| | gene | name | fitness | t score | description | |
|---|
| b1261 | trpB | -7.2 | -5.0 | tryptophan synthase subunit beta (NCBI) | compare |
| b2838 | lysA | -6.7 | -7.9 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b1281 | pyrF | -6.2 | -4.3 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0072 | leuC | -5.7 | -14.8 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2951 | yggS | -5.7 | -6.8 | predicted enzyme (NCBI) | compare |
| b1693 | aroD | -5.6 | -5.4 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0907 | serC | -5.5 | -10.0 | phosphoserine aminotransferase (NCBI) | compare |
| b2020 | hisD | -5.5 | -10.6 | histidinol dehydrogenase (NCBI) | compare |
| b4006 | purH | -5.5 | -12.8 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b4388 | serB | -5.5 | -9.1 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2329 | aroC | -5.5 | -3.8 | chorismate synthase (NCBI) | compare |
| b4005 | purD | -5.3 | -10.2 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0074 | leuA | -5.2 | -14.3 | 2-isopropylmalate synthase (NCBI) | compare |
| b3941 | metF | -5.1 | -13.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0523 | purE | -5.1 | -4.9 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b3389 | aroB | -5.0 | -13.8 | 3-dehydroquinate synthase (NCBI) | compare |
| b0908 | aroA | -5.0 | -8.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b3281 | aroE | -5.0 | -19.5 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0243 | proA | -4.8 | -12.1 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2913 | serA | -4.8 | -11.1 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b2312 | purF | -4.8 | -8.0 | amidophosphoribosyltransferase (NCBI) | compare |
| b2021 | hisC | -4.8 | -7.3 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0073 | leuB | -4.7 | -10.1 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0071 | leuD | -4.6 | -9.9 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b3774 | ilvC | -4.6 | -17.7 | ketol-acid reductoisomerase (NCBI) | compare |
| b2499 | purM | -4.5 | -6.2 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b3771 | ilvD | -4.5 | -17.0 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0242 | proB | -4.5 | -9.1 | gamma-glutamyl kinase (NCBI) | compare |
| b3960 | argH | -4.4 | -15.8 | argininosuccinate lyase (NCBI) | compare |
| b2557 | purL | -4.4 | -12.0 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b3828 | metR | -4.3 | -13.7 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3172 | argG | -4.2 | -15.2 | argininosuccinate synthase (NCBI) | compare |
| b3770 | ilvE | -4.2 | -17.3 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2784 | relA | -4.1 | -12.8 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b2022 | hisB | -4.1 | -9.5 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2023 | hisH | -4.0 | -7.9 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b1062 | pyrC | -3.9 | -9.5 | dihydroorotase (NCBI) | compare |
| b2025 | hisF | -3.9 | -6.5 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2818 | argA | -3.9 | -10.2 | N-acetylglutamate synthase (NCBI) | compare |
| b0386 | proC | -3.9 | -6.9 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b3956 | ppc | -3.8 | -17.6 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b2600 | tyrA | -3.8 | -6.9 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b1260 | trpA | -3.7 | -4.8 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3829 | metE | -3.7 | -16.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b4214 | cysQ | -3.6 | -14.4 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0889 | lrp | -3.6 | -4.8 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b2024 | hisA | -3.5 | -2.5 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b0004 | thrC | -3.5 | -10.9 | threonine synthase (NCBI) | compare |
| b0145 | dksA | -3.4 | -2.4 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0945 | pyrD | -3.4 | -9.9 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2476 | purC | -3.3 | -2.6 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b2750 | cysC | -3.0 | -9.5 | adenylylsulfate kinase (NCBI) | compare |
| b3958 | argC | -3.0 | -13.6 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b1192 | ldcA | -2.9 | -7.7 | L,D-carboxypeptidase A (NCBI) | compare |
| b3642 | pyrE | -2.9 | -5.8 | orotate phosphoribosyltransferase (NCBI) | compare |
| b2764 | cysJ | -2.8 | -10.6 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3959 | argB | -2.8 | -10.2 | acetylglutamate kinase (RefSeq) | compare |
| b0032 | carA | -2.8 | -5.9 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3957 | argE | -2.8 | -13.1 | acetylornithine deacetylase (NCBI) | compare |
| b1361 | ydaW | -2.8 | -1.3 | orf, hypothetical protein (VIMSS) | compare |
| b0033 | carB | -2.8 | -13.5 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2599 | pheA | -2.7 | -5.3 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b2019 | hisG | -2.7 | -4.7 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0522 | purK | -2.7 | -9.1 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3772 | ilvA | -2.6 | -12.3 | threonine dehydratase (NCBI) | compare |
| b0003 | thrB | -2.6 | -8.5 | homoserine kinase (NCBI) | compare |
| b3368 | cysG | -2.6 | -16.4 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b2762 | cysH | -2.6 | -9.0 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b1865 | nudB | -2.6 | -3.3 | dATP pyrophosphohydrolase (NCBI) | compare |
| b1882 | cheY | -2.5 | -1.2 | chemotaxis regulator transmitting signal to flagellar motor component (NCBI) | compare |
| b2026 | hisI | -2.5 | -6.2 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2017 | yefM | -2.5 | -2.2 | orf, hypothetical protein (VIMSS) | compare |
| b0439 | lon | -2.4 | -6.4 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3781 | trxA | -2.4 | -5.8 | thioredoxin 1 (VIMSS) | compare |
| b2414 | cysK | -2.4 | -11.6 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0002 | thrA | -2.3 | -12.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b0049 | apaH | -2.3 | -3.5 | diadenosinetetraphosphatase (NCBI) | compare |
| b0730 | mngR | -2.3 | -1.6 | DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) | compare |
| b2501 | ppk | -2.3 | -9.4 | polyphosphate kinase (NCBI) | compare |
| b3706 | trmE | -2.3 | -3.7 | tRNA modification GTPase (NCBI) | compare |
| b2763 | cysI | -2.3 | -7.3 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0437 | clpP | -2.2 | -6.8 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b0720 | gltA | -2.2 | -5.7 | citrate synthase (NCBI) | compare |
| b0737 | tolQ | -2.2 | -4.1 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0142 | folK | -2.2 | -1.0 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0688 | pgm | -2.2 | -4.3 | phosphoglucomutase (NCBI) | compare |
| b1290 | sapF | -2.1 | -2.5 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0113 | pdhR | -2.1 | -5.3 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b2330 | yfcB | -2.0 | -1.9 | putative adenine-specific methylase (VIMSS) | compare |
| b3916 | pfkA | -2.0 | -2.3 | 6-phosphofructokinase (NCBI) | compare |
| b3741 | gidA | -2.0 | -2.7 | glucose-inhibited division protein A (NCBI) | compare |
| b2751 | cysN | -2.0 | -7.0 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0438 | clpX | -1.9 | -6.5 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b0726 | sucA | -1.9 | -4.2 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3671 | ilvB | -1.9 | -11.9 | acetolactate synthase large subunit (NCBI) | compare |
| b4245 | pyrB | -1.9 | -7.8 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2752 | cysD | -1.9 | -4.6 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b4451 | ryhB | -1.9 | -2.5 | Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) | compare |
| b1262 | trpC | -1.8 | -3.7 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b1332 | ynaJ | -1.8 | -1.2 | predicted inner membrane protein (NCBI) | compare |
| b0564 | appY | -1.8 | -1.0 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b3870 | glnA | -1.8 | -1.8 | glutamine synthetase (NCBI) | compare |
| b0077 | ilvI | -1.8 | -8.5 | acetolactate synthase III large subunit (NCBI) | compare |
| b0078 | ilvH | -1.8 | -8.6 | acetolactate synthase small subunit (NCBI) | compare |
| b2839 | lysR | -1.8 | -5.5 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1506 | yneL | -1.7 | -2.0 | predicted transcriptional regulator (NCBI) | compare |
| b2424 | cysU | -1.7 | -2.7 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2830 | nudH | -1.6 | -1.9 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b4413 | sokC | -1.6 | -1.9 | regulatory antisense RNA (NCBI) | compare |
| b4171 | miaA | -1.6 | -3.2 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b1235 | rssB | -1.6 | -7.4 | response regulator of RpoS (NCBI) | compare |
| b0200 | gmhB | -1.6 | -1.8 | hypothetical protein (NCBI) | compare |
| b3290 | trkA | -1.5 | -1.5 | potassium transporter peripheral membrane component (NCBI) | compare |
| b0075 | leuL | -1.5 | -4.1 | leu operon leader peptide (NCBI) | compare |
| b3236 | mdh | -1.5 | -8.0 | malate dehydrogenase (NCBI) | compare |
| b3053 | glnE | -1.5 | -7.4 | fused deadenylyltransferase/adenylyltransferase for glutamine synthetase (NCBI) | compare |
| b4042 | dgkA | -1.5 | -2.2 | diacylglycerol kinase (NCBI) | compare |
| b0053 | surA | -1.5 | -5.6 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b3863 | polA | -1.5 | -1.4 | DNA polymerase I (NCBI) | compare |
| b3650 | spoT | -1.5 | -5.7 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b3613 | yibP | -1.5 | -3.8 | putative membrane protein (VIMSS) | compare |
| b1850 | eda | -1.5 | -3.3 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b4647 | mokA | -1.4 | -0.9 | no description | compare |
| b2340 | sixA | -1.4 | -4.5 | phosphohistidine phosphatase (NCBI) | compare |
| b2620 | smpB | -1.4 | -1.3 | SsrA-binding protein (NCBI) | compare |
| b1730 | ydjO | -1.4 | -1.0 | predicted protein (RefSeq) | compare |
| b3204 | ptsN | -1.4 | -4.4 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b3237 | argR | -1.4 | -4.4 | arginine repressor (NCBI) | compare |
| b4155 | yjeA | -1.3 | -0.9 | putative lysyl-tRNA synthetase (VIMSS) | compare |
| b1859 | znuB | -1.3 | -6.6 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b3979 | thrT | -1.3 | -0.6 | tRNA-Thr (NCBI) | compare |
| b0683 | fur | -1.3 | -1.5 | ferric uptake regulator (NCBI) | compare |
| b1984 | asnW | -1.3 | -1.5 | tRNA-Asn (NCBI) | compare |
| b3008 | metC | -1.3 | -7.7 | cystathionine beta-lyase (NCBI) | compare |
| b4535 | yniD | -1.2 | -1.6 | predicted protein (RefSeq) | compare |
| b2500 | purN | -1.2 | -4.3 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b1291 | sapD | -1.2 | -1.6 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b2911 | ssrS | -1.2 | -1.7 | 6S regulatory RNA (NCBI) | compare |
| b0767 | ybhE | -1.2 | -3.4 | 6-phosphogluconolactonase (NCBI) | compare |
| b1358 | ydaT | -1.2 | -1.8 | Rac prophage; predicted protein (NCBI) | compare |
| b3021 | ygiT | -1.2 | -2.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b1263 | trpD | -1.2 | -2.6 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2894 | xerD | -1.1 | -0.7 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b4631 | ykgQ | -1.1 | -1.8 | no description | compare |
| b2935 | tktA | -1.1 | -2.0 | transketolase 1, thiamin-binding (NCBI) | compare |
| b1861 | ruvA | -1.1 | -1.3 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b1150 | ymfR | -1.1 | -1.2 | e14 prophage; predicted protein (NCBI) | compare |
| b1842 | holE | -1.1 | -2.3 | DNA polymerase III, theta subunit (NCBI) | compare |
| b1236 | galU | -1.1 | -3.9 | glucose-1-phosphate uridylyltransferase (NCBI) | compare |
| b3761 | trpT | -1.1 | -1.7 | tRNA-Trp (NCBI) | compare |
| b4592 | yccB | -1.1 | -2.2 | hypothetical protein (RefSeq) | compare |
| b3163 | nlpI | -1.1 | -4.3 | hypothetical protein (NCBI) | compare |
| b3962 | udhA | -1.1 | -4.9 | putative oxidoreductase (VIMSS) | compare |
| b3764 | yifE | -1.1 | -3.4 | hypothetical protein (NCBI) | compare |
| b2820 | recB | -1.1 | -0.7 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b4375 | prfC | -1.1 | -3.2 | peptide chain release factor 3 (NCBI) | compare |
| b2422 | cysA | -1.1 | -5.3 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b4515 | ybgT | -1.1 | -1.9 | hypothetical protein (NCBI) | compare |
| b2007 | yeeX | -1.1 | -2.2 | conserved protein (RefSeq) | compare |
| b3844 | fre | -1.0 | -3.8 | NAD(P)H-flavin reductase (NCBI) | compare |
| b2279 | nuoK | -1.0 | -1.2 | NADH dehydrogenase subunit K (NCBI) | compare |
| b2423 | cysW | -1.0 | -3.8 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3849 | trkH | -1.0 | -6.7 | potassium transporter (NCBI) | compare |
| b3860 | dsbA | -1.0 | -5.3 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b1579 | intQ | -1.0 | -2.3 | Qin prophage; predicted defective integrase (RefSeq) | compare |
| b2814 | metZ | -1.0 | -1.5 | tRNA-Met (NCBI) | compare |
| b0888 | trxB | -1.0 | -2.7 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b3162 | deaD | -1.0 | -3.7 | inducible ATP-independent RNA helicase (VIMSS) | compare |
| b1101 | ptsG | -1.0 | -6.3 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b1058 | yceO | -1.0 | -0.6 | hypothetical protein (NCBI) | compare |
| b2504 | yfgG | -1.0 | -1.1 | Negative regulator of nickel and cobalt uptake (YfgG) (from data) | compare |
| b1048 | mdoG | -1.0 | -3.8 | glucan biosynthesis protein, periplasmic (NCBI) | compare |
| b3670 | ilvN | -1.0 | -4.1 | acetolactate synthase small subunit (NCBI) | compare |
| b1951 | rcsA | -1.0 | -1.1 | DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) | compare |
| b1600 | mdtJ | -1.0 | -1.4 | multidrug efflux system transporter (NCBI) | compare |
| b2571 | rseB | -1.0 | -4.5 | periplasmic negative regulator of sigmaE (NCBI) | compare |
| b1696 | ydiP | -1.0 | -2.1 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3619 | rfaD | -0.9 | -2.8 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b1084 | rne | -0.9 | -3.0 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b3398 | yrfF | -0.9 | -2.4 | predicted inner membrane protein (NCBI) | compare |
| b0114 | aceE | -0.9 | -0.6 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b3247 | cafA | -0.9 | -6.4 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b2258 | b2258 | -0.9 | -1.2 | putative transport/receptor protein (VIMSS) | compare |
| b0953 | rmf | -0.9 | -2.8 | ribosome modulation factor (NCBI) | compare |
| b3443 | yrhA | -0.9 | -1.5 | orf, hypothetical protein (VIMSS) | compare |
| b2512 | yfgL | -0.9 | -3.4 | protein assembly complex, lipoprotein component (NCBI) | compare |
| b4163 | glyV | -0.9 | -1.7 | tRNA-Gly (NCBI) | compare |
| b2846 | yqeH | -0.9 | -0.5 | orf, hypothetical protein (VIMSS) | compare |
| b2187 | yejL | -0.9 | -2.2 | hypothetical protein (NCBI) | compare |
| b2783 | chpR | -0.9 | -1.9 | antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) | compare |
| b3405 | ompR | -0.9 | -3.5 | osmolarity response regulator (NCBI) | compare |
| b0303 | ykgI | -0.9 | -0.6 | orf, hypothetical protein (VIMSS) | compare |
| b0122 | yacC | -0.9 | -3.0 | orf, hypothetical protein (VIMSS) | compare |
| b1563 | relE | -0.9 | -1.4 | Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) | compare |
| b0627 | tatE | -0.9 | -1.6 | twin arginine translocase protein E (NCBI) | compare |
| b3839 | tatC | -0.9 | -4.3 | TatABCE protein translocation system subunit (NCBI) | compare |
| b0928 | aspC | -0.9 | -4.9 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b4144 | yjeI | -0.8 | -2.1 | orf, hypothetical protein (VIMSS) | compare |
| b4676 | yoaK | -0.8 | -0.5 | expressed protein (RefSeq) | compare |
| b2518 | ndk | -0.8 | -1.5 | nucleoside diphosphate kinase (NCBI) | compare |