Experiment set41IT064 for Escherichia coli BW25113

Compare to:

LB + carbenicillin Time3hr

200 most important genes:

  gene name fitness t score description  
b4053 alr -7.8 -12.0 alanine racemase (NCBI) compare
b0462 acrB -7.6 -27.8 multidrug efflux system protein (NCBI) compare
b0463 acrA -7.3 -19.0 multidrug efflux system (NCBI) compare
b4237 nrdG -5.4 -6.4 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4238 nrdD -4.9 -12.3 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b4041 plsB -4.1 -5.7 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1334 fnr -3.1 -2.1 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0912 ihfB -2.8 -3.9 integration host factor subunit beta (NCBI) compare
b2330 yfcB -2.4 -1.6 putative adenine-specific methylase (VIMSS) compare
b0386 proC -2.2 -6.5 pyrroline-5-carboxylate reductase (NCBI) compare
b4201 priB -2.2 -4.9 primosomal replication protein N (NCBI) compare
b3035 tolC -2.1 -2.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0990 cspG -2.1 -2.5 DNA-binding transcriptional regulator (NCBI) compare
b0949 uup -2.0 -11.8 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1850 eda -1.9 -3.3 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b0243 proA -1.8 -12.6 gamma-glutamyl phosphate reductase (NCBI) compare
b1860 ruvB -1.8 -1.2 Holliday junction DNA helicase B (NCBI) compare
b1291 sapD -1.8 -2.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0902 pflA -1.7 -7.5 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b2830 nudH -1.7 -2.1 dinucleoside polyphosphate hydrolase (NCBI) compare
b2846 yqeH -1.7 -1.0 orf, hypothetical protein (VIMSS) compare
b2912 ygfA -1.6 -3.7 putative ligase (VIMSS) compare
b1292 sapC -1.6 -3.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0242 proB -1.5 -6.2 gamma-glutamyl kinase (NCBI) compare
b2642 yfjW -1.5 -2.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b3977 tyrU -1.4 -1.5 tRNA-Tyr (NCBI) compare
b1187 fadR -1.4 -3.2 fatty acid metabolism regulator (NCBI) compare
b1124 potC -1.3 -7.1 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3868 glnG -1.3 -8.3 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b1125 potB -1.3 -6.0 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1293 sapB -1.2 -2.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1123 potD -1.2 -6.2 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b2820 recB -1.1 -1.0 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3781 trxA -1.1 -5.4 thioredoxin 1 (VIMSS) compare
b0728 sucC -1.1 -6.8 succinyl-CoA synthetase subunit beta (NCBI) compare
b0167 glnD -1.1 -5.3 PII uridylyl-transferase (NCBI) compare
b1648 b1648 -1.1 -2.6 orf, hypothetical protein (VIMSS) compare
b1855 lpxM -1.1 -4.2 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0740 tolB -1.1 -2.5 translocation protein TolB precursor (NCBI) compare
b1126 potA -1.1 -5.6 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b2017 yefM -1.0 -1.4 orf, hypothetical protein (VIMSS) compare
b0903 pflB -1.0 -7.8 pyruvate formate lyase I (NCBI) compare
b0014 dnaK -1.0 -3.7 molecular chaperone DnaK (NCBI) compare
b1286 rnb -1.0 -2.2 exoribonuclease II (NCBI) compare
b0729 sucD -1.0 -4.6 succinyl-CoA synthetase subunit alpha (NCBI) compare
b0200 gmhB -1.0 -1.5 hypothetical protein (NCBI) compare
b4202 rpsR -1.0 -2.0 30S ribosomal protein S18 (NCBI) compare
b1865 nudB -1.0 -1.6 dATP pyrophosphohydrolase (NCBI) compare
b4066 yjcF -1.0 -0.6 hypothetical protein (NCBI) compare
b3935 priA -0.9 -3.5 primosome assembly protein PriA (NCBI) compare
b0739 tolA -0.9 -2.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b4535 yniD -0.9 -1.7 predicted protein (RefSeq) compare
b4177 purA -0.9 -2.2 adenylosuccinate synthetase (NCBI) compare
b0688 pgm -0.9 -2.8 phosphoglucomutase (NCBI) compare
b3741 gidA -0.9 -2.9 glucose-inhibited division protein A (NCBI) compare
b3162 deaD -0.9 -4.1 inducible ATP-independent RNA helicase (VIMSS) compare
b1358 ydaT -0.8 -1.0 Rac prophage; predicted protein (NCBI) compare
b1861 ruvA -0.8 -0.9 Holliday junction DNA helicase motor protein (NCBI) compare
b3229 sspA -0.8 -2.2 stringent starvation protein A (NCBI) compare
b1259 yciG -0.8 -2.4 orf, hypothetical protein (VIMSS) compare
b2659 b2659 -0.8 -3.0 orf, hypothetical protein (VIMSS) compare
b1818 manY -0.8 -2.0 mannose-specific enzyme IIC component of PTS (NCBI) compare
b0741 pal -0.8 -2.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b4163 glyV -0.8 -1.7 tRNA-Gly (NCBI) compare
b2699 recA -0.8 -0.5 recombinase A (NCBI) compare
b0683 fur -0.8 -1.5 ferric uptake regulator (NCBI) compare
b1804 rnd -0.8 -2.9 ribonuclease D (NCBI) compare
b0737 tolQ -0.8 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1278 pgpB -0.8 -2.0 phosphatidylglycerophosphatase B (NCBI) compare
b2576 srmB -0.8 -2.8 ATP-dependent RNA helicase (NCBI) compare
b1550 b1550 -0.7 -1.2 orf, hypothetical protein (VIMSS) compare
b2808 gcvA -0.7 -3.1 DNA-binding transcriptional dual regulator (NCBI) compare
b4503 yafF -0.7 -0.9 no description compare
b1863 ruvC -0.7 -1.1 Holliday junction resolvase (NCBI) compare
b2501 ppk -0.7 -4.9 polyphosphate kinase (NCBI) compare
b1830 prc -0.7 -3.7 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4375 prfC -0.7 -2.1 peptide chain release factor 3 (NCBI) compare
b2110 yehC -0.7 -1.2 predicted periplasmic pilin chaperone (NCBI) compare
b2620 smpB -0.7 -0.9 SsrA-binding protein (NCBI) compare
b2343 b2343 -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b1677 lpp -0.6 -1.7 murein lipoprotein (NCBI) compare
b3619 rfaD -0.6 -2.6 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3390 aroK -0.6 -1.8 shikimate kinase I (NCBI) compare
b3493 pitA -0.6 -4.1 phosphate transporter, low-affinity (NCBI) compare
b1628 rsxB -0.6 -2.5 electron transport complex protein RnfB (NCBI) compare
b1217 chaB -0.6 -1.6 cation transport regulator (NCBI) compare
b4462 ygaQ -0.6 -1.4 hypothetical protein (RefSeq) compare
b0125 hpt -0.6 -3.3 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b2498 upp -0.6 -1.8 uracil phosphoribosyltransferase (VIMSS) compare
b3204 ptsN -0.6 -3.4 sugar-specific enzyme IIA component of PTS (NCBI) compare
b1088 yceD -0.6 -2.5 hypothetical protein (NCBI) compare
b1730 ydjO -0.6 -0.8 predicted protein (RefSeq) compare
b3916 pfkA -0.6 -1.9 6-phosphofructokinase (NCBI) compare
b2215 ompC -0.6 -4.3 outer membrane porin protein C (NCBI) compare
b3609 secB -0.6 -2.4 export protein SecB (NCBI) compare
b1726 yniB -0.6 -1.8 predicted inner membrane protein (NCBI) compare
b4426 isrA -0.6 -1.6 unknown RNA (NCBI) compare
b3649 rpoZ -0.6 -2.7 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0237 pepD -0.6 -4.3 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b4702 mgtL -0.6 -1.8 regulatory leader peptide for mgtA (NCBI) compare
b3792 wzxE -0.6 -3.6 O-antigen translocase (NCBI) compare
b3706 trmE -0.6 -2.4 tRNA modification GTPase (NCBI) compare
b1537 ydeJ -0.5 -2.3 competence damage-inducible protein A (NCBI) compare
b2569 lepA -0.5 -2.6 GTP-binding protein LepA (NCBI) compare
b1593 b1593 -0.5 -3.0 orf, hypothetical protein (VIMSS) compare
b3930 menA -0.5 -4.8 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b1236 galU -0.5 -2.3 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2754 ygbF -0.5 -2.1 orf, hypothetical protein (VIMSS) compare
b2262 menB -0.5 -3.1 naphthoate synthase (NCBI) compare
b1108 ycfP -0.5 -1.0 orf, hypothetical protein (VIMSS) compare
b1438 ydcQ -0.5 -2.0 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1269 rluB -0.5 -2.8 23S rRNA pseudouridylate synthase (NCBI) compare
b1171 b1171 -0.5 -2.1 orf, hypothetical protein (VIMSS) compare
b1192 ldcA -0.5 -1.2 L,D-carboxypeptidase A (NCBI) compare
b4552 yrhC -0.5 -1.0 no description compare
b2189 proL -0.5 -1.4 tRNA-Pro (NCBI) compare
b2646 ypjF -0.5 -1.8 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b0053 surA -0.5 -3.3 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3052 rfaE -0.5 -2.5 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1636 pdxY -0.5 -2.8 pyridoxine kinase (NCBI) compare
b0685 ybfE -0.5 -1.9 orf, hypothetical protein (VIMSS) compare
b3405 ompR -0.5 -2.2 osmolarity response regulator (NCBI) compare
b2822 recC -0.5 -2.9 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b2911 ssrS -0.5 -1.5 6S regulatory RNA (NCBI) compare
b0948 ycbY -0.5 -3.3 predicted methyltransferase (NCBI) compare
b2258 b2258 -0.5 -1.1 putative transport/receptor protein (VIMSS) compare
b4416 rybA -0.5 -1.2 unknown RNA (NCBI) compare
b1588 ynfF -0.5 -2.6 oxidoreductase subunit (RefSeq) compare
b2297 pta -0.5 -0.4 phosphate acetyltransferase (NCBI) compare
b3183 obgE -0.5 -0.6 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1620 malI -0.5 -1.9 DNA-binding transcriptional repressor (NCBI) compare
b1148 ymfM -0.5 -2.1 e14 prophage; predicted protein (NCBI) compare
b1563 relE -0.5 -0.9 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b1247 oppF -0.5 -2.1 oligopeptide transporter subunit (NCBI) compare
b0149 mrcB -0.4 -3.9 penicillin-binding protein 1b (NCBI) compare
b1271 yciK -0.4 -1.6 short chain dehydrogenase (NCBI) compare
b3163 nlpI -0.4 -2.1 hypothetical protein (NCBI) compare
b1685 ydiH -0.4 -1.2 predicted protein (RefSeq) compare
b1104 ycfL -0.4 -0.7 hypothetical protein (NCBI) compare
b3620 rfaF -0.4 -2.6 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b1513 lsrA -0.4 -2.6 fused AI2 transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1575 dicB -0.4 -1.0 Qin prophage; cell division inhibition protein (NCBI) compare
b1290 sapF -0.4 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3026 qseC -0.4 -1.6 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1560 ydfU -0.4 -2.7 Qin prophage; predicted protein (RefSeq) compare
b0965 b0965 -0.4 -2.0 orf, hypothetical protein (VIMSS) compare
b3811 xerC -0.4 -0.7 site-specific tyrosine recombinase XerC (NCBI) compare
b3652 recG -0.4 -3.4 ATP-dependent DNA helicase (NCBI) compare
b0088 murD -0.4 -1.6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1594 dgsA -0.4 -1.9 DNA-binding transcriptional repressor (NCBI) compare
b4191 ulaR -0.4 -2.4 DNA-binding transcriptional dual regulator (NCBI) compare
b2329 aroC -0.4 -2.3 chorismate synthase (NCBI) compare
b1612 fumA -0.4 -2.3 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b3621 rfaC -0.4 -2.1 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b2093 gatB -0.4 -2.4 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b3728 pstS -0.4 -2.0 phosphate transporter subunit (NCBI) compare
b3341 rpsG -0.4 -0.8 30S ribosomal protein S7 (NCBI) compare
b0560 nohB -0.4 -2.0 DLP12 prophage; DNA packaging protein (NCBI) compare
b1531 marA -0.4 -1.9 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b4255 yjgD -0.4 -2.7 hypothetical protein (NCBI) compare
b0118 acnB -0.4 -0.4 aconitate hydratase (NCBI) compare
b2894 xerD -0.4 -0.4 site-specific tyrosine recombinase XerD (NCBI) compare
b1814 sdaA -0.4 -1.8 L-serine deaminase I (NCBI) compare
b1523 yneG -0.4 -1.4 hypothetical protein (NCBI) compare
b3238 yhcN -0.4 -1.7 orf, hypothetical protein (VIMSS) compare
b1642 slyA -0.4 -1.0 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0603 ybdO -0.4 -0.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b4151 frdD -0.4 -2.0 fumarate reductase subunit D (NCBI) compare
b2318 truA -0.4 -1.0 tRNA pseudouridine synthase A (NCBI) compare
b1890 motA -0.4 -1.8 flagellar motor protein MotA (NCBI) compare
b4414 tff -0.4 -1.8 unknown RNA (NCBI) compare
b0145 dksA -0.4 -1.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2047 wcaJ -0.4 -2.6 predicted UDP-glucose lipid carrier transferase (NCBI) compare
b0234 yafP -0.4 -0.9 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b2562 yfhL -0.4 -2.9 predicted 4Fe-4S cluster-containing protein (NCBI) compare
b0890 ftsK -0.4 -1.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0908 aroA -0.4 -2.9 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b2285 nuoE -0.4 -1.2 NADH dehydrogenase subunit E (NCBI) compare
b1907 tyrP -0.4 -1.9 tyrosine transporter (NCBI) compare
b3863 polA -0.4 -0.5 DNA polymerase I (NCBI) compare
b1931 yedK -0.4 -2.0 hypothetical protein (NCBI) compare
b1617 uidA -0.4 -2.3 beta-D-glucuronidase (NCBI) compare
b3404 envZ -0.4 -2.9 osmolarity sensor protein (NCBI) compare
b3813 uvrD -0.4 -3.3 DNA-dependent ATPase I and helicase II (NCBI) compare
b1524 yneH -0.4 -0.6 predicted glutaminase (NCBI) compare
b0303 ykgI -0.4 -0.4 orf, hypothetical protein (VIMSS) compare
b1540 ydfH -0.4 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b4025 pgi -0.4 -2.8 glucose-6-phosphate isomerase (NCBI) compare
b2081 yegQ -0.4 -2.8 predicted peptidase (NCBI) compare
b3778 rep -0.4 -2.8 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1516 lsrB -0.4 -1.9 AI2 transporter (NCBI) compare
b1262 trpC -0.4 -2.1 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) compare
b1322 ycjF -0.4 -2.6 hypothetical protein (NCBI) compare
b1522 yneF -0.3 -2.2 predicted diguanylate cyclase (NCBI) compare
b2058 wcaB -0.3 -0.7 predicted acyl transferase (NCBI) compare
b3098 yqjD -0.3 -1.8 hypothetical protein (NCBI) compare
b2299 yfcD -0.3 -2.1 predicted NUDIX hydrolase (NCBI) compare
b0767 ybhE -0.3 -1.9 6-phosphogluconolactonase (NCBI) compare
b1589 ynfG -0.3 -1.8 oxidoreductase, Fe-S subunit (NCBI) compare
b2553 glnB -0.3 -1.6 regulatory protein P-II for glutamine synthetase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Carbenicillin disodium salt across organisms