Experiment set41IT017 for Escherichia coli BW25113

Compare to:

LB + ciprofloxacin Time3hr

200 most detrimental genes:

  gene name fitness t score description  
b2934 cmtB +1.3 1.1 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b1361 ydaW +1.2 0.9 orf, hypothetical protein (VIMSS) compare
b0630 lipB +1.2 2.1 protein of lipoate biosynthesis (VIMSS) compare
b1332 ynaJ +1.0 1.1 predicted inner membrane protein (NCBI) compare
b1765 ydjA +1.0 1.5 predicted oxidoreductase (NCBI) compare
b1480 sra +0.9 2.4 30S ribosomal subunit protein S22 (NCBI) compare
b1882 cheY +0.9 0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b4699 fnrS +0.8 1.1 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b4603 rseX +0.7 0.8 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b0730 mngR +0.7 1.4 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b3120 yhaB +0.7 1.9 orf, hypothetical protein (VIMSS) compare
b4538 yoeF +0.6 1.6 hypothetical protein (RefSeq) compare
b1753 ynjA +0.6 1.3 hypothetical protein (NCBI) compare
b1476 fdnI +0.6 0.9 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b2051 wcaH +0.6 1.9 GDP-mannose mannosyl hydrolase (VIMSS) compare
b1143 ymfI +0.6 2.0 orf, hypothetical protein (VIMSS) compare
b4596 yciZ +0.6 1.6 hypothetical protein (RefSeq) compare
b1506 yneL +0.6 1.2 predicted transcriptional regulator (NCBI) compare
b1792 yeaO +0.5 2.5 orf, hypothetical protein (VIMSS) compare
b4698 mgrR +0.5 2.1 sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq) compare
b2433 b2433 +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b4551 yheV +0.5 2.1 hypothetical protein (NCBI) compare
b1195 ymgE +0.5 2.1 predicted inner membrane protein (NCBI) compare
b4503 yafF +0.5 0.8 no description compare
b1686 ydiI +0.5 1.2 hypothetical protein (NCBI) compare
b0247 ykfG +0.5 1.2 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b4509 ylcG +0.5 1.5 DLP12 prophage; predicted protein (NCBI) compare
b1733 chbG +0.5 3.1 hypothetical protein (NCBI) compare
b4451 ryhB +0.5 0.8 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b0998 torD +0.5 0.9 chaperone protein TorD (NCBI) compare
b0852 rimK +0.5 3.0 ribosomal protein S6 modification protein (NCBI) compare
b0381 ddlA +0.5 3.5 D-alanylalanine synthetase (NCBI) compare
b1502 ydeQ +0.4 1.4 predicted fimbrial-like adhesin protein (NCBI) compare
b0798 ybiA +0.4 1.8 hypothetical protein (NCBI) compare
b1461 ydcE +0.4 2.0 4-oxalocrotonate tautomerase (NCBI) compare
b1566 flxA +0.4 2.2 Qin prophage; predicted protein (NCBI) compare
b2279 nuoK +0.4 1.2 NADH dehydrogenase subunit K (NCBI) compare
b1930 yedF +0.4 2.6 hypothetical protein (NCBI) compare
b2587 kgtP +0.4 2.5 alpha-ketoglutarate transporter (NCBI) compare
b2809 b2809 +0.4 1.7 orf, hypothetical protein (VIMSS) compare
b2188 yejM +0.4 3.3 predicted hydrolase, inner membrane (NCBI) compare
b1709 btuD +0.4 0.8 vitamin B12-transporter ATPase (NCBI) compare
b4045 yjbJ +0.4 1.1 predicted stress response protein (NCBI) compare
b4614 sokA +0.4 1.7 no description compare
b1739 osmE +0.4 1.5 DNA-binding transcriptional activator (NCBI) compare
b3889 yiiE +0.4 1.5 predicted transcriptional regulator (RefSeq) compare
b2058 wcaB +0.4 0.8 predicted acyl transferase (NCBI) compare
b1669 ydhT +0.4 1.5 hypothetical protein (NCBI) compare
b4701 sokX +0.4 0.5 sok-related sRNA, function unknown (RefSeq) compare
b0549 ybcO +0.4 1.7 DLP12 prophage; predicted protein (NCBI) compare
b0617 citD +0.4 1.6 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b4640 yoeG +0.4 1.2 no description compare
b1768 ydjB +0.4 2.3 orf, hypothetical protein (VIMSS) compare
b1357 ydaS +0.4 1.2 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b1176 minC +0.4 1.2 septum formation inhibitor (NCBI) compare
b1557 cspB +0.3 1.0 Qin prophage; cold shock protein (NCBI) compare
b4592 yccB +0.3 1.2 hypothetical protein (RefSeq) compare
b0880 cspD +0.3 1.2 cold shock protein homolog (NCBI) compare
b4558 yifL +0.3 1.8 predicted lipoprotein (NCBI) compare
b4527 b1354 +0.3 1.7 orf, hypothetical protein (VIMSS) compare
b1258 yciF +0.3 0.5 hypothetical protein (NCBI) compare
b2212 alkB +0.3 2.2 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions (NCBI) compare
b1511 ydeV +0.3 1.5 putative kinase (VIMSS) compare
b3037 ygiB +0.3 1.9 conserved outer membrane protein (RefSeq) compare
b4618 tisB +0.3 1.9 lexA-regulated toxic peptide (RefSeq) compare
b4505 insX +0.3 0.7 predicted IS protein (RefSeq) compare
b4376 osmY +0.3 1.9 periplasmic protein (NCBI) compare
b1362 rzpR +0.3 1.5 putative Rac prophage endopeptidase (VIMSS) compare
b1565 ydfV +0.3 1.5 Qin prophage; predicted protein (NCBI) compare
b0641 rlpB +0.3 1.5 minor lipoprotein (NCBI) compare
b1113 ycfS +0.3 2.3 hypothetical protein (NCBI) compare
b4367 fhuF +0.3 2.5 ferric iron reductase involved in ferric hydroximate transport (NCBI) compare
b1427 rimL +0.3 1.1 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b3624 rfaZ +0.3 1.2 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2498 upp +0.3 1.1 uracil phosphoribosyltransferase (VIMSS) compare
b1418 cybB +0.3 0.9 cytochrome b(561) (VIMSS) compare
b1724 ydiZ +0.3 0.7 hypothetical protein (NCBI) compare
b3860 dsbA +0.3 2.6 periplasmic protein disulfide isomerase I (NCBI) compare
b1849 purT +0.3 2.1 phosphoribosylglycinamide formyltransferase 2 (NCBI) compare
b4511 ybdZ +0.3 1.7 hypothetical protein (NCBI) compare
b4363 yjjB +0.3 1.5 conserved inner membrane protein (RefSeq) compare
b2248 yfaX +0.3 0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2992 hybE +0.3 1.8 hydrogenase 2-specific chaperone (NCBI) compare
b4460 araH +0.3 1.0 fused L-arabinose transporter subunits of ABC superfamily: membrane components (RefSeq) compare
b1073 flgB +0.3 2.1 flagellar basal-body rod protein B (NCBI) compare
b4157 yjeN +0.3 1.6 hypothetical protein (NCBI) compare
b1976 b1976 +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b2019 hisG +0.3 2.0 ATP phosphoribosyltransferase (NCBI) compare
b4573 insZ +0.3 1.5 no description compare
b1150 ymfR +0.3 0.5 e14 prophage; predicted protein (NCBI) compare
b0367 tauC +0.3 1.8 taurine transporter subunit (NCBI) compare
b1838 pphA +0.3 1.9 protein phosphatase 1 modulates phosphoproteins, signals protein misfolding (VIMSS) compare
b0995 torR +0.3 1.7 DNA-binding response regulator in two-component regulatory system with TorS (NCBI) compare
b2804 fucU +0.3 1.4 L-fucose mutarotase (NCBI) compare
b1293 sapB +0.3 0.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2356 yfdM +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b1831 proQ +0.3 1.0 putative solute/DNA competence effector (NCBI) compare
b0509 glxR +0.3 1.6 tartronate semialdehyde reductase, NADH-dependent (NCBI) compare
b1360 ydaV +0.3 1.0 Rac prophage; predicted DNA replication protein (NCBI) compare
b1948 fliP +0.3 1.7 flagellar biosynthesis protein P (NCBI) compare
b2287 nuoB +0.3 1.2 NADH dehydrogenase subunit B (NCBI) compare
b0713 ybgL +0.3 2.1 hypothetical protein (NCBI) compare
b4017 arpA +0.3 1.6 regulator of acetyl CoA synthetase (NCBI) compare
b1737 chbC +0.3 2.0 N,N'-diacetylchitobiose-specific enzyme IIC component of PTS (NCBI) compare
b1847 yebF +0.3 0.6 predicted protein (RefSeq) compare
b1524 yneH +0.3 0.4 predicted glutaminase (NCBI) compare
b0864 artP +0.3 1.4 arginine transporter subunit (NCBI) compare
b2486 hyfF +0.3 1.9 NADH dehydrogenase subunit N (NCBI) compare
b0193 yaeF +0.3 2.2 orf, hypothetical protein (VIMSS) compare
b2199 ccmC +0.3 1.7 heme exporter subunit (NCBI) compare
b2444 yffM +0.3 0.9 CPZ-55 prophage; predicted protein (NCBI) compare
b4656 yjhY +0.3 1.8 no description compare
b3068 ygjF +0.3 1.0 G/U mismatch-specific DNA glycosylase (NCBI) compare
b2774 ygcW +0.3 1.6 putative oxidoreductase (VIMSS) compare
b2673 nrdH +0.3 1.6 glutaredoxin-like protein (NCBI) compare
b0632 dacA +0.3 2.0 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b4631 ykgQ +0.3 0.9 no description compare
b1942 fliJ +0.3 0.6 flagellar biosynthesis chaperone (NCBI) compare
b3686 ibpB +0.3 2.1 heat shock chaperone (NCBI) compare
b0192 nlpE +0.3 1.8 lipoprotein involved with copper homeostasis and adhesion (NCBI) compare
b1387 maoC +0.3 1.3 fused aldehyde dehydrogenase/enoyl-CoA hydratase (NCBI) compare
b2209 eco +0.3 0.8 ecotin precursor (NCBI) compare
b2282 nuoH +0.3 1.4 NADH dehydrogenase subunit H (NCBI) compare
b0865 ybjP +0.3 0.8 predicted lipoprotein (NCBI) compare
b2408 yfeN +0.3 1.9 conserved outer membrane protein (NCBI) compare
b1348 lar +0.3 0.8 Rac prophage; restriction alleviation protein (NCBI) compare
b0018 mokC +0.3 0.6 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b0804 ybiX +0.3 1.3 putative enzyme (VIMSS) compare
b4646 yrdE +0.3 1.5 no description compare
b2959 yggL +0.3 1.5 orf, hypothetical protein (VIMSS) compare
b1764 selD +0.3 1.2 selenophosphate synthetase (NCBI) compare
b4487 yjdP +0.3 1.7 hypothetical protein (NCBI) compare
b0843 ybjH +0.3 0.6 hypothetical protein (NCBI) compare
b0429 cyoD +0.3 1.2 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b1919 yedO +0.3 0.7 putative 1-aminocyclopropane-1-carboxylate deaminase (VIMSS) compare
b2419 yfeK +0.3 0.9 hypothetical protein (NCBI) compare
b1742 b1742 +0.2 1.1 orf, hypothetical protein (VIMSS) compare
b4444 rygA +0.2 1.2 unknown RNA (NCBI) compare
b2534 yfhR +0.2 2.0 predicted peptidase (RefSeq) compare
b0542 renD +0.2 1.0 orf, hypothetical protein (VIMSS) compare
b2266 elaB +0.2 1.0 hypothetical protein (NCBI) compare
b2004 yeeU +0.2 1.4 CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b3613 yibP +0.2 0.7 putative membrane protein (VIMSS) compare
b0872 hcr +0.2 1.7 HCP oxidoreductase, NADH-dependent (NCBI) compare
b4381 deoC +0.2 1.6 deoxyribose-phosphate aldolase (NCBI) compare
b2442 intZ +0.2 1.4 CPZ-55 prophage; predicted integrase (RefSeq) compare
b4704 arrS +0.2 0.1 Antisense sRNA ArrS, function unknown (NCBI) compare
b2204 napH +0.2 1.4 quinol dehydrogenase membrane component (NCBI) compare
b4506 ykgO +0.2 1.3 rpmJ (L36) paralog (NCBI) compare
b2435 amiA +0.2 1.8 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b2765 ygcM +0.2 1.2 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (NCBI) compare
b1415 aldA +0.2 1.4 Lactaldehyde / glycolaldehyde dehydrogenase aldA (EC 1.2.1.22; EC 1.2.1.21) (from data) compare
b3100 yqjK +0.2 1.4 hypothetical protein (NCBI) compare
b0269 yagF +0.2 1.8 CP4-6 prophage; predicted dehydratase (NCBI) compare
b2499 purM +0.2 1.4 phosphoribosylaminoimidazole synthetase (NCBI) compare
b1531 marA +0.2 1.3 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1070 flgN +0.2 0.6 export chaperone for FlgK and FlgL (NCBI) compare
b3483 yhhH +0.2 0.1 orf, hypothetical protein (VIMSS) compare
b2208 napF +0.2 1.1 ferredoxin-type protein, predicted role in electron transfer to periplasmic nitrate reductase (NapA) (NCBI) compare
b1342 ydaN +0.2 1.5 zinc transporter (NCBI) compare
b1478 adhP +0.2 1.1 alcohol dehydrogenase (VIMSS) compare
b3973 birA +0.2 0.9 biotin--protein ligase (NCBI) compare
b0714 nei +0.2 1.6 endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase (NCBI) compare
b0393 rdgC +0.2 1.9 recombination associated protein (NCBI) compare
b2377 yfdY +0.2 0.9 predicted inner membrane protein (NCBI) compare
b2015 yeeY +0.2 1.8 putative transcriptional regulator LYSR-type (VIMSS) compare
b1614 ydgA +0.2 0.9 hypothetical protein (NCBI) compare
b2141 yohJ +0.2 1.0 hypothetical protein (NCBI) compare
b4246 pyrL +0.2 1.0 pyrBI operon leader peptide (NCBI) compare
b4468 glcE +0.2 1.3 glycolate oxidase FAD binding subunit (NCBI) compare
b1287 yciW +0.2 1.2 putative oxidoreductase (VIMSS) compare
b4380 yjjI +0.2 1.8 hypothetical protein (NCBI) compare
b4176 yjeT +0.2 1.4 conserved inner membrane protein (NCBI) compare
b2302 yfcG +0.2 1.7 predicted glutathione S-transferase (NCBI) compare
b4480 hdfR +0.2 1.5 transcriptional regulator HdfR (NCBI) compare
b2783 chpR +0.2 0.8 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b2454 eutJ +0.2 1.9 predicted chaperonin, ethanolamine utilization protein (NCBI) compare
b0765 modC +0.2 1.6 molybdate transporter subunit (NCBI) compare
b4561 insM +0.2 1.3 transposase (RefSeq) compare
b2510 b2510 +0.2 1.0 orf, hypothetical protein (VIMSS) compare
b1376 ynaF +0.2 1.5 putative filament protein (VIMSS) compare
b0933 ssuB +0.2 1.2 alkanesulfonate transporter subunit (NCBI) compare
b1079 flgH +0.2 1.5 flagellar L-ring protein precursor H (NCBI) compare
b2426 ucpA +0.2 1.0 putative oxidoreductase (VIMSS) compare
b1683 ynhE +0.2 1.7 orf, hypothetical protein (VIMSS) compare
b2622 intA +0.2 1.5 CP4-57 prophage; integrase (NCBI) compare
b4409 blr +0.2 1.6 beta-lactam resistance membrane protein (NCBI) compare
b1153 ymfQ +0.2 1.1 e14 prophage; conserved protein (NCBI) compare
b2794 yqcD +0.2 1.6 hypothetical protein (NCBI) compare
b4325 yjiC +0.2 1.2 orf, hypothetical protein (VIMSS) compare
b2481 hyfA +0.2 1.2 hydrogenase 4 Fe-S subunit (VIMSS) compare
b3844 fre +0.2 1.4 NAD(P)H-flavin reductase (NCBI) compare
b1586 b1586 +0.2 1.0 orf, hypothetical protein (VIMSS) compare
b4522 yciX_1 +0.2 1.0 hypothetical protein (NCBI) compare
b4481 rffT +0.2 1.4 4-alpha-L-fucosyltransferase (NCBI) compare
b1339 abgR +0.2 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2776 ygcE +0.2 1.7 predicted kinase (NCBI) compare
b1487 ddpA +0.2 1.5 D-ala-D-a la transporter subunit (NCBI) compare
b0521 ybcF +0.2 1.2 predicted carbamate kinase (NCBI) compare
b2738 ygbL +0.2 1.2 hypothetical protein (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Ciprofloxacin Hydrochloride across organisms