Experiment set36IT071 for Escherichia coli BW25113

Compare to:

Phage_N4_cage_4_mice _Feces_40 hr

200 most important genes:

  gene name fitness t score description  
b4053 alr -9.2 -18.6 alanine racemase (NCBI) compare
b3035 tolC -8.1 -17.0 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1855 lpxM -7.8 -9.0 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0222 lpcA -7.6 -4.3 phosphoheptose isomerase (NCBI) compare
b1850 eda -7.5 -2.8 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3839 tatC -7.1 -16.5 TatABCE protein translocation system subunit (NCBI) compare
b3621 rfaC -7.0 -4.9 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3052 rfaE -7.0 -9.5 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3619 rfaD -6.9 -4.8 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0740 tolB -6.8 -4.7 translocation protein TolB precursor (NCBI) compare
b0737 tolQ -6.4 -4.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0741 pal -6.2 -8.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0739 tolA -6.1 -4.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0688 pgm -6.1 -7.3 phosphoglucomutase (NCBI) compare
b3613 yibP -6.0 -4.2 putative membrane protein (VIMSS) compare
b1236 galU -6.0 -9.1 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3620 rfaF -5.7 -15.6 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0738 tolR -5.6 -3.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4042 dgkA -5.5 -4.8 diacylglycerol kinase (NCBI) compare
b1192 ldcA -5.4 -5.6 L,D-carboxypeptidase A (NCBI) compare
b1677 lpp -5.3 -3.8 murein lipoprotein (NCBI) compare
b1882 cheY -5.1 -1.0 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0200 gmhB -5.1 -2.7 hypothetical protein (NCBI) compare
b3631 rfaG -4.9 -25.8 glucosyltransferase I (NCBI) compare
b1860 ruvB -4.6 -1.9 Holliday junction DNA helicase B (NCBI) compare
b3741 gidA -4.2 -11.1 glucose-inhibited division protein A (NCBI) compare
b2699 recA -4.2 -2.5 recombinase A (NCBI) compare
b3811 xerC -4.1 -2.9 site-specific tyrosine recombinase XerC (NCBI) compare
b3816 corA -4.1 -15.1 magnesium/nickel/cobalt transporter (NCBI) compare
b0463 acrA -4.1 -12.4 multidrug efflux system (NCBI) compare
b0890 ftsK -4.1 -6.9 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3838 tatB -4.0 -6.9 sec-independent translocase (NCBI) compare
b3405 ompR -4.0 -8.5 osmolarity response regulator (NCBI) compare
b0014 dnaK -3.9 -2.8 molecular chaperone DnaK (NCBI) compare
b2620 smpB -3.8 -2.4 SsrA-binding protein (NCBI) compare
b2017 yefM -3.8 -2.9 orf, hypothetical protein (VIMSS) compare
b3290 trkA -3.8 -5.2 potassium transporter peripheral membrane component (NCBI) compare
b0683 fur -3.5 -2.5 ferric uptake regulator (NCBI) compare
b2330 yfcB -3.5 -3.3 putative adenine-specific methylase (VIMSS) compare
b2894 xerD -3.5 -1.4 site-specific tyrosine recombinase XerD (NCBI) compare
b1175 minD -3.3 -6.4 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b2830 nudH -3.3 -2.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b1830 prc -3.3 -11.8 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0902 pflA -3.3 -8.4 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b2934 cmtB -3.3 -1.2 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b0053 surA -3.2 -7.8 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b4146 yjeK -3.2 -6.5 predicted lysine aminomutase (NCBI) compare
b3261 fis -3.2 -4.8 DNA-binding protein Fis (NCBI) compare
b3628 rfaB -3.1 -15.1 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b3183 obgE -3.1 -2.2 GTPase involved in cell partioning and DNA repair (NCBI) compare
b2158 yeiH -3.1 -12.1 conserved inner membrane protein (NCBI) compare
b4375 prfC -3.0 -10.6 peptide chain release factor 3 (NCBI) compare
b0049 apaH -3.0 -5.8 diadenosinetetraphosphatase (NCBI) compare
b2567 rnc -3.0 -1.3 ribonuclease III (NCBI) compare
b3977 tyrU -3.0 -1.4 tRNA-Tyr (NCBI) compare
b0903 pflB -2.9 -16.0 pyruvate formate lyase I (NCBI) compare
b1130 phoP -2.8 -2.0 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1863 ruvC -2.8 -2.8 Holliday junction resolvase (NCBI) compare
b4177 purA -2.8 -1.9 adenylosuccinate synthetase (NCBI) compare
b0145 dksA -2.8 -4.1 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3082 ygjM -2.8 -3.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2188 yejM -2.8 -11.9 predicted hydrolase, inner membrane (NCBI) compare
b3792 wzxE -2.7 -9.0 O-antigen translocase (NCBI) compare
b4172 hfq -2.7 -1.2 RNA-binding protein Hfq (NCBI) compare
b3229 sspA -2.7 -4.8 stringent starvation protein A (NCBI) compare
b2297 pta -2.7 -1.4 phosphate acetyltransferase (NCBI) compare
b0114 aceE -2.6 -3.9 pyruvate dehydrogenase subunit E1 (NCBI) compare
b4171 miaA -2.5 -4.5 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1241 adhE -2.5 -13.8 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b3706 trmE -2.5 -6.4 tRNA modification GTPase (NCBI) compare
b3627 rfaI -2.4 -11.7 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b3725 pstB -2.4 -2.8 phosphate transporter subunit (NCBI) compare
b0949 uup -2.4 -11.4 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b4155 yjeA -2.4 -1.3 putative lysyl-tRNA synthetase (VIMSS) compare
b2820 recB -2.3 -3.4 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b1334 fnr -2.3 -3.4 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4202 rpsR -2.3 -1.9 30S ribosomal protein S18 (NCBI) compare
b3916 pfkA -2.3 -4.6 6-phosphofructokinase (NCBI) compare
b3863 polA -2.2 -1.9 DNA polymerase I (NCBI) compare
b2501 ppk -2.2 -10.9 polyphosphate kinase (NCBI) compare
b3961 oxyR -2.2 -13.1 DNA-binding transcriptional dual regulator (NCBI) compare
b3933 ftsN -2.1 -7.0 essential cell division protein (NCBI) compare
b2808 gcvA -2.1 -6.0 DNA-binding transcriptional dual regulator (NCBI) compare
b0462 acrB -2.1 -16.1 multidrug efflux system protein (NCBI) compare
b2576 srmB -2.1 -4.3 ATP-dependent RNA helicase (NCBI) compare
b3867 hemN -2.0 -13.7 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b2935 tktA -2.0 -3.9 transketolase 1, thiamin-binding (NCBI) compare
b4179 vacB -1.9 -6.8 putative enzyme (VIMSS) compare
b2822 recC -1.9 -6.4 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b3778 rep -1.9 -9.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1176 minC -1.9 -2.9 septum formation inhibitor (NCBI) compare
b0088 murD -1.9 -2.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0658 ybeX -1.9 -1.8 predicteed ion transport (NCBI) compare
b1861 ruvA -1.9 -1.2 Holliday junction DNA helicase motor protein (NCBI) compare
b3341 rpsG -1.9 -1.2 30S ribosomal protein S7 (NCBI) compare
b2528 iscA -1.8 -2.2 iron-sulfur cluster assembly protein (NCBI) compare
b3726 pstA -1.8 -4.6 phosphate transporter subunit (NCBI) compare
b3781 trxA -1.8 -5.5 thioredoxin 1 (VIMSS) compare
b2318 truA -1.8 -3.6 tRNA pseudouridine synthase A (NCBI) compare
b4025 pgi -1.7 -9.0 glucose-6-phosphate isomerase (NCBI) compare
b3728 pstS -1.7 -5.4 phosphate transporter subunit (NCBI) compare
b3842 rfaH -1.7 -5.6 transcriptional activator RfaH (NCBI) compare
b2476 purC -1.7 -2.7 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b3404 envZ -1.7 -7.9 osmolarity sensor protein (NCBI) compare
b4402 yjjY -1.7 -1.1 hypothetical protein (NCBI) compare
b0630 lipB -1.7 -1.7 protein of lipoate biosynthesis (VIMSS) compare
b1346 ydaQ -1.6 -1.8 orf, hypothetical protein (VIMSS) compare
b3032 cpdA -1.6 -9.2 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b0908 aroA -1.6 -8.7 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b4477 dgoA -1.6 -3.2 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b0149 mrcB -1.6 -11.5 penicillin-binding protein 1b (NCBI) compare
b2287 nuoB -1.6 -3.7 NADH dehydrogenase subunit B (NCBI) compare
b1545 pinQ -1.6 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b0019 nhaA -1.6 -8.8 pH-dependent sodium/proton antiporter (NCBI) compare
b3636 rpmG -1.6 -2.0 50S ribosomal protein L33 (NCBI) compare
b0015 dnaJ -1.6 -7.8 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b3979 thrT -1.6 -0.5 tRNA-Thr (NCBI) compare
b4163 glyV -1.6 -2.1 tRNA-Gly (NCBI) compare
b0161 degP -1.5 -5.6 serine endoprotease (protease Do), membrane-associated (NCBI) compare
b1286 rnb -1.5 -3.1 exoribonuclease II (NCBI) compare
b3836 b3836 -1.5 -2.5 orf, hypothetical protein (VIMSS) compare
b3727 pstC -1.5 -6.9 phosphate transporter subunit (NCBI) compare
b2329 aroC -1.5 -6.1 chorismate synthase (NCBI) compare
b4685 yrbN -1.5 -2.4 expressed protein (RefSeq) compare
b0439 lon -1.5 -5.1 DNA-binding ATP-dependent protease La (NCBI) compare
b2800 fucA -1.5 -6.8 L-fuculose phosphate aldolase (NCBI) compare
b0605 ahpC -1.5 -5.5 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4651 yibW -1.5 -0.6 no description compare
b3198 kdsC -1.5 -3.3 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b1258 yciF -1.5 -1.4 hypothetical protein (NCBI) compare
b4201 priB -1.5 -2.7 primosomal replication protein N (NCBI) compare
b1159 mcrA -1.5 -1.6 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b3162 deaD -1.5 -4.8 inducible ATP-independent RNA helicase (VIMSS) compare
b1040 csgD -1.5 -2.0 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b1123 potD -1.5 -5.9 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b3164 pnp -1.4 -2.4 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2947 gshB -1.4 -3.8 glutathione synthetase (NCBI) compare
b2569 lepA -1.4 -5.1 GTP-binding protein LepA (NCBI) compare
b3652 recG -1.4 -8.1 ATP-dependent DNA helicase (NCBI) compare
b3935 priA -1.4 -2.1 primosome assembly protein PriA (NCBI) compare
b4243 yjgF -1.4 -6.0 orf, hypothetical protein (VIMSS) compare
b0523 purE -1.4 -3.7 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b0726 sucA -1.4 -3.9 alpha-ketoglutarate decarboxylase (NCBI) compare
b1291 sapD -1.4 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4178 yjeB -1.4 -6.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b3612 gpmI -1.4 -10.9 phosphoglyceromutase (NCBI) compare
b0401 brnQ -1.4 -7.8 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b3463 ftsE -1.4 -0.9 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3630 rfaP -1.4 -8.8 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3210 arcB -1.3 -5.5 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b2064 asmA -1.3 -7.2 predicted assembly protein (NCBI) compare
b1476 fdnI -1.3 -1.0 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b2512 yfgL -1.3 -4.7 protein assembly complex, lipoprotein component (NCBI) compare
b1129 phoQ -1.3 -2.4 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b1536 ydeI -1.3 -1.8 hypothetical protein (NCBI) compare
b2450 yffS -1.3 -1.5 CPZ-55 prophage; predicted protein (RefSeq) compare
b3199 yrbK -1.3 -1.5 hypothetical protein (NCBI) compare
b0957 ompA -1.3 -2.3 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2215 ompC -1.2 -6.4 outer membrane porin protein C (NCBI) compare
b1074 flgC -1.2 -1.8 flagellar basal-body rod protein C (NCBI) compare
b3237 argR -1.2 -5.6 arginine repressor (NCBI) compare
b3642 pyrE -1.2 -3.9 orotate phosphoribosyltransferase (NCBI) compare
b1292 sapC -1.2 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0406 tgt -1.2 -4.6 queuine tRNA-ribosyltransferase (NCBI) compare
b0386 proC -1.2 -4.9 pyrroline-5-carboxylate reductase (NCBI) compare
b4203 rplI -1.2 -3.2 50S ribosomal protein L9 (NCBI) compare
b2288 nuoA -1.2 -3.0 NADH dehydrogenase I chain A (VIMSS) compare
b3600 mtlD -1.2 -4.7 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b3138 agaB -1.2 -3.7 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b4322 uxuA -1.2 -7.4 mannonate dehydratase (NCBI) compare
b3649 rpoZ -1.2 -3.4 DNA-directed RNA polymerase subunit omega (NCBI) compare
b2284 nuoF -1.2 -3.7 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b1126 potA -1.2 -6.3 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b4481 rffT -1.1 -4.6 4-alpha-L-fucosyltransferase (NCBI) compare
b0677 nagA -1.1 -4.6 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3787 rffD -1.1 -7.4 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3609 secB -1.1 -2.5 export protein SecB (NCBI) compare
b2579 yfiD -1.1 -1.6 pyruvate formate lyase subunit (NCBI) compare
b0904 focA -1.1 -3.9 formate transporter (NCBI) compare
b3623 rfaK -1.1 -2.3 lipopolysaccharide core biosynthesis (NCBI) compare
b3871 bipA -1.1 -8.1 GTP-binding protein (NCBI) compare
b4577 sgrS -1.1 -1.0 small antisense RNA (NCBI) compare
b0678 nagB -1.1 -4.2 glucosamine-6-phosphate deaminase (NCBI) compare
b2277 nuoM -1.1 -4.7 NADH dehydrogenase subunit M (NCBI) compare
b1095 fabF -1.1 -5.6 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3124 garK -1.1 -5.7 glycerate kinase I (RefSeq) compare
b3930 menA -1.1 -8.8 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3462 ftsX -1.1 -7.2 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3791 rffA -1.1 -5.0 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b0781 moaA -1.0 -5.1 molybdenum cofactor biosynthesis protein A (NCBI) compare
b3658 selC -1.0 -3.5 tRNA-Sec (NCBI) compare
b4596 yciZ -1.0 -1.3 hypothetical protein (RefSeq) compare
b2038 rfbC -1.0 -5.9 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b0472 recR -1.0 -4.8 recombination protein RecR (NCBI) compare
b2156 lysP -1.0 -6.1 lysine transporter (NCBI) compare
b1187 fadR -1.0 -2.6 fatty acid metabolism regulator (NCBI) compare
b1062 pyrC -1.0 -6.3 dihydroorotase (NCBI) compare
b3790 rffC -1.0 -3.6 TDP-fucosamine acetyltransferase (RefSeq) compare
b0436 tig -1.0 -4.6 trigger factor (NCBI) compare
b3794 rffM -1.0 -5.5 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare


Specific Phenotypes

For 13 genes in this experiment

For phage Phage_N4 in Escherichia coli BW25113

For phage Phage_N4 across organisms