| | gene | name | fitness | t score | description | |
|---|
| b2020 | hisD | -6.1 | -7.3 | histidinol dehydrogenase (NCBI) | compare |
| b1260 | trpA | -5.9 | -4.8 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0907 | serC | -5.9 | -8.0 | phosphoserine aminotransferase (NCBI) | compare |
| b2022 | hisB | -5.8 | -6.9 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2023 | hisH | -5.8 | -5.6 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b3389 | aroB | -5.8 | -11.1 | 3-dehydroquinate synthase (NCBI) | compare |
| b2838 | lysA | -5.8 | -5.6 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0071 | leuD | -5.7 | -5.6 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0073 | leuB | -5.7 | -10.2 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b3281 | aroE | -5.7 | -14.7 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b3774 | ilvC | -5.7 | -11.5 | ketol-acid reductoisomerase (NCBI) | compare |
| b0072 | leuC | -5.6 | -10.1 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0523 | purE | -5.6 | -5.4 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0243 | proA | -5.6 | -6.6 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b0074 | leuA | -5.5 | -10.0 | 2-isopropylmalate synthase (NCBI) | compare |
| b2312 | purF | -5.5 | -6.5 | amidophosphoribosyltransferase (NCBI) | compare |
| b1261 | trpB | -5.4 | -3.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b3941 | metF | -5.4 | -11.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b2025 | hisF | -5.3 | -3.7 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2019 | hisG | -5.2 | -6.2 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0033 | carB | -5.2 | -15.9 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b4006 | purH | -5.1 | -12.0 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b4005 | purD | -5.1 | -8.5 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0945 | pyrD | -5.0 | -9.0 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2329 | aroC | -5.0 | -3.4 | chorismate synthase (NCBI) | compare |
| b3828 | metR | -4.9 | -9.5 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b1693 | aroD | -4.9 | -8.9 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b2913 | serA | -4.9 | -5.8 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b3771 | ilvD | -4.9 | -12.7 | dihydroxy-acid dehydratase (NCBI) | compare |
| b2021 | hisC | -4.9 | -3.4 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0004 | thrC | -4.8 | -7.4 | threonine synthase (NCBI) | compare |
| b3956 | ppc | -4.8 | -16.1 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b2762 | cysH | -4.7 | -7.2 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0242 | proB | -4.7 | -7.1 | gamma-glutamyl kinase (NCBI) | compare |
| b2557 | purL | -4.7 | -7.1 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b4388 | serB | -4.6 | -7.7 | 3-phosphoserine phosphatase (NCBI) | compare |
| b4245 | pyrB | -4.6 | -12.8 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b0386 | proC | -4.6 | -8.3 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b3770 | ilvE | -4.6 | -7.7 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b4214 | cysQ | -4.6 | -13.5 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2414 | cysK | -4.6 | -9.3 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b3829 | metE | -4.6 | -17.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b3957 | argE | -4.5 | -16.0 | acetylornithine deacetylase (NCBI) | compare |
| b0522 | purK | -4.5 | -6.8 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3172 | argG | -4.5 | -11.9 | argininosuccinate synthase (NCBI) | compare |
| b1062 | pyrC | -4.5 | -8.0 | dihydroorotase (NCBI) | compare |
| b3960 | argH | -4.5 | -10.4 | argininosuccinate lyase (NCBI) | compare |
| b0032 | carA | -4.4 | -7.4 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0003 | thrB | -4.2 | -8.4 | homoserine kinase (NCBI) | compare |
| b2024 | hisA | -4.2 | -2.8 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3008 | metC | -4.1 | -12.5 | cystathionine beta-lyase (NCBI) | compare |
| b0908 | aroA | -4.0 | -9.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2600 | tyrA | -4.0 | -7.3 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b0052 | pdxA | -4.0 | -12.5 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2818 | argA | -4.0 | -8.9 | N-acetylglutamate synthase (NCBI) | compare |
| b3772 | ilvA | -4.0 | -13.0 | threonine dehydratase (NCBI) | compare |
| b2026 | hisI | -4.0 | -8.4 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3642 | pyrE | -3.8 | -2.6 | orotate phosphoribosyltransferase (NCBI) | compare |
| b4013 | metA | -3.8 | -6.8 | homoserine O-succinyltransferase (NCBI) | compare |
| b2476 | purC | -3.8 | -3.0 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b0145 | dksA | -3.8 | -3.7 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0049 | apaH | -3.8 | -6.3 | diadenosinetetraphosphatase (NCBI) | compare |
| b3959 | argB | -3.7 | -11.2 | acetylglutamate kinase (RefSeq) | compare |
| b2320 | pdxB | -3.7 | -11.8 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b3958 | argC | -3.7 | -15.4 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b0002 | thrA | -3.7 | -16.6 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2564 | pdxJ | -3.7 | -6.1 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b2501 | ppk | -3.6 | -12.3 | polyphosphate kinase (NCBI) | compare |
| b2499 | purM | -3.6 | -6.0 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2750 | cysC | -3.6 | -7.2 | adenylylsulfate kinase (NCBI) | compare |
| b3107 | yhaL | -3.5 | -1.1 | orf, hypothetical protein (VIMSS) | compare |
| b1257 | yciE | -3.5 | -2.0 | hypothetical protein (NCBI) | compare |
| b1281 | pyrF | -3.4 | -2.4 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0630 | lipB | -3.4 | -2.4 | protein of lipoate biosynthesis (VIMSS) | compare |
| b0889 | lrp | -3.3 | -4.4 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b3390 | aroK | -3.2 | -3.8 | shikimate kinase I (NCBI) | compare |
| b2763 | cysI | -3.2 | -10.4 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0726 | sucA | -3.1 | -3.1 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b4603 | rseX | -3.1 | -1.0 | sRNA regulating ompA and ompC translation, with Hfq (RefSeq) | compare |
| b2764 | cysJ | -3.1 | -9.4 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3761 | trpT | -3.0 | -1.4 | tRNA-Trp (NCBI) | compare |
| b0720 | gltA | -3.0 | -5.7 | citrate synthase (NCBI) | compare |
| b2839 | lysR | -3.0 | -6.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0142 | folK | -3.0 | -1.0 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b1848 | yebG | -3.0 | -1.0 | conserved protein regulated by LexA (NCBI) | compare |
| b4407 | thiS | -2.9 | -2.1 | sulfur carrier protein ThiS (NCBI) | compare |
| b4025 | pgi | -2.9 | -9.7 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3939 | metB | -2.8 | -12.9 | cystathionine gamma-synthase (NCBI) | compare |
| b3916 | pfkA | -2.8 | -3.3 | 6-phosphofructokinase (NCBI) | compare |
| b3368 | cysG | -2.8 | -16.0 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b2479 | gcvR | -2.8 | -5.4 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0750 | nadA | -2.8 | -6.7 | quinolinate synthetase (NCBI) | compare |
| b0928 | aspC | -2.8 | -9.0 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0592 | fepB | -2.6 | -9.7 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2424 | cysU | -2.6 | -3.1 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1273 | yciN | -2.6 | -2.3 | hypothetical protein (NCBI) | compare |
| b0585 | fes | -2.6 | -7.1 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b3773 | ilvY | -2.5 | -9.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1263 | trpD | -2.5 | -2.4 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0683 | fur | -2.5 | -1.8 | ferric uptake regulator (NCBI) | compare |
| b0590 | fepD | -2.5 | -7.1 | iron-enterobactin transporter subunit (NCBI) | compare |
| b1192 | ldcA | -2.5 | -7.2 | L,D-carboxypeptidase A (NCBI) | compare |
| b1183 | umuD | -2.5 | -1.3 | DNA polymerase V, subunit D (NCBI) | compare |
| b1217 | chaB | -2.5 | -1.7 | cation transport regulator (NCBI) | compare |
| b1426 | ydcH | -2.4 | -1.4 | orf, hypothetical protein (VIMSS) | compare |
| b1850 | eda | -2.4 | -1.9 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b1262 | trpC | -2.4 | -3.4 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b4699 | fnrS | -2.3 | -0.7 | FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) | compare |
| b2500 | purN | -2.3 | -5.9 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b2318 | truA | -2.3 | -4.1 | tRNA pseudouridine synthase A (NCBI) | compare |
| b2830 | nudH | -2.2 | -2.6 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2450 | yffS | -2.2 | -1.9 | CPZ-55 prophage; predicted protein (RefSeq) | compare |
| b2620 | smpB | -2.2 | -2.2 | SsrA-binding protein (NCBI) | compare |
| b2599 | pheA | -2.2 | -3.9 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b1151 | ymfO | -2.1 | -3.4 | e14 prophage; conserved protein (RefSeq) | compare |
| b4279 | yjhB | -2.1 | -4.0 | putative transport protein (VIMSS) | compare |
| b0589 | fepG | -2.1 | -6.6 | iron-enterobactin transporter subunit (NCBI) | compare |
| b4177 | purA | -2.1 | -2.0 | adenylosuccinate synthetase (NCBI) | compare |
| b0114 | aceE | -2.1 | -2.8 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b4246 | pyrL | -2.1 | -1.8 | pyrBI operon leader peptide (NCBI) | compare |
| b2058 | wcaB | -2.1 | -0.6 | predicted acyl transferase (NCBI) | compare |
| b0623 | cspE | -2.0 | -1.6 | cold shock protein E (NCBI) | compare |
| b0437 | clpP | -2.0 | -8.1 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b1685 | ydiH | -2.0 | -0.6 | predicted protein (RefSeq) | compare |
| b0888 | trxB | -2.0 | -4.2 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b3811 | xerC | -2.0 | -3.8 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b0588 | fepC | -2.0 | -8.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2313 | cvpA | -2.0 | -4.8 | membrane protein required for colicin V production (NCBI) | compare |
| b0990 | cspG | -1.9 | -1.8 | DNA-binding transcriptional regulator (NCBI) | compare |
| b3204 | ptsN | -1.9 | -5.6 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b1290 | sapF | -1.9 | -2.8 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0439 | lon | -1.9 | -6.0 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b0109 | nadC | -1.9 | -6.6 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b4533 | ynfO | -1.8 | -1.6 | Qin prophage; predicted protein (NCBI) | compare |
| b3429 | glgA | -1.8 | -10.0 | glycogen synthase (NCBI) | compare |
| b1839 | yebY | -1.8 | -2.6 | hypothetical protein (NCBI) | compare |
| b2752 | cysD | -1.8 | -4.2 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3935 | priA | -1.8 | -1.7 | primosome assembly protein PriA (NCBI) | compare |
| b3442 | yhhZ | -1.8 | -2.7 | hypothetical protein (NCBI) | compare |
| b0200 | gmhB | -1.7 | -2.3 | hypothetical protein (NCBI) | compare |
| b3870 | glnA | -1.7 | -2.4 | glutamine synthetase (NCBI) | compare |
| b3992 | thiF | -1.7 | -6.6 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3462 | ftsX | -1.7 | -5.5 | predicted transporter subunit: membrane component of ABC superfamily (NCBI) | compare |
| b0624 | crcB | -1.7 | -2.7 | camphor resistance protein CrcB (NCBI) | compare |
| b2751 | cysN | -1.7 | -5.6 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0118 | acnB | -1.7 | -3.9 | aconitate hydratase (NCBI) | compare |
| b3650 | spoT | -1.7 | -4.9 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b4515 | ybgT | -1.6 | -1.0 | hypothetical protein (NCBI) | compare |
| b2659 | b2659 | -1.6 | -1.5 | orf, hypothetical protein (VIMSS) | compare |
| b3463 | ftsE | -1.6 | -4.7 | predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) | compare |
| b2962 | yggX | -1.6 | -2.3 | hypothetical protein (NCBI) | compare |
| b1486 | ddpB | -1.6 | -2.4 | D-ala-D-ala transporter subunit (NCBI) | compare |
| b3994 | thiC | -1.5 | -9.8 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b3068 | ygjF | -1.5 | -1.7 | G/U mismatch-specific DNA glycosylase (NCBI) | compare |
| b3386 | rpe | -1.5 | -1.0 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b0113 | pdhR | -1.5 | -4.8 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b1847 | yebF | -1.5 | -1.9 | predicted protein (RefSeq) | compare |
| b2456 | cchB | -1.5 | -2.2 | predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) | compare |
| b2188 | yejM | -1.5 | -6.6 | predicted hydrolase, inner membrane (NCBI) | compare |
| b0767 | ybhE | -1.5 | -3.5 | 6-phosphogluconolactonase (NCBI) | compare |
| b3121 | yhaC | -1.5 | -2.3 | hypothetical protein (NCBI) | compare |
| b3082 | ygjM | -1.4 | -2.1 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3236 | mdh | -1.4 | -5.6 | malate dehydrogenase (NCBI) | compare |
| b3993 | thiE | -1.4 | -5.5 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3572 | avtA | -1.4 | -7.5 | valine--pyruvate transaminase (NCBI) | compare |
| b0740 | tolB | -1.4 | -5.8 | translocation protein TolB precursor (NCBI) | compare |
| b1936 | intG | -1.4 | -1.3 | predicted defective phage integrase (pseudogene) (RefSeq) | compare |
| b2911 | ssrS | -1.4 | -0.6 | 6S regulatory RNA (NCBI) | compare |
| b3483 | yhhH | -1.4 | -1.6 | orf, hypothetical protein (VIMSS) | compare |
| b1264 | trpE | -1.3 | -3.5 | anthranilate synthase component I (NCBI) | compare |
| b3991 | thiG | -1.3 | -5.6 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b1861 | ruvA | -1.3 | -2.2 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3990 | thiH | -1.3 | -4.9 | thiamine biosynthesis protein ThiH (NCBI) | compare |
| b1013 | ycdC | -1.3 | -1.6 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b1545 | pinQ | -1.3 | -1.4 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b3290 | trkA | -1.3 | -3.3 | potassium transporter peripheral membrane component (NCBI) | compare |
| b2894 | xerD | -1.2 | -1.2 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3725 | pstB | -1.2 | -2.9 | phosphate transporter subunit (NCBI) | compare |
| b0603 | ybdO | -1.2 | -2.6 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3781 | trxA | -1.2 | -3.0 | thioredoxin 1 (VIMSS) | compare |
| b2601 | aroF | -1.2 | -3.9 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible (NCBI) | compare |
| b4441 | glmY | -1.2 | -1.1 | sRNA activator of glmS mRNA (RefSeq) | compare |
| b3052 | rfaE | -1.2 | -5.2 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b4066 | yjcF | -1.2 | -2.3 | hypothetical protein (NCBI) | compare |
| b3769 | ilvM | -1.2 | -2.9 | acetolactate synthase II, small subunit (NCBI) | compare |
| b1523 | yneG | -1.2 | -1.5 | hypothetical protein (NCBI) | compare |
| b2574 | nadB | -1.2 | -5.9 | L-aspartate oxidase (NCBI) | compare |
| b2103 | thiD | -1.2 | -4.1 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b4411 | ecnB | -1.1 | -2.0 | entericidin B membrane lipoprotein (NCBI) | compare |
| b1432 | insQ | -1.1 | -4.2 | IS609 transposase B (RefSeq) | compare |
| b3619 | rfaD | -1.1 | -4.1 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b1708 | nlpC | -1.1 | -2.4 | predicted lipoprotein (NCBI) | compare |
| b0741 | pal | -1.1 | -3.4 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b1503 | ydeR | -1.1 | -4.2 | predicted fimbrial-like adhesin protein (NCBI) | compare |
| b1271 | yciK | -1.1 | -2.4 | short chain dehydrogenase (NCBI) | compare |
| b1148 | ymfM | -1.1 | -2.1 | e14 prophage; predicted protein (NCBI) | compare |
| b1857 | yebL | -1.1 | -3.7 | putative adhesin (VIMSS) | compare |
| b0222 | lpcA | -1.1 | -1.9 | phosphoheptose isomerase (NCBI) | compare |
| b1346 | ydaQ | -1.1 | -2.4 | orf, hypothetical protein (VIMSS) | compare |
| b1164 | ycgZ | -1.1 | -1.9 | hypothetical protein (NCBI) | compare |