| | gene | name | fitness | t score | description | |
|---|
| b0004 | thrC | -8.2 | -5.7 | threonine synthase (NCBI) | compare |
| b2021 | hisC | -8.0 | -5.5 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b2023 | hisH | -7.9 | -5.5 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b1281 | pyrF | -7.8 | -4.8 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b3172 | argG | -7.7 | -11.8 | argininosuccinate synthase (NCBI) | compare |
| b3956 | ppc | -7.2 | -24.4 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b0386 | proC | -6.9 | -4.7 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2499 | purM | -6.8 | -4.7 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2329 | aroC | -6.8 | -4.7 | chorismate synthase (NCBI) | compare |
| b0072 | leuC | -6.5 | -13.2 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2557 | purL | -6.5 | -12.5 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b4005 | purD | -6.5 | -13.2 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b3774 | ilvC | -6.3 | -19.6 | ketol-acid reductoisomerase (NCBI) | compare |
| b3389 | aroB | -6.3 | -17.6 | 3-dehydroquinate synthase (NCBI) | compare |
| b1260 | trpA | -6.3 | -4.0 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3281 | aroE | -6.2 | -20.7 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b3941 | metF | -6.2 | -11.5 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3772 | ilvA | -6.1 | -16.5 | threonine dehydratase (NCBI) | compare |
| b2022 | hisB | -6.0 | -10.1 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b4388 | serB | -5.9 | -9.4 | 3-phosphoserine phosphatase (NCBI) | compare |
| b1062 | pyrC | -5.8 | -9.6 | dihydroorotase (NCBI) | compare |
| b2024 | hisA | -5.7 | -2.1 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b0073 | leuB | -5.7 | -9.4 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b1192 | ldcA | -5.7 | -8.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b4006 | purH | -5.6 | -15.7 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b0243 | proA | -5.5 | -10.3 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b1613 | manA | -5.5 | -3.6 | mannose-6-phosphate isomerase (VIMSS) | compare |
| b3960 | argH | -5.5 | -13.1 | argininosuccinate lyase (NCBI) | compare |
| b2763 | cysI | -5.4 | -10.8 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0908 | aroA | -5.4 | -13.5 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0032 | carA | -5.3 | -5.5 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2764 | cysJ | -5.3 | -11.8 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b0071 | leuD | -5.3 | -7.5 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0074 | leuA | -5.2 | -9.1 | 2-isopropylmalate synthase (NCBI) | compare |
| b0003 | thrB | -5.2 | -7.5 | homoserine kinase (NCBI) | compare |
| b3957 | argE | -5.1 | -11.9 | acetylornithine deacetylase (NCBI) | compare |
| b3958 | argC | -5.1 | -11.0 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3771 | ilvD | -5.1 | -14.5 | dihydroxy-acid dehydratase (NCBI) | compare |
| b2838 | lysA | -5.1 | -9.9 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3770 | ilvE | -5.1 | -11.6 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2312 | purF | -5.1 | -7.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b0242 | proB | -5.0 | -6.9 | gamma-glutamyl kinase (NCBI) | compare |
| b0907 | serC | -4.9 | -5.7 | phosphoserine aminotransferase (NCBI) | compare |
| b0033 | carB | -4.9 | -13.1 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b1693 | aroD | -4.8 | -9.4 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b3959 | argB | -4.8 | -9.8 | acetylglutamate kinase (RefSeq) | compare |
| b2818 | argA | -4.7 | -8.3 | N-acetylglutamate synthase (NCBI) | compare |
| b0002 | thrA | -4.7 | -11.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2750 | cysC | -4.7 | -6.6 | adenylylsulfate kinase (NCBI) | compare |
| b2026 | hisI | -4.6 | -6.4 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3368 | cysG | -4.6 | -17.2 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b0720 | gltA | -4.6 | -6.5 | citrate synthase (NCBI) | compare |
| b1493 | gadB | -4.6 | -1.2 | glutamate decarboxylase B, PLP-dependent (NCBI) | compare |
| b0726 | sucA | -4.6 | -3.2 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3183 | obgE | -4.5 | -2.2 | GTPase involved in cell partioning and DNA repair (NCBI) | compare |
| b1261 | trpB | -4.4 | -2.3 | tryptophan synthase subunit beta (NCBI) | compare |
| b0945 | pyrD | -4.4 | -12.0 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2019 | hisG | -4.2 | -3.9 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2025 | hisF | -4.1 | -3.5 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2020 | hisD | -4.1 | -6.2 | histidinol dehydrogenase (NCBI) | compare |
| b0990 | cspG | -4.1 | -1.8 | DNA-binding transcriptional regulator (NCBI) | compare |
| b2479 | gcvR | -4.1 | -6.6 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b2414 | cysK | -4.1 | -8.2 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2913 | serA | -3.9 | -9.8 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b3008 | metC | -3.7 | -8.7 | cystathionine beta-lyase (NCBI) | compare |
| b3939 | metB | -3.5 | -9.0 | cystathionine gamma-synthase (NCBI) | compare |
| b0522 | purK | -3.5 | -7.4 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3773 | ilvY | -3.5 | -7.5 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3870 | glnA | -3.5 | -2.4 | glutamine synthetase (NCBI) | compare |
| b0523 | purE | -3.5 | -3.2 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b1262 | trpC | -3.3 | -3.3 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0200 | gmhB | -3.3 | -2.2 | hypothetical protein (NCBI) | compare |
| b4676 | yoaK | -3.2 | -1.1 | expressed protein (RefSeq) | compare |
| b2600 | tyrA | -3.1 | -5.9 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b2762 | cysH | -3.1 | -7.8 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0113 | pdhR | -3.1 | -5.0 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0049 | apaH | -3.1 | -4.3 | diadenosinetetraphosphatase (NCBI) | compare |
| b2476 | purC | -3.0 | -2.8 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b4013 | metA | -3.0 | -6.4 | homoserine O-succinyltransferase (NCBI) | compare |
| b1865 | nudB | -3.0 | -1.3 | dATP pyrophosphohydrolase (NCBI) | compare |
| b0145 | dksA | -2.9 | -3.7 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b3642 | pyrE | -2.9 | -3.9 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3916 | pfkA | -2.9 | -2.8 | 6-phosphofructokinase (NCBI) | compare |
| b1232 | purU | -2.9 | -4.8 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b3390 | aroK | -2.8 | -2.7 | shikimate kinase I (NCBI) | compare |
| b2839 | lysR | -2.7 | -3.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1164 | ycgZ | -2.7 | -2.5 | hypothetical protein (NCBI) | compare |
| b1860 | ruvB | -2.7 | -1.4 | Holliday junction DNA helicase B (NCBI) | compare |
| b4214 | cysQ | -2.6 | -10.0 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0888 | trxB | -2.6 | -4.8 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b2500 | purN | -2.5 | -5.5 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b3237 | argR | -2.5 | -5.1 | arginine repressor (NCBI) | compare |
| b2599 | pheA | -2.5 | -3.5 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b4245 | pyrB | -2.5 | -8.0 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b3169 | nusA | -2.4 | -2.4 | transcription elongation factor NusA (NCBI) | compare |
| b0564 | appY | -2.4 | -0.8 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b1236 | galU | -2.3 | -6.6 | glucose-1-phosphate uridylyltransferase (NCBI) | compare |
| b1818 | manY | -2.2 | -3.0 | mannose-specific enzyme IIC component of PTS (NCBI) | compare |
| b2518 | ndk | -2.2 | -2.6 | nucleoside diphosphate kinase (NCBI) | compare |
| b0758 | galT | -2.1 | -3.8 | galactose-1-phosphate uridylyltransferase (NCBI) | compare |
| b1130 | phoP | -2.1 | -1.4 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b0014 | dnaK | -2.0 | -1.5 | molecular chaperone DnaK (NCBI) | compare |
| b3204 | ptsN | -2.0 | -3.3 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b1258 | yciF | -1.9 | -1.2 | hypothetical protein (NCBI) | compare |
| b1506 | yneL | -1.9 | -2.1 | predicted transcriptional regulator (NCBI) | compare |
| b2934 | cmtB | -1.9 | -0.9 | predicted mannitol-specific enzyme IIA component of PTS (NCBI) | compare |
| b3463 | ftsE | -1.8 | -3.9 | predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) | compare |
| b3609 | secB | -1.7 | -3.3 | export protein SecB (NCBI) | compare |
| b2699 | recA | -1.7 | -2.1 | recombinase A (NCBI) | compare |
| b1551 | b1551 | -1.7 | -0.8 | orf, hypothetical protein (VIMSS) | compare |
| b3613 | yibP | -1.7 | -6.8 | putative membrane protein (VIMSS) | compare |
| b1257 | yciE | -1.7 | -0.8 | hypothetical protein (NCBI) | compare |
| b4538 | yoeF | -1.6 | -1.6 | hypothetical protein (RefSeq) | compare |
| b2290 | yfbQ | -1.6 | -7.9 | aspartate aminotransferase (NCBI) | compare |
| b0840 | deoR | -1.6 | -3.5 | DNA-binding transcriptional repressor (NCBI) | compare |
| b1819 | manZ | -1.6 | -3.8 | mannose-specific enzyme IID component of PTS (NCBI) | conserved |
| b0560 | nohB | -1.6 | -2.4 | DLP12 prophage; DNA packaging protein (NCBI) | compare |
| b4146 | yjeK | -1.6 | -2.9 | predicted lysine aminomutase (NCBI) | compare |
| b2553 | glnB | -1.6 | -4.1 | regulatory protein P-II for glutamine synthetase (NCBI) | compare |
| b1346 | ydaQ | -1.5 | -1.6 | orf, hypothetical protein (VIMSS) | compare |
| b3027 | ygiZ | -1.5 | -0.7 | conserved inner membrane protein (NCBI) | compare |
| b1976 | b1976 | -1.5 | -2.7 | orf, hypothetical protein (VIMSS) | compare |
| b1863 | ruvC | -1.4 | -2.1 | Holliday junction resolvase (NCBI) | compare |
| b3205 | yhbJ | -1.4 | -4.8 | hypothetical protein (NCBI) | compare |
| b3624 | rfaZ | -1.4 | -2.9 | lipopolysaccharide core biosynthesis protein (NCBI) | compare |
| b3484 | yhhI | -1.4 | -2.5 | predicted transposase (NCBI) | compare |
| b1727 | yniC | -1.4 | -2.5 | predicted hydrolase (NCBI) | compare |
| b1263 | trpD | -1.4 | -1.6 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2501 | ppk | -1.4 | -5.3 | polyphosphate kinase (NCBI) | compare |
| b3236 | mdh | -1.4 | -5.2 | malate dehydrogenase (NCBI) | compare |
| b0802 | ybiJ | -1.3 | -2.2 | hypothetical protein (NCBI) | compare |
| b0928 | aspC | -1.3 | -4.9 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b1817 | manX | -1.3 | -2.9 | fused mannose-specific PTS enzymes: IIA component/IIB component (NCBI) | conserved |
| b1558 | cspF | -1.3 | -2.3 | Qin prophage; cold shock protein (NCBI) | compare |
| b4018 | iclR | -1.3 | -4.8 | repressor of aceBA operon (VIMSS) | compare |
| b0730 | mngR | -1.3 | -1.4 | DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) | compare |
| b1264 | trpE | -1.3 | -1.9 | anthranilate synthase component I (NCBI) | compare |
| b2318 | truA | -1.3 | -1.9 | tRNA pseudouridine synthase A (NCBI) | compare |
| b3781 | trxA | -1.3 | -1.6 | thioredoxin 1 (VIMSS) | compare |
| b2935 | tktA | -1.3 | -2.4 | transketolase 1, thiamin-binding (NCBI) | compare |
| b3213 | gltD | -1.3 | -6.0 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b1553 | ydfP | -1.2 | -1.7 | Qin prophage; conserved protein (NCBI) | compare |
| b4191 | ulaR | -1.2 | -2.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0075 | leuL | -1.2 | -2.8 | leu operon leader peptide (NCBI) | compare |
| b1712 | ihfA | -1.2 | -2.1 | integration host factor subunit alpha (NCBI) | compare |
| b1984 | asnW | -1.2 | -1.0 | tRNA-Asn (NCBI) | compare |
| b2784 | relA | -1.2 | -4.5 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b2603 | yfiR | -1.2 | -4.1 | hypothetical protein (NCBI) | compare |
| b0340 | cynS | -1.2 | -2.9 | cyanate hydratase (NCBI) | compare |
| b3545 | proK | -1.2 | -2.1 | tRNA-Pro (NCBI) | compare |
| b1103 | ycfF | -1.2 | -1.5 | orf, hypothetical protein (VIMSS) | compare |
| b3429 | glgA | -1.2 | -5.5 | glycogen synthase (NCBI) | compare |
| b3212 | gltB | -1.1 | -7.8 | glutamate synthase, large subunit (NCBI) | compare |
| b1168 | b1168 | -1.1 | -4.6 | putative proteases (VIMSS) | compare |
| b1285 | gmr | -1.1 | -3.6 | modulator of Rnase II stability (NCBI) | compare |
| b3101 | yqjF | -1.1 | -2.2 | orf, hypothetical protein (VIMSS) | compare |
| b2752 | cysD | -1.1 | -3.0 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b1025 | ycdT | -1.1 | -1.6 | predicted diguanylate cyclase (NCBI) | compare |
| b2471 | yffB | -1.1 | -2.5 | hypothetical protein (NCBI) | compare |
| b3742 | mioC | -1.1 | -3.0 | flavodoxin (NCBI) | compare |
| b1235 | rssB | -1.1 | -3.9 | response regulator of RpoS (NCBI) | compare |
| b1348 | lar | -1.1 | -1.5 | Rac prophage; restriction alleviation protein (NCBI) | compare |
| b0767 | ybhE | -1.1 | -2.5 | 6-phosphogluconolactonase (NCBI) | compare |
| b3462 | ftsX | -1.1 | -4.5 | predicted transporter subunit: membrane component of ABC superfamily (NCBI) | compare |
| b1573 | ydfC | -1.1 | -0.7 | Qin prophage; predicted protein (RefSeq) | compare |
| b4494 | arpB | -1.1 | -2.3 | no description | compare |
| b4593 | ymgI | -1.1 | -0.6 | hypothetical protein (RefSeq) | compare |
| b0357 | yaiN | -1.1 | -1.1 | putative alpha helix chain (VIMSS) | compare |
| b0530 | sfmA | -1.1 | -3.1 | putative fimbrial-like protein (VIMSS) | compare |
| b1575 | dicB | -1.0 | -0.9 | Qin prophage; cell division inhibition protein (NCBI) | compare |
| b1804 | rnd | -1.0 | -3.2 | ribonuclease D (NCBI) | compare |
| b1048 | mdoG | -1.0 | -3.4 | glucan biosynthesis protein, periplasmic (NCBI) | compare |
| b2340 | sixA | -1.0 | -2.0 | phosphohistidine phosphatase (NCBI) | compare |
| b3247 | cafA | -1.0 | -5.2 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b1658 | purR | -1.0 | -2.4 | DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) | compare |
| b3792 | wzxE | -1.0 | -3.9 | O-antigen translocase (NCBI) | compare |
| b0303 | ykgI | -1.0 | -0.6 | orf, hypothetical protein (VIMSS) | compare |
| b0078 | ilvH | -1.0 | -4.5 | acetolactate synthase small subunit (NCBI) | compare |
| b1669 | ydhT | -1.0 | -2.0 | hypothetical protein (NCBI) | compare |
| b3131 | agaR | -1.0 | -2.3 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2330 | yfcB | -1.0 | -1.2 | putative adenine-specific methylase (VIMSS) | compare |
| b0759 | galE | -1.0 | -3.3 | UDP-galactose-4-epimerase (VIMSS) | compare |
| b1049 | mdoH | -1.0 | -4.5 | glucosyltransferase MdoH (NCBI) | compare |
| b0407 | yajC | -0.9 | -1.3 | preprotein translocase subunit YajC (NCBI) | compare |
| b1129 | phoQ | -0.9 | -1.9 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b4553 | ysaB | -0.9 | -5.2 | hypothetical protein (NCBI) | compare |
| b3043 | ygiL | -0.9 | -2.8 | predicted fimbrial-like adhesin protein (NCBI) | compare |
| b2601 | aroF | -0.9 | -3.7 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b4655 | ythA | -0.9 | -0.8 | expressed protein (RefSeq) | compare |
| b1987 | cbl | -0.9 | -4.3 | DNA-binding transcriptional activator of cysteine biosynthesis (NCBI) | compare |
| b3779 | gpp | -0.9 | -5.4 | guanosine pentaphosphatase/exopolyphosphatase (NCBI) | compare |
| b0723 | sdhA | -0.9 | -3.9 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b0750 | nadA | -0.9 | -4.1 | quinolinate synthetase (NCBI) | compare |
| b1505 | ydeT | -0.9 | -1.6 | hypothetical protein (RefSeq) | compare |
| b2751 | cysN | -0.9 | -2.7 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0817 | mntR | -0.9 | -2.0 | DNA-binding transcriptional regulator of mntH (NCBI) | compare |
| b1604 | ydgH | -0.9 | -1.7 | hypothetical protein (NCBI) | compare |
| b1600 | mdtJ | -0.9 | -1.5 | multidrug efflux system transporter (NCBI) | compare |
| b1595 | ynfL | -0.9 | -1.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b0467 | priC | -0.9 | -2.8 | primosomal replication protein N'' (NCBI) | compare |