpB -0.9 -0.3 SsrA-binding protein (NCBI) compare
b2948 yqgE -0.9 -1.3 orf, hypothetical protein (VIMSS) compare
b0850 ybjC -0.9 -1.0 predicted inner membrane protein (NCBI) compare
b1618 uidR -0.9 -1.7 DNA-binding transcriptional repressor (NCBI) compare
b3205 yhbJ -0.9 -1.9 hypothetical protein (NCBI) compare
b2286 nuoC -0.9 -2.3 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b0791 ybhQ -0.9 -1.5 predicted inner membrane protein (NCBI) compare
b2350 yfdG -0.9 -4.9 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b3002 yqhA -0.9 -1.0 hypothetical protein (NCBI) compare
b2904 gcvH -0.9 -1.1 glycine cleavage system protein H (NCBI) compare
b1744 astE -0.9 -3.3 succinylglutamate desuccinylase (NCBI) compare
b0802 ybiJ -0.9 -1.7 hypothetical protein (NCBI) compare
b1846 yebE -0.9 -1.5 hypothetical protein (NCBI) compare
b3389 aroB -0.9 -4.1 3-dehydroquinate synthase (NCBI) compare
b4596 yciZ -0.9 -1.1 hypothetical protein (RefSeq) compare
b0143 pcnB -0.9 -2.6 poly(A) polymerase I (VIMSS) compare
b0080 fruR -0.9 -3.2 DNA-binding transcriptional dual regulator (NCBI) compare
b2331 yfcN -0.9 -2.3 hypothetical protein (NCBI) compare
b4573 insZ -0.9 -2.7 no description compare
b3466 yhhL -0.9 -2.4 conserved inner membrane protein (NCBI) compare
b1335 ogt -0.9 -1.7 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b4179 vacB -0.9 -4.1 putative enzyme (VIMSS) compare
b1138 ymfE -0.9 -0.9 e14 prophage; predicted inner membrane protein (NCBI) compare
b3836 b3836 -0.9 -2.4 orf, hypothetical protein (VIMSS) compare
b2637 yfjT -0.9 -1.3 CP4-57 prophage; predicted protein (NCBI) compare
b1628 rsxB -0.9 -1.5 electron transport complex protein RnfB (NCBI) compare
b2395 yfeA -0.9 -3.8 orf, hypothetical protein (VIMSS) compare
b1930 yedF -0.9 -2.6 hypothetical protein (NCBI) compare
b2597 yfiA -0.9 -0.8 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b0630 lipB -0.9 -0.4 protein of lipoate biosynthesis (VIMSS) compare
b1600 mdtJ -0.9 -0.6 multidrug efflux system transporter (NCBI) compare
b3095 yqjA -0.9 -3.8 conserved inner membrane protein (NCBI) compare
b0655 gltI -0.9 -2.0 glutamate and aspartate transporter subunit (NCBI) compare
b3870 glnA -0.9 -1.7 glutamine synthetase (NCBI) compare
b1486 ddpB -0.8 -1.5 D-ala-D-ala transporter subunit (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For phage N4 in Escherichia coli BW25113

For phage N4 across organisms