| | gene | name | fitness | t score | description | |
|---|
| b2838 | lysA | -6.2 | -13.2 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0523 | purE | -5.6 | -5.4 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b2024 | hisA | -5.1 | -3.3 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b2023 | hisH | -4.9 | -8.8 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2022 | hisB | -4.9 | -10.4 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b1261 | trpB | -4.8 | -5.1 | tryptophan synthase subunit beta (NCBI) | compare |
| b0908 | aroA | -4.7 | -12.2 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0907 | serC | -4.5 | -10.6 | phosphoserine aminotransferase (NCBI) | compare |
| b3281 | aroE | -4.5 | -22.5 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b2312 | purF | -4.5 | -8.9 | amidophosphoribosyltransferase (NCBI) | compare |
| b0071 | leuD | -4.3 | -11.4 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b2913 | serA | -4.3 | -14.0 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b3389 | aroB | -4.3 | -16.6 | 3-dehydroquinate synthase (NCBI) | compare |
| b2329 | aroC | -4.3 | -8.6 | chorismate synthase (NCBI) | compare |
| b1281 | pyrF | -4.3 | -4.3 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b4005 | purD | -4.2 | -12.7 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b3771 | ilvD | -4.2 | -18.1 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0073 | leuB | -4.2 | -12.9 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b2557 | purL | -4.2 | -14.0 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b4006 | purH | -4.1 | -15.7 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b0004 | thrC | -4.1 | -12.3 | threonine synthase (NCBI) | compare |
| b0242 | proB | -4.0 | -9.0 | gamma-glutamyl kinase (NCBI) | compare |
| b0072 | leuC | -3.9 | -14.0 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b3941 | metF | -3.9 | -12.4 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0074 | leuA | -3.9 | -13.1 | 2-isopropylmalate synthase (NCBI) | compare |
| b4388 | serB | -3.9 | -10.6 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2499 | purM | -3.8 | -7.2 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0945 | pyrD | -3.8 | -11.8 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2476 | purC | -3.8 | -5.1 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b2021 | hisC | -3.7 | -8.1 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3774 | ilvC | -3.7 | -17.6 | ketol-acid reductoisomerase (NCBI) | compare |
| b3770 | ilvE | -3.7 | -14.5 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b3642 | pyrE | -3.6 | -6.3 | orotate phosphoribosyltransferase (NCBI) | compare |
| b1260 | trpA | -3.6 | -8.0 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3828 | metR | -3.5 | -15.0 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0243 | proA | -3.5 | -12.3 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b3829 | metE | -3.5 | -18.7 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0033 | carB | -3.5 | -16.0 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2025 | hisF | -3.5 | -5.6 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b2020 | hisD | -3.5 | -8.7 | histidinol dehydrogenase (NCBI) | compare |
| b3172 | argG | -3.5 | -13.6 | argininosuccinate synthase (NCBI) | compare |
| b1192 | ldcA | -3.4 | -7.2 | L,D-carboxypeptidase A (NCBI) | compare |
| b2784 | relA | -3.4 | -14.7 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b0683 | fur | -3.3 | -3.2 | ferric uptake regulator (NCBI) | compare |
| b0889 | lrp | -3.3 | -5.0 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b1693 | aroD | -3.3 | -8.2 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0386 | proC | -3.2 | -8.5 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b0032 | carA | -3.2 | -9.2 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b3960 | argH | -3.2 | -13.4 | argininosuccinate lyase (NCBI) | compare |
| b2600 | tyrA | -3.2 | -8.1 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b0003 | thrB | -3.1 | -10.0 | homoserine kinase (NCBI) | compare |
| b0439 | lon | -3.1 | -7.1 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b0145 | dksA | -3.0 | -3.6 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b1062 | pyrC | -3.0 | -10.8 | dihydroorotase (NCBI) | compare |
| b4214 | cysQ | -3.0 | -14.9 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0002 | thrA | -2.9 | -15.0 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b3772 | ilvA | -2.9 | -14.4 | threonine dehydratase (NCBI) | compare |
| b2818 | argA | -2.8 | -13.3 | N-acetylglutamate synthase (NCBI) | compare |
| b4245 | pyrB | -2.8 | -11.0 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2479 | gcvR | -2.8 | -8.6 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b3956 | ppc | -2.7 | -19.2 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b2026 | hisI | -2.7 | -9.8 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3405 | ompR | -2.7 | -7.2 | osmolarity response regulator (NCBI) | compare |
| b0437 | clpP | -2.6 | -7.5 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b2599 | pheA | -2.6 | -7.1 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3957 | argE | -2.6 | -15.0 | acetylornithine deacetylase (NCBI) | compare |
| b2750 | cysC | -2.6 | -10.2 | adenylylsulfate kinase (NCBI) | compare |
| b2762 | cysH | -2.5 | -10.3 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0142 | folK | -2.4 | -1.1 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b2414 | cysK | -2.4 | -11.7 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2839 | lysR | -2.4 | -4.1 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2019 | hisG | -2.4 | -4.9 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0720 | gltA | -2.3 | -7.0 | citrate synthase (NCBI) | compare |
| b0049 | apaH | -2.3 | -3.8 | diadenosinetetraphosphatase (NCBI) | compare |
| b3958 | argC | -2.3 | -13.4 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3959 | argB | -2.3 | -12.8 | acetylglutamate kinase (RefSeq) | compare |
| b2188 | yejM | -2.2 | -12.1 | predicted hydrolase, inner membrane (NCBI) | compare |
| b0522 | purK | -2.2 | -8.5 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b0438 | clpX | -2.1 | -7.9 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3613 | yibP | -2.1 | -5.1 | putative membrane protein (VIMSS) | compare |
| b0113 | pdhR | -2.0 | -5.7 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0232 | yafN | -2.0 | -1.3 | predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) | compare |
| b3398 | yrfF | -2.0 | -5.5 | predicted inner membrane protein (NCBI) | compare |
| b2752 | cysD | -2.0 | -7.0 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b0564 | appY | -2.0 | -1.1 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b3671 | ilvB | -2.0 | -14.3 | acetolactate synthase large subunit (NCBI) | compare |
| b2763 | cysI | -1.9 | -9.8 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b3916 | pfkA | -1.9 | -3.3 | 6-phosphofructokinase (NCBI) | compare |
| b2764 | cysJ | -1.9 | -9.9 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b3008 | metC | -1.8 | -11.8 | cystathionine beta-lyase (NCBI) | compare |
| b3368 | cysG | -1.8 | -14.0 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b1865 | nudB | -1.8 | -1.6 | dATP pyrophosphohydrolase (NCBI) | compare |
| b0726 | sucA | -1.8 | -4.4 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b0200 | gmhB | -1.7 | -1.9 | hypothetical protein (NCBI) | compare |
| b1232 | purU | -1.7 | -8.2 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b2830 | nudH | -1.7 | -1.9 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b0890 | ftsK | -1.7 | -4.3 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b1262 | trpC | -1.7 | -4.0 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b4647 | mokA | -1.6 | -1.1 | no description | compare |
| b3390 | aroK | -1.6 | -2.0 | shikimate kinase I (NCBI) | compare |
| b1290 | sapF | -1.6 | -2.7 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b4155 | yjeA | -1.6 | -1.1 | putative lysyl-tRNA synthetase (VIMSS) | compare |
| b1857 | yebL | -1.6 | -7.3 | putative adhesin (VIMSS) | compare |
| b0957 | ompA | -1.6 | -5.2 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b4013 | metA | -1.6 | -8.1 | homoserine O-succinyltransferase (NCBI) | compare |
| b4042 | dgkA | -1.5 | -2.6 | diacylglycerol kinase (NCBI) | compare |
| b3053 | glnE | -1.5 | -7.7 | fused deadenylyltransferase/adenylyltransferase for glutamine synthetase (NCBI) | compare |
| b3979 | thrT | -1.5 | -0.7 | tRNA-Thr (NCBI) | compare |
| b3204 | ptsN | -1.5 | -5.5 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b3839 | tatC | -1.5 | -7.5 | TatABCE protein translocation system subunit (NCBI) | compare |
| b1524 | yneH | -1.4 | -1.4 | predicted glutaminase (NCBI) | compare |
| b0077 | ilvI | -1.4 | -8.9 | acetolactate synthase III large subunit (NCBI) | compare |
| b0737 | tolQ | -1.4 | -3.0 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0075 | leuL | -1.4 | -4.2 | leu operon leader peptide (NCBI) | compare |
| b0078 | ilvH | -1.4 | -9.6 | acetolactate synthase small subunit (NCBI) | compare |
| b1263 | trpD | -1.4 | -3.0 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b0149 | mrcB | -1.4 | -10.4 | penicillin-binding protein 1b (NCBI) | compare |
| b3290 | trkA | -1.4 | -2.2 | potassium transporter peripheral membrane component (NCBI) | compare |
| b3939 | metB | -1.3 | -8.2 | cystathionine gamma-synthase (NCBI) | compare |
| b3773 | ilvY | -1.3 | -8.1 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2751 | cysN | -1.3 | -6.2 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b1860 | ruvB | -1.3 | -1.2 | Holliday junction DNA helicase B (NCBI) | compare |
| b0740 | tolB | -1.3 | -4.0 | translocation protein TolB precursor (NCBI) | compare |
| b3935 | priA | -1.3 | -2.7 | primosome assembly protein PriA (NCBI) | compare |
| b3026 | qseC | -1.3 | -3.9 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b4701 | sokX | -1.3 | -1.4 | sok-related sRNA, function unknown (RefSeq) | compare |
| b2423 | cysW | -1.3 | -5.3 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1859 | znuB | -1.3 | -7.2 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b0990 | cspG | -1.3 | -1.1 | DNA-binding transcriptional regulator (NCBI) | compare |
| b3164 | pnp | -1.3 | -3.3 | polynucleotide phosphorylase/polyadenylase (RefSeq) | compare |
| b3870 | glnA | -1.2 | -2.5 | glutamine synthetase (NCBI) | compare |
| b1850 | eda | -1.2 | -2.6 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b3741 | gidA | -1.2 | -4.1 | glucose-inhibited division protein A (NCBI) | compare |
| b4171 | miaA | -1.2 | -3.3 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b2290 | yfbQ | -1.2 | -8.0 | aspartate aminotransferase (NCBI) | compare |
| b2422 | cysA | -1.2 | -6.1 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3237 | argR | -1.2 | -3.9 | arginine repressor (NCBI) | compare |
| b1858 | znuC | -1.2 | -5.0 | high-affinity zinc transporter ATPase (NCBI) | compare |
| b2318 | truA | -1.1 | -2.5 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0767 | ybhE | -1.1 | -4.3 | 6-phosphogluconolactonase (NCBI) | compare |
| b2820 | recB | -1.1 | -1.0 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b1058 | yceO | -1.1 | -0.7 | hypothetical protein (NCBI) | compare |
| b1292 | sapC | -1.1 | -2.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1060 | yceP | -1.1 | -4.4 | orf, hypothetical protein (VIMSS) | compare |
| b3863 | polA | -1.1 | -1.4 | DNA polymerase I (NCBI) | compare |
| b3849 | trkH | -1.1 | -7.4 | potassium transporter (NCBI) | compare |
| b2935 | tktA | -1.1 | -2.0 | transketolase 1, thiamin-binding (NCBI) | compare |
| b3120 | yhaB | -1.1 | -1.2 | orf, hypothetical protein (VIMSS) | compare |
| b1101 | ptsG | -1.0 | -6.8 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b3670 | ilvN | -1.0 | -6.3 | acetolactate synthase small subunit (NCBI) | compare |
| b2846 | yqeH | -1.0 | -0.6 | orf, hypothetical protein (VIMSS) | compare |
| b2340 | sixA | -1.0 | -3.4 | phosphohistidine phosphatase (NCBI) | compare |
| b1235 | rssB | -1.0 | -5.7 | response regulator of RpoS (NCBI) | compare |
| b1861 | ruvA | -1.0 | -1.4 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b0303 | ykgI | -1.0 | -0.7 | orf, hypothetical protein (VIMSS) | compare |
| b1129 | phoQ | -1.0 | -1.6 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2313 | cvpA | -1.0 | -3.7 | membrane protein required for colicin V production (NCBI) | compare |
| b3213 | gltD | -1.0 | -6.7 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b3781 | trxA | -1.0 | -3.3 | thioredoxin 1 (VIMSS) | compare |
| b1476 | fdnI | -1.0 | -1.2 | formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) | compare |
| b2814 | metZ | -0.9 | -1.7 | tRNA-Met (NCBI) | compare |
| b0738 | tolR | -0.9 | -2.6 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2894 | xerD | -0.9 | -0.8 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3021 | ygiT | -0.9 | -1.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3650 | spoT | -0.9 | -4.7 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b4596 | yciZ | -0.9 | -2.1 | hypothetical protein (RefSeq) | compare |
| b4025 | pgi | -0.9 | -5.6 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3212 | gltB | -0.9 | -7.7 | glutamate synthase, large subunit (NCBI) | compare |
| b0585 | fes | -0.9 | -4.1 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b4595 | yciY | -0.9 | -2.5 | hypothetical protein (RefSeq) | compare |
| b3250 | mreC | -0.9 | -1.6 | cell wall structural complex MreBCD transmembrane component MreC (NCBI) | compare |
| b4246 | pyrL | -0.8 | -1.8 | pyrBI operon leader peptide (NCBI) | compare |
| b4509 | ylcG | -0.8 | -2.6 | DLP12 prophage; predicted protein (NCBI) | compare |
| b3169 | nusA | -0.8 | -1.7 | transcription elongation factor NusA (NCBI) | compare |
| b4048 | yjbM | -0.8 | -1.1 | hypothetical protein (NCBI) | compare |
| b3052 | rfaE | -0.8 | -3.6 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b1351 | racC | -0.8 | -0.5 | Rac prophage; predicted protein (NCBI) | compare |
| b0798 | ybiA | -0.8 | -2.6 | hypothetical protein (NCBI) | compare |
| b3247 | cafA | -0.8 | -5.8 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b3252 | yhdA | -0.8 | -6.7 | conserved inner membrane protein (NCBI) | compare |
| b2518 | ndk | -0.8 | -1.8 | nucleoside diphosphate kinase (NCBI) | compare |
| b2424 | cysU | -0.8 | -2.0 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1502 | ydeQ | -0.8 | -1.6 | predicted fimbrial-like adhesin protein (NCBI) | compare |
| b0109 | nadC | -0.8 | -4.6 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b3811 | xerC | -0.8 | -1.2 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b1217 | chaB | -0.8 | -1.6 | cation transport regulator (NCBI) | compare |
| b0739 | tolA | -0.8 | -2.4 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b2699 | recA | -0.8 | -1.1 | recombinase A (NCBI) | compare |
| b1739 | osmE | -0.8 | -1.3 | DNA-binding transcriptional activator (NCBI) | compare |
| b2419 | yfeK | -0.8 | -1.7 | hypothetical protein (NCBI) | compare |
| b3838 | tatB | -0.8 | -3.6 | sec-independent translocase (NCBI) | compare |
| b1103 | ycfF | -0.8 | -1.4 | orf, hypothetical protein (VIMSS) | compare |
| b0222 | lpcA | -0.8 | -2.0 | phosphoheptose isomerase (NCBI) | compare |
| b3620 | rfaF | -0.8 | -3.2 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b1853 | yebK | -0.7 | -2.2 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3940 | metL | -0.7 | -5.8 | bifunctional aspartate kinase II/homoserine dehydrogenase II (NCBI) | compare |
| b3619 | rfaD | -0.7 | -2.5 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b0888 | trxB | -0.7 | -1.9 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b3236 | mdh | -0.7 | -5.2 | malate dehydrogenase (NCBI) | compare |
| b1161 | ycgX | -0.7 | -0.8 | hypothetical protein (NCBI) | compare |