Experiment set36IT032 for Escherichia coli BW25113

Compare to:

Phage_N4_cage_3_mouse_2_Cecum_40 hr

200 most important genes:

  gene name fitness t score description  
b4053 alr -10.1 -7.0 alanine racemase (NCBI) compare
b3035 tolC -9.0 -8.8 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1855 lpxM -7.6 -8.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0222 lpcA -7.5 -3.7 phosphoheptose isomerase (NCBI) compare
b1850 eda -7.4 -2.4 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3052 rfaE -7.0 -8.3 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3621 rfaC -6.9 -4.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3839 tatC -6.9 -18.7 TatABCE protein translocation system subunit (NCBI) compare
b3341 rpsG -6.9 -2.0 30S ribosomal protein S7 (NCBI) compare
b3619 rfaD -6.8 -4.7 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1192 ldcA -6.7 -5.9 L,D-carboxypeptidase A (NCBI) compare
b1236 galU -6.4 -4.4 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2620 smpB -6.4 -2.1 SsrA-binding protein (NCBI) compare
b0737 tolQ -6.2 -3.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3183 obgE -6.2 -2.1 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0739 tolA -6.0 -4.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3613 yibP -5.9 -4.1 putative membrane protein (VIMSS) compare
b0741 pal -5.9 -7.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b4042 dgkA -5.8 -3.3 diacylglycerol kinase (NCBI) compare
b1863 ruvC -5.6 -2.8 Holliday junction resolvase (NCBI) compare
b0740 tolB -5.6 -9.4 translocation protein TolB precursor (NCBI) compare
b0688 pgm -5.1 -7.3 phosphoglucomutase (NCBI) compare
b3631 rfaG -5.1 -24.7 glucosyltransferase I (NCBI) compare
b0200 gmhB -5.0 -2.4 hypothetical protein (NCBI) compare
b3816 corA -4.9 -13.2 magnesium/nickel/cobalt transporter (NCBI) compare
b0738 tolR -4.8 -6.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2528 iscA -4.7 -2.1 iron-sulfur cluster assembly protein (NCBI) compare
b1860 ruvB -4.5 -1.7 Holliday junction DNA helicase B (NCBI) compare
b0142 folK -4.3 -0.7 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b3620 rfaF -4.2 -9.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3261 fis -4.2 -2.8 DNA-binding protein Fis (NCBI) compare
b1861 ruvA -4.1 -1.5 Holliday junction DNA helicase motor protein (NCBI) compare
b3838 tatB -4.1 -7.1 sec-independent translocase (NCBI) compare
b2699 recA -4.0 -2.1 recombinase A (NCBI) compare
b4402 yjjY -4.0 -1.3 hypothetical protein (NCBI) compare
b3811 xerC -4.0 -2.7 site-specific tyrosine recombinase XerC (NCBI) compare
b3792 wzxE -3.9 -12.0 O-antigen translocase (NCBI) compare
b0630 lipB -3.8 -3.0 protein of lipoate biosynthesis (VIMSS) compare
b3979 thrT -3.7 -0.6 tRNA-Thr (NCBI) compare
b3728 pstS -3.7 -6.6 phosphate transporter subunit (NCBI) compare
b3741 gidA -3.5 -11.3 glucose-inhibited division protein A (NCBI) compare
b0902 pflA -3.5 -7.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0463 acrA -3.5 -10.8 multidrug efflux system (NCBI) compare
b3229 sspA -3.5 -5.4 stringent starvation protein A (NCBI) compare
b4375 prfC -3.5 -9.5 peptide chain release factor 3 (NCBI) compare
b1291 sapD -3.5 -2.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1936 intG -3.4 -1.1 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1677 lpp -3.4 -2.0 murein lipoprotein (NCBI) compare
b0683 fur -3.4 -2.2 ferric uptake regulator (NCBI) compare
b0053 surA -3.4 -7.9 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0890 ftsK -3.4 -10.1 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2894 xerD -3.3 -1.2 site-specific tyrosine recombinase XerD (NCBI) compare
b3706 trmE -3.3 -8.5 tRNA modification GTPase (NCBI) compare
b2820 recB -3.1 -2.1 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b0903 pflB -3.1 -13.6 pyruvate formate lyase I (NCBI) compare
b0439 lon -3.0 -6.7 DNA-binding ATP-dependent protease La (NCBI) compare
b2531 iscR -3.0 -1.9 DNA-binding transcriptional repressor (NCBI) compare
b2158 yeiH -2.9 -8.5 conserved inner membrane protein (NCBI) compare
b1025 ycdT -2.9 -2.5 predicted diguanylate cyclase (NCBI) compare
b1175 minD -2.9 -6.9 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b2567 rnc -2.9 -1.1 ribonuclease III (NCBI) compare
b2846 yqeH -2.8 -0.8 orf, hypothetical protein (VIMSS) compare
b4503 yafF -2.8 -0.9 no description compare
b3405 ompR -2.8 -4.4 osmolarity response regulator (NCBI) compare
b0114 aceE -2.8 -3.4 pyruvate dehydrogenase subunit E1 (NCBI) compare
b2318 truA -2.7 -3.8 tRNA pseudouridine synthase A (NCBI) compare
b1334 fnr -2.7 -2.5 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4177 purA -2.7 -1.9 adenylosuccinate synthetase (NCBI) compare
b1129 phoQ -2.7 -1.8 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b1176 minC -2.6 -2.6 septum formation inhibitor (NCBI) compare
b3162 deaD -2.6 -6.2 inducible ATP-independent RNA helicase (VIMSS) compare
b4146 yjeK -2.6 -4.1 predicted lysine aminomutase (NCBI) compare
b2297 pta -2.6 -1.2 phosphate acetyltransferase (NCBI) compare
b3725 pstB -2.6 -1.8 phosphate transporter subunit (NCBI) compare
b1476 fdnI -2.6 -1.1 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b3977 tyrU -2.5 -1.1 tRNA-Tyr (NCBI) compare
b2830 nudH -2.5 -1.6 dinucleoside polyphosphate hydrolase (NCBI) compare
b2935 tktA -2.5 -4.1 transketolase 1, thiamin-binding (NCBI) compare
b0145 dksA -2.5 -3.8 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2188 yejM -2.5 -8.7 predicted hydrolase, inner membrane (NCBI) compare
b3933 ftsN -2.5 -9.9 essential cell division protein (NCBI) compare
b3778 rep -2.5 -8.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3627 rfaI -2.4 -10.9 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b4702 mgtL -2.4 -2.8 regulatory leader peptide for mgtA (NCBI) compare
b3082 ygjM -2.3 -2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b0949 uup -2.3 -6.8 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2569 lepA -2.3 -5.3 GTP-binding protein LepA (NCBI) compare
b3726 pstA -2.3 -6.6 phosphate transporter subunit (NCBI) compare
b1241 adhE -2.3 -9.1 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b2330 yfcB -2.3 -2.1 putative adenine-specific methylase (VIMSS) compare
b3916 pfkA -2.3 -4.9 6-phosphofructokinase (NCBI) compare
b4155 yjeA -2.3 -1.1 putative lysyl-tRNA synthetase (VIMSS) compare
b2822 recC -2.2 -6.8 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b3628 rfaB -2.2 -10.0 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b0658 ybeX -2.2 -1.5 predicteed ion transport (NCBI) compare
b0462 acrB -2.2 -14.3 multidrug efflux system protein (NCBI) compare
b2501 ppk -2.1 -8.4 polyphosphate kinase (NCBI) compare
b3961 oxyR -2.1 -9.9 DNA-binding transcriptional dual regulator (NCBI) compare
b2859 ygeO -2.1 -2.2 hypothetical protein (RefSeq) compare
b3867 hemN -2.1 -10.7 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b3500 gor -2.1 -2.3 glutathione reductase (NCBI) compare
b1830 prc -2.1 -5.8 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0605 ahpC -2.0 -3.6 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b0730 mngR -2.0 -2.3 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b2576 srmB -2.0 -3.1 ATP-dependent RNA helicase (NCBI) compare
b3199 yrbK -2.0 -2.4 hypothetical protein (NCBI) compare
b3836 b3836 -1.9 -3.1 orf, hypothetical protein (VIMSS) compare
b4546 ypeB -1.9 -1.3 hypothetical protein (NCBI) compare
b1130 phoP -1.9 -3.0 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b2808 gcvA -1.8 -3.8 DNA-binding transcriptional dual regulator (NCBI) compare
b0908 aroA -1.8 -7.1 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b3842 rfaH -1.8 -5.1 transcriptional activator RfaH (NCBI) compare
b0401 brnQ -1.8 -7.8 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b4171 miaA -1.8 -3.5 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b4202 rpsR -1.8 -1.6 30S ribosomal protein S18 (NCBI) compare
b1292 sapC -1.8 -3.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3863 polA -1.8 -1.3 DNA polymerase I (NCBI) compare
b2038 rfbC -1.7 -7.0 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b4179 vacB -1.7 -5.3 putative enzyme (VIMSS) compare
b1160 elbA -1.7 -1.2 hypothetical protein (NCBI) compare
b3210 arcB -1.7 -5.6 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b1269 rluB -1.7 -3.7 23S rRNA pseudouridylate synthase (NCBI) compare
b4203 rplI -1.7 -4.0 50S ribosomal protein L9 (NCBI) compare
b0088 murD -1.7 -2.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b3462 ftsX -1.7 -8.4 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3237 argR -1.6 -3.7 arginine repressor (NCBI) compare
b0746 valZ -1.6 -2.2 tRNA-Val (NCBI) compare
b3652 recG -1.6 -7.0 ATP-dependent DNA helicase (NCBI) compare
b2652 ileY -1.6 -0.9 tRNA-Ile (NCBI) compare
b0759 galE -1.6 -5.5 UDP-galactose-4-epimerase (VIMSS) compare
b1126 potA -1.6 -5.1 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b3386 rpe -1.6 -1.9 ribulose-phosphate 3-epimerase (NCBI) compare
b2476 purC -1.5 -2.8 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b4477 dgoA -1.5 -2.9 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b1545 pinQ -1.5 -0.2 Qin prophage; predicted site-specific recombinase (NCBI) compare
b3857 mobA -1.5 -6.8 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b1332 ynaJ -1.5 -0.6 predicted inner membrane protein (NCBI) compare
b3636 rpmG -1.5 -2.3 50S ribosomal protein L33 (NCBI) compare
b0523 purE -1.5 -4.0 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b1124 potC -1.4 -4.9 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1691 ydiN -1.4 -3.8 predicted transporter (RefSeq) compare
b3612 gpmI -1.4 -10.0 phosphoglyceromutase (NCBI) compare
b0406 tgt -1.4 -3.6 queuine tRNA-ribosyltransferase (NCBI) compare
b0149 mrcB -1.4 -8.8 penicillin-binding protein 1b (NCBI) compare
b4651 yibW -1.4 -0.5 no description compare
b2446 yffO -1.4 -1.7 CPZ-55 prophage; predicted protein (NCBI) compare
b1290 sapF -1.4 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3032 cpdA -1.4 -6.8 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b3600 mtlD -1.4 -5.1 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b3164 pnp -1.4 -2.5 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4066 yjcF -1.4 -0.5 hypothetical protein (NCBI) compare
b4025 pgi -1.4 -7.3 glucose-6-phosphate isomerase (NCBI) compare
b2157 yeiE -1.4 -3.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b0009 mog -1.4 -7.6 molybdenum cofactor biosynthesis protein (NCBI) compare
b1676 pykF -1.3 -2.8 pyruvate kinase (NCBI) compare
b2329 aroC -1.3 -3.7 chorismate synthase (NCBI) compare
b1125 potB -1.3 -2.3 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b2040 rfbD -1.3 -7.7 dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase (NCBI) compare
b1123 potD -1.3 -4.5 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b3871 bipA -1.3 -7.5 GTP-binding protein (NCBI) compare
b2163 yeiL -1.3 -3.6 putative transcriptional regulator (VIMSS) compare
b3463 ftsE -1.3 -0.9 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0484 copA -1.3 -8.6 copper transporter (NCBI) compare
b4685 yrbN -1.3 -1.8 expressed protein (RefSeq) compare
b1007 b1007 -1.3 -1.3 orf, hypothetical protein (VIMSS) compare
b1095 fabF -1.3 -4.6 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0015 dnaJ -1.3 -6.2 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b3226 yhcK -1.3 -4.7 putative FADA-type transcriptional regulator (VIMSS) compare
b3609 secB -1.3 -4.6 export protein SecB (NCBI) compare
b3260 dusB -1.3 -3.9 tRNA-dihydrouridine synthase B (NCBI) compare
b3404 envZ -1.3 -5.9 osmolarity sensor protein (NCBI) compare
b1921 fliZ -1.2 -2.1 orf, hypothetical protein (VIMSS) compare
b2314 dedD -1.2 -2.9 putative lipoprotein (VIMSS) compare
b0785 moaE -1.2 -3.8 molybdopterin synthase, large subunit (NCBI) compare
b4178 yjeB -1.2 -3.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2156 lysP -1.2 -5.6 lysine transporter (NCBI) compare
b4322 uxuA -1.2 -5.6 mannonate dehydratase (NCBI) compare
b2564 pdxJ -1.2 -2.8 pyridoxal phosphate biosynthetic protein (NCBI) compare
b4458 oxyS -1.2 -1.3 global regulatory RNA (NCBI) compare
b2444 yffM -1.2 -1.9 CPZ-55 prophage; predicted protein (NCBI) compare
b0019 nhaA -1.2 -5.5 pH-dependent sodium/proton antiporter (NCBI) compare
b2948 yqgE -1.2 -2.0 orf, hypothetical protein (VIMSS) compare
b1304 pspA -1.2 -2.9 regulatory protein for phage-shock-protein operon (NCBI) compare
b0678 nagB -1.2 -4.2 glucosamine-6-phosphate deaminase (NCBI) compare
b2136 yohD -1.2 -2.7 orf, hypothetical protein (VIMSS) compare
b1976 b1976 -1.2 -2.1 orf, hypothetical protein (VIMSS) compare
b1187 fadR -1.2 -2.3 fatty acid metabolism regulator (NCBI) compare
b3629 rfaS -1.2 -2.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4590 ybfK -1.2 -1.4 hypothetical protein (RefSeq) compare
b2892 recJ -1.2 -6.5 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b3624 rfaZ -1.2 -2.9 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2284 nuoF -1.2 -4.1 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0049 apaH -1.2 -2.7 diadenosinetetraphosphatase (NCBI) compare
b3930 menA -1.2 -8.0 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b0407 yajC -1.1 -2.6 preprotein translocase subunit YajC (NCBI) compare
b3781 trxA -1.1 -2.7 thioredoxin 1 (VIMSS) compare
b1048 mdoG -1.1 -4.1 glucan biosynthesis protein, periplasmic (NCBI) compare
b2064 asmA -1.1 -5.3 predicted assembly protein (NCBI) compare
b3761 trpT -1.1 -1.2 tRNA-Trp (NCBI) compare
b3623 rfaK -1.1 -2.4 lipopolysaccharide core biosynthesis (NCBI) compare


Specific Phenotypes

For 13 genes in this experiment

For phage Phage_N4 in Escherichia coli BW25113

For phage Phage_N4 across organisms