| Pathway | #Steps | #Present | #Specific |
|---|
| 2-oxoisovalerate decarboxylation to isobutanoyl-CoA | 3 | 3 | 3 |
| L-serine degradation | 3 | 3 | 3 |
| glycine biosynthesis I | 1 | 1 | 1 |
| acetate conversion to acetyl-CoA | 1 | 1 | 1 |
| long-chain fatty acid activation | 1 | 1 | 1 |
| acetate and ATP formation from acetyl-CoA III | 1 | 1 | 1 |
| L-glutamine biosynthesis I | 1 | 1 | 1 |
| glycine betaine degradation III | 7 | 7 | 6 |
| L-cysteine degradation II | 3 | 3 | 2 |
| glycine degradation | 3 | 3 | 2 |
| D-serine degradation | 3 | 2 | 2 |
| L-tryptophan degradation II (via pyruvate) | 3 | 2 | 2 |
| β-alanine degradation II | 2 | 2 | 1 |
| ammonia assimilation cycle I | 2 | 2 | 1 |
| CO2 fixation into oxaloacetate (anaplerotic) | 2 | 2 | 1 |
| 4-aminobenzoate biosynthesis I | 2 | 2 | 1 |
| ammonia assimilation cycle II | 2 | 2 | 1 |
| L-alanine degradation I | 2 | 2 | 1 |
| glycine betaine degradation I | 8 | 6 | 4 |
| γ-linolenate biosynthesis II (animals) | 2 | 1 | 1 |
| 4-aminobenzoate biosynthesis II | 2 | 1 | 1 |
| β-alanine degradation I | 2 | 1 | 1 |
| linoleate biosynthesis II (animals) | 2 | 1 | 1 |
| felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis | 5 | 2 | 2 |
| superpathway of ammonia assimilation (plants) | 3 | 3 | 1 |
| glycine biosynthesis II | 3 | 3 | 1 |
| dTMP de novo biosynthesis (mitochondrial) | 3 | 3 | 1 |
| ethanol degradation IV | 3 | 3 | 1 |
| ethanol degradation II | 3 | 3 | 1 |
| ammonia assimilation cycle III | 3 | 3 | 1 |
| glycine cleavage | 3 | 3 | 1 |
| pyruvate decarboxylation to acetyl CoA I | 3 | 3 | 1 |
| 2-oxoglutarate decarboxylation to succinyl-CoA | 3 | 3 | 1 |
| superpathway of acetate utilization and formation | 3 | 3 | 1 |
| L-methionine biosynthesis II | 6 | 5 | 2 |
| L-isoleucine biosynthesis V | 3 | 2 | 1 |
| L-aspartate degradation II (aerobic) | 3 | 2 | 1 |
| L-aspartate degradation III (anaerobic) | 3 | 2 | 1 |
| ethanol degradation III | 3 | 2 | 1 |
| 3-methyl-branched fatty acid α-oxidation | 6 | 3 | 2 |
| oleate biosynthesis I (plants) | 3 | 1 | 1 |
| N-acetylneuraminate and N-acetylmannosamine degradation II | 3 | 1 | 1 |
| alkane biosynthesis II | 3 | 1 | 1 |
| partial TCA cycle (obligate autotrophs) | 8 | 8 | 2 |
| superpathway of L-serine and glycine biosynthesis I | 4 | 4 | 1 |
| nitrogen remobilization from senescing leaves | 8 | 6 | 2 |
| phytol degradation | 4 | 3 | 1 |
| L-mimosine degradation | 8 | 4 | 2 |
| sulfoquinovose degradation III | 4 | 2 | 1 |
| chitin deacetylation | 4 | 2 | 1 |
| glutathione-mediated detoxification I | 8 | 3 | 2 |
| glycine betaine degradation II (mammalian) | 4 | 1 | 1 |
| wax esters biosynthesis II | 4 | 1 | 1 |
| long chain fatty acid ester synthesis (engineered) | 4 | 1 | 1 |
| phosphatidylcholine acyl editing | 4 | 1 | 1 |
| sporopollenin precursors biosynthesis | 18 | 4 | 4 |
| 2-methylcitrate cycle I | 5 | 5 | 1 |
| octane oxidation | 5 | 4 | 1 |
| folate polyglutamylation | 5 | 4 | 1 |
| cytosolic NADPH production (yeast) | 5 | 4 | 1 |
| propanoyl-CoA degradation II | 5 | 3 | 1 |
| acrylate degradation I | 5 | 3 | 1 |
| sphingosine and sphingosine-1-phosphate metabolism | 10 | 4 | 2 |
| sulfoquinovose degradation VI | 5 | 2 | 1 |
| sulfoquinovose degradation I | 5 | 1 | 1 |
| fatty acid salvage | 6 | 6 | 1 |
| β-alanine biosynthesis II | 6 | 5 | 1 |
| 2-methylcitrate cycle II | 6 | 5 | 1 |
| stearate biosynthesis II (bacteria and plants) | 6 | 5 | 1 |
| purine nucleobases degradation II (anaerobic) | 24 | 16 | 4 |
| L-isoleucine biosynthesis IV | 6 | 4 | 1 |
| stearate biosynthesis IV | 6 | 4 | 1 |
| pyruvate fermentation to butanol II (engineered) | 6 | 4 | 1 |
| 6-gingerol analog biosynthesis (engineered) | 6 | 3 | 1 |
| superpathway of bitter acids biosynthesis | 18 | 3 | 3 |
| colupulone and cohumulone biosynthesis | 6 | 1 | 1 |
| stearate biosynthesis I (animals) | 6 | 1 | 1 |
| lupulone and humulone biosynthesis | 6 | 1 | 1 |
| adlupulone and adhumulone biosynthesis | 6 | 1 | 1 |
| formaldehyde assimilation I (serine pathway) | 13 | 7 | 2 |
| pyridoxal 5'-phosphate biosynthesis I | 7 | 7 | 1 |
| L-glutamate and L-glutamine biosynthesis | 7 | 6 | 1 |
| C4 photosynthetic carbon assimilation cycle, NADP-ME type | 7 | 4 | 1 |
| capsaicin biosynthesis | 7 | 3 | 1 |
| ceramide degradation by α-oxidation | 7 | 2 | 1 |
| arachidonate biosynthesis III (6-desaturase, mammals) | 7 | 1 | 1 |
| icosapentaenoate biosynthesis III (8-desaturase, mammals) | 7 | 1 | 1 |
| sulfoquinovose degradation V | 7 | 1 | 1 |
| myo-inositol degradation I | 7 | 1 | 1 |
| 2,4-dinitrotoluene degradation | 7 | 1 | 1 |
| icosapentaenoate biosynthesis II (6-desaturase, mammals) | 7 | 1 | 1 |
| superpathway of L-lysine, L-threonine and L-methionine biosynthesis II | 15 | 13 | 2 |
| superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) | 8 | 7 | 1 |
| mixed acid fermentation | 16 | 12 | 2 |
| L-valine degradation I | 8 | 6 | 1 |
| 2-deoxy-D-ribose degradation II | 8 | 4 | 1 |
| ceramide and sphingolipid recycling and degradation (yeast) | 16 | 4 | 2 |
| L-lysine degradation V | 9 | 9 | 1 |
| folate transformations III (E. coli) | 9 | 9 | 1 |
| TCA cycle V (2-oxoglutarate synthase) | 9 | 8 | 1 |
| TCA cycle IV (2-oxoglutarate decarboxylase) | 9 | 8 | 1 |
| Entner-Doudoroff pathway I | 9 | 8 | 1 |
| TCA cycle VII (acetate-producers) | 9 | 8 | 1 |
| TCA cycle VI (Helicobacter) | 9 | 7 | 1 |
| sucrose biosynthesis I (from photosynthesis) | 9 | 7 | 1 |
| photorespiration III | 9 | 6 | 1 |
| photorespiration I | 9 | 6 | 1 |
| reductive glycine pathway of autotrophic CO2 fixation | 9 | 5 | 1 |
| cis-geranyl-CoA degradation | 9 | 2 | 1 |
| L-arginine biosynthesis II (acetyl cycle) | 10 | 10 | 1 |
| TCA cycle I (prokaryotic) | 10 | 9 | 1 |
| superpathway of coenzyme A biosynthesis II (plants) | 10 | 9 | 1 |
| glycolysis IV | 10 | 8 | 1 |
| superpathway of tetrahydrofolate biosynthesis | 10 | 8 | 1 |
| photorespiration II | 10 | 7 | 1 |
| suberin monomers biosynthesis | 20 | 4 | 2 |
| myo-, chiro- and scyllo-inositol degradation | 10 | 1 | 1 |
| superpathway of fatty acid biosynthesis II (plant) | 43 | 38 | 4 |
| folate transformations II (plants) | 11 | 10 | 1 |
| superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle | 22 | 18 | 2 |
| glycolysis II (from fructose 6-phosphate) | 11 | 9 | 1 |
| glycolysis III (from glucose) | 11 | 9 | 1 |
| pyruvate fermentation to hexanol (engineered) | 11 | 8 | 1 |
| C4 photosynthetic carbon assimilation cycle, NAD-ME type | 11 | 7 | 1 |
| glycolysis VI (from fructose) | 11 | 7 | 1 |
| reductive TCA cycle I | 11 | 7 | 1 |
| superpathway of candicidin biosynthesis | 11 | 4 | 1 |
| superpathway of glyoxylate bypass and TCA | 12 | 11 | 1 |
| superpathway of pyridoxal 5'-phosphate biosynthesis and salvage | 12 | 11 | 1 |
| formaldehyde assimilation III (dihydroxyacetone cycle) | 12 | 10 | 1 |
| superpathway of tetrahydrofolate biosynthesis and salvage | 12 | 10 | 1 |
| gluconeogenesis III | 12 | 9 | 1 |
| homolactic fermentation | 12 | 9 | 1 |
| ethene biosynthesis V (engineered) | 25 | 18 | 2 |
| superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass | 26 | 22 | 2 |
| gluconeogenesis I | 13 | 11 | 1 |
| glycolysis I (from glucose 6-phosphate) | 13 | 10 | 1 |
| folate transformations I | 13 | 9 | 1 |
| C4 photosynthetic carbon assimilation cycle, PEPCK type | 14 | 8 | 1 |
| Bifidobacterium shunt | 15 | 12 | 1 |
| palmitate biosynthesis II (type II fatty acid synthase) | 31 | 29 | 2 |
| glycerol degradation to butanol | 16 | 9 | 1 |
| cutin biosynthesis | 16 | 1 | 1 |
| superpathway of glucose and xylose degradation | 17 | 14 | 1 |
| superpathway of glycolysis and the Entner-Doudoroff pathway | 17 | 14 | 1 |
| superpathway of hexitol degradation (bacteria) | 18 | 13 | 1 |
| heterolactic fermentation | 18 | 12 | 1 |
| gluconeogenesis II (Methanobacterium thermoautotrophicum) | 18 | 9 | 1 |
| hexitol fermentation to lactate, formate, ethanol and acetate | 19 | 14 | 1 |
| superpathway of anaerobic sucrose degradation | 19 | 13 | 1 |
| methylaspartate cycle | 19 | 10 | 1 |
| superpathway of N-acetylneuraminate degradation | 22 | 12 | 1 |
| superpathway of fatty acids biosynthesis (E. coli) | 53 | 51 | 2 |
| 1-butanol autotrophic biosynthesis (engineered) | 27 | 19 | 1 |
| palmitate biosynthesis III | 29 | 28 | 1 |
| oleate β-oxidation | 35 | 30 | 1 |
| superpathway of L-lysine degradation | 43 | 23 | 1 |
| Methanobacterium thermoautotrophicum biosynthetic metabolism | 56 | 21 | 1 |
| superpathway of chorismate metabolism | 59 | 42 | 1 |