Experiment set42IT005 for Escherichia coli BW25113

Compare to:

LB + ciprofloxacin Time24hr

200 most important genes:

  gene name fitness t score description  
b4053 alr -7.1 -15.8 alanine racemase (NCBI) compare
b4237 nrdG -5.6 -6.7 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4238 nrdD -5.2 -10.0 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b4041 plsB -5.0 -4.8 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4025 pgi -3.4 -15.6 glucose-6-phosphate isomerase (NCBI) compare
b0386 proC -3.0 -7.3 pyrroline-5-carboxylate reductase (NCBI) compare
b1334 fnr -2.5 -3.6 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b2620 smpB -2.1 -2.3 SsrA-binding protein (NCBI) compare
b1850 eda -2.1 -3.1 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b0949 uup -2.0 -12.6 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0243 proA -1.9 -11.9 gamma-glutamyl phosphate reductase (NCBI) compare
b0902 pflA -1.7 -9.8 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0242 proB -1.6 -5.6 gamma-glutamyl kinase (NCBI) compare
b0232 yafN -1.6 -1.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0912 ihfB -1.6 -3.3 integration host factor subunit beta (NCBI) compare
b4202 rpsR -1.6 -2.9 30S ribosomal protein S18 (NCBI) compare
b2912 ygfA -1.5 -3.7 putative ligase (VIMSS) compare
b0688 pgm -1.3 -4.4 phosphoglucomutase (NCBI) compare
b0739 tolA -1.3 -3.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0741 pal -1.3 -3.9 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3781 trxA -1.2 -4.9 thioredoxin 1 (VIMSS) compare
b3341 rpsG -1.2 -2.1 30S ribosomal protein S7 (NCBI) compare
b3977 tyrU -1.2 -1.3 tRNA-Tyr (NCBI) compare
b1123 potD -1.2 -7.2 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b3035 tolC -1.2 -5.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1159 mcrA -1.1 -1.8 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b2297 pta -1.1 -0.7 phosphate acetyltransferase (NCBI) compare
b2894 xerD -1.1 -0.7 site-specific tyrosine recombinase XerD (NCBI) compare
b0908 aroA -1.1 -7.8 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b3863 polA -1.1 -1.2 DNA polymerase I (NCBI) compare
b3636 rpmG -1.0 -2.4 50S ribosomal protein L33 (NCBI) compare
b1861 ruvA -1.0 -1.2 Holliday junction DNA helicase motor protein (NCBI) compare
b2830 nudH -1.0 -1.3 dinucleoside polyphosphate hydrolase (NCBI) compare
b1863 ruvC -1.0 -1.6 Holliday junction resolvase (NCBI) compare
b0903 pflB -1.0 -7.9 pyruvate formate lyase I (NCBI) compare
b1049 mdoH -1.0 -7.5 glucosyltransferase MdoH (NCBI) compare
b1126 potA -1.0 -4.8 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b4593 ymgI -1.0 -1.2 hypothetical protein (RefSeq) compare
b1124 potC -0.9 -5.2 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0728 sucC -0.9 -5.9 succinyl-CoA synthetase subunit beta (NCBI) compare
b2168 fruK -0.9 -1.2 1-phosphofructokinase (NCBI) compare
b2576 srmB -0.9 -3.5 ATP-dependent RNA helicase (NCBI) compare
b3389 aroB -0.9 -7.4 3-dehydroquinate synthase (NCBI) compare
b2329 aroC -0.9 -4.9 chorismate synthase (NCBI) compare
b1860 ruvB -0.9 -1.3 Holliday junction DNA helicase B (NCBI) compare
b3868 glnG -0.9 -5.7 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b3281 aroE -0.9 -7.9 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b1493 gadB -0.9 -1.4 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1048 mdoG -0.9 -4.6 glucan biosynthesis protein, periplasmic (NCBI) compare
b2330 yfcB -0.9 -1.3 putative adenine-specific methylase (VIMSS) compare
b1236 galU -0.8 -3.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3162 deaD -0.8 -4.2 inducible ATP-independent RNA helicase (VIMSS) compare
b1693 aroD -0.8 -4.7 3-dehydroquinate dehydratase (NCBI) compare
b1192 ldcA -0.8 -2.1 L,D-carboxypeptidase A (NCBI) compare
b0014 dnaK -0.8 -3.3 molecular chaperone DnaK (NCBI) compare
b0729 sucD -0.8 -3.4 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1347 ydaC -0.8 -0.5 Rac prophage; predicted protein (NCBI) compare
b2820 recB -0.8 -1.0 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3405 ompR -0.8 -3.6 osmolarity response regulator (NCBI) compare
b0303 ykgI -0.8 -0.9 orf, hypothetical protein (VIMSS) compare
b0740 tolB -0.8 -2.2 translocation protein TolB precursor (NCBI) compare
b4177 purA -0.8 -2.0 adenylosuccinate synthetase (NCBI) compare
b0053 surA -0.8 -4.6 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b4179 vacB -0.7 -5.2 putative enzyme (VIMSS) compare
b4545 ypdJ -0.7 -2.1 no description compare
b1968 yedV -0.7 -3.2 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b0890 ftsK -0.7 -2.7 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0167 glnD -0.7 -3.0 PII uridylyl-transferase (NCBI) compare
b1551 b1551 -0.7 -0.6 orf, hypothetical protein (VIMSS) compare
b0705 ybfL -0.7 -0.4 putative receptor protein (VIMSS) compare
b2659 b2659 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b4066 yjcF -0.7 -0.6 hypothetical protein (NCBI) compare
b0237 pepD -0.7 -5.5 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b2846 yqeH -0.7 -0.6 orf, hypothetical protein (VIMSS) compare
b1171 b1171 -0.7 -2.5 orf, hypothetical protein (VIMSS) compare
b0603 ybdO -0.7 -0.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2343 b2343 -0.7 -2.4 orf, hypothetical protein (VIMSS) compare
b1125 potB -0.7 -2.8 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0149 mrcB -0.7 -5.8 penicillin-binding protein 1b (NCBI) compare
b0439 lon -0.7 -2.9 DNA-binding ATP-dependent protease La (NCBI) compare
b2318 truA -0.7 -2.0 tRNA pseudouridine synthase A (NCBI) compare
b3811 xerC -0.7 -0.9 site-specific tyrosine recombinase XerC (NCBI) compare
b3493 pitA -0.7 -4.4 phosphate transporter, low-affinity (NCBI) compare
b0142 folK -0.7 -0.6 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2110 yehC -0.6 -1.5 predicted periplasmic pilin chaperone (NCBI) compare
b2259 pmrD -0.6 -1.4 polymyxin resistance protein B (VIMSS) compare
b0082 mraW -0.6 -3.2 S-adenosyl-methyltransferase (NCBI) compare
b1497 b1497 -0.6 -0.4 putative enzyme (VIMSS) compare
b2501 ppk -0.6 -4.9 polyphosphate kinase (NCBI) compare
b4426 isrA -0.6 -1.9 unknown RNA (NCBI) compare
b1217 chaB -0.6 -1.9 cation transport regulator (NCBI) compare
b1001 yccE -0.6 -0.3 hypothetical protein (NCBI) compare
b2055 wcaE -0.6 -0.3 predicted glycosyl transferase (NCBI) compare
b1865 nudB -0.6 -1.4 dATP pyrophosphohydrolase (NCBI) compare
b1291 sapD -0.6 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1730 ydjO -0.6 -1.1 predicted protein (RefSeq) compare
b2567 rnc -0.6 -0.3 ribonuclease III (NCBI) compare
b0500 ybbD -0.6 -0.3 hypothetical protein (RefSeq) compare
b4685 yrbN -0.6 -2.5 expressed protein (RefSeq) compare
b2024 hisA -0.6 -2.7 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b2652 ileY -0.6 -0.8 tRNA-Ile (NCBI) compare
b1536 ydeI -0.6 -0.9 hypothetical protein (NCBI) compare
b4294 insA-7 -0.6 -0.9 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b1628 rsxB -0.6 -3.2 electron transport complex protein RnfB (NCBI) compare
b4413 sokC -0.6 -1.7 regulatory antisense RNA (NCBI) compare
b4577 sgrS -0.6 -1.9 small antisense RNA (NCBI) compare
b2569 lepA -0.6 -3.0 GTP-binding protein LepA (NCBI) compare
b0437 clpP -0.6 -3.3 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1167 ymgC -0.6 -0.3 hypothetical protein (NCBI) compare
b2498 upp -0.6 -1.8 uracil phosphoribosyltransferase (VIMSS) compare
b3609 secB -0.6 -2.5 export protein SecB (NCBI) compare
b2699 recA -0.6 -0.7 recombinase A (NCBI) compare
b0737 tolQ -0.6 -1.3 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3261 fis -0.6 -0.6 DNA-binding protein Fis (NCBI) compare
b3619 rfaD -0.6 -2.2 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1671 ydhX -0.6 -1.5 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b4402 yjjY -0.5 -0.6 hypothetical protein (NCBI) compare
b0738 tolR -0.5 -1.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2479 gcvR -0.5 -3.1 transcriptional regulation of gcv operon (VIMSS) compare
b1346 ydaQ -0.5 -0.8 orf, hypothetical protein (VIMSS) compare
b3238 yhcN -0.5 -2.2 orf, hypothetical protein (VIMSS) compare
b1257 yciE -0.5 -0.3 hypothetical protein (NCBI) compare
b3158 yhbU -0.5 -4.1 predicted peptidase (collagenase-like) (NCBI) compare
b1576 ydfD -0.5 -0.3 Qin prophage; predicted protein (NCBI) compare
b1499 ydeO -0.5 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b3631 rfaG -0.5 -4.8 glucosyltransferase I (NCBI) compare
b4191 ulaR -0.5 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b1627 rsxA -0.5 -2.1 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b4653 yicT -0.5 -2.3 no description compare
b0200 gmhB -0.5 -0.9 hypothetical protein (NCBI) compare
b4462 ygaQ -0.5 -1.5 hypothetical protein (RefSeq) compare
b4497 yeeL -0.5 -0.9 no description compare
b0438 clpX -0.5 -3.5 ATP-dependent protease ATP-binding subunit (NCBI) compare
b4131 cadA -0.5 -4.8 lysine decarboxylase 1 (NCBI) compare
b3164 pnp -0.5 -2.3 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1690 ydiM -0.5 -1.7 predicted transporter (NCBI) compare
b1104 ycfL -0.5 -1.0 hypothetical protein (NCBI) compare
b0118 acnB -0.5 -0.6 aconitate hydratase (NCBI) compare
b2625 yfjI -0.5 -1.3 CP4-57 prophage; predicted protein (NCBI) compare
b3930 menA -0.5 -4.3 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b1231 tyrT -0.5 -1.0 tRNA-Tyr (NCBI) compare
b1273 yciN -0.5 -1.5 hypothetical protein (NCBI) compare
b4414 tff -0.5 -1.9 unknown RNA (NCBI) compare
b0881 clpS -0.5 -1.6 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b0234 yafP -0.5 -1.3 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b0080 fruR -0.5 -2.9 DNA-binding transcriptional dual regulator (NCBI) compare
b2531 iscR -0.5 -1.2 DNA-binding transcriptional repressor (NCBI) compare
b3390 aroK -0.5 -0.9 shikimate kinase I (NCBI) compare
b1292 sapC -0.5 -1.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4443 gcvB -0.5 -0.2 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b1942 fliJ -0.5 -0.8 flagellar biosynthesis chaperone (NCBI) compare
b3119 tdcR -0.5 -1.0 threonine dehydratase operon activator protein (VIMSS) compare
b1360 ydaV -0.5 -1.5 Rac prophage; predicted DNA replication protein (NCBI) compare
b1235 rssB -0.5 -3.3 response regulator of RpoS (NCBI) compare
b0828 iaaA -0.5 -1.6 L-asparaginase (NCBI) compare
b4543 ypaA -0.5 -2.5 predicted protein (NCBI) compare
b2114 metG -0.5 -1.9 methionyl-tRNA synthetase (NCBI) compare
b3082 ygjM -0.5 -1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b0279 yagM -0.4 -0.4 CP4-6 prophage; predicted protein (NCBI) compare
b2847 yqeI -0.4 -0.3 predicted transcriptional regulator (NCBI) compare
b2081 yegQ -0.4 -3.4 predicted peptidase (NCBI) compare
b4493 gapC -0.4 -1.1 no description compare
b1147 ymfL -0.4 -2.1 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b3806 cyaA -0.4 -2.6 adenylate cyclase (NCBI) compare
b3159 yhbV -0.4 -3.6 orf, hypothetical protein (VIMSS) compare
b3204 ptsN -0.4 -2.5 sugar-specific enzyme IIA component of PTS (NCBI) compare
b4375 prfC -0.4 -1.5 peptide chain release factor 3 (NCBI) compare
b2562 yfhL -0.4 -3.2 predicted 4Fe-4S cluster-containing protein (NCBI) compare
b3728 pstS -0.4 -2.0 phosphate transporter subunit (NCBI) compare
b0990 cspG -0.4 -0.9 DNA-binding transcriptional regulator (NCBI) compare
b1877 yecT -0.4 -1.5 orf, hypothetical protein (VIMSS) compare
b0049 apaH -0.4 -1.2 diadenosinetetraphosphatase (NCBI) compare
b2814 metZ -0.4 -1.1 tRNA-Met (NCBI) compare
b2369 evgA -0.4 -2.1 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1130 phoP -0.4 -0.8 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b3247 cafA -0.4 -3.5 bundles of cytoplasmic filaments (VIMSS) compare
b1465 narV -0.4 -1.1 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b2754 ygbF -0.4 -1.5 orf, hypothetical protein (VIMSS) compare
b3387 dam -0.4 -3.2 DNA adenine methylase (NCBI) compare
b1692 ydiB -0.4 -2.0 quinate/shikimate 5-dehydrogenase, NAD(P)-binding (NCBI) compare
b1762 b1762 -0.4 -1.5 orf, hypothetical protein (VIMSS) compare
b3612 gpmI -0.4 -3.7 phosphoglyceromutase (NCBI) compare
b2288 nuoA -0.4 -2.1 NADH dehydrogenase I chain A (VIMSS) compare
b1853 yebK -0.4 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b4132 cadB -0.4 -3.7 predicted lysine/cadaverine transporter (NCBI) compare
b1182 hlyE -0.4 -0.3 hemolysin E (VIMSS) compare
b3465 yhhF -0.4 -2.6 predicted methyltransferase (NCBI) compare
b3180 yhbY -0.4 -2.5 predicted RNA-binding protein (NCBI) compare
b4695 ykgT -0.4 -1.1 no description compare
b1271 yciK -0.4 -1.1 short chain dehydrogenase (NCBI) compare
b2822 recC -0.4 -2.5 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b3842 rfaH -0.4 -2.6 transcriptional activator RfaH (NCBI) compare
b0051 ksgA -0.4 -1.9 dimethyladenosine transferase (NCBI) compare
b3630 rfaP -0.4 -3.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2683 ygaH -0.4 -2.7 predicted inner membrane protein (NCBI) compare
b0013 yaaI -0.4 -2.6 hypothetical protein (NCBI) compare
b1648 b1648 -0.4 -1.2 orf, hypothetical protein (VIMSS) compare
b1259 yciG -0.4 -1.4 orf, hypothetical protein (VIMSS) compare
b2553 glnB -0.4 -1.9 regulatory protein P-II for glutamine synthetase (NCBI) compare
b0948 ycbY -0.4 -2.6 predicted methyltransferase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Ciprofloxacin Hydrochloride across organisms