Experiment set38IT027 for Pseudomonas putida KT2440

Compare to:

R2A with Polymyxin B sulfate 0.001 mg/ml

200 most detrimental genes:

  gene name fitness t score description  
PP_0903 +4.2 7.5 conserved protein of unknown function compare
PP_4058 +4.1 28.8 1,4-alpha-glucan branching enzyme compare
PP_0904 +2.4 13.8 InaA protein compare
PP_2862 +2.1 13.2 Undecaprenyl-diphosphatase compare
PP_4199 +1.8 3.3 putative Lipoprotein compare
PP_0025 +1.8 3.7 hypothetical protein compare
PP_4811 +1.7 4.3 Gamma-glutamyl phosphate reductase compare
PP_3902 +1.6 1.9 conserved protein of unknown function compare
PP_0346 +1.6 9.3 putative Heptose kinase WapQ compare
PP_2136 +1.6 6.1 enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase compare
PP_1655 +1.5 2.0 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD compare
PP_2345 +1.2 5.9 conserved exported protein of unknown function compare
PP_4738 +1.2 2.3 conserved exported protein of unknown function compare
PP_0900 +1.2 2.5 PAP2 family protein compare
PP_0959 +1.2 4.5 phospholipid ABC transporter compare
PP_1110 +1.1 2.3 serine acetyltransferase compare
PP_1770 +1.1 1.7 3-phosphoshikimate 1-carboxyvinyltransferase compare
PP_1111 +1.1 4.5 putative Synthetase compare
PP_4549 +1.1 7.5 long-chain-fatty-acid/CoA ligase compare
PP_4296 +1.1 2.5 conserved exported protein of unknown function compare
PP_3190 +1.1 2.2 Ornithine cyclodeaminase/mu-crystallin family protein compare
PP_3035 +1.1 2.6 conserved protein of unknown function compare
PP_2970 +1.1 2.1 conserved exported protein of unknown function compare
PP_2999 +1.1 2.3 Glyoxalase family protein compare
PP_4820 +1.1 3.6 tRNA-dihydrouridine synthase B compare
PP_5508 +1.0 1.6 conserved protein of unknown function compare
PP_5712 +1.0 3.6 conserved protein of unknown function compare
PP_1109 +1.0 5.6 Transcriptional regulator, GntR family compare
PP_4988 +1.0 5.5 signal transduction histidine kinase CheA/CheY-like receiver compare
PP_4993 +1.0 4.3 Glutathione synthetase compare
PP_2848 +0.9 4.1 urease accessory protein compare
PP_1099 +0.9 2.3 Cold shock protein CapB compare
PP_3935 +0.9 3.3 conserved protein of unknown function compare
PP_2429 +0.9 2.0 putative Membrane protein compare
PP_2575 +0.9 2.5 conserved exported protein of unknown function compare
PP_3043 +0.9 2.1 conserved protein of unknown function compare
PP_4726 +0.9 2.4 Chaperone protein DnaJ compare
PP_4910 +0.9 1.7 conserved protein of unknown function compare
PP_t13 +0.9 1.3 tRNA-Lys compare
PP_2903 +0.8 2.9 peptidyl-prolyl cis-trans isomerase B (rotamase B) compare
PP_1738 +0.8 5.0 conserved exported protein of unknown function compare
PP_0781 +0.8 2.0 conserved protein of unknown function compare
PP_5471 +0.8 1.4 putative response regulator receiver protein compare
PP_2433 +0.8 1.9 conserved protein of unknown function compare
PP_5661 +0.8 3.6 putative lipoprotein compare
PP_4122 +0.8 1.8 proton-pumping NADH:ubiquinone oxidoreductase, respiratory complex I, subunit E compare
PP_3346 +0.8 1.9 Nickel transporter ATP-binding protein compare
PP_3971 +0.8 1.6 conserved protein of unknown function compare
PP_4180 +0.8 2.7 conserved protein of unknown function compare
PP_2247 +0.7 2.1 putative Endoribonuclease compare
PP_1048 +0.7 2.2 putative protein secretion protein for export compare
PP_2513 +0.7 2.4 4-oxalomesaconate tautomerase compare
PP_0634 +0.7 1.9 Fimbrial protein compare
PP_1575 +0.7 1.9 conserved protein of unknown function compare
PP_0262 +0.7 2.0 conserved protein of unknown function compare
PP_4444 +0.7 1.8 transposase compare
PP_1737 +0.7 5.0 conserved protein of unknown function compare
PP_2148 +0.7 5.3 transcription-repair coupling factor compare
PP_5583 +0.7 1.6 conserved protein of unknown function compare
PP_3233 +0.7 2.4 transcriptional regulator with 4Fe-4S cluster, Crp/Fnr family compare
PP_2018 +0.7 3.2 adhesin-associated BNR repeat protein (from data) compare
PP_3020 +0.7 2.1 putative Serine/threonine protein phosphatase compare
PP_5177 +0.7 3.1 spermidine/putrescine ABC transporter - permease subunit compare
PP_4870 +0.7 1.9 Azurin compare
PP_1759 +0.7 3.6 conserved exported protein of unknown function compare
PP_4944 +0.7 1.3 Carbamoyltransferase compare
PP_2701 +0.7 3.1 Transcriptional regulator, LysR family compare
PP_4073 +0.7 1.1 conserved exported protein of unknown function compare
PP_0762 +0.7 2.9 Glycerate dehydrogenase compare
PP_0197 +0.7 4.1 conserved protein of unknown function compare
PP_4520 +0.7 2.0 conserved protein of unknown function compare
PP_4470 +0.7 3.0 putative transcriptional regulator (Arc domain-containing) compare
PP_2795 +0.7 2.4 AMP-binding domain protein compare
PP_3307 +0.7 1.5 conserved protein of unknown function compare
PP_3434 +0.7 1.6 conserved protein of unknown function compare
PP_0803 +0.6 4.6 Protein secretion ABC efflux system, membrane fusion protein compare
PP_4620 +0.6 4.2 Fumarylacetoacetase compare
PP_0152 +0.6 1.1 conserved exported protein of unknown function compare
PP_2745 +0.6 1.2 Universal stress protein family compare
PP_3102 +0.6 1.2 conserved protein of unknown function compare
PP_1062 +0.6 2.5 MutT/nudix family protein compare
PP_3671 +0.6 2.2 Oxidoreductase, aldo/keto reductase family compare
PP_1026 +0.6 1.5 Peptidase, M23/M37 family compare
PP_4143 +0.6 3.0 conserved protein of unknown function compare
PP_2950 +0.6 1.8 conserved protein of unknown function compare
PP_3475 +0.6 1.9 putative type II secretory pathway, pseudopilin pulG-related signal peptide protein compare
PP_5365 +0.6 4.4 putative fatty acid methyltransferase compare
PP_5028 +0.6 2.8 proline iminopeptidase compare
PP_1876 +0.6 0.9 putative ATP/GTP-binding protein of the AAA+ family compare
PP_2416 +0.6 1.1 putative Iron ABC transporter, ATP-binding protein compare
PP_0425 +0.6 1.7 conserved protein of unknown function compare
PP_1560 +0.6 1.1 conserved protein of unknown function compare
PP_1683 +0.6 1.5 Transcriptional regulator, MarR family compare
PP_3906 +0.6 1.4 conserved protein of unknown function compare
PP_4166 +0.6 2.7 conserved protein of unknown function compare
PP_3400 +0.6 2.0 alpha-ketoglutarate- and Fe(II)-dependent dioxygenase compare
PP_5522 +0.6 1.6 protein of unknown function compare
PP_3551 +0.6 1.1 DNA-binding response regulator, LuxR family compare
PP_1395 +0.6 2.8 Transcriptional regulator, AraC family compare
PP_2740 +0.6 1.5 Transcriptional regulator, MerR family compare
PP_1324 +0.6 1.7 putative endonuclease distantly related to archaeal Holliday junction resolvase compare
PP_1836 +0.6 1.4 putative metal transporter, ZIP family compare
PP_0806 +0.6 5.2 putative Surface adhesion protein compare
PP_5674 +0.6 1.5 conserved protein of unknown function compare
PP_2127 +0.6 1.0 Sensor histidine kinase compare
PP_2695 +0.6 2.5 Transcriptional regulator, LysR family compare
PP_5054 +0.6 1.8 glutaredoxin 3 compare
PP_4778 +0.6 2.5 23S rRNA pseudouridine 2457 synthase compare
PP_0804 +0.5 3.1 Protein secretion ABC efflux system, permease and ATP-binding protein compare
PP_5669 +0.5 2.2 ABC transporter related compare
PP_2773 +0.5 1.2 conserved protein of unknown function compare
PP_1255 +0.5 1.6 putative cis-4-hydroxy-D-proline oxidase compare
PP_4891 +0.5 2.4 integral membrane ATP-dependent zinc metallopeptidase / HflK-HflC complex compare
PP_5423 +0.5 1.4 conserved membrane protein of unknown function compare
PP_4787 +0.5 1.2 putative protein with nucleoside triphosphate hydrolase domain compare
PP_5448 +0.5 1.4 conserved protein of unknown function compare
PP_4874 +0.5 0.8 50S ribosomal protein L9 compare
PP_0574 +0.5 3.7 DNA-binding response regulator, LuxR family compare
PP_3892 +0.5 0.9 conserved protein of unknown function compare
PP_1729 +0.5 1.2 conserved protein of unknown function compare
PP_5181 +0.5 3.9 spermidine/putrescine ABC transporter - periplasmic subunit compare
PP_3110 +0.5 1.5 protein of unknown function compare
PP_4238 +0.5 0.7 conserved protein of unknown function compare
PP_0352 +0.5 2.1 RNA polymerase sigma-70 factor, ECF subfamily compare
PP_2726 +0.5 1.7 conserved membrane protein of unknown function compare
PP_2078 +0.5 1.2 transcriptional activator protein LysR compare
PP_2497 +0.5 1.5 conserved protein of unknown function compare
PP_2171 +0.5 1.0 Transporter, LysE family compare
PP_4684 +0.5 2.8 conserved protein of unknown function with kinase-like domain compare
PP_2677 +0.5 1.6 conserved exported protein of unknown function compare
PP_0254 +0.5 1.4 conserved protein of unknown function compare
PP_0948 +0.5 0.9 Phosphocarrier protein HPr compare
PP_4247 +0.5 1.0 Exonuclease compare
PP_1675 +0.5 2.6 Subunit of adenosylcobinamide-phosphate synthase beta component compare
PP_2642 +0.5 2.2 Transcriptional regulator, GntR family compare
PP_3511 +0.5 2.7 Branched-chain-amino-acid aminotransferase compare
PP_3819 +0.5 3.1 glutathione reductase (NADPH) compare
PP_0547 +0.5 1.6 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase compare
PP_2520 +0.5 2.1 conserved protein of unknown function compare
PP_4223 +0.5 1.0 diaminobutyrate-2-oxoglutarate transaminase compare
PP_0674 +0.5 3.1 ADP/ATP ratio sensor and inhibitor of translation compare
PP_2796 +0.5 1.5 conserved protein of unknown function compare
PP_2070 +0.5 1.3 Transcriptional regulator, AraC family compare
PP_5654 +0.5 1.0 putative phosphotriesterase compare
PP_0805 +0.5 3.4 Outer membrane efflux protein compare
PP_3883 +0.5 1.9 putative Phage holin compare
PP_4680 +0.5 3.2 acetohydroxybutanoate synthase / acetolactate synthase compare
PP_5156 +0.5 1.0 conserved exported protein of unknown function compare
PP_4769 +0.5 1.7 conserved protein of unknown function compare
PP_2160 +0.5 1.6 NADPH-dependent 7-cyano-7-deazaguanine reductase compare
PP_0257 +0.5 1.6 protein sulfur transferase compare
PP_4647 +0.5 1.9 transcriptional regulator, LuxR family compare
PP_0775 +0.5 1.2 conserved protein of unknown function compare
PP_2186 +0.5 1.2 putative Formate dehydrogenase, delta subunit compare
PP_4538 +0.5 2.0 FMN-dependent NADH-azoreductase 2 compare
PP_5702 +0.5 2.0 conserved protein of unknown function compare
PP_5537 +0.5 1.5 conserved membrane protein of unknown function compare
PP_4995 +0.5 2.2 putative protein possibly involved in the control of exopolysaccharide production compare
PP_5469 +0.5 1.7 putative SAM-dependent methyltransferase compare
PP_0332 +0.5 1.5 putative Acyltransferase compare
PP_4642 +0.5 0.8 Cyclic diguanosine monophosphate-binding protein compare
PP_4233 +0.5 1.8 putative Oxidoreductase, small subunit compare
PP_1826 +0.5 1.0 Hydrolase, isochorismatase family compare
PP_1518 +0.5 2.2 conserved exported protein of unknown function compare
PP_3900 +0.5 2.1 hypothetical protein compare
PP_0891 +0.5 1.5 conserved exported protein of unknown function compare
PP_5092 +0.5 2.4 putative exported NLP/P60 protein compare
PP_4212 +0.5 1.1 pyoverdine biosynthesis related protein compare
PP_2019 +0.5 3.4 adhesin-associated MmpL efflux pump (from data) compare
PP_3118 +0.5 1.2 DNA linked enzyme involved in DNA repair compare
PP_4108 +0.5 1.6 2-aminoadipate transaminase (EC 2.6.1.39) (from data) compare
PP_2757 +0.5 1.8 putative Sugar-binding protein compare
PP_5201 +0.5 1.2 conserved protein of unknown function, UPF0149 family compare
PP_2756 +0.5 1.0 conserved protein of unknown function compare
PP_0502 +0.5 1.3 conserved protein of unknown function compare
PP_4561 +0.5 0.7 stress response protein compare
PP_5047 +0.5 1.8 two-component system sensory histidine kinase/phosphatase GlnL/GlnG compare
PP_3685 +0.5 1.5 conserved protein of unknown function compare
PP_0062 +0.5 2.1 3-methyl-adenine DNA glycosylase I compare
PP_0244 +0.5 2.4 conserved protein of unknown function compare
PP_2678 +0.5 1.8 putative Hydrolase compare
PP_5376 +0.5 3.4 conserved exported protein of unknown function compare
PP_3075 +0.5 1.5 putative transcriptional regulator compare
PP_3438 +0.5 1.4 conserved membrane protein of unknown function compare
PP_4101 +0.5 2.0 Acetyltransferase, GNAT family compare
PP_3509 +0.5 0.8 Glyoxalase family protein compare
PP_2474 +0.5 0.9 Glutathione S-transferase family protein compare
PP_2439 +0.5 1.7 peroxiredoxin, alkylhydroperoxide reductase - small subunit compare
PP_1364 +0.5 2.8 conserved exported protein of unknown function compare
PP_2965 +0.5 1.7 putative tnpA repressor TnpC compare
PP_2836 +0.5 1.1 putative 2-keto-3-deoxyxylonate dehydratase compare
PP_3763 +0.4 2.1 putative CobF protein compare
PP_2579 +0.4 3.1 putative phosphoethanolamine transferase CptA compare
PP_5358 +0.4 2.5 conserved protein of unknown function compare
PP_0820 +0.4 2.2 GCN5-related N-acetyltransferase compare
PP_2055 +0.4 1.2 putative isomerase compare
PP_4837 +0.4 1.5 conserved protein of unknown function compare
PP_3181 +0.4 1.8 Site-specific recombinase, phage integrase family compare
PP_2935 +0.4 1.4 conserved membrane protein of unknown function compare
PP_3512 +0.4 1.9 conserved membrane protein of unknown function compare


Specific Phenotypes

For 3 genes in this experiment

For stress Polymyxin B sulfate in Pseudomonas putida KT2440

For stress Polymyxin B sulfate across organisms