Experiment set38IT007 for Escherichia coli BW25113

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LB

200 most important genes:

  gene name fitness t score description  
b0683 fur -3.9 -2.4 ferric uptake regulator (NCBI) compare
b1361 ydaW -2.7 -1.0 orf, hypothetical protein (VIMSS) compare
b0688 pgm -2.6 -4.8 phosphoglucomutase (NCBI) compare
b2279 nuoK -2.4 -2.4 NADH dehydrogenase subunit K (NCBI) compare
b0740 tolB -2.3 -6.0 translocation protein TolB precursor (NCBI) compare
b0142 folK -2.3 -0.8 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2281 nuoI -2.2 -3.7 NADH dehydrogenase subunit I (NCBI) compare
b2567 rnc -2.2 -1.5 ribonuclease III (NCBI) compare
b2283 nuoG -2.2 -8.4 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b0722 sdhD -2.2 -6.7 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b0741 pal -2.1 -4.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0726 sucA -2.1 -4.4 alpha-ketoglutarate decarboxylase (NCBI) compare
b2276 nuoN -2.1 -6.8 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b4042 dgkA -2.1 -2.0 diacylglycerol kinase (NCBI) compare
b1192 ldcA -2.1 -5.1 L,D-carboxypeptidase A (NCBI) compare
b3613 yibP -2.0 -4.7 putative membrane protein (VIMSS) compare
b0149 mrcB -2.0 -13.8 penicillin-binding protein 1b (NCBI) compare
b2017 yefM -2.0 -2.3 orf, hypothetical protein (VIMSS) compare
b1105 ycfM -2.0 -5.7 predicted outer membrane lipoprotein (NCBI) compare
b2528 iscA -1.9 -2.7 iron-sulfur cluster assembly protein (NCBI) compare
b0232 yafN -1.9 -1.0 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3164 pnp -1.8 -4.2 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2808 gcvA -1.8 -4.7 DNA-binding transcriptional dual regulator (NCBI) compare
b3962 udhA -1.8 -7.4 putative oxidoreductase (VIMSS) compare
b4603 rseX -1.8 -0.9 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2278 nuoL -1.8 -9.1 NADH dehydrogenase subunit L (NCBI) compare
b3636 rpmG -1.8 -2.7 50S ribosomal protein L33 (NCBI) compare
b0737 tolQ -1.8 -3.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1850 eda -1.8 -2.9 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b4535 yniD -1.7 -1.9 predicted protein (RefSeq) compare
b2282 nuoH -1.7 -3.4 NADH dehydrogenase subunit H (NCBI) compare
b3075 ebgR -1.7 -6.7 DNA-binding transcriptional repressor (NCBI) compare
b0080 fruR -1.7 -7.2 DNA-binding transcriptional dual regulator (NCBI) compare
b2277 nuoM -1.7 -6.1 NADH dehydrogenase subunit M (NCBI) compare
b4146 yjeK -1.7 -1.6 predicted lysine aminomutase (NCBI) compare
b1292 sapC -1.6 -2.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0145 dksA -1.6 -3.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0439 lon -1.6 -5.5 DNA-binding ATP-dependent protease La (NCBI) compare
b3398 yrfF -1.6 -4.5 predicted inner membrane protein (NCBI) compare
b2286 nuoC -1.6 -6.0 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2912 ygfA -1.6 -4.5 putative ligase (VIMSS) compare
b0088 murD -1.6 -2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b2287 nuoB -1.6 -2.9 NADH dehydrogenase subunit B (NCBI) compare
b2897 ygfY -1.6 -4.4 hypothetical protein (NCBI) compare
b3778 rep -1.5 -7.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4631 ykgQ -1.5 -1.4 no description compare
b0912 ihfB -1.5 -4.0 integration host factor subunit beta (NCBI) compare
b4375 prfC -1.5 -3.5 peptide chain release factor 3 (NCBI) compare
b1642 slyA -1.5 -1.7 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0739 tolA -1.4 -3.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1084 rne -1.4 -5.0 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b2280 nuoJ -1.4 -4.7 NADH dehydrogenase subunit J (NCBI) compare
b3169 nusA -1.4 -3.6 transcription elongation factor NusA (NCBI) compare
b4246 pyrL -1.4 -2.3 pyrBI operon leader peptide (NCBI) compare
b1062 pyrC -1.4 -6.6 dihydroorotase (NCBI) compare
b0630 lipB -1.4 -0.9 protein of lipoate biosynthesis (VIMSS) compare
b3979 thrT -1.4 -0.5 tRNA-Thr (NCBI) compare
b1236 galU -1.4 -4.6 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3290 trkA -1.4 -1.6 potassium transporter peripheral membrane component (NCBI) compare
b0723 sdhA -1.4 -8.4 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b3621 rfaC -1.4 -5.0 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3630 rfaP -1.3 -7.9 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b4155 yjeA -1.3 -0.9 putative lysyl-tRNA synthetase (VIMSS) compare
b2497 uraA -1.3 -8.3 uracil transporter (NCBI) compare
b0161 degP -1.3 -6.5 serine endoprotease (protease Do), membrane-associated (NCBI) compare
b3021 ygiT -1.3 -3.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b3726 pstA -1.3 -4.9 phosphate transporter subunit (NCBI) compare
b3162 deaD -1.3 -4.7 inducible ATP-independent RNA helicase (VIMSS) compare
b0738 tolR -1.3 -2.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3619 rfaD -1.3 -3.6 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0945 pyrD -1.3 -7.4 dihydroorotate dehydrogenase (NCBI) compare
b3387 dam -1.3 -9.2 DNA adenine methylase (NCBI) compare
b2498 upp -1.3 -2.4 uracil phosphoribosyltransferase (VIMSS) compare
b0729 sucD -1.3 -3.5 succinyl-CoA synthetase subunit alpha (NCBI) compare
b3026 qseC -1.3 -3.5 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3236 mdh -1.3 -6.2 malate dehydrogenase (NCBI) compare
b1382 ynbE -1.3 -1.5 predicted lipoprotein (NCBI) compare
b0724 sdhB -1.3 -4.8 succinate dehydrogenase, FeS subunit (NCBI) compare
b0200 gmhB -1.3 -1.5 hypothetical protein (NCBI) compare
b2168 fruK -1.3 -1.5 1-phosphofructokinase (NCBI) compare
b1235 rssB -1.3 -6.4 response regulator of RpoS (NCBI) compare
b4314 fimA -1.3 -5.2 major type 1 subunit fimbrin (pilin) (NCBI) compare
b3493 pitA -1.3 -6.7 phosphate transporter, low-affinity (NCBI) compare
b4232 fbp -1.3 -8.7 fructose-1,6-bisphosphatase (NCBI) compare
b2101 yegW -1.3 -5.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b4481 rffT -1.2 -5.7 4-alpha-L-fucosyltransferase (NCBI) compare
b4320 fimH -1.2 -8.7 minor component of type 1 fimbriae (NCBI) compare
b0222 lpcA -1.2 -2.7 phosphoheptose isomerase (NCBI) compare
b1290 sapF -1.2 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1950 fliR -1.2 -2.9 flagellar biosynthesis protein R (NCBI) compare
b0928 aspC -1.2 -5.3 aspartate aminotransferase, PLP-dependent (NCBI) compare
b0437 clpP -1.2 -5.4 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b3849 trkH -1.2 -8.4 potassium transporter (NCBI) compare
b2646 ypjF -1.2 -2.4 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b1612 fumA -1.2 -2.3 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b3237 argR -1.2 -4.3 arginine repressor (NCBI) compare
b4179 vacB -1.2 -5.5 putative enzyme (VIMSS) compare
b2284 nuoF -1.2 -3.9 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b2330 yfcB -1.2 -1.6 putative adenine-specific methylase (VIMSS) compare
b3867 hemN -1.2 -9.1 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b0523 purE -1.2 -2.9 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b1518 lsrG -1.2 -1.6 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b3806 cyaA -1.2 -4.4 adenylate cyclase (NCBI) compare
b0889 lrp -1.2 -3.0 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b3791 rffA -1.2 -5.0 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b4509 ylcG -1.2 -3.3 DLP12 prophage; predicted protein (NCBI) compare
b4319 fimG -1.2 -5.6 minor component of type 1 fimbriae (NCBI) compare
b1286 rnb -1.2 -2.4 exoribonuclease II (NCBI) compare
b3631 rfaG -1.2 -9.0 glucosyltransferase I (NCBI) compare
b0676 nagC -1.1 -6.8 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) compare
b4139 aspA -1.1 -6.8 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b1861 ruvA -1.1 -1.2 Holliday junction DNA helicase motor protein (NCBI) compare
b0721 sdhC -1.1 -3.4 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b2288 nuoA -1.1 -3.0 NADH dehydrogenase I chain A (VIMSS) compare
b0728 sucC -1.1 -5.9 succinyl-CoA synthetase subunit beta (NCBI) compare
b3842 rfaH -1.1 -4.9 transcriptional activator RfaH (NCBI) compare
b3860 dsbA -1.1 -6.8 periplasmic protein disulfide isomerase I (NCBI) compare
b4317 fimD -1.1 -10.1 outer membrane usher protein, type 1 fimbrial synthesis (NCBI) compare
b4316 fimC -1.1 -6.6 periplasmic chaperone, required for type 1 fimbriae (VIMSS) compare
b2906 visC -1.1 -5.9 hypothetical protein (NCBI) compare
b0430 cyoC -1.1 -3.6 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b2340 sixA -1.1 -3.6 phosphohistidine phosphatase (NCBI) compare
b0004 thrC -1.1 -6.4 threonine synthase (NCBI) compare
b1049 mdoH -1.1 -6.2 glucosyltransferase MdoH (NCBI) compare
b0890 ftsK -1.1 -3.2 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1594 dgsA -1.1 -3.1 DNA-binding transcriptional repressor (NCBI) compare
b3844 fre -1.1 -3.6 NAD(P)H-flavin reductase (NCBI) compare
b0658 ybeX -1.1 -0.7 predicteed ion transport (NCBI) compare
b4178 yjeB -1.1 -4.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b0438 clpX -1.1 -5.0 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1863 ruvC -1.0 -1.8 Holliday junction resolvase (NCBI) compare
b3794 rffM -1.0 -5.9 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3257 yhdT -1.0 -4.2 conserved inner membrane protein (NCBI) compare
b3741 gidA -1.0 -3.4 glucose-inhibited division protein A (NCBI) compare
b1476 fdnI -1.0 -0.9 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b3790 rffC -1.0 -4.3 TDP-fucosamine acetyltransferase (RefSeq) compare
b2935 tktA -1.0 -1.8 transketolase 1, thiamin-binding (NCBI) compare
b4585 sroB -1.0 -1.0 Novel sRNA, function unknown (RefSeq) compare
b1860 ruvB -1.0 -0.9 Holliday junction DNA helicase B (NCBI) compare
b0018 mokC -1.0 -1.0 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b3786 rffE -1.0 -7.9 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b1712 ihfA -1.0 -1.6 integration host factor subunit alpha (NCBI) compare
b2318 truA -1.0 -2.0 tRNA pseudouridine synthase A (NCBI) compare
b3210 arcB -1.0 -5.5 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b4171 miaA -1.0 -2.6 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b3601 mtlR -1.0 -3.9 DNA-binding repressor (NCBI) compare
b4202 rpsR -1.0 -1.5 30S ribosomal protein S18 (NCBI) compare
b4416 rybA -1.0 -1.1 unknown RNA (NCBI) compare
b3628 rfaB -1.0 -6.1 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b4312 fimB -1.0 -6.3 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b2707 srlR -1.0 -4.2 DNA-bindng transcriptional repressor (NCBI) compare
b3973 birA -1.0 -2.3 biotin--protein ligase (NCBI) compare
b1335 ogt -1.0 -2.1 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b4025 pgi -1.0 -5.3 glucose-6-phosphate isomerase (NCBI) compare
b2175 spr -1.0 -3.1 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b2513 yfgM -1.0 -3.2 hypothetical protein (NCBI) compare
b3620 rfaF -1.0 -4.2 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3627 rfaI -0.9 -5.9 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b1048 mdoG -0.9 -4.2 glucan biosynthesis protein, periplasmic (NCBI) compare
b4191 ulaR -0.9 -3.4 DNA-binding transcriptional dual regulator (NCBI) compare
b1104 ycfL -0.9 -1.2 hypothetical protein (NCBI) compare
b1777 b1777 -0.9 -1.7 orf, hypothetical protein (VIMSS) compare
b1058 yceO -0.9 -0.4 hypothetical protein (NCBI) compare
b2285 nuoE -0.9 -2.1 NADH dehydrogenase subunit E (NCBI) compare
b4203 rplI -0.9 -2.6 50S ribosomal protein L9 (NCBI) compare
b3082 ygjM -0.9 -1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b0049 apaH -0.9 -2.3 diadenosinetetraphosphatase (NCBI) compare
b2188 yejM -0.9 -6.1 predicted hydrolase, inner membrane (NCBI) compare
b0121 speE -0.9 -4.3 spermidine synthase (NCBI) compare
b1259 yciG -0.9 -1.4 orf, hypothetical protein (VIMSS) compare
b3035 tolC -0.9 -5.4 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3811 xerC -0.9 -1.1 site-specific tyrosine recombinase XerC (NCBI) compare
b4324 uxuR -0.9 -5.6 DNA-binding transcriptional repressor (NCBI) compare
b3232 yhcM -0.9 -5.6 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b0113 pdhR -0.9 -2.6 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b1070 flgN -0.9 -1.1 export chaperone for FlgK and FlgL (NCBI) compare
b2809 b2809 -0.9 -1.5 orf, hypothetical protein (VIMSS) compare
b1281 pyrF -0.9 -1.9 orotidine 5'-phosphate decarboxylase (NCBI) compare
b3226 yhcK -0.9 -3.6 putative FADA-type transcriptional regulator (VIMSS) compare
b1090 plsX -0.9 -2.9 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b3438 gntR -0.9 -4.4 DNA-binding transcriptional repressor (NCBI) compare
b3188 sfsB -0.9 -3.1 DNA-binding transcriptional activator of maltose metabolism (NCBI) compare
b2820 recB -0.9 -0.8 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b4515 ybgT -0.9 -1.3 hypothetical protein (NCBI) compare
b2830 nudH -0.9 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b1503 ydeR -0.9 -2.3 predicted fimbrial-like adhesin protein (NCBI) compare
b2189 proL -0.9 -1.2 tRNA-Pro (NCBI) compare
b1604 ydgH -0.9 -3.1 hypothetical protein (NCBI) compare
b1658 purR -0.9 -3.4 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b3787 rffD -0.9 -5.8 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b1334 fnr -0.9 -2.2 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b2569 lepA -0.9 -3.0 GTP-binding protein LepA (NCBI) compare
b0677 nagA -0.9 -3.8 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3465 yhhF -0.9 -4.5 predicted methyltransferase (NCBI) compare
b3443 yrhA -0.9 -1.2 orf, hypothetical protein (VIMSS) compare
b4388 serB -0.8 -3.9 3-phosphoserine phosphatase (NCBI) compare
b1148 ymfM -0.8 -2.4 e14 prophage; predicted protein (NCBI) compare
b4315 fimI -0.8 -5.5 fimbrial protein (VIMSS) compare
b2846 yqeH -0.8 -0.5 orf, hypothetical protein (VIMSS) compare
b1600 mdtJ -0.8 -1.3 multidrug efflux system transporter (NCBI) compare


Specific Phenotypes

For 8 genes in this experiment